Philipp Schuetz

Summary

Affiliation: University Hospital
Country: Switzerland

Publications

  1. pmc The association of endothelial cell signaling, severity of illness, and organ dysfunction in sepsis
    Nathan I Shapiro
    Department of Emergency Medicine, Beth Israel Deaconess Medical Center, 1 Deaconess Road CC2 W, Boston, MA 02215, USA
    Crit Care 14:R182. 2010
  2. ncbi request reprint Long-term stability of procalcitonin in frozen samples and comparison of Kryptor and VIDAS automated immunoassays
    Philipp Schuetz
    Department of Internal Medicine, University Hospital Basel, Basel, Switzerland
    Clin Biochem 43:341-4. 2010
  3. ncbi request reprint Procalcitonin for guidance of antibiotic therapy
    Philipp Schuetz
    Harvard School of Public Health, MA, USA
    Expert Rev Anti Infect Ther 8:575-87. 2010
  4. pmc Prohormones for prediction of adverse medical outcome in community-acquired pneumonia and lower respiratory tract infections
    Philipp Schuetz
    Department of Internal Medicine, Division of Endocrinology, Diabetes and Clinical Nutrition, University Hospital Basel, Petersgraben 4, 4031 Basel, Switzerland
    Crit Care 14:R106. 2010
  5. pmc Endothelin-1 precursor peptides correlate with severity of disease and outcome in patients with community acquired pneumonia
    Philipp Schuetz
    Department of Internal Medicine, University Hospital Basel, Switzerland
    BMC Infect Dis 8:22. 2008
  6. pmc Predicting mortality with pneumonia severity scores: importance of model recalibration to local settings
    P Schuetz
    University Hospital Basel, Department of Internal Medicine, Basel, Switzerland
    Epidemiol Infect 136:1628-37. 2008
  7. pmc Effect of a 14-day course of systemic corticosteroids on the hypothalamic-pituitary-adrenal-axis in patients with acute exacerbation of chronic obstructive pulmonary disease
    Philipp Schuetz
    Division of Endocrinology, Diabetes and Clinical Nutrition, University Hospital Basel, Petersgraben 4, CH 4031 Basel, Switzerland
    BMC Pulm Med 8:1. 2008
  8. pmc Circulating precursor levels of endothelin-1 and adrenomedullin, two endothelium-derived, counteracting substances, in sepsis
    Philipp Schuetz
    Department of Internal Medicine, University Hospital Basel, Switzerland
    Endothelium 14:345-51. 2007
  9. pmc Procalcitonin guided antibiotic therapy and hospitalization in patients with lower respiratory tract infections: a prospective, multicenter, randomized controlled trial
    Philipp Schuetz
    Department of Internal Medicine, Diabetes and Clinical Nutrition, University Hospital Basel, Petersgraben 4, Basel, Switzerland
    BMC Health Serv Res 7:102. 2007
  10. pmc Clostridium perfringens type C isolates rapidly upregulate their toxin production upon contact with host cells: new insights into virulence?
    Bruce McClane
    Department of Microbiology and Molecular Genetics, University of Pittsburgh School of Medicine, Pittsburgh, PA, USA
    Virulence 1:97-100. 2010

Detail Information

Publications61

  1. pmc The association of endothelial cell signaling, severity of illness, and organ dysfunction in sepsis
    Nathan I Shapiro
    Department of Emergency Medicine, Beth Israel Deaconess Medical Center, 1 Deaconess Road CC2 W, Boston, MA 02215, USA
    Crit Care 14:R182. 2010
    ..We investigated the association between biomarkers of endothelial cell activation and sepsis severity, organ dysfunction sequential organ failure assessment (SOFA) score, and death...
  2. ncbi request reprint Long-term stability of procalcitonin in frozen samples and comparison of Kryptor and VIDAS automated immunoassays
    Philipp Schuetz
    Department of Internal Medicine, University Hospital Basel, Basel, Switzerland
    Clin Biochem 43:341-4. 2010
    ..To assess long-term stability of PCT in deep-frozen samples and assess whether Kryptor procalcitonin cutoff ranges can be transferred on the bioMérieux VIDAS system...
