Martin E Schwab

Summary

Affiliation: University of Zurich
Country: Switzerland

Publications

  1. doi request reprint The sphingolipid receptor S1PR2 is a receptor for Nogo-a repressing synaptic plasticity
    Anissa Kempf
    Brain Research Institute, University of Zurich, and Dept of Health Sciences and Technology, Swiss Federal Institute of Technology, Zurich, Switzerland
    PLoS Biol 12:e1001763. 2014
  2. ncbi request reprint Neuronal repair. Asynchronous therapy restores motor control by rewiring of the rat corticospinal tract after stroke
    A S Wahl
    Department of Health Sciences and Technology, ETH Zurich, Zurich, Switzerland Brain Research Institute, University of Zurich, Zurich, Switzerland
    Science 344:1250-5. 2014
  3. pmc Nogo-a regulates neural precursor migration in the embryonic mouse cortex
    Carole Mathis
    Brain Research Institute, University of Zurich and Department of Biology, ETH Zurich, 8057 Zurich, Switzerland
    Cereb Cortex 20:2380-90. 2010
  4. doi request reprint Functions of Nogo proteins and their receptors in the nervous system
    Martin E Schwab
    University of Zurich and ETH, Zurich, Winterthurerstrasse 190, CH 8057 Zurich, Switzerland
    Nat Rev Neurosci 11:799-811. 2010
  5. doi request reprint Rewiring of hindlimb corticospinal neurons after spinal cord injury
    Arko Ghosh
    Brain Research Institute, University of Zurich and Swiss Federal Institute of Technology Zurich, Zurich, Switzerland
    Nat Neurosci 13:97-104. 2010
  6. ncbi request reprint Systemic deletion of the myelin-associated outgrowth inhibitor Nogo-A improves regenerative and plastic responses after spinal cord injury
    Marjo Simonen
    Brain Research Institute, University of Zurich, CH 8057, Zurich, Switzerland
    Neuron 38:201-11. 2003
  7. ncbi request reprint Synaptic destabilization by neuronal Nogo-A
    Elisabeth M Aloy
    Brain Research Institute, University of Zurich and Department of Biology, Swiss Federal Institute of Technology ETH, Zurich, Winterthurerstrasse 190, Zurich, CH 8057, Switzerland
    Brain Cell Biol 35:137-56. 2006
  8. ncbi request reprint Nogo-A inhibits neurite outgrowth and cell spreading with three discrete regions
    Thomas Oertle
    Brain Research Institute, University of Zurich, and Department of Biology, Swiss Federal Institute of Technology, CH 8057 Zurich, Switzerland
    J Neurosci 23:5393-406. 2003
  9. ncbi request reprint The injured spinal cord spontaneously forms a new intraspinal circuit in adult rats
    Florence M Bareyre
    Department of Neuromorphology, Brain Research Institute, University of Zurich, Switzerland
    Nat Neurosci 7:269-77. 2004
  10. doi request reprint Constraint-induced movement therapy in the adult rat after unilateral corticospinal tract injury
    Irin C Maier
    Brain Research Institute, University of Zurich, and Department of Biology, Swiss Federal Institute of Technology, 8057 Zurich, Switzerland
    J Neurosci 28:9386-403. 2008

Detail Information

Publications68

  1. doi request reprint The sphingolipid receptor S1PR2 is a receptor for Nogo-a repressing synaptic plasticity
    Anissa Kempf
    Brain Research Institute, University of Zurich, and Dept of Health Sciences and Technology, Swiss Federal Institute of Technology, Zurich, Switzerland
    PLoS Biol 12:e1001763. 2014
    ..Elucidating Nogo-A/S1PR2 signaling platforms will provide new insights into regulation of synaptic plasticity. ..
  2. ncbi request reprint Neuronal repair. Asynchronous therapy restores motor control by rewiring of the rat corticospinal tract after stroke
    A S Wahl
    Department of Health Sciences and Technology, ETH Zurich, Zurich, Switzerland Brain Research Institute, University of Zurich, Zurich, Switzerland
    Science 344:1250-5. 2014
    ..Pharmacogenetic experiments identified a subset of corticospinal fibers originating in the intact half of the forebrain, side-switching in the spinal cord to newly innervate the impaired limb and restore skilled motor function. ..
