Research Topics
Genomes and Genes | Philipp SchuetzSummaryAffiliation: University Hospital Country: Switzerland Publications
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Publications
The association of endothelial cell signaling, severity of illness, and organ dysfunction in sepsisNathan I Shapiro
Department of Emergency Medicine, Beth Israel Deaconess Medical Center, 1 Deaconess Road CC2 W, Boston, MA 02215, USA
Crit Care 14:R182. 2010..We investigated the association between biomarkers of endothelial cell activation and sepsis severity, organ dysfunction sequential organ failure assessment (SOFA) score, and death...
Effect of a 14-day course of systemic corticosteroids on the hypothalamic-pituitary-adrenal-axis in patients with acute exacerbation of chronic obstructive pulmonary diseasePhilipp Schuetz
Division of Endocrinology, Diabetes and Clinical Nutrition, University Hospital Basel, Petersgraben 4, CH 4031 Basel, Switzerland
BMC Pulm Med 8:1. 2008....
Predicting mortality with pneumonia severity scores: importance of model recalibration to local settingsP Schuetz
University Hospital Basel, Department of Internal Medicine, Basel, Switzerland
Epidemiol Infect 136:1628-37. 2008....
Prohormones for prediction of adverse medical outcome in community-acquired pneumonia and lower respiratory tract infectionsPhilipp Schuetz
Department of Internal Medicine, Division of Endocrinology, Diabetes and Clinical Nutrition, University Hospital Basel, Petersgraben 4, 4031 Basel, Switzerland
Crit Care 14:R106. 2010..Measurement of prohormones representing different pathophysiological pathways could enhance risk stratification in patients with community-acquired pneumonia (CAP) and other lower respiratory tract infections (LRTI)...
Circulating precursor levels of endothelin-1 and adrenomedullin, two endothelium-derived, counteracting substances, in sepsisPhilipp Schuetz
Department of Internal Medicine, University Hospital Basel, Switzerland
Endothelium 14:345-51. 2007..The ratio of the two counteracting peptides correlates with mortality and shows a prognostic accuracy to predict adverse outcome comparable to the APACHE II score...
Procalcitonin for guidance of antibiotic therapyPhilipp Schuetz
Harvard School of Public Health, MA, USA
Expert Rev Anti Infect Ther 8:575-87. 2010..This review aims to provide physicians with an overview of the strengths and limitations of procalcitonin guidance for antibiotic therapy when used in different clinical settings and in patients with different underlying infections...
Guidance of antibiotic therapy with procalcitonin in lower respiratory tract infections: insights into the ProHOSP studyPhilipp Schuetz
Department of Internal Medicine, Division of Endocrinology, Diabetes and Clinical Nutrition, University Hospital Basel, Basel, Switzerland
Virulence 1:88-92. 2010..In lower respiratory tract infections, PCT guidance had a differential effect on antibiotic exposure depending on the underlying type and severity of respiratory tract infection...
Procalcitonin guided antibiotic therapy and hospitalization in patients with lower respiratory tract infections: a prospective, multicenter, randomized controlled trialPhilipp Schuetz
Department of Internal Medicine, Diabetes and Clinical Nutrition, University Hospital Basel, Petersgraben 4, Basel, Switzerland
BMC Health Serv Res 7:102. 2007....
Clostridium perfringens type C isolates rapidly upregulate their toxin production upon contact with host cells: new insights into virulence?Bruce McClane
Department of Microbiology and Molecular Genetics, University of Pittsburgh School of Medicine, Pittsburgh, PA, USA
Virulence 1:97-100. 2010..However, except for some foodborne botulism cases, clostridial diseases are not intoxications involving preformed toxins; rather, these illnesses are true infections involving toxin production by bacteria growing inside the host...
Long-term stability of procalcitonin in frozen samples and comparison of Kryptor and VIDAS automated immunoassaysPhilipp Schuetz
Department of Internal Medicine, University Hospital Basel, Basel, Switzerland
Clin Biochem 43:341-4. 2010..To assess long-term stability of PCT in deep-frozen samples and assess whether Kryptor procalcitonin cutoff ranges can be transferred on the bioMérieux VIDAS system...
