Research Topics
Genomes and Genes
| P SchneiderSummaryAffiliation: University of Lausanne Country: Switzerland Publications
| Collaborators
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Detail Information
Publications
Apoptosis induced by death receptorsP Schneider
Institute of Biochemistry, University of Lausanne, Epalinges, Switzerland
Pharm Acta Helv 74:281-6. 2000..It interacts with both FADD and Caspase-8 to inhibits the apoptotic signal of death receptors and, at the same time, can activate other signalling pathways such as that leading to NF-kappa B activation...- Characterization of Fas (Apo-1, CD95)-Fas ligand interactionP Schneider
Institute of Biochemistry, University of Lausanne, BIL Biomedical Research Center, CH 1066 Epalinges, Switzerland
J Biol Chem 272:18827-33. 1997..Interestingly, mutant Y218F could induce apoptosis in murine, but not human cells... - Fas triggers an alternative, caspase-8-independent cell death pathway using the kinase RIP as effector moleculeN Holler
Institute of Biochemistry, University of Lausanne, BIL Biomedical Research Center, Chemin des Boveresses 155, CH 1066 Epalinges, Switzerland
Nat Immunol 1:489-95. 2000..Thus, Fas, TRAIL and TNF receptors can initiate cell death by two alternative pathways, one relying on caspase-8 and the other dependent on the kinase RIP... - Equine herpesvirus-2 E10 gene product, but not its cellular homologue, activates NF-kappaB transcription factor and c-Jun N-terminal kinaseM Thome
Institute of Biochemistry, University of Lausanne, Switzerland
J Biol Chem 274:9962-8. 1999..Through activation of NF-kappaB, v-CARMEN may regulate the expression of the cellular and viral genes important for viral replication... - BAFF-R, a newly identified TNF receptor that specifically interacts with BAFFJ S Thompson
Biogen, 12 Cambridge Center, Cambridge, MA 02142, USA, The Institute of Biochemistry, University of Lausanne, CH 1066, Epalinges, Switzerland
Science 293:2108-11. 2001..Thus, BAFF-R appears to be the principal receptor for BAFF-mediated mature B cell survival... - TRAIL receptors 1 (DR4) and 2 (DR5) signal FADD-dependent apoptosis and activate NF-kappaBP Schneider
Institute of Biochemistry, University of Lausanne, Switzerland
Immunity 7:831-6. 1997..Thus, TRAIL receptors can signal both death and gene transcription, functions reminiscent of those of TNFR1 and TRAMP, two other members of the death receptor family... 
FIST/HIPK3: a Fas/FADD-interacting serine/threonine kinase that induces FADD phosphorylation and inhibits fas-mediated Jun NH(2)-terminal kinase activationV Rochat-Steiner
Institute of Biochemistry, University of Lausanne, BIL Biomedical Research Center, CH 1066 Epalinges, Switzerland
J Exp Med 192:1165-74. 2000..These results suggest that Fas-associated FIST/HIPK3 modulates one of the two major signaling pathways of Fas...- Inhibition of death receptor signals by cellular FLIPM Irmler
Institute of Biochemistry, Lausanne Branch, University of Lausanne, Switzerland
Nature 388:190-5. 1997..High levels of FLIP(L) protein are also detectable in melanoma cell lines and malignant melanoma tumours. Thus FLIP may be implicated in tissue homeostasis as an important regulator of apoptosis... - BAFF, a novel ligand of the tumor necrosis factor family, stimulates B cell growthP Schneider
Institute of Biochemistry, University of Lausanne, Switzerland
J Exp Med 189:1747-56. 1999..These results suggest that BAFF plays an important role as costimulator of B cell proliferation and function... - Characterization of two receptors for TRAILP Schneider
Institute of Biochemistry, University of Lausanne, Epalinges, Switzerland
FEBS Lett 416:329-34. 1997..All three TRAIL receptors bind TRAIL with similar affinity, suggesting a complex regulation of TRAIL-mediated signals... - APRIL, a new ligand of the tumor necrosis factor family, stimulates tumor cell growthM Hahne
Institute of Biochemistry, Lausanne Branch, University of Lausanne, Epalinges, Switzerland