  3. pmc Nogo-a regulates neural precursor migration in the embryonic mouse cortex
    Carole Mathis
    Brain Research Institute, University of Zurich and Department of Biology, ETH Zurich, 8057 Zurich, Switzerland
    Cereb Cortex 20:2380-90. 2010
    ..These findings suggest that Nogo-A and its receptor complex play a role in the interplay of adhesive and repulsive cell interactions in radial migration during cortical development...
  4. doi request reprint Functions of Nogo proteins and their receptors in the nervous system
    Martin E Schwab
    University of Zurich and ETH, Zurich, Winterthurerstrasse 190, CH 8057 Zurich, Switzerland
    Nat Rev Neurosci 11:799-811. 2010
    ..In addition, Nogo proteins interact with various intracellular components and may have roles in the regulation of endoplasmic reticulum (ER) structure, processing of amyloid precursor protein and cell survival...
  5. doi request reprint Rewiring of hindlimb corticospinal neurons after spinal cord injury
    Arko Ghosh
    Brain Research Institute, University of Zurich and Swiss Federal Institute of Technology Zurich, Zurich, Switzerland
    Nat Neurosci 13:97-104. 2010
    ..Therefore, axotomized hindlimb corticospinal neurons can be incorporated into the sensorimotor circuits of the unaffected forelimb...
  6. ncbi request reprint Systemic deletion of the myelin-associated outgrowth inhibitor Nogo-A improves regenerative and plastic responses after spinal cord injury
    Marjo Simonen
    Brain Research Institute, University of Zurich, CH 8057, Zurich, Switzerland
    Neuron 38:201-11. 2003
    ..CST fibers caudal to the lesion-regenerating and/or sprouting from spared intact fibers-were also found to be more frequent in Nogo-A-deficient animals...
  7. ncbi request reprint Synaptic destabilization by neuronal Nogo-A
    Elisabeth M Aloy
    Brain Research Institute, University of Zurich and Department of Biology, Swiss Federal Institute of Technology ETH, Zurich, Winterthurerstrasse 190, Zurich, CH 8057, Switzerland
    Brain Cell Biol 35:137-56. 2006
    ..Our data suggest that neuronal Nogo-A might play a role in the maintenance of inhibitory synapses by modulating the expression of synaptic anchoring molecules...
  8. ncbi request reprint Nogo-A inhibits neurite outgrowth and cell spreading with three discrete regions
    Thomas Oertle
    Brain Research Institute, University of Zurich, and Department of Biology, Swiss Federal Institute of Technology, CH 8057 Zurich, Switzerland
    J Neurosci 23:5393-406. 2003
    ..This suggests that Nogo-A could have a second membrane topology. The two proposed topological variants may have different intracellular as well as extracellular functions...
  9. ncbi request reprint The injured spinal cord spontaneously forms a new intraspinal circuit in adult rats
    Florence M Bareyre
    Department of Neuromorphology, Brain Research Institute, University of Zurich, Switzerland
    Nat Neurosci 7:269-77. 2004
    ..Hence, after incomplete spinal cord injury, spontaneous extensive remodeling occurs, based on axonal sprout formation and removal. Such remodeling may be crucial for rehabilitation in humans...
  10. doi request reprint Constraint-induced movement therapy in the adult rat after unilateral corticospinal tract injury
    Irin C Maier
    Brain Research Institute, University of Zurich, and Department of Biology, Swiss Federal Institute of Technology, 8057 Zurich, Switzerland
    J Neurosci 28:9386-403. 2008
    ....
  11. doi request reprint Neutralization of the membrane protein Nogo-A enhances growth and reactive sprouting in established organotypic hippocampal slice cultures
    Luis M Craveiro
    Brain Research Institute, University of Zurich, Zurich, Switzerland
    Eur J Neurosci 28:1808-24. 2008
    ..Nogo-A may therefore act as a tonic growth suppressor/stabilizer in the adult intact hippocampus...
