P Schneider

Summary

Affiliation: University of Lausanne
Country: Switzerland

Publications

  1. ncbi Apoptosis induced by death receptors
    P Schneider
    Institute of Biochemistry, University of Lausanne, Epalinges, Switzerland
    Pharm Acta Helv 74:281-6. 2000
  2. ncbi Characterization of Fas (Apo-1, CD95)-Fas ligand interaction
    P Schneider
    Institute of Biochemistry, University of Lausanne, BIL Biomedical Research Center, CH 1066 Epalinges, Switzerland
    J Biol Chem 272:18827-33. 1997
  3. ncbi Fas triggers an alternative, caspase-8-independent cell death pathway using the kinase RIP as effector molecule
    N Holler
    Institute of Biochemistry, University of Lausanne, BIL Biomedical Research Center, Chemin des Boveresses 155, CH 1066 Epalinges, Switzerland
    Nat Immunol 1:489-95. 2000
  4. ncbi Equine herpesvirus-2 E10 gene product, but not its cellular homologue, activates NF-kappaB transcription factor and c-Jun N-terminal kinase
    M Thome
    Institute of Biochemistry, University of Lausanne, Switzerland
    J Biol Chem 274:9962-8. 1999
  5. ncbi BAFF-R, a newly identified TNF receptor that specifically interacts with BAFF
    J S Thompson
    Biogen, 12 Cambridge Center, Cambridge, MA 02142, USA, The Institute of Biochemistry, University of Lausanne, CH 1066, Epalinges, Switzerland
    Science 293:2108-11. 2001
  6. ncbi TRAIL receptors 1 (DR4) and 2 (DR5) signal FADD-dependent apoptosis and activate NF-kappaB
    P Schneider
    Institute of Biochemistry, University of Lausanne, Switzerland
    Immunity 7:831-6. 1997
  7. pmc FIST/HIPK3: a Fas/FADD-interacting serine/threonine kinase that induces FADD phosphorylation and inhibits fas-mediated Jun NH(2)-terminal kinase activation
    V Rochat-Steiner
    Institute of Biochemistry, University of Lausanne, BIL Biomedical Research Center, CH 1066 Epalinges, Switzerland
    J Exp Med 192:1165-74. 2000
  8. ncbi Inhibition of death receptor signals by cellular FLIP
    M Irmler
    Institute of Biochemistry, Lausanne Branch, University of Lausanne, Switzerland
    Nature 388:190-5. 1997
  9. pmc BAFF, a novel ligand of the tumor necrosis factor family, stimulates B cell growth
    P Schneider
    Institute of Biochemistry, University of Lausanne, Switzerland
    J Exp Med 189:1747-56. 1999
  10. ncbi Characterization of two receptors for TRAIL
    P Schneider
    Institute of Biochemistry, University of Lausanne, Epalinges, Switzerland
    FEBS Lett 416:329-34. 1997