Endothelin-1 precursor peptides correlate with severity of disease and outcome in patients with community acquired pneumoniaPhilipp Schuetz
Department of Internal Medicine, University Hospital Basel, Switzerland
BMC Infect Dis 8:22. 2008..The objective of this study was to assess the diagnostic and prognostic value of proET-1 in a prospective cohort of mainly septic patients with community-acquired pneumonia...
Procalcitonin-guided antibiotic use vs a standard approach for acute respiratory tract infections in primary careMatthias Briel
Department of Internal Medicine, University Hospital Basel, Petersgraben 4, 4031 Basel, Switzerland
Arch Intern Med 168:2000-7; discussion 2007-8. 2008..We consider whether antibiotic therapy guided by procalcitonin reduces the use of antibiotics without increasing the restrictions experienced by patients by more than 1 day...
Effect of procalcitonin-based guidelines vs standard guidelines on antibiotic use in lower respiratory tract infections: the ProHOSP randomized controlled trialPhilipp Schuetz
Department of Internal Medicine, Kantonsspital Aarau, Tellstrasse, CH 5001 Aarau, Switzerland
JAMA 302:1059-66. 2009..In previous smaller trials, a procalcitonin (PCT) algorithm reduced antibiotic use in patients with lower respiratory tract infections (LRTIs)...
Procalcitonin levels predict bacteremia in patients with community-acquired pneumonia: a prospective cohort trialFabian Müller
Department of Internal Medicine, Division of Endocrinology, Diabetes and Clinical Nutrition, University Hospital Basel, Basel, Switzerland
Chest 138:121-9. 2010..However, the yield of true-positive results is low. We investigated the benefit of procalcitonin (PCT) on hospital admission to predict blood culture positivity in CAP...
A combined cardiorenal assessment for the prediction of acute kidney injury in lower respiratory tract infectionsTobias Breidthardt
Department of Internal Medicine, University Hospital, Basel, Switzerland
Am J Med 125:168-75. 2012..The accurate prediction of acute kidney injury (AKI) is an unmet clinical need. A combined assessment of cardiac stress and renal tubular damage might improve early AKI detection...
Procalcitonin to initiate or discontinue antibiotics in acute respiratory tract infectionsPhilipp Schuetz
Department of Emergency Medicine, Harvard School of Public Health, Boston, MA, USA
Cochrane Database Syst Rev 9:CD007498. 2012....
Procalcitonin algorithms for antibiotic therapy decisions: a systematic review of randomized controlled trials and recommendations for clinical algorithmsPhilipp Schuetz
Department of Emergency Medicine, Harvard School of Public Health, Boston, MA 02115, USA
Arch Intern Med 171:1322-31. 2011..We propose specific procalcitonin algorithms for low-, moderate-, and high-acuity patients as a basis for future trials aiming at reducing antibiotic overconsumption...
Midregional pro-atrial natriuretic peptide and outcome in patients with acute ischemic strokeMira Katan
Department of Endocrinology, University Hospital Basel, Basel, Switzerland
J Am Coll Cardiol 56:1045-53. 2010..The purpose of this study was to examine the prognostic value of midregional pro-atrial natriuretic peptide (MR-proANP) in patients with acute ischemic stroke...
Procalcitonin-guided antibiotic use versus a standard approach for acute respiratory tract infections in primary care: study protocol for a randomised controlled trial and baseline characteristics of participating general practitioners [ISRCTN73182671]Matthias Briel
Basel Institute for Clinical Epidemiology, University Hospital Basel, CH 4031 Basel, Switzerland
BMC Fam Pract 6:34. 2005..The aim of this trial is to compare a ProCT-guided antibiotic therapy with a standard approach based on evidence-based guidelines for patients with ARTI in primary care...
Mannose-binding lectin deficiency is associated with smaller infarction size and favorable outcome in ischemic stroke patientsMichael Osthoff
Laboratory of Clinical Immunology, Department of Biomedicine and Clinic for Internal Medicine, University Hospital Basel, Basel, Switzerland
PLoS ONE 6:e21338. 2011....