  12. ncbi request reprint Nogo-A, -B, and -C are found on the cell surface and interact together in many different cell types
    Dana A Dodd
    Brain Research Institute, University of Zurich and Department of Biology, ETH Zurich, CH 8057 Zurich, Switzerland
    J Biol Chem 280:12494-502. 2005
    ..Nogo-A, -B, and -C share a 180-amino acid C-terminal domain with two highly conserved hydrophobic stretches that could form a channel or transporter in the ER and/or on the cell surface...
  13. ncbi request reprint Intrathecally infused antibodies against Nogo-A penetrate the CNS and downregulate the endogenous neurite growth inhibitor Nogo-A
    Oliver Weinmann
    Brain Research Institute, University of Zurich and Department Biology, ETH Zurich, Winterthurerstr 190 8057 Zurich, Switzerland
    Mol Cell Neurosci 32:161-73. 2006
    ..These results demonstrate that antibodies against a CNS cell surface protein reach their antigen through the CSF and can induce its downregulation...
  14. pmc Remodeling of axonal connections contributes to recovery in an animal model of multiple sclerosis
    Martin Kerschensteiner
    Department of Neuromorphology, Brain Research Institute, University of Zurich, Switzerland
    J Exp Med 200:1027-38. 2004
    ..This framework will help to understand the endogenous repair capacity of the CNS and to develop therapeutic strategies to support it...
  15. doi request reprint Infusion of anti-Nogo-A antibodies in adult rats increases growth and synapse related proteins in the absence of behavioral alterations
    Luis M Craveiro
    Brain Research Institute, University of Zurich, Zurich, Switzerland Department of Health Sciences and Technology, ETH Zurich, Zurich, Switzerland
    Exp Neurol 250:52-68. 2013
    ..The data indicate that anti-Nogo-A therapy appears safe in the adult CNS over 4weeks of continuous administration. ..
  16. ncbi request reprint Reorganization of descending motor tracts in the rat spinal cord
    Olivier Raineteau
    Brain Research Institute, University and ETH Zurich, Winterthurerstrasse 190, 8057 Zurich, Switzerland
    Eur J Neurosci 16:1761-71. 2002
    ....
  17. doi request reprint Nogo-A and myelin-associated glycoprotein differently regulate oligodendrocyte maturation and myelin formation
    Vincent Pernet
    Department of Biology, Brain Research Institute, University of Zurich, Swiss Federal Institute of Technology, CH 8057 Zurich, Switzerland
    J Neurosci 28:7435-44. 2008
    ..Together, our results demonstrate that Nogo-A and MAG are differently involved in oligodendrocyte maturation in vivo, and suggest that Nogo-A may influence also remyelination in pathological conditions such as multiple sclerosis...
  18. doi request reprint Differential effects of anti-Nogo-A antibody treatment and treadmill training in rats with incomplete spinal cord injury
    Irin C Maier
    Brain Research Institute, Winterthurerstrasse 190, Zurich, Switzerland
    Brain 132:1426-40. 2009
    ....
  19. doi request reprint Neuronal Nogo-A regulates neurite fasciculation, branching and extension in the developing nervous system
    Marija M Petrinovic
    Brain Research Institute, University of Zurich and Department of Biology, ETH Zurich, Winterthurerstrasse 190, 8057 Zurich, Switzerland
    Development 137:2539-50. 2010
    ..Thus, Nogo-A is a developmental neurite growth regulatory factor with a role as a negative regulator of axon-axon adhesion and growth, and as a facilitator of neurite branching...
  20. doi request reprint Sprouting of brainstem-spinal tracts in response to unilateral motor cortex stroke in mice
    Lukas C Bachmann
    Brain Research Institute, University of Zurich, 8057 Zurich, Switzerland, and Department Health Sciences and Technology, ETH Zurich, 8057 Zurich, Switzerland
    J Neurosci 34:3378-89. 2014
    ....