Collaborators

Detail Information

Publications31

  1. ncbi Apoptosis induced by death receptors
    P Schneider
    Institute of Biochemistry, University of Lausanne, Epalinges, Switzerland
    Pharm Acta Helv 74:281-6. 2000
    ..It interacts with both FADD and Caspase-8 to inhibits the apoptotic signal of death receptors and, at the same time, can activate other signalling pathways such as that leading to NF-kappa B activation...
  2. ncbi Characterization of Fas (Apo-1, CD95)-Fas ligand interaction
    P Schneider
    Institute of Biochemistry, University of Lausanne, BIL Biomedical Research Center, CH 1066 Epalinges, Switzerland
    J Biol Chem 272:18827-33. 1997
    ..Interestingly, mutant Y218F could induce apoptosis in murine, but not human cells...
  3. ncbi Fas triggers an alternative, caspase-8-independent cell death pathway using the kinase RIP as effector molecule
    N Holler
    Institute of Biochemistry, University of Lausanne, BIL Biomedical Research Center, Chemin des Boveresses 155, CH 1066 Epalinges, Switzerland
    Nat Immunol 1:489-95. 2000
    ..Thus, Fas, TRAIL and TNF receptors can initiate cell death by two alternative pathways, one relying on caspase-8 and the other dependent on the kinase RIP...
  4. ncbi Equine herpesvirus-2 E10 gene product, but not its cellular homologue, activates NF-kappaB transcription factor and c-Jun N-terminal kinase
    M Thome
    Institute of Biochemistry, University of Lausanne, Switzerland
    J Biol Chem 274:9962-8. 1999
    ..Through activation of NF-kappaB, v-CARMEN may regulate the expression of the cellular and viral genes important for viral replication...
  5. ncbi BAFF-R, a newly identified TNF receptor that specifically interacts with BAFF
    J S Thompson
    Biogen, 12 Cambridge Center, Cambridge, MA 02142, USA, The Institute of Biochemistry, University of Lausanne, CH 1066, Epalinges, Switzerland
    Science 293:2108-11. 2001
    ..Thus, BAFF-R appears to be the principal receptor for BAFF-mediated mature B cell survival...
  6. ncbi TRAIL receptors 1 (DR4) and 2 (DR5) signal FADD-dependent apoptosis and activate NF-kappaB
    P Schneider
    Institute of Biochemistry, University of Lausanne, Switzerland
    Immunity 7:831-6. 1997
    ..Thus, TRAIL receptors can signal both death and gene transcription, functions reminiscent of those of TNFR1 and TRAMP, two other members of the death receptor family...
  7. pmc FIST/HIPK3: a Fas/FADD-interacting serine/threonine kinase that induces FADD phosphorylation and inhibits fas-mediated Jun NH(2)-terminal kinase activation
    V Rochat-Steiner
    Institute of Biochemistry, University of Lausanne, BIL Biomedical Research Center, CH 1066 Epalinges, Switzerland
    J Exp Med 192:1165-74. 2000
    ..These results suggest that Fas-associated FIST/HIPK3 modulates one of the two major signaling pathways of Fas...
  8. ncbi Inhibition of death receptor signals by cellular FLIP
    M Irmler
    Institute of Biochemistry, Lausanne Branch, University of Lausanne, Switzerland
    Nature 388:190-5. 1997
    ..High levels of FLIP(L) protein are also detectable in melanoma cell lines and malignant melanoma tumours. Thus FLIP may be implicated in tissue homeostasis as an important regulator of apoptosis...
  9. pmc BAFF, a novel ligand of the tumor necrosis factor family, stimulates B cell growth
    P Schneider
    Institute of Biochemistry, University of Lausanne, Switzerland
    J Exp Med 189:1747-56. 1999
    ..These results suggest that BAFF plays an important role as costimulator of B cell proliferation and function...
  10. ncbi Characterization of two receptors for TRAIL
    P Schneider
    Institute of Biochemistry, University of Lausanne, Epalinges, Switzerland
    FEBS Lett 416:329-34. 1997
    ..All three TRAIL receptors bind TRAIL with similar affinity, suggesting a complex regulation of TRAIL-mediated signals...
  11. pmc APRIL, a new ligand of the tumor necrosis factor family, stimulates tumor cell growth
    M Hahne
    Institute of Biochemistry, Lausanne Branch, University of Lausanne, Epalinges, Switzerland
    J Exp Med 188:1185-90. 1998
    ..Moreover, APRIL-transfected NIH-3T3 cells show an increased rate of tumor growth in nude mice compared with the parental cell line. These findings suggest that APRIL may be implicated in the regulation of tumor cell growth...
