M Lienhard Schmitz

Summary

Affiliation: University of Bern
Country: Switzerland

Publications

  1. ncbi request reprint NF-kappaB activation pathways induced by T cell costimulation
    M Lienhard Schmitz
    University of Bern, Department of Chemistry and Biochemistry, Switzerland
    FASEB J 17:2187-93. 2003
  2. ncbi request reprint T cell receptor-induced lipid raft recruitment of the I kappa B kinase complex is necessary and sufficient for NF-kappa B activation occurring in the cytosol
    Andrea Sebald
    University of Bern, Department of Chemistry and Biochemistry, Bern, Switzerland
    Eur J Immunol 35:318-25. 2005
  3. ncbi request reprint Inducible phosphorylation of NF-kappa B p65 at serine 468 by T cell costimulation is mediated by IKK epsilon
    Ivan Mattioli
    Department of Chemistry and Biochemistry, University of Bern, Freiestrasse 3, 3012 Bern, Switzerland
    J Biol Chem 281:6175-83. 2006
  4. pmc Autoregulatory control of the p53 response by caspase-mediated processing of HIPK2
    Ekaterina Gresko
    Department of Chemistry and Biochemistry, University of Bern, Switzerland
    EMBO J 25:1883-94. 2006
  5. ncbi request reprint Comparative analysis of T-cell costimulation and CD43 activation reveals novel signaling pathways and target genes
    Ivan Mattioli
    Department of Chemistry and Biochemistry, University of Bern, Freiestr 3, 3012 Bern, Switzerland
    Blood 104:3302-4. 2004
  6. ncbi request reprint Inhibition of NF-kappaB activation and expression of inflammatory mediators by polyacetylene spiroketals from Plagius flosculosus
    Marco A Calzado
    Department of Chemistry and Biochemistry, University of Bern, Switzerland
    Biochim Biophys Acta 1729:88-93. 2005
  7. ncbi request reprint Transient and selective NF-kappa B p65 serine 536 phosphorylation induced by T cell costimulation is mediated by I kappa B kinase beta and controls the kinetics of p65 nuclear import
    Ivan Mattioli
    University of Bern, Department of Chemistry and Biochemistry, Bern, Switzerland
    J Immunol 172:6336-44. 2004
  8. ncbi request reprint NF-kappaB: a multifaceted transcription factor regulated at several levels
    M Lienhard Schmitz
    University of Bern, Department of Chemistry and Biochemistry, Freiestrasse 3, 3012 Bern, Switzerland
    Chembiochem 5:1348-58. 2004
  9. ncbi request reprint The NF-kappaB pathway as a potential target for autoimmune disease therapy
    Susanne Bacher
    University of Bern, Department of Chemistry and Biochemistry, Freiestr 3, CH 3012, Switzerland
    Curr Pharm Des 10:2827-37. 2004
  10. ncbi request reprint Covalent modification of human homeodomain interacting protein kinase 2 by SUMO-1 at lysine 25 affects its stability
    Ekaterina Gresko
    University of Bern, Department of Chemistry and Biochemistry, Freiestr 3, CH 3012 Bern, Switzerland
    Biochem Biophys Res Commun 329:1293-9. 2005