Circulating levels of GH predict mortality and complement prognostic scores in critically ill medical patientsPhilipp Schuetz
Division of Endocrinology, Diabetes and Clinical Nutrition, Department of Internal Medicine, Diabetes and Clinical Nutrition, University Hospital Basel, Basel, Switzerland
Eur J Endocrinol 160:157-63. 2009..We assessed the prognostic implications of GH on admission and during follow-up in critically ill adult patients admitted to a medical intensive care unit...
Clinical predictors for Legionella in patients presenting with community-acquired pneumonia to the emergency departmentRico Fiumefreddo
Department of Internal Medicine, Kantonsspital Aarau, Tellstrasse, CH 5001 Aarau, Switzerland
BMC Pulm Med 9:4. 2009..Accurate clinical predictors to assess the likelihood of Legionella community-acquired pneumonia (CAP) in patients presenting to the emergency department are lacking...
Procalcitonin and other biomarkers to improve assessment and antibiotic stewardship in infections--hope for hype?Philipp Schuetz
Department of Internal Medicine, University Hospital, Basel, Switzerland
Swiss Med Wkly 139:318-26. 2009..Future intervention studies must prove if these biomarkers indeed improve clinical decision making and thus the overall medical management of patients...
Procalcitonin for diagnosis of infection and guide to antibiotic decisions: past, present and futurePhilipp Schuetz
Harvard School of Public Health, 667 Huntington Ave, 02115 Boston MA, USA
BMC Med 9:107. 2011..The aim of this review is to summarize the current evidence for PCT in different infections and clinical settings, and discuss the reliability of this marker when used with validated diagnostic algorithms...
Quality of care delivered by fee-for-service and DRG hospitals in Switzerland in patients with community-acquired pneumoniaPhilipp Schuetz
Department of Emergency Medicine, Beth Israel Deaconess Medical Center, and Harvard School of Public Health, Boston, MA, USA
Swiss Med Wkly 141:w13228. 2011....
Repeated measurements of endothelin-1 precursor peptides predict the outcome in community-acquired pneumoniaPhilipp Schuetz
Harvard School of Public Health, 677 Huntington Avenue, Boston, MA 02115, USA
Intensive Care Med 37:970-80. 2011..Our aim was to investigate precursor peptides of endothelin-1 (proET1) on admission and during follow-up on days 3, 5 and 7 in a prospective cohort of 925 patients with community-acquired pneumonia...
Dexamethasone suppression test predicts later development of an impaired adrenal function after a 14-day course of prednisone in healthy volunteersStefanie Neidert
Division of Endocrinology, Diabetes and Clinical Nutrition, Department of Internal Medicine, University Hospital Basel, Basel, Switzerland
Eur J Endocrinol 162:943-9. 2010..Identification of patients at risk is of clinical importance. We hypothesized that the dexamethasone suppression test predicts the development of corticosteroid-induced impaired adrenal function...
Do sepsis biomarkers in the emergency room allow transition from bundled sepsis care to personalized patient care?Philipp Schuetz
Department of Internal Medicine, Kantonsspital Aarau, Switzerland
Curr Opin Crit Care 18:341-9. 2012....
MR-pro-atrial natriuretic peptide (MR-proANP) predicts short- and long-term outcomes in respiratory tract infections: a prospective validation studyMiriam Vazquez
Department of Internal Medicine, Division of Endocrinology, Diabetes and Clinical Nutrition, University Hospital Basel, Switzerland
Int J Cardiol 156:16-23. 2012..This study aims to validate these findings and describe patterns of MR-proANP in a large cohort of patients with lower respiratory tract infections...
Which patients with lower respiratory tract infections need inpatient treatment? Perceptions of physicians, nurses, patients and relativesClaudia Baehni
Department of Internal Medicine, University Hospital Basel, Basel, Switzerland
BMC Pulm Med 10:12. 2010..This survey analyzed perceptions of physicians, nurses, patients and relatives about feasibility of outpatient management and required duration of hospital stay...
Prognostic impact of plasma lipids in patients with lower respiratory tract infections - an observational studyMaja Gruber
Clinic of Endocrinology, Diabetology and Clinical Nutrition, University Hospital, Basel, Switzerland
Swiss Med Wkly 139:166-72. 2009..Whether lipids have prognostic implications or could help to differentiate community-acquired pneumonia from other lower respiratory tract infections remains unknown...