  3. ncbi request reprint Procalcitonin for guidance of antibiotic therapy
    Philipp Schuetz
    Harvard School of Public Health, MA, USA
    Expert Rev Anti Infect Ther 8:575-87. 2010
    ..This review aims to provide physicians with an overview of the strengths and limitations of procalcitonin guidance for antibiotic therapy when used in different clinical settings and in patients with different underlying infections...
  4. pmc Prohormones for prediction of adverse medical outcome in community-acquired pneumonia and lower respiratory tract infections
    Philipp Schuetz
    Department of Internal Medicine, Division of Endocrinology, Diabetes and Clinical Nutrition, University Hospital Basel, Petersgraben 4, 4031 Basel, Switzerland
    Crit Care 14:R106. 2010
    ..Measurement of prohormones representing different pathophysiological pathways could enhance risk stratification in patients with community-acquired pneumonia (CAP) and other lower respiratory tract infections (LRTI)...
  5. pmc Endothelin-1 precursor peptides correlate with severity of disease and outcome in patients with community acquired pneumonia
    Philipp Schuetz
    Department of Internal Medicine, University Hospital Basel, Switzerland
    BMC Infect Dis 8:22. 2008
    ..The objective of this study was to assess the diagnostic and prognostic value of proET-1 in a prospective cohort of mainly septic patients with community-acquired pneumonia...
  6. pmc Predicting mortality with pneumonia severity scores: importance of model recalibration to local settings
    P Schuetz
    University Hospital Basel, Department of Internal Medicine, Basel, Switzerland
    Epidemiol Infect 136:1628-37. 2008
    ....
  7. pmc Effect of a 14-day course of systemic corticosteroids on the hypothalamic-pituitary-adrenal-axis in patients with acute exacerbation of chronic obstructive pulmonary disease
    Philipp Schuetz
    Division of Endocrinology, Diabetes and Clinical Nutrition, University Hospital Basel, Petersgraben 4, CH 4031 Basel, Switzerland
    BMC Pulm Med 8:1. 2008
    ....
  8. pmc Circulating precursor levels of endothelin-1 and adrenomedullin, two endothelium-derived, counteracting substances, in sepsis
    Philipp Schuetz
    Department of Internal Medicine, University Hospital Basel, Switzerland
    Endothelium 14:345-51. 2007
    ..The ratio of the two counteracting peptides correlates with mortality and shows a prognostic accuracy to predict adverse outcome comparable to the APACHE II score...
  9. pmc Procalcitonin guided antibiotic therapy and hospitalization in patients with lower respiratory tract infections: a prospective, multicenter, randomized controlled trial
    Philipp Schuetz
    Department of Internal Medicine, Diabetes and Clinical Nutrition, University Hospital Basel, Petersgraben 4, Basel, Switzerland
    BMC Health Serv Res 7:102. 2007
    ....
  10. pmc Clostridium perfringens type C isolates rapidly upregulate their toxin production upon contact with host cells: new insights into virulence?
    Bruce McClane
    Department of Microbiology and Molecular Genetics, University of Pittsburgh School of Medicine, Pittsburgh, PA, USA
    Virulence 1:97-100. 2010
    ..However, except for some foodborne botulism cases, clostridial diseases are not intoxications involving preformed toxins; rather, these illnesses are true infections involving toxin production by bacteria growing inside the host...
  11. doi request reprint Guidance of antibiotic therapy with procalcitonin in lower respiratory tract infections: insights into the ProHOSP study
    Philipp Schuetz
    Department of Internal Medicine, Division of Endocrinology, Diabetes and Clinical Nutrition, University Hospital Basel, Basel, Switzerland
    Virulence 1:88-92. 2010
    ..In lower respiratory tract infections, PCT guidance had a differential effect on antibiotic exposure depending on the underlying type and severity of respiratory tract infection...
  12. doi request reprint Procalcitonin-guided antibiotic use vs a standard approach for acute respiratory tract infections in primary care
    Matthias Briel
    Department of Internal Medicine, University Hospital Basel, Petersgraben 4, 4031 Basel, Switzerland
    Arch Intern Med 168:2000-7; discussion 2007-8. 2008
    ..We consider whether antibiotic therapy guided by procalcitonin reduces the use of antibiotics without increasing the restrictions experienced by patients by more than 1 day...