Collaborators

  • Giovanni Appendino
  • Yinon Ben-Neriah
  • M Kracht
  • Thomas G Hofmann
  • Hong He
  • Guy Haegeman
  • Eduardo Candelario-Jalil
  • J J M Hoozemans
  • Jozefa Wesierska-Gadek
  • Vladimir Todorov
  • Dirk Schluter
  • H Nakano
  • Marco A Calzado
  • Andreas Möller
  • Ivan Mattioli
  • Ekaterina Gresko
  • Ana Roscic
  • Susanne Bacher
  • Andrea Sebald
  • Holger Buss
  • Florian Renner
  • Katharina Schmid Lüdi
  • Wulf Dröge
  • Tobias Wittwer
  • Katri Saavalainen
  • Arieh Moussaieff
  • Bernd L Fiebich
  • Yukiko Aikawa
  • Eduardo Munoz
  • Anne Waschbisch
  • David Lagnoux
  • Cyril Bucher
  • Klaus Resch
  • Anneke Dörrie
  • Mark Livingstone
  • Huseyin Sirma
  • Oliver Dienz
  • Elisabeth Klimczak
  • Hans Will
  • Dimitry Spitkovsky
  • Thao V Nheu
  • Lingtao You
  • Heike Bantel
  • Timothy Bowen
  • Ester Fride
  • Carsten Carlberg
  • Markku I Tammi
  • Raphael Mechoulam
  • Yoel Kashman
  • Esther Shohami
  • Nina Virtainen
  • Kyoichi Isono
  • Yusuke Tagata
  • Helen Slawik
  • Hui Geng
  • Nobuyuki Takakura
  • Stefanie Ritterhoff
  • Michael Hodel
  • Juha Yrjänheikki
  • Michael Hull
  • Haruhiko Koseki
  • Giannino Del Sal
  • Anton Vichalkovski
  • Ravi Shankar Akundi
  • Robert Veerhuis
  • Verena C Wimmer
  • Lan Anh Nguyen
  • Issay Kitabayashi
  • Jean Louis Reymond
  • Simona Prosperini
  • Mauro Ballero
  • Bernd Fiebich
  • Tamis Darbre
  • Oliver Dittrich-Breiholz
  • Elke Hoffmann
  • Ronald Frank
  • Takahiro Doi
  • Roch Philippe Charles
  • Andreas Strecker
  • Nadja Stephan
  • Peter H Krammer
  • Sven Rueffer
  • Hannah Staege
  • Antony W Burgess
  • Hiroshi Maruta
  • Armin Raible
  • Ikuko Suzuki-Takahashi
  • Lore Florin
  • John Wood
  • Kazuhiko Tamaki