Low triiodothyronine syndrome: a prognostic marker for outcome in sepsis?Stefanie Meyer
Department of Internal Medicine, Division of Endocrinology Diabetes and Clinical Nutrition, University Hospital Basel, Basel, Switzerland
Endocrine 39:167-74. 2011..04 and P = 0.02). T3 and fT4 levels on admission were not prognostic in this cohort of critically ill patients. A decrease in fT4 levels in the course of disease, however, may point to adverse outcome...
Copeptin is associated with mortality and outcome in patients with acute intracerebral hemorrhageChristian Zweifel
Department of Neurosurgery, University Hospital of Basel, Spitalstrasse 21, 4031 Basel, Switzerland
BMC Neurol 10:34. 2010..Copeptin, the C-terminal part of provasopressin, has emerged as a new prognostic marker in a variety of diseases, but its prognostic value in ICH is unknown...
Diabetes is not associated with increased mortality in emergency department patients with sepsisPhilipp Schuetz
Department of Emergency Medicine, Beth Israel Deaconess Medical Center, Boston, MA, USA
Ann Emerg Med 58:438-44. 2011..Our aim is to investigate the association of diabetes and initial glucose level with mortality in patients with suspected infection from the ED...
Role of procalcitonin in managing adult patients with respiratory tract infectionsPhilipp Schuetz
Harvard School of Public Health, Department of Medicine, Massachusetts General Hospital, Boston, MA 02115, USA
Chest 141:1063-73. 2012....
The value of serum procalcitonin level for differentiation of infectious from noninfectious causes of fever after orthopaedic surgerySabina Hunziker
Department of Internal Medicine, University Hospital Basel, Petersgraben 4, CH 4031 Basel, Switzerland
J Bone Joint Surg Am 92:138-48. 2010..There are currently no reliable diagnostic markers to differentiate infectious from noninfectious causes of postoperative fever. We investigated the value of the serum procalcitonin level in febrile patients after orthopaedic surgery...
Short versus conventional term glucocorticoid therapy in acute exacerbation of chronic obstructive pulmonary disease - the "REDUCE" trialPhilipp Schuetz
Clinic of Internal Medicine, University Hospital Basel, Switzerland
Swiss Med Wkly 140:w13109. 2010....
Proof of principle: the predisposition, infection, response, organ failure sepsis staging systemMichael D Howell
Pulmonary and Critical Care Division, Department of Medicine, Beth Israel Deaconess Medical Center and Harvard Medical School, Boston, MA, USA
Crit Care Med 39:322-7. 2011..The objective of this investigation was to derive and validate a sepsis staging system based on the PIRO concept that risk stratifies patients with suspected infection...
Procalcitonin-guided antibiotic therapy for chronic obstructive pulmonary disease exacerbationsSofya Tokman
Department of Internal Medicine, University of California, San Francisco, CA, USA
Expert Rev Anti Infect Ther 9:727-35. 2011....
Copeptin: a novel, independent prognostic marker in patients with ischemic strokeMira Katan
Department of Endocrinology, University Hospital Basel, Switzerland
Ann Neurol 66:799-808. 2009..Vasopressin is a stress hormone. Its production rate is mirrored in circulating levels of copeptin, a fragment of provasopressin. We evaluated the prognostic value of copeptin in acute stroke patients...
Biomarkers to improve diagnostic and prognostic accuracy in systemic infectionsPhilipp Schuetz
Department of Internal Medicine, University Hospital Basel, Basel, Switzerland
Curr Opin Crit Care 13:578-85. 2007..We review the advantages and drawbacks of biomarkers in the diagnostic and prognostic assessment of systemic infections...
Dynamics and association of different acute stress markers with performance during a simulated resuscitationSabina Hunziker
Intensive Care Unit, University Hospital Basel and University Basel, Basel, Switzerland
Resuscitation 83:572-8. 2012..Our aim was to compare self-reported, biochemical and physiological stress measures in regard to CPR performance...
Predictors for length of hospital stay in patients with community-acquired Pneumonia: results from a Swiss Multicenter studyIsabelle Suter-Widmer
Department of Internal Medicine, Division of Endocrinology, Diabetes and Metabolism, University Hospital Basel, Basel, Switzerland
BMC Pulm Med 12:21. 2012..Accurate estimation of LOS on admission and during follow-up may result in earlier and more efficient discharge strategies...