  21. ncbi request reprint Nogo-A-deficient mice reveal strain-dependent differences in axonal regeneration
    Leda Dimou
    Brain Research Institute, University of Zurich, Department Biology, Swiss Federal Institute of Technology, CH 8057 Zurich, Switzerland
    J Neurosci 26:5591-603. 2006
    ....
  22. doi request reprint Constitutive genetic deletion of the growth regulator Nogo-A induces schizophrenia-related endophenotypes
    Roman Willi
    Brain Research Institute, University of Zurich, Zurich, Switzerland
    J Neurosci 30:556-67. 2010
    ..This study provides the first experimental demonstration that Nogo-A bears neuropsychiatric relevance, and alterations in its expression may be one etiological factor in schizophrenia and related disorders...
  23. ncbi request reprint Rewiring of the corticospinal tract in the adult rat after unilateral stroke and anti-Nogo-A therapy
    Nicolas T Lindau
    Brain Research Institute, University of Zurich and Department of Health Science and Technology Swiss Federal Institute of Technology Zurich, Switzerland
    Brain 137:739-56. 2014
    ....
  24. ncbi request reprint Long-lasting sprouting and gene expression changes induced by the monoclonal antibody IN-1 in the adult spinal cord
    Florence M Bareyre
    Brain Research Institute, Department of Biology, University of Zurich, ETH Zurich, 8057 Zurich, Switzerland
    J Neurosci 22:7097-110. 2002
    ..These gene expression changes may contribute to attraction, guidance, and stabilization of sprouting CST fibers...
  25. pmc Neuronal Nogo-A modulates growth cone motility via Rho-GTP/LIMK1/cofilin in the unlesioned adult nervous system
    Laura Montani
    Brain Research Institute and Functional Genomics Center, University of Zurich, Switzerland
    J Biol Chem 284:10793-807. 2009
    ..Our study suggests that in the unlesioned adult nervous system, neuronal Nogo-A can restrict neuronal growth through negative modulation of growth cone motility...
  26. doi request reprint Nogo-A antibodies and training reduce muscle spasms in spinal cord-injured rats
    Roman R Gonzenbach
    Brain Research Institute, University of Zurich, Winterthurerstrasse 190, Zurich, Switzerland
    Ann Neurol 68:48-57. 2010
    ....
  27. pmc Pincher-generated Nogo-A endosomes mediate growth cone collapse and retrograde signaling
    Armela Joset
    Brain Research Institute, University of Zurich, Zurich, Switzerland
    J Cell Biol 188:271-85. 2010
    ..Thus, Pincher-dependent macroendocytosis leads to the formation of Nogo-A signaling endosomes, which act both within growth cones and after retrograde transport in the cell body to negatively regulate the neuronal growth program...
  28. doi request reprint Tail spasms in rat spinal cord injury: changes in interneuronal connectivity
    Sandra Kapitza
    Brain Research Institute, University and ETH Zurich, Winterthurerstrasse 190, 8057 Zurich, Switzerland
    Exp Neurol 236:179-89. 2012
    ....
  29. ncbi request reprint Behavioral testing strategies in a localized animal model of multiple sclerosis
    Bigna S Buddeberg
    Brain Research Institute, University of Zurich and Department Biology Swiss Federal Institute of Technology, Winterthurerstrasse 190, CH 8057, Zurich, Switzerland
    J Neuroimmunol 153:158-70. 2004
    ..Such refined behavioral testing in EAE will be crucial for the analysis of new therapeutic approaches for MS that seek to improve or prevent neurological impairment...
  30. ncbi request reprint Profiling locomotor recovery: comprehensive quantification of impairments after CNS damage in rodents
    Björn Zörner
    Brain Research Institute, University and ETH Zurich, Zurich, Switzerland
    Nat Methods 7:701-8. 2010
    ..Our testing and analysis method enables comprehensive assessment of locomotor function in rodents and has broad application in various fields of life science research...
  31. ncbi request reprint Nogo-A antibody improves regeneration and locomotion of spinal cord-injured rats
    Thomas Liebscher
    University and ETH Zurich, Brain Research Institute, Zurich, Switzerland
    Ann Neurol 58:706-19. 2005
    ....