Detail Information

Publications35

  1. ncbi request reprint NF-kappaB activation pathways induced by T cell costimulation
    M Lienhard Schmitz
    University of Bern, Department of Chemistry and Biochemistry, Switzerland
    FASEB J 17:2187-93. 2003
    ..Many members of the NF-kappaB activation cascade, including the IKKs, are either constitutively or inducibly translocated to the lipid raft fraction, showing a highly organized spatial distribution of these NF-kappaB activating proteins...
  2. ncbi request reprint T cell receptor-induced lipid raft recruitment of the I kappa B kinase complex is necessary and sufficient for NF-kappa B activation occurring in the cytosol
    Andrea Sebald
    University of Bern, Department of Chemistry and Biochemistry, Bern, Switzerland
    Eur J Immunol 35:318-25. 2005
    ....
  3. ncbi request reprint Inducible phosphorylation of NF-kappa B p65 at serine 468 by T cell costimulation is mediated by IKK epsilon
    Ivan Mattioli
    Department of Chemistry and Biochemistry, University of Bern, Freiestrasse 3, 3012 Bern, Switzerland
    J Biol Chem 281:6175-83. 2006
    ..These results also provide a mechanistic link that helps to explain the relevance of IKKepsilon for the expression of a subset of NF-kappaB target genes without affecting cytosolic IkappaBalpha degradation...
  4. pmc Autoregulatory control of the p53 response by caspase-mediated processing of HIPK2
    Ekaterina Gresko
    Department of Chemistry and Biochemistry, University of Bern, Switzerland
    EMBO J 25:1883-94. 2006
    ..The active HIPK2 fragments are further degraded during the execution and termination phase of apoptosis, thus ensuring the occurrence of HIPK2 signaling only during the early phases of apoptosis induction...
  5. ncbi request reprint Comparative analysis of T-cell costimulation and CD43 activation reveals novel signaling pathways and target genes
    Ivan Mattioli
    Department of Chemistry and Biochemistry, University of Bern, Freiestr 3, 3012 Bern, Switzerland
    Blood 104:3302-4. 2004
    ..Microarray analysis of inflammatory genes shows 1 group of genes coregulated by both stimuli and 2 further groups of target genes affected solely by costimulation or primarily by CD43...
  6. ncbi request reprint Inhibition of NF-kappaB activation and expression of inflammatory mediators by polyacetylene spiroketals from Plagius flosculosus
    Marco A Calzado
    Department of Chemistry and Biochemistry, University of Bern, Switzerland
    Biochim Biophys Acta 1729:88-93. 2005
    ..Accordingly, compound 1, which is also found in the widely used medicinal herb chamomile, interfered with the LPS-induced production of IL-1, IL-6, TNF, and PGE2 in primary human monocytes...
  7. ncbi request reprint Transient and selective NF-kappa B p65 serine 536 phosphorylation induced by T cell costimulation is mediated by I kappa B kinase beta and controls the kinetics of p65 nuclear import
    Ivan Mattioli
    University of Bern, Department of Chemistry and Biochemistry, Bern, Switzerland
    J Immunol 172:6336-44. 2004
    ....
  8. ncbi request reprint NF-kappaB: a multifaceted transcription factor regulated at several levels
    M Lienhard Schmitz
    University of Bern, Department of Chemistry and Biochemistry, Freiestrasse 3, 3012 Bern, Switzerland
    Chembiochem 5:1348-58. 2004
    ..The signaling pathways and enzymes controlling this second level of regulation and their potential use as therapeutic targets for the treatment of NF-kappaB-associated pathologies are discussed here...
  9. ncbi request reprint The NF-kappaB pathway as a potential target for autoimmune disease therapy
    Susanne Bacher
    University of Bern, Department of Chemistry and Biochemistry, Freiestr 3, CH 3012, Switzerland
    Curr Pharm Des 10:2827-37. 2004
    ..The assets and drawbacks of systemic or cell-type specific NF-kappaB inhibitors and their potential use in therapy of autoimmune diseases are critically discussed...
  10. ncbi request reprint Covalent modification of human homeodomain interacting protein kinase 2 by SUMO-1 at lysine 25 affects its stability
    Ekaterina Gresko
    University of Bern, Department of Chemistry and Biochemistry, Freiestr 3, CH 3012 Bern, Switzerland
    Biochem Biophys Res Commun 329:1293-9. 2005
    ..The N-terminal SUMO-1 modification site is conserved between all vertebrate HIPK2 proteins and is found in all members of the HIPK family of protein kinases. Accordingly, also human HIPK3 is modified by sumoylation...
  11. ncbi request reprint Inhibition of mitosis by glycopeptide dendrimer conjugates of colchicine
    David Lagnoux
    Department of Chemistry and Biochemistry, University of Berne, Freiestrasse 3, 3012 Berne, Switzerland
    Chemistry 11:3941-50. 2005
    ..In comparison, non-glycosylated dendrimers and colchicine itself showed a selectivity of 10-fold or less for HeLa cells...
  12. ncbi request reprint The K252a derivatives, inhibitors for the PAK/MLK kinase family selectively block the growth of RAS transformants
    Thao V Nheu
    Ludwig Institute for Cancer Research, Royal Melbourne Hospital, Parkville, Australia
    Cancer J 8:328-36. 2002