  13. doi request reprint Procalcitonin to initiate or discontinue antibiotics in acute respiratory tract infections
    Philipp Schuetz
    Department of Emergency Medicine, Harvard School of Public Health, Boston, MA 02115, USA
    Evid Based Child Health 8:1297-371. 2013
    ....
  14. doi request reprint Effect of procalcitonin-based guidelines vs standard guidelines on antibiotic use in lower respiratory tract infections: the ProHOSP randomized controlled trial
    Philipp Schuetz
    Department of Internal Medicine, Kantonsspital Aarau, Tellstrasse, CH 5001 Aarau, Switzerland
    JAMA 302:1059-66. 2009
    ..In previous smaller trials, a procalcitonin (PCT) algorithm reduced antibiotic use in patients with lower respiratory tract infections (LRTIs)...
  15. doi request reprint Procalcitonin levels predict bacteremia in patients with community-acquired pneumonia: a prospective cohort trial
    Fabian Müller
    Department of Internal Medicine, Division of Endocrinology, Diabetes and Clinical Nutrition, University Hospital Basel, Basel, Switzerland
    Chest 138:121-9. 2010
    ..However, the yield of true-positive results is low. We investigated the benefit of procalcitonin (PCT) on hospital admission to predict blood culture positivity in CAP...
  16. ncbi request reprint A combined cardiorenal assessment for the prediction of acute kidney injury in lower respiratory tract infections
    Tobias Breidthardt
    Department of Internal Medicine, University Hospital, Basel, Switzerland
    Am J Med 125:168-75. 2012
    ..The accurate prediction of acute kidney injury (AKI) is an unmet clinical need. A combined assessment of cardiac stress and renal tubular damage might improve early AKI detection...
  17. doi request reprint Procalcitonin to initiate or discontinue antibiotics in acute respiratory tract infections
    Philipp Schuetz
    Department of Emergency Medicine, Harvard School of Public Health, Boston, MA, USA
    Cochrane Database Syst Rev 9:CD007498. 2012
    ....
  18. ncbi request reprint Procalcitonin algorithms for antibiotic therapy decisions: a systematic review of randomized controlled trials and recommendations for clinical algorithms
    Philipp Schuetz
    Department of Emergency Medicine, Harvard School of Public Health, Boston, MA 02115, USA
    Arch Intern Med 171:1322-31. 2011
    ..We propose specific procalcitonin algorithms for low-, moderate-, and high-acuity patients as a basis for future trials aiming at reducing antibiotic overconsumption...
  19. doi request reprint Head-to-head comparison of fee-for-service and diagnosis related groups in two tertiary referral hospitals in Switzerland: an observational study
    Noemi Weissenberger
    Division of Internal Medicine, University Hospital Basel, Switzerland
    Swiss Med Wkly 143:w13790. 2013
    ..We compared length of hospital stay (LOS), patient satisfaction and quality of life between the two systems before a nation-wide implementation of DRG...
  20. pmc Predictors for length of hospital stay in patients with community-acquired pneumonia: results from a Swiss multicenter study
    Isabelle Suter-Widmer
    Department of Internal Medicine, Division of Endocrinology, Diabetes and Metabolism, University Hospital Basel, Basel, Switzerland
    BMC Pulm Med 12:21. 2012
    ..Accurate estimation of LOS on admission and during follow-up may result in earlier and more efficient discharge strategies...
  21. doi request reprint Midregional pro-atrial natriuretic peptide and outcome in patients with acute ischemic stroke
    Mira Katan
    Department of Endocrinology, University Hospital Basel, Basel, Switzerland
    J Am Coll Cardiol 56:1045-53. 2010
    ..The purpose of this study was to examine the prognostic value of midregional pro-atrial natriuretic peptide (MR-proANP) in patients with acute ischemic stroke...
  22. pmc Mannose-binding lectin deficiency is associated with smaller infarction size and favorable outcome in ischemic stroke patients
    Michael Osthoff
    Laboratory of Clinical Immunology, Department of Biomedicine and Clinic for Internal Medicine, University Hospital Basel, Basel, Switzerland
    PLoS ONE 6:e21338. 2011
    ....