  12. ncbi FLIP prevents apoptosis induced by death receptors but not by perforin/granzyme B, chemotherapeutic drugs, and gamma irradiation
    T Kataoka
    Institute of Biochemistry, University of Lausanne, Epalinges, Switzerland
    J Immunol 161:3936-42. 1998
    ..e., doxorubicin, etoposide, and vincristine) and gamma irradiation was not affected by FLIP or the absence of Fas, indicating that these treatments can induce cell death in a Fas-independent and FLIP-insensitive manner...
  13. ncbi Mutations leading to X-linked hypohidrotic ectodermal dysplasia affect three major functional domains in the tumor necrosis factor family member ectodysplasin-A
    P Schneider
    Institute of Biochemistry, BIL Biomedical Research Center, University of Lausanne, Boveresses 156, CH-1066 Epalinges, Switzerland
    J Biol Chem 276:18819-27. 2001
    ..Thus a proteolytically processed, oligomeric form of EDA-A1 is required in vivo for proper morphogenesis...
  14. ncbi Viral FLICE-inhibitory proteins (FLIPs) prevent apoptosis induced by death receptors
    M Thome
    Institute of Biochemistry, University of Lausanne, Epalinges, Switzerland
    Nature 386:517-21. 1997
    ..Protection of virus-infected cells against death-receptor-induced apoptosis may lead to higher virus production and contribute to the persistence and oncogenicity of several FLIP-encoding viruses...
  15. ncbi TRAMP, a novel apoptosis-mediating receptor with sequence homology to tumor necrosis factor receptor 1 and Fas(Apo-1/CD95)
    J L Bodmer
    Institute of Biochemistry, University of Lausanne, Switzerland
    Immunity 6:79-88. 1997
    ..TRAMP-induced cell death is inhibited by an inhibitor of ICE-like proteases, but not by Bcl-2. In addition, TRAMP does not appear to interact with any of the known apoptosis-inducing ligands of the TNF family...
  16. ncbi Interaction of Fas(Apo-1/CD95) with proteins implicated in the ubiquitination pathway
    K Becker
    Institute of Biochemistry, University of Lausanne, Epalinges, Switzerland
    FEBS Lett 412:102-6. 1997
    ..1996) Proc. Natl. Acad. Sci. USA 92, 11894-11898), was found to contain sequences similar to ubiquitin. These results suggest that proteins related to the ubiquitination pathway may modulate the Fas signaling pathway...
  17. pmc Maturation of marginal zone and follicular B cells requires B cell activating factor of the tumor necrosis factor family and is independent of B cell maturation antigen
    P Schneider
    Institute of Biochemistry, BIL Biomedical Research Center, University of Lausanne, Epalinges, Switzerland
    J Exp Med 194:1691-7. 2001
    ..This demonstrates a crucial role for BAFF in B cell maturation and strongly suggests that it signals via a BCMA-independent pathway and in an APRIL-dispensable way...
  18. ncbi MyD88, an adapter protein involved in interleukin-1 signaling
    K Burns
    Institute of Biochemistry, Lausanne Branch, University of Lausanne, Switzerland
    J Biol Chem 273:12203-9. 1998
    ..MyD88 coimmunoprecipitates with the IL-1R signaling complex in an IL-1-dependent manner...
  19. pmc A soluble form of B cell maturation antigen, a receptor for the tumor necrosis factor family member APRIL, inhibits tumor cell growth
    P Rennert
    Institute of Biochemistry, BIL Biomedical Research Center, University of Lausanne, CH 1066 Epalinges, Switzerland
    J Exp Med 192:1677-84. 2000
    ..Growth of HT29 colon carcinoma cells is blocked when mice are treated once per week with the soluble receptor. These results suggest an important role for APRIL in tumorigenesis and point towards a novel anticancer strategy...
  20. pmc The death domain-containing protein Unc5CL is a novel MyD88-independent activator of the pro-inflammatory IRAK signaling cascade
    L X Heinz
    Department of Biochemistry, University of Lausanne, CH 1066 Epalinges, Switzerland
    Cell Death Differ 19:722-31. 2012
    ....
  21. ncbi Ectopic expression of the serine protease inhibitor PI9 modulates death receptor-mediated apoptosis
    J A Kummer
    Department of Biochemistry, University of Lausanne, BIL Biomedical Research Center, Chemin des Boveresses 155, CH 1066 Epalinges, Switzerland
    Cell Death Differ 14:1486-96. 2007