    ..Thus, we have explored such a PAK1 inhibitor(s) among synthetic derivatives of an adenosine triphosphate antagonist...
  13. ncbi request reprint Src homology 2 domain-containing leukocyte phosphoprotein of 76 kDa and phospholipase C gamma 1 are required for NF-kappa B activation and lipid raft recruitment of protein kinase C theta induced by T cell costimulation
    Oliver Dienz
    Division of Immunochemistry, German Cancer Research Center Deutsches Krebsforschungszentrum, Im Neuenheimer Feld, Heidelberg, Germany
    J Immunol 170:365-72. 2003
    ..These results show the importance of SLP-76 and PLCgamma1 for NF-kappaB activation and raft translocation of PKCtheta and IKKgamma...
  14. ncbi request reprint Incensole acetate, a novel anti-inflammatory compound isolated from Boswellia resin, inhibits nuclear factor-kappa B activation
    Arieh Moussaieff
    Department of Medicinal Chemistry and Natural Products, Medical Faculty, Hebrew University, Jerusalem 91120, Israel
    Mol Pharmacol 72:1657-64. 2007
    ..Cembrenoid diterpenoids, specifically IA and its derivatives, may thus constitute a potential novel group of NF-kappaB inhibitors, originating from an ancient anti-inflammatory herbal remedy...
  15. ncbi request reprint Integration of the activation of the human hyaluronan synthase 2 gene promoter by common cofactors of the transcription factors retinoic acid receptor and nuclear factor kappaB
    Katri Saavalainen
    Department of Biochemistry, University of Kuopio, FIN 70211 Kuopio, Finland
    J Biol Chem 282:11530-9. 2007
    ..These findings partially explain the induction of HAS2 mRNA by all-trans-RA and TNF-alpha and provide an example how the action of different transcription factor families can use the same cofactors...
  16. ncbi request reprint NF-kappaB inhibitors for the treatment of inflammatory diseases and cancer
    Marco A Calzado
    Institute of Biochemistry, Medical Faculty, Friedrichstrasse 24, Justus Liebig University, D 35392 Giessen, Germany
    Curr Med Chem 14:367-76. 2007
    ..Here we discuss recent progress in the identification of druggable components of the NF-kappaB signaling system and the development and potential use of novel NF-kappaB inhibitors...
  17. ncbi request reprint Interleukin-1 beta-induced expression of the prostaglandin E-receptor subtype EP3 in U373 astrocytoma cells depends on protein kinase C and nuclear factor-kappaB
    Anne Waschbisch
    Department of Psychiatry, University of Freiburg Medical School, Freiburg, Germany
    J Neurochem 96:680-93. 2006
    ....
  18. pmc Roles of HIPK1 and HIPK2 in AML1- and p300-dependent transcription, hematopoiesis and blood vessel formation
    Yukiko Aikawa
    Molecular Oncology Division, National Cancer Center Research Institute, Chuo Ku, Tokyo, Japan
    EMBO J 25:3955-65. 2006
    ..HIPK2 also phosphorylates another co-activator, MOZ, in an AML1-dependent manner. We discuss a possible mechanism by which transcription factors could regulate local histone acetylation and transcription of their target genes...
  19. ncbi request reprint HIPK2: a versatile switchboard regulating the transcription machinery and cell death
    Marco A Calzado
    Institute of Biochemistry, Medical Faculty, Justus Liebig University, Giessen, Germany
    Cell Cycle 6:139-43. 2007
    ..Here we discuss recent findings from biochemical and functional experiments that allow a deeper understanding of the pleiotropic effects mediated by HIPK2...
  20. ncbi request reprint Roscovitine-activated HIP2 kinase induces phosphorylation of wt p53 at Ser-46 in human MCF-7 breast cancer cells
    Jozefa Wesierska-Gadek
    Cell Cycle Regulation Group, Division Institute of Cancer Research, Department of Medicine I, Medical University of Vienna, Borschkegasse 8 a, A 1090 Vienna, Austria
    J Cell Biochem 100:865-74. 2007
    ..These results identify HIPK2 as a component of the ROSC-induced signaling pathway leading to the stabilization and activation of wt p53 protein...
  21. ncbi request reprint Phosphorylation-dependent control of Pc2 SUMO E3 ligase activity by its substrate protein HIPK2
    Ana Roscic
    Institute of Biochemistry, Medical Faculty, Friedrichstrasse 24, Justus Liebig University, D 35392 Giessen, Germany
    Mol Cell 24:77-89. 2006
    ..Sumoylation enhances the ability of HIPK2 to mediate transcriptional repression, thus providing a mechanistic link for DNA damage-induced transcriptional silencing...
  22. ncbi request reprint Regulation of p53 activity by its interaction with homeodomain-interacting protein kinase-2
    Thomas G Hofmann
    Division of Immunochemistry G0200 German Cancer Research Center DKFZ, Im Neuenheimer Feld 280, 69120 Heidelberg, Germany
    Nat Cell Biol 4:1-10. 2002
    ..Interference with HIPK2 expression by antisense oligonucleotides impairs UV-induced apoptosis. Our results imply that HIPK2 is a novel regulator of p53 effector functions involved in cell growth, proliferation and apoptosis...
  23. ncbi request reprint Role of CREB1 and NF{kappa}B-p65 in the down-regulation of renin gene expression by tumor necrosis factor {alpha}
    Vladimir T Todorov