J Exp Med 188:1185-90. 1998..Moreover, APRIL-transfected NIH-3T3 cells show an increased rate of tumor growth in nude mice compared with the parental cell line. These findings suggest that APRIL may be implicated in the regulation of tumor cell growth... - FLIP prevents apoptosis induced by death receptors but not by perforin/granzyme B, chemotherapeutic drugs, and gamma irradiationT Kataoka
Institute of Biochemistry, University of Lausanne, Epalinges, Switzerland
J Immunol 161:3936-42. 1998..e., doxorubicin, etoposide, and vincristine) and gamma irradiation was not affected by FLIP or the absence of Fas, indicating that these treatments can induce cell death in a Fas-independent and FLIP-insensitive manner... - Mutations leading to X-linked hypohidrotic ectodermal dysplasia affect three major functional domains in the tumor necrosis factor family member ectodysplasin-AP Schneider
Institute of Biochemistry, BIL Biomedical Research Center, University of Lausanne, Boveresses 156, CH-1066 Epalinges, Switzerland
J Biol Chem 276:18819-27. 2001..Thus a proteolytically processed, oligomeric form of EDA-A1 is required in vivo for proper morphogenesis... - Viral FLICE-inhibitory proteins (FLIPs) prevent apoptosis induced by death receptorsM Thome
Institute of Biochemistry, University of Lausanne, Epalinges, Switzerland
Nature 386:517-21. 1997..Protection of virus-infected cells against death-receptor-induced apoptosis may lead to higher virus production and contribute to the persistence and oncogenicity of several FLIP-encoding viruses... - TRAMP, a novel apoptosis-mediating receptor with sequence homology to tumor necrosis factor receptor 1 and Fas(Apo-1/CD95)J L Bodmer
Institute of Biochemistry, University of Lausanne, Switzerland
Immunity 6:79-88. 1997..TRAMP-induced cell death is inhibited by an inhibitor of ICE-like proteases, but not by Bcl-2. In addition, TRAMP does not appear to interact with any of the known apoptosis-inducing ligands of the TNF family... - Interaction of Fas(Apo-1/CD95) with proteins implicated in the ubiquitination pathwayK Becker
Institute of Biochemistry, University of Lausanne, Epalinges, Switzerland
FEBS Lett 412:102-6. 1997..1996) Proc. Natl. Acad. Sci. USA 92, 11894-11898), was found to contain sequences similar to ubiquitin. These results suggest that proteins related to the ubiquitination pathway may modulate the Fas signaling pathway... - Maturation of marginal zone and follicular B cells requires B cell activating factor of the tumor necrosis factor family and is independent of B cell maturation antigenP Schneider
Institute of Biochemistry, BIL Biomedical Research Center, University of Lausanne, Epalinges, Switzerland
J Exp Med 194:1691-7. 2001..This demonstrates a crucial role for BAFF in B cell maturation and strongly suggests that it signals via a BCMA-independent pathway and in an APRIL-dispensable way... - MyD88, an adapter protein involved in interleukin-1 signalingK Burns
Institute of Biochemistry, Lausanne Branch, University of Lausanne, Switzerland
J Biol Chem 273:12203-9. 1998..MyD88 coimmunoprecipitates with the IL-1R signaling complex in an IL-1-dependent manner... - A soluble form of B cell maturation antigen, a receptor for the tumor necrosis factor family member APRIL, inhibits tumor cell growthP Rennert
Institute of Biochemistry, BIL Biomedical Research Center, University of Lausanne, CH 1066 Epalinges, Switzerland
J Exp Med 192:1677-84. 2000..Growth of HT29 colon carcinoma cells is blocked when mice are treated once per week with the soluble receptor. These results suggest an important role for APRIL in tumorigenesis and point towards a novel anticancer strategy... - The death domain-containing protein Unc5CL is a novel MyD88-independent activator of the pro-inflammatory IRAK signaling cascadeL X Heinz
Department of Biochemistry, University of Lausanne, CH 1066 Epalinges, Switzerland
Cell Death Differ 19:722-31. 2012.... - Ectopic expression of the serine protease inhibitor PI9 modulates death receptor-mediated apoptosisJ A Kummer
Department of Biochemistry, University of Lausanne, BIL Biomedical Research Center, Chemin des Boveresses 155, CH 1066 Epalinges, Switzerland