  32. doi request reprint Delayed anti-nogo-a antibody application after spinal cord injury shows progressive loss of responsiveness
    Roman R Gonzenbach
    Universitatsspital Zurich, Neurologische Klinik, Zurich, Switzerland
    J Neurotrauma 29:567-78. 2012
    ..These results show that the time frame for treatment of spinal cord lesions with anti-Nogo-A antibodies is restricted to less than 2 weeks in adult rodents...
  33. ncbi request reprint Electromyographic activity associated with spontaneous functional recovery after spinal cord injury in rats
    Sibille Kaegi
    Brain Research Institute, University of Zurich and Department of Biology ETH Zurich, 8057 Zurich, Switzerland
    Eur J Neurosci 16:249-58. 2002
    ..Activity overlap between flexor and extensor muscles might be directly caused by altered descending input or by maladaptation of central pattern generating networks and/or sensory feedback...
  34. pmc Targeting experimental autoimmune encephalomyelitis lesions to a predetermined axonal tract system allows for refined behavioral testing in an animal model of multiple sclerosis
    Martin Kerschensteiner
    Brain Research Institute, University of Zurich, and the Department of Biology, Swiss Federal Institute of Technology, Zurich, Switzerland
    Am J Pathol 164:1455-69. 2004
    ..We believe that this targeted EAE model will become a helpful new tool for the evaluation of therapeutic approaches for MS that attempt to protect axons or support their repair...
  35. doi request reprint Lamina-specific restoration of serotonergic projections after Nogo-A antibody treatment of spinal cord injury in rats
    Angela Müllner
    Brain Research Institute, University of Zurich, Winterthurerstrasse 190, CH 8057 Zurich, Switzerland
    Eur J Neurosci 27:326-33. 2008
    ..This appropriate restitution of the serotonergic innervation below the lesion site probably contributes to the impressive recovery of motor function...
  36. ncbi request reprint Motor deficits and recovery in rats with unilateral spinal cord hemisection mimic the Brown-Sequard syndrome
    Linard Filli
    Brain Research Institute, University and ETH Zurich, Winterthurerstrasse 190, 8057 Zurich, Switzerland
    Brain 134:2261-73. 2011
    ..Understanding these differences may help to develop future therapeutic strategies to improve upper and lower limb function in patients with incomplete cervical spinal cord injuries...
  37. pmc Synthetic microRNA-mediated downregulation of Nogo-A in transgenic rats reveals its role as regulator of synaptic plasticity and cognitive function
    Björn Tews
    Brain Research Institute, University of Zürich and Department of Health Sciences and Technology, Eidgenössiche Technische Hochschule, Switzerland, 8057 Zurich, Switzerland
    Proc Natl Acad Sci U S A 110:6583-8. 2013
    ..This fast and efficient microRNA-mediated knockdown provides a way to silence gene expression in vivo in transgenic rats and shows a role of Nogo-A in regulating higher cognitive brain functions...
  38. doi request reprint Nogo-A represses anatomical and synaptic plasticity in the central nervous system
    Anissa Kempf
    Brain Research Institute, University of Zurich, Switzerland
    Physiology (Bethesda) 28:151-63. 2013
    ..This review summarizes current knowledge on how myelin and neuronal Nogo-A and its receptors exert physiological functions ranging from the regulation of growth suppression to synaptic plasticity in the developing and adult intact CNS...
  39. doi request reprint Functional and anatomical reorganization of the sensory-motor cortex after incomplete spinal cord injury in adult rats
    Arko Ghosh
    Brain Research Institute and Institute for Biomedical Engineering, University of Zurich and Swiss Federal Institute of Technology Zurich, 8057 Zurich, Switzerland
    J Neurosci 29:12210-9. 2009
    ..Our results demonstrate profound reorganizations of the intact sensory-motor cortex after unilateral spinal cord injury. These changes may contribute to the behavioral adaptations, notably for the recovery of the ipsilesional hindlimb...