    Institute of Physiology, Institute of Pathology, and Department of Immunology, Regensburg University, D 93040 Regensburg, Germany
    J Biol Chem 280:24356-62. 2005
    ..Our results suggest that TNFalpha inhibits renin gene expression by decreasing the transactivating capacity of NFkappaB-p65 and partially by attenuating CREB1 binding to CRE...
  24. ncbi request reprint The human papillomavirus oncoprotein E7 attenuates NF-kappa B activation by targeting the Ikappa B kinase complex
    Dimitry Spitkovsky
    Institute for Vegetative Physiology, University of Cologne, Robert Koch Strasse 39, Germany
    J Biol Chem 277:25576-82. 2002
    ..We suggest that HPV oncogene-mediated suppression of NF-kappaB activity contributes to HPV escape from the immune system...
  25. ncbi request reprint Phenotype and regulation of persistent intracerebral T cells in murine Toxoplasma encephalitis
    Dirk Schluter
    Institut fur Medizinische Mikrobiologie und Hygiene, Universitatsklinikum Mannheim, Universitat Heidelberg, Mannheim, Germany
    J Immunol 169:315-22. 2002
    ..In chronic TE, T cell recruitment is terminated, the phenotype of intracerebral T cells changes, and their number is gradually downsized by low level apoptosis, which, however, does not completely resolve the T cell infiltrates...
  26. ncbi request reprint Lipoteichoic acid selectively induces the ERK signaling pathway in the cornea
    Lingtao You
    Department of Ophthalmology, University of Heidelberg Medical School, INF 400, 69120 Heidelberg, Germany
    Invest Ophthalmol Vis Sci 43:2272-7. 2002
    ..To identify signal transduction pathways and gene expression induced by the bacterial cell wall component lipoteichoic acid (LTA) in human corneal keratocytes...
  27. ncbi request reprint Critical role of NF-kappaB and stress-activated protein kinases in steroid unresponsiveness
    Heike Bantel
    Institute of Molecular Medicine, University of Dusseldorf, Germany
    FASEB J 16:1832-4. 2002
    ..Thus, our results suggest that steroid resistance is associated with increased epithelial activation of stress-activated protein kinases and NF-kappaB, which might inhibit the anti-inflammatory action of a limited number of GRs...
  28. ncbi request reprint The promoter context determines mutual repression or synergism between NF-kappaB and the glucocorticoid receptor
    Thomas G Hofmann
    Department of General Virology, Heinrich Pette Institute for Experimental Virology and Immunology, Martinistrasse 52, D 20251 Hamburg, Germany
    Biol Chem 383:1947-51. 2002
    ..These experiments reveal that the functional interplay between NF-kappaB and the GR also involves--dependent on the promoter context--synergistic stimulation of transcription...
  29. ncbi request reprint PML is required for homeodomain-interacting protein kinase 2 (HIPK2)-mediated p53 phosphorylation and cell cycle arrest but is dispensable for the formation of HIPK domains
    Andreas Möller
    Division of Immunochemistry, German Cancer Research Center DKFZ, 69120 Heidelberg, Germany
    Cancer Res 63:4310-4. 2003
    ..Whereas the architecture of HIPK domains is PML independent, HIPK2-mediated enhancement of p53-dependent transcription, p53 serine 46 phosphorylation and the antiproliferative function of HIPK2 strictly rely on the presence of PML...
  30. ncbi request reprint Sp100 is important for the stimulatory effect of homeodomain-interacting protein kinase-2 on p53-dependent gene expression
    Andreas Möller
    German Cancer Research Center, Division of Immunochemistry G0200, Im Neuenheimer Feld 280, Heidelberg D 69120, Germany
    Oncogene 22:8731-7. 2003
    ..In summary, these experiments reveal a novel function for Sp100 as a coactivator for HIPK2-mediated p53 activation...
  31. ncbi request reprint HIPK2 regulates transforming growth factor-beta-induced c-Jun NH(2)-terminal kinase activation and apoptosis in human hepatoma cells
    Thomas G Hofmann
    Heinrich Pette Institut fur experimentelle Virologie und Immunologie an der Universitat Hamburg, Hamburg, Germany
    Cancer Res 63:8271-7. 2003
    ..Taken together, our findings indicate that HIPK2 participates in the TGF-beta signaling pathway leading to JNK activation and apoptosis...
  32. pmc Of mice and men
    Yinon Ben-Neriah
    The Lautenberg Center for Immunology, Hebrew University Hadassah Medical School, Jerusalem 91120, Israel
    EMBO Rep 5:668-73. 2004
  33. ncbi request reprint Phosphorylation of serine 468 by GSK-3beta negatively regulates basal p65 NF-kappaB activity
    Holger Buss
    Institute of Pharmacology, Medical School Hannover, Carl Neuberg Strasse 1, D 30625 Hannover, Germany
    J Biol Chem 279:49571-4. 2004
    ..Collectively our results suggest that a GSK-3beta-PP1-dependent mechanism regulates phosphorylation of p65 NF-kappaB at Ser(468) in unstimulated cells and thereby controls the basal activity of NF-kappaB...
  34. ncbi request reprint Constitutive and interleukin-1-inducible phosphorylation of p65 NF-{kappa}B at serine 536 is mediated by multiple protein kinases including I{kappa}B kinase (IKK)-{alpha}, IKK{beta}, IKK{epsilon}, TRAF family member-associated (TANK)-binding kinase