  23. pmc Procalcitonin-guided antibiotic use versus a standard approach for acute respiratory tract infections in primary care: study protocol for a randomised controlled trial and baseline characteristics of participating general practitioners [ISRCTN73182671]
    Matthias Briel
    Basel Institute for Clinical Epidemiology, University Hospital Basel, CH 4031 Basel, Switzerland
    BMC Fam Pract 6:34. 2005
    ..The aim of this trial is to compare a ProCT-guided antibiotic therapy with a standard approach based on evidence-based guidelines for patients with ARTI in primary care...
  24. doi request reprint Circulating levels of GH predict mortality and complement prognostic scores in critically ill medical patients
    Philipp Schuetz
    Division of Endocrinology, Diabetes and Clinical Nutrition, Department of Internal Medicine, Diabetes and Clinical Nutrition, University Hospital Basel, Basel, Switzerland
    Eur J Endocrinol 160:157-63. 2009
    ..We assessed the prognostic implications of GH on admission and during follow-up in critically ill adult patients admitted to a medical intensive care unit...
  25. pmc Clinical predictors for Legionella in patients presenting with community-acquired pneumonia to the emergency department
    Rico Fiumefreddo
    Department of Internal Medicine, Kantonsspital Aarau, Tellstrasse, CH 5001 Aarau, Switzerland
    BMC Pulm Med 9:4. 2009
    ..Accurate clinical predictors to assess the likelihood of Legionella community-acquired pneumonia (CAP) in patients presenting to the emergency department are lacking...
  26. ncbi request reprint Head-to-head comparison of length of stay, patients' outcome and satisfaction in Switzerland before and after SwissDRG-Implementation in 2012 in 2012: an observational study in two tertiary university centers
    Désirée Thommen
    Division of Internal Medicine, University Hospital Basel, Switzerland
    Swiss Med Wkly 144:w13972. 2014
    ..With the introduction of the new payment system we aim to answer questions raised regarding length of stay as well as patients' outcome and satisfaction...
  27. doi request reprint Quality of care delivered by fee-for-service and DRG hospitals in Switzerland in patients with community-acquired pneumonia
    Philipp Schuetz
    Department of Emergency Medicine, Beth Israel Deaconess Medical Center, and Harvard School of Public Health, Boston, MA, USA
    Swiss Med Wkly 141:w13228. 2011
    ....
  28. doi request reprint Dexamethasone suppression test predicts later development of an impaired adrenal function after a 14-day course of prednisone in healthy volunteers
    Stefanie Neidert
    Division of Endocrinology, Diabetes and Clinical Nutrition, Department of Internal Medicine, University Hospital Basel, Basel, Switzerland
    Eur J Endocrinol 162:943-9. 2010
    ..Identification of patients at risk is of clinical importance. We hypothesized that the dexamethasone suppression test predicts the development of corticosteroid-induced impaired adrenal function...
  29. pmc Procalcitonin for diagnosis of infection and guide to antibiotic decisions: past, present and future
    Philipp Schuetz
    Harvard School of Public Health, 667 Huntington Ave, 02115 Boston MA, USA
    BMC Med 9:107. 2011
    ..The aim of this review is to summarize the current evidence for PCT in different infections and clinical settings, and discuss the reliability of this marker when used with validated diagnostic algorithms...
  30. doi request reprint Procalcitonin and other biomarkers to improve assessment and antibiotic stewardship in infections--hope for hype?
    Philipp Schuetz
    Department of Internal Medicine, University Hospital, Basel, Switzerland
    Swiss Med Wkly 139:318-26. 2009
    ..Future intervention studies must prove if these biomarkers indeed improve clinical decision making and thus the overall medical management of patients...
  31. doi request reprint Repeated measurements of endothelin-1 precursor peptides predict the outcome in community-acquired pneumonia
    Philipp Schuetz
    Harvard School of Public Health, 677 Huntington Avenue, Boston, MA 02115, USA
    Intensive Care Med 37:970-80. 2011
    ..Our aim was to investigate precursor peptides of endothelin-1 (proET1) on admission and during follow-up on days 3, 5 and 7 in a prospective cohort of 925 patients with community-acquired pneumonia...