The hypothalamic-pituitary-adrenal axis in critical illnessPhilipp Schuetz
Clinic of Endocrinology, Diabetes and Clinical Nutrition, Department of Internal Medicine, University Hospital Basel, Petersgraben 4, Basel CH-4031, Switzerland
Endocrinol Metab Clin North Am 35:823-38, x. 2006..This outline attempts to touch briefly some of the debated issues, stir the discussion, and thereby contribute to resolving the dispute...
Value of arterial blood gas analysis in patients with acute dyspnea: an observational studyEmanuel Burri
Department of Internal Medicine, University Hospital Basel, Petersgraben 4, Basel, Switzerland
Crit Care 15:R145. 2011..The diagnostic and prognostic value of arterial blood gas analysis (ABGA) parameters in unselected patients presenting with acute dyspnea to the Emergency Department (ED) is largely unknown...
Circulating biomarkers as surrogates for bloodstream infectionsBeat Muller
Department of Internal Medicine, University Hospital Basel, Petersgraben 4, CH 4031 Basel, Switzerland
Int J Antimicrob Agents 30:S16-23. 2007..Specific cut-off ranges must be proposed and intervention studies conducted to tackle the existing vicious cycle of diagnostic uncertainty, antibiotic overuse and emerging multi-resistance...
Physiological Achilles tendon length and its relation to tibia lengthClaudio Rosso
Orthopaedic Department, University Hospital Basel, University of Basel, Basel, Switzerland
Clin J Sport Med 22:483-7. 2012..To date, the resting ATL and its relation to tibia length (TL) have never been defined in healthy subjects. We thus performed metric measurements of the ATL and TL...
Blood biomarkers for personalized treatment and patient management decisions in community-acquired pneumoniaPhilipp Schuetz
Medical University Clinic, Department of Internal Medicine, Kantonsspital Aarau, Aarau, Switzerland
Curr Opin Infect Dis 26:159-67. 2013....
Lymphocyte counts in patients with ANCA-associated vasculitisAndreas Holbro
Division of Hematology, University Hospital Basel, 4031, Basel, Switzerland
Rheumatol Int 29:807-10. 2009..By contrast, on a patient-level, variability of lymphocyte counts impedes meaningful interpretation of individual measurements...
Biomarkers in the management of pneumoniaMirjam Christ Crain
University Hospitals, Petersgraben 4, CH 4031 Basel, Switzerland
Expert Rev Respir Med 2:565-72. 2008..Future studies will show whether an assessment with those novel biomarkers is able to guide prognostic decision-making and improve the allocation of healthcare resources and hospitalization costs...
Disruption of a toxin gene by introduction of a foreign gene into the chromosome of Clostridium perfringens using targetron-induced mutagenesisYue Chen
Department of Infectious Diseases and Microbiology, Graduate School of Public Health, University of Pittsburgh, 430 Parran Hall, GSPH, 130 DeSoto Street, Pittsburgh, PA 15261, USA
Plasmid 58:182-9. 2007..Upon oral feeding of the mutant bacteria to mice, intact p27 protein was detected in the lower GI tract. The re-engineered C. perfringens provides a biosafe efficient oral vehicle to deliver antigen to the gastrointestinal tract...
[Procalcitonin - importance for the diagnosis of bacterial infections]Mirjam Christ-Crain
Bereich Innere Medizin, Universitatsspital Basel
Ther Umsch 65:559-68. 2008..Together, Procalcitonin has improved the diagnosis of bacterial infections, however should always be used in context with other laboratory markers, clinical exam and medical history...
Free and total cortisol levels as predictors of severity and outcome in community-acquired pneumoniaMirjam Christ-Crain
Department of Endocrinology, William Harvey Research Institute, Barts and The London, Queen Mary s School of Medicine and Dentistry, London, United Kingdom
Am J Respir Crit Care Med 176:913-20. 2007..Whether FC concentrations better reflect outcome is uncertain. Objectives: To investigate the predictive value of TC and FC in community-acquired pneumonia (CAP)...
Meta-analysis of procalcitonin for sepsis detectionBeat Muller
Lancet Infect Dis 7:498-9; author reply 502-3. 2007