Cell Death Differ 14:1486-96. 2007..Indeed, PI9 inhibited apoptotic death by directly interacting with the intermediate active forms of caspase-8 and -10. This indicates that PI9 can regulate pro-apoptotic apical caspases... - Melanoma cell expression of Fas(Apo-1/CD95) ligand: implications for tumor immune escapeM Hahne
Institute of Biochemistry, University of Lausanne, CH 1066 Epalinges, Switzerland
Science 274:1363-6. 1996..In contrast, tumorigenesis was delayed in Fas-deficient lpr mutant mice in which immune effector cells cannot be killed by FasL. Thus, FasL may contribute to the immune privilege of tumors... - Selection of peptides and synthesis of pentameric peptabody molecules reacting specifically with ErbB-2 receptorM Houimel
Institute of Biochemistry, University of Lausanne, Lausanne, Switzerland
Int J Cancer 92:748-55. 2001..In conclusion, a novel type of ErbB-2-specific ligand is described that might complement presently available monoclonal antibodies... - MARCKS-related protein (MRP) is a substrate for the Leishmania major surface protease leishmanolysin (gp63)S Corradin
Institute of Biochemistry, University of Lausanne, 1066 Epalinges, Switzerland
J Biol Chem 274:25411-8. 1999..Moreover, an MRP construct in which the effector domain had been deleted was resistant to cleavage. Thus, Leishmania infection may result in leishmanolysin-dependent hydrolysis of MRP, a major protein kinase C substrate in macrophages... - Structure of the laccase from Coprinus cinereus at 1.68 A resolution: evidence for different 'type 2 Cu-depleted' isoformsV Ducros
Department of Chemistry, University of York, Heslington, York YO10 5DD, England
Acta Crystallogr D Biol Crystallogr 57:333-6. 2001..The three-dimensional structure of the 'blue' multi-copper oxidase laccase from the fungus Coprinus cinereus at 1.68 A reveals the structural basis for isoforms of the type 2 Cu-depleted species... - Formulating the alginate-polyornithine biocapsule for prolonged stability: evaluation of composition and manufacturing techniqueC G Thanos
LCT BioPharma, Incorporated, Providence, Rhode Island 02906, USA
J Biomed Mater Res A 83:216-24. 2007.... - Endostatin variations in childhood acute lymphoblastic leukaemia--comparison with basic fibroblast growth factor and vascular endothelial growth factorP Schneider
Groupe de Recherche MERCI, Faculte de Medecine Pharmacie, CHU Charles Nicolle, Laboratoire d Hématolologie Publique, 1 rue de Germont, 76000 Rouen, France
Leuk Res 31:629-38. 2007..No prognostic value of plasma endostatin could be assessed. In conclusion, the present data indicate that an anti-angiogenic response is observed in some ALL children, but its physiopathological importance remains to be established... - T cell costimulation by the TNF ligand BAFFB Huard
Department of Dermatology, Geneva University Medical Center, Geneva, Switzerland
J Immunol 167:6225-31. 2001..This highlights some differences in the BAFF signaling pathway in T and B cells. In conclusion, our results indicate that BAFF may play a role in the development of T cell responses, in addition to its role in B cell homeostasis... - Thy-1 binds to integrin beta(3) on astrocytes and triggers formation of focal contact sitesL Leyton
ICBM Faculty of Medicine, University of Chile, Santiago, Chile
Curr Biol 11:1028-38. 2001..In this paper, a ligand molecule for Thy-1 was identified, and the consequences of Thy-1 binding for astrocyte function were investigated... - Discordant increases in CD4+ T cells in human immunodeficiency virus-infected patients experiencing virologic treatment failure: role of changes in thymic output and T cell deathD Lecossier
INSERM U552, , Paris, France
J Infect Dis 183:1009-16. 2001.... - Primary structure of CD52A Treumann
Department of Biochemistry, University of Dundee, Scotland, United Kingdom
J Biol Chem 270:6088-99. 1995..The alkali-lability of the CD52 epitope recognized by the Campath-1H monoclonal antibody was studied. The data suggest that the alkali-labile hydroxyester-linked fatty acids of the GPI anchor are necessary for antibody binding...