  32. pmc Association of adrenal function and disease severity in community-acquired pneumonia
    Cornelia Mueller
    Department of Endocrinology, Diabetology and Metabolism, UniversityHospital, Basel, Switzerland
    PLoS ONE 9:e99518. 2014
    ..We herein validated the prognostic value of the adrenal hormones DHEA, DHEA-Sulfate (DHEAS), cortisol/DHEA-, cortisol/DHEAS- and DHEA/DHEAS-ratios in patients with CAP...
  33. ncbi request reprint Blood biomarkers for personalized treatment and patient management decisions in community-acquired pneumonia
    Philipp Schuetz
    Medical University Clinic, Department of Internal Medicine, Kantonsspital Aarau, Aarau, Switzerland
    Curr Opin Infect Dis 26:159-67. 2013
    ....
  34. doi request reprint Do sepsis biomarkers in the emergency room allow transition from bundled sepsis care to personalized patient care?
    Philipp Schuetz
    Department of Internal Medicine, Kantonsspital Aarau, Switzerland
    Curr Opin Crit Care 18:341-9. 2012
    ....
  35. doi request reprint MR-pro-atrial natriuretic peptide (MR-proANP) predicts short- and long-term outcomes in respiratory tract infections: a prospective validation study
    Miriam Vazquez
    Department of Internal Medicine, Division of Endocrinology, Diabetes and Clinical Nutrition, University Hospital Basel, Switzerland
    Int J Cardiol 156:16-23. 2012
    ..This study aims to validate these findings and describe patterns of MR-proANP in a large cohort of patients with lower respiratory tract infections...
  36. pmc Copeptin is associated with mortality and outcome in patients with acute intracerebral hemorrhage
    Christian Zweifel
    Department of Neurosurgery, University Hospital of Basel, Spitalstrasse 21, 4031 Basel, Switzerland
    BMC Neurol 10:34. 2010
    ..Copeptin, the C-terminal part of provasopressin, has emerged as a new prognostic marker in a variety of diseases, but its prognostic value in ICH is unknown...
  37. doi request reprint Prognostic impact of plasma lipids in patients with lower respiratory tract infections - an observational study
    Maja Gruber
    Clinic of Endocrinology, Diabetology and Clinical Nutrition, University Hospital, Basel, Switzerland
    Swiss Med Wkly 139:166-72. 2009
    ..Whether lipids have prognostic implications or could help to differentiate community-acquired pneumonia from other lower respiratory tract infections remains unknown...
  38. doi request reprint Low triiodothyronine syndrome: a prognostic marker for outcome in sepsis?
    Stefanie Meyer
    Department of Internal Medicine, Division of Endocrinology Diabetes and Clinical Nutrition, University Hospital Basel, Basel, Switzerland
    Endocrine 39:167-74. 2011
    ..04 and P = 0.02). T3 and fT4 levels on admission were not prognostic in this cohort of critically ill patients. A decrease in fT4 levels in the course of disease, however, may point to adverse outcome...
  39. pmc Which patients with lower respiratory tract infections need inpatient treatment? Perceptions of physicians, nurses, patients and relatives
    Claudia Baehni
    Department of Internal Medicine, University Hospital Basel, Basel, Switzerland
    BMC Pulm Med 10:12. 2010
    ..This survey analyzed perceptions of physicians, nurses, patients and relatives about feasibility of outpatient management and required duration of hospital stay...
  40. pmc Diabetes is not associated with increased mortality in emergency department patients with sepsis
    Philipp Schuetz
    Department of Emergency Medicine, Beth Israel Deaconess Medical Center, Boston, MA, USA
    Ann Emerg Med 58:438-44. 2011
    ..Our aim is to investigate the association of diabetes and initial glucose level with mortality in patients with suspected infection from the ED...
  41. ncbi request reprint BNP but Not s-cTnln Is Associated with Cardioembolic Aetiology and Predicts Short and Long Term Prognosis after Cerebrovascular Events
    Nicole Nigro
    Department of Endocrinology, University Hospital Basel, Basel, Switzerland Department of Clinical Research, University Hospital Basel, Basel, Switzerland
    PLoS ONE 9:e102704. 2014
    ..We analyzed the prognostic value of b-type natriuretic peptide (BNP) and sensitive cardiac Troponin (s-cTnI) in patients with ischemic stroke or transient ischemic attack (TIA) and their significance in predicting stroke aetiology...