  40. pmc Neuronal Nogo-A negatively regulates dendritic morphology and synaptic transmission in the cerebellum
    Marija M Petrinovic
    Brain Research Institute, University of Zurich, 8057 Zurich, Switzerland
    Proc Natl Acad Sci U S A 110:1083-8. 2013
    ..Thus, Nogo-A appears as a negative regulator of PC input synapses, which orchestrates cerebellar connectivity through regulation of synapse morphology and the size of the PC dendritic tree...
  41. ncbi request reprint Repair of the injured spinal cord. A joint approach of basic and clinical research
    Anita D Buchli
    Brain Research Institute, University and ETH Zurich, Zurich, Switzerland
    Neurodegener Dis 4:51-6. 2007
    ....
  42. ncbi request reprint Inhibition of Nogo: a key strategy to increase regeneration, plasticity and functional recovery of the lesioned central nervous system
    Anita D Buchli
    Brain Research Institute, University of Zurich and Department of Biology, Swiss Federal Institute of Technology Zurich, Winterthurerstrasse 190, CH 8057 Zurich, Switzerland
    Ann Med 37:556-67. 2005
    ....
  43. ncbi request reprint Rapid induction of autoantibodies against Nogo-A and MOG in the absence of an encephalitogenic T cell response: implication for immunotherapeutic approaches in neurological diseases
    Doron Merkler
    Brain Research Institute, University of Zurich and Department of Biology, Swiss Federal Institute of Technology Zurich, CH 8057 Zurich, Switzerland
    FASEB J 17:2275-7. 2003
    ..Our findings have critical implications for future strategies in the development of safe and efficient therapeutic vaccines for neurological diseases...
  44. pmc Combined delivery of Nogo-A antibody, neurotrophin-3 and the NMDA-NR2d subunit establishes a functional 'detour' in the hemisected spinal cord
    Lisa Schnell
    Brain Research Institute, University and ETH of Zurich, Zurich, Switzerland
    Eur J Neurosci 34:1256-67. 2011
    ..This novel combination treatment may help to improve function of the damaged spinal cord...
  45. ncbi request reprint Deep brain stimulation of the midbrain locomotor region improves paretic hindlimb function after spinal cord injury in rats
    Lukas C Bachmann
    Brain Research Institute, University of Zurich, 8057 Zurich, Switzerland
    Sci Transl Med 5:208ra146. 2013
    ..We propose that therapeutic MLR DBS using the brain's own motor command circuits may offer a potential new approach to treat persistent gait disturbances in patients suffering from chronic incomplete spinal cord injury. ..
  46. pmc Nogo-A expressed in Schwann cells impairs axonal regeneration after peripheral nerve injury
    Caroline Pot
    Brain Research Institute, University of Zurich, and Department of Biology, Swiss Federal Institute of Technology Zurich, CH 8057 Zurich, Switzerland
    J Cell Biol 159:29-35. 2002
    ..Nogo-A thus overrides the growth-permissive and -promoting effects of the lesioned peripheral nerve, demonstrating its in vivo potency as an inhibitor of axonal regeneration...
  47. ncbi request reprint Inflammation, degeneration and regeneration in the injured spinal cord: insights from DNA microarrays
    Florence M Bareyre
    Brain Research Institute, University of Zurich, Winterthurerstrasse 190, 8057 Zurich, Switzerland
    Trends Neurosci 26:555-63. 2003
    ..DNA microarrays have the potential to aid discovery of new targets for neuroprotective or restorative therapeutic approaches..
  48. doi request reprint Heterogeneous spine loss in layer 5 cortical neurons after spinal cord injury
    Arko Ghosh
    Brain Research Institute, University of Zurich and Swiss Federal Institute of Technology, ETH, 8057 Zurich, Switzerland
    Cereb Cortex 22:1309-17. 2012
    ..The spine loss may reflect fast rearrangements of cortical circuits after axotomy, for example, by a disconnection of HL cortical neurons from synaptic inputs that no longer provide useful information...
  49. ncbi request reprint A reticular rhapsody: phylogenic evolution and nomenclature of the RTN/Nogo gene family
    Thomas Oertle
    Brain Research Institute, University of Zurich, and Department of Biology, ETH Zurich, 8057 Zurich, Switzerland
    FASEB J 17:1238-47. 2003
    ..These data emphasize on the one hand the universal role of reticulons in the eukaryotic system and on the other hand the acquisition of putative new functions through acquirement of novel amino-terminal exons...