    ..Indeed, PI9 inhibited apoptotic death by directly interacting with the intermediate active forms of caspase-8 and -10. This indicates that PI9 can regulate pro-apoptotic apical caspases...
  22. ncbi Melanoma cell expression of Fas(Apo-1/CD95) ligand: implications for tumor immune escape
    M Hahne
    Institute of Biochemistry, University of Lausanne, CH 1066 Epalinges, Switzerland
    Science 274:1363-6. 1996
    ..In contrast, tumorigenesis was delayed in Fas-deficient lpr mutant mice in which immune effector cells cannot be killed by FasL. Thus, FasL may contribute to the immune privilege of tumors...
  23. ncbi Selection of peptides and synthesis of pentameric peptabody molecules reacting specifically with ErbB-2 receptor
    M Houimel
    Institute of Biochemistry, University of Lausanne, Lausanne, Switzerland
    Int J Cancer 92:748-55. 2001
    ..In conclusion, a novel type of ErbB-2-specific ligand is described that might complement presently available monoclonal antibodies...
  24. ncbi MARCKS-related protein (MRP) is a substrate for the Leishmania major surface protease leishmanolysin (gp63)
    S Corradin
    Institute of Biochemistry, University of Lausanne, 1066 Epalinges, Switzerland
    J Biol Chem 274:25411-8. 1999
    ..Moreover, an MRP construct in which the effector domain had been deleted was resistant to cleavage. Thus, Leishmania infection may result in leishmanolysin-dependent hydrolysis of MRP, a major protein kinase C substrate in macrophages...
  25. ncbi Structure of the laccase from Coprinus cinereus at 1.68 A resolution: evidence for different 'type 2 Cu-depleted' isoforms
    V Ducros
    Department of Chemistry, University of York, Heslington, York YO10 5DD, England
    Acta Crystallogr D Biol Crystallogr 57:333-6. 2001
    ..The three-dimensional structure of the 'blue' multi-copper oxidase laccase from the fungus Coprinus cinereus at 1.68 A reveals the structural basis for isoforms of the type 2 Cu-depleted species...
  26. ncbi Formulating the alginate-polyornithine biocapsule for prolonged stability: evaluation of composition and manufacturing technique
    C G Thanos
    LCT BioPharma, Incorporated, Providence, Rhode Island 02906, USA
    J Biomed Mater Res A 83:216-24. 2007
    ....
  27. ncbi Endostatin variations in childhood acute lymphoblastic leukaemia--comparison with basic fibroblast growth factor and vascular endothelial growth factor
    P Schneider
    Groupe de Recherche MERCI, Faculte de Medecine Pharmacie, CHU Charles Nicolle, Laboratoire d Hématolologie Publique, 1 rue de Germont, 76000 Rouen, France
    Leuk Res 31:629-38. 2007
    ..No prognostic value of plasma endostatin could be assessed. In conclusion, the present data indicate that an anti-angiogenic response is observed in some ALL children, but its physiopathological importance remains to be established...
  28. ncbi T cell costimulation by the TNF ligand BAFF
    B Huard
    Department of Dermatology, Geneva University Medical Center, Geneva, Switzerland
    J Immunol 167:6225-31. 2001
    ..This highlights some differences in the BAFF signaling pathway in T and B cells. In conclusion, our results indicate that BAFF may play a role in the development of T cell responses, in addition to its role in B cell homeostasis...
  29. ncbi Thy-1 binds to integrin beta(3) on astrocytes and triggers formation of focal contact sites
    L Leyton
    ICBM Faculty of Medicine, University of Chile, Santiago, Chile
    Curr Biol 11:1028-38. 2001
    ..In this paper, a ligand molecule for Thy-1 was identified, and the consequences of Thy-1 binding for astrocyte function were investigated...
  30. ncbi Discordant increases in CD4+ T cells in human immunodeficiency virus-infected patients experiencing virologic treatment failure: role of changes in thymic output and T cell death
    D Lecossier
    INSERM U552, , Paris, France
    J Infect Dis 183:1009-16. 2001
    ....
  31. ncbi Primary structure of CD52
    A Treumann
    Department of Biochemistry, University of Dundee, Scotland, United Kingdom
    J Biol Chem 270:6088-99. 1995
    ..The alkali-lability of the CD52 epitope recognized by the Campath-1H monoclonal antibody was studied. The data suggest that the alkali-labile hydroxyester-linked fatty acids of the GPI anchor are necessary for antibody binding...