  42. doi request reprint Role of procalcitonin in managing adult patients with respiratory tract infections
    Philipp Schuetz
    Harvard School of Public Health, Department of Medicine, Massachusetts General Hospital, Boston, MA 02115, USA
    Chest 141:1063-73. 2012
    ....
  43. doi request reprint The value of serum procalcitonin level for differentiation of infectious from noninfectious causes of fever after orthopaedic surgery
    Sabina Hunziker
    Department of Internal Medicine, University Hospital Basel, Petersgraben 4, CH 4031 Basel, Switzerland
    J Bone Joint Surg Am 92:138-48. 2010
    ..There are currently no reliable diagnostic markers to differentiate infectious from noninfectious causes of postoperative fever. We investigated the value of the serum procalcitonin level in febrile patients after orthopaedic surgery...
  44. doi request reprint Short versus conventional term glucocorticoid therapy in acute exacerbation of chronic obstructive pulmonary disease - the "REDUCE" trial
    Philipp Schuetz
    Clinic of Internal Medicine, University Hospital Basel, Switzerland
    Swiss Med Wkly 140:w13109. 2010
    ....
  45. doi request reprint Proof of principle: the predisposition, infection, response, organ failure sepsis staging system
    Michael D Howell
    Pulmonary and Critical Care Division, Department of Medicine, Beth Israel Deaconess Medical Center and Harvard Medical School, Boston, MA, USA
    Crit Care Med 39:322-7. 2011
    ..The objective of this investigation was to derive and validate a sepsis staging system based on the PIRO concept that risk stratifies patients with suspected infection...
  46. pmc Corticosteroid treatment for community-acquired pneumonia - the STEP trial: study protocol for a randomized controlled trial
    Claudine A Blum
    Endocrinology, Diabetology and Metabolism, Department of Internal Medicine, University Hospital Basel, Petersgraben 4, 4031 Basel, Switzerland
    Trials 15:257. 2014
    ..Available studies show controversial results, and the question about benefits and harms of adjunct corticosteroid therapy has not been conclusively resolved, particularly in the non-critical care setting...
  47. ncbi request reprint Biomarkers to improve diagnostic and prognostic accuracy in systemic infections
    Philipp Schuetz
    Department of Internal Medicine, University Hospital Basel, Basel, Switzerland
    Curr Opin Crit Care 13:578-85. 2007
    ..We review the advantages and drawbacks of biomarkers in the diagnostic and prognostic assessment of systemic infections...
  48. doi request reprint Copeptin: a novel, independent prognostic marker in patients with ischemic stroke
    Mira Katan
    Department of Endocrinology, University Hospital Basel, Switzerland
    Ann Neurol 66:799-808. 2009
    ..Vasopressin is a stress hormone. Its production rate is mirrored in circulating levels of copeptin, a fragment of provasopressin. We evaluated the prognostic value of copeptin in acute stroke patients...
  49. doi request reprint Procalcitonin-guided antibiotic therapy for chronic obstructive pulmonary disease exacerbations
    Sofya Tokman
    Department of Internal Medicine, University of California, San Francisco, CA, USA
    Expert Rev Anti Infect Ther 9:727-35. 2011
    ....
  50. pmc Procalcitonin guidance to reduce antibiotic treatment of lower respiratory tract infection in children and adolescents (ProPAED): a randomized controlled trial
    Gurli Baer
    Department of Pediatrics, University Basel, Basel, Switzerland
    PLoS ONE 8:e68419. 2013
    ..Antibiotics are overused in children and adolescents with lower respiratory tract infection (LRTI). Serum-procalcitonin (PCT) can be used to guide treatment when bacterial infection is suspected. Its role in pediatric LRTI is unclear...
  51. ncbi request reprint The hypothalamic-pituitary-adrenal axis in critical illness
    Philipp Schuetz
    Clinic of Endocrinology, Diabetes and Clinical Nutrition, Department of Internal Medicine, University Hospital Basel, Petersgraben 4, Basel CH 4031, Switzerland
    Endocrinol Metab Clin North Am 35:823-38, x. 2006
    ..This outline attempts to touch briefly some of the debated issues, stir the discussion, and thereby contribute to resolving the dispute...