  50. doi request reprint The role of Nogo-A in axonal plasticity, regrowth and repair
    Vincent Pernet
    Brain Research Institute, University of Zürich ETH, Department of Health Sciences and Technology ETH Zürich, Winterthurerstrasse 190, Room 55J34a, 8057 Zurich, Switzerland
    Cell Tissue Res 349:97-104. 2012
    ..Function-blocking anti-Nogo-A antibodies are currently being tested in a clinical trial for improved outcome after spinal cord injury...
  51. ncbi request reprint Genomic structure and functional characterisation of the promoters of human and mouse nogo/rtn4
    Thomas Oertle
    Brain Research Institute, University of Zurich and Department of Biology, Swiss Federal Institute of Technology, Switzerland
    J Mol Biol 325:299-323. 2003
    ..The 5'UTR of Nogo-C harbours a negative control element. These data may help to identify factors that can modulate Nogo transcription, thus offering an alternative approach for Nogo neutralisation...
  52. ncbi request reprint Nogo and its paRTNers
    Thomas Oertle
    Brain Research Institute, University of Zurich and Dept of Biology, ETH Zurich, Winterthurerstrasse 190, Switzerland
    Trends Cell Biol 13:187-94. 2003
    ..Here, we review the taxonomic distribution and tissue expression of RTNs, summarize recent discoveries about RTN localization and membrane topology, and discuss the possible functions of RTNs...
  53. ncbi request reprint Sequential loss of myelin proteins during Wallerian degeneration in the rat spinal cord
    Armin Buss
    Department Biology, ETH Zurich and Brain Research Institute, University of Zurich, Zurich, Switzerland
    Glia 42:424-32. 2003
    ..In contrast, the bulk of myelin destruction is due to phagocytosis known to be slow, prolonged, and inefficient in the CNS. These results may also have implications for future intervention strategies aiming at enhancing CNS regeneration...
  54. doi request reprint Long-distance axonal regeneration induced by CNTF gene transfer is impaired by axonal misguidance in the injured adult optic nerve
    Vincent Pernet
    Brain Research Institute, University of Zurich, and Dept of Health Sciences and Technology, ETH Zurich, Winterthurerstrasse 190, CH 8057 Zurich, Switzerland
    Neurobiol Dis 51:202-13. 2013
    ....
  55. doi request reprint Anti-Nogo-A and training: can one plus one equal three?
    Michelle L Starkey
    Brain Research Institute, University of Zurich, Winterthurerstrasse 190, CH 8057, Zurich, Switzerland
    Exp Neurol 235:53-61. 2012
    ..We then discuss the efforts of rehabilitative training and the potential combination of the two therapies...
  56. doi request reprint Rehabilitative training following unilateral pyramidotomy in adult rats improves forelimb function in a non-task-specific way
    Michelle L Starkey
    Brain Research Institute, University of Zurich and ETH Zurich, Winterthurerstrasse 190, 8057, Zurich, Switzerland
    Exp Neurol 232:81-9. 2011
    ..Anatomically, only single pellet grasping training was associated with enhanced sprouting of the intact corticospinal tract across the cervical spinal cord midline to innervate the denervated side of the spinal cord...
  57. ncbi request reprint Repairing the injured spinal cord
    Martin E Schwab
    Brain Research Institute, University of Zurich, and Department of Biology, Swiss Federal Institute of Technology Zurich, Winterthurerstrasse 190, 8057 Zurich, Switzerland
    Science 295:1029-31. 2002
    ..Certain cell, molecular, and bioengineering strategies for repairing the injured spinal cord are showing encouraging results (either alone or in combination) in animal models, with limited recovery of mobility being reported in some cases...