  52. doi request reprint Dynamics and association of different acute stress markers with performance during a simulated resuscitation
    Sabina Hunziker
    Intensive Care Unit, University Hospital Basel and University Basel, Basel, Switzerland
    Resuscitation 83:572-8. 2012
    ..Our aim was to compare self-reported, biochemical and physiological stress measures in regard to CPR performance...
  53. ncbi request reprint Circulating biomarkers as surrogates for bloodstream infections
    Beat Muller
    Department of Internal Medicine, University Hospital Basel, Petersgraben 4, CH 4031 Basel, Switzerland
    Int J Antimicrob Agents 30:S16-23. 2007
    ..Specific cut-off ranges must be proposed and intervention studies conducted to tackle the existing vicious cycle of diagnostic uncertainty, antibiotic overuse and emerging multi-resistance...
  54. pmc Value of arterial blood gas analysis in patients with acute dyspnea: an observational study
    Emanuel Burri
    Department of Internal Medicine, University Hospital Basel, Petersgraben 4, Basel, Switzerland
    Crit Care 15:R145. 2011
    ..The diagnostic and prognostic value of arterial blood gas analysis (ABGA) parameters in unselected patients presenting with acute dyspnea to the Emergency Department (ED) is largely unknown...
  55. doi request reprint Physiological Achilles tendon length and its relation to tibia length
    Claudio Rosso
    Orthopaedic Department, University Hospital Basel, University of Basel, Basel, Switzerland
    Clin J Sport Med 22:483-7. 2012
    ..To date, the resting ATL and its relation to tibia length (TL) have never been defined in healthy subjects. We thus performed metric measurements of the ATL and TL...
  56. doi request reprint Lymphocyte counts in patients with ANCA-associated vasculitis
    Andreas Holbro
    Division of Hematology, University Hospital Basel, 4031, Basel, Switzerland
    Rheumatol Int 29:807-10. 2009
    ..By contrast, on a patient-level, variability of lymphocyte counts impedes meaningful interpretation of individual measurements...
  57. ncbi request reprint Biomarkers in the management of pneumonia
    Mirjam Christ Crain
    University Hospitals, Petersgraben 4, CH 4031 Basel, Switzerland
    Expert Rev Respir Med 2:565-72. 2008
    ..Future studies will show whether an assessment with those novel biomarkers is able to guide prognostic decision-making and improve the allocation of healthcare resources and hospitalization costs...
  58. pmc Disruption of a toxin gene by introduction of a foreign gene into the chromosome of Clostridium perfringens using targetron-induced mutagenesis
    Yue Chen
    Department of Infectious Diseases and Microbiology, Graduate School of Public Health, University of Pittsburgh, 430 Parran Hall, GSPH, 130 DeSoto Street, Pittsburgh, PA 15261, USA
    Plasmid 58:182-9. 2007
    ..Upon oral feeding of the mutant bacteria to mice, intact p27 protein was detected in the lower GI tract. The re-engineered C. perfringens provides a biosafe efficient oral vehicle to deliver antigen to the gastrointestinal tract...
  59. ncbi request reprint Free and total cortisol levels as predictors of severity and outcome in community-acquired pneumonia
    Mirjam Christ-Crain
    Department of Endocrinology, William Harvey Research Institute, Barts and The London, Queen Mary s School of Medicine and Dentistry, London, United Kingdom
    Am J Respir Crit Care Med 176:913-20. 2007
    ..The predictive value of cortisol in pneumonia is unknown. Routinely available assays measure serum total cortisol (TC) and not free cortisol (FC). Whether FC concentrations better reflect outcome is uncertain...
  60. ncbi request reprint Meta-analysis of procalcitonin for sepsis detection
    Beat Muller
    Lancet Infect Dis 7:498-9; author reply 502-3. 2007
  61. doi request reprint [Procalcitonin - importance for the diagnosis of bacterial infections]
    Mirjam Christ-Crain
    Bereich Innere Medizin, Universitatsspital Basel
    Ther Umsch 65:559-68. 2008
    ..Together, Procalcitonin has improved the diagnosis of bacterial infections, however should always be used in context with other laboratory markers, clinical exam and medical history...