  58. doi request reprint Upregulation of axon guidance molecules in the adult central nervous system of Nogo-A knockout mice restricts neuronal growth and regeneration
    Anissa Kempf
    Department of Health Sciences and Technology, Brain Research Institute, University of Zurich, Swiss Federal Institute of Technology ETH Zurich, Winterthurerstrasse 190, CH 8057, Zurich, Switzerland
    Eur J Neurosci 38:3567-79. 2013
    ..g. the EphrinA3/EphA4 ligand/receptor pair, and support their role in restricting neurite outgrowth in the absence of Nogo-A. ..
  59. ncbi request reprint Patterns of Nogo mRNA and protein expression in the developing and adult rat and after CNS lesions
    Andrea B Huber
    Brain Research Institute, University of Zurich, Zurich, 8057 Switzerland
    J Neurosci 22:3553-67. 2002
    ....
  60. ncbi request reprint Increasing plasticity and functional recovery of the lesioned spinal cord
    Martin E Schwab
    Department of Neuromorphology, Brain Research Institute, University of Zurich, Swiss Federal Institute of Technology, Winterthurerstr 190, 8057 Zurich, Switzerland
    Prog Brain Res 137:351-9. 2002
    ..Enhanced growth is paralleled by various degrees of functional recovery...
  61. ncbi request reprint Do cancer cells die because of Nogo-B?
    Thomas Oertle
    Brain Research Institute, University of Zurich and Department of Biology, ETH Zurich, Switzerland
    Oncogene 22:1390-9. 2003
    ..Our data do not support a function of Nogo-B as a physiological pro-apoptotic protein in certain types of cancer...
  62. doi request reprint Anti-Nogo on the go: from animal models to a clinical trial
    Björn Zörner
    Brain Research Institute, University and ETH Zurich, Zurich, Switzerland
    Ann N Y Acad Sci 1198:E22-34. 2010
    ..A Phase I clinical trial applying anti-Nogo-A antibody to subjects with acute SCI has been successfully conducted and a multicentric, multinational Phase II trial is currently in preparation...
  63. doi request reprint Nogo and Nogo receptor: relevance to schizophrenia?
    Roman Willi
    Brain Research Institute, University of Zurich, Zurich, Switzerland
    Neurobiol Dis 54:150-7. 2013
    ....
  64. pmc Nogo-A is a negative regulator of CNS angiogenesis
    Thomas Wälchli
    Brain Research Institute, University of Zurich, CH 8057 Zurich, Switzerland
    Proc Natl Acad Sci U S A 110:E1943-52. 2013
    ..These findings identify Nogo-A as an important negative regulator of developmental angiogenesis in the CNS. They may have important implications in CNS pathologies involving angiogenesis such as stroke, brain tumors, and retinopathies...
  65. doi request reprint The rocky road to translation in spinal cord repair
    Linard Filli
    Brain Research Institute, University Zurich and Department of Health Sciences and Technology, ETH Zurich, Zurich, Switzerland
    Ann Neurol 72:491-501. 2012
    ..The time has come to translate the biologic-mechanistic knowledge from basic science into efficacious treatments able to improve the conditions of humans suffering from spinal cord injury...
  66. ncbi request reprint Nogo and axon regeneration
    Martin E Schwab
    Brain Research Institute University of Zurich, and Department of Biology, Swiss Federal Institute of Technology, Winterthurerstrasse 190, 8057 Zurich, Switzerland
    Curr Opin Neurobiol 14:118-24. 2004
    ....
  67. pmc Sprouting, regeneration and circuit formation in the injured spinal cord: factors and activity
    Irin C Maier
    Brain Research Institute, University and ETH Zurich, Winterthurerstrasse 190, 8057 Zurich, Switzerland
    Philos Trans R Soc Lond B Biol Sci 361:1611-34. 2006
    ....
  68. doi request reprint Distinct roles of Nogo-a and Nogo receptor 1 in the homeostatic regulation of adult neural stem cell function and neuroblast migration
    Chiara Rolando
    Department of Neuroscience, University of Turin, I 10126 Turin, Italy
    J Neurosci 32:17788-99. 2012
    ..Our findings reveal a new unprecedented function for Nogo-A and NgR1 in the homeostatic regulation of the pace of neurogenesis in the adult mouse SVZ and in the migration of neuroblasts along the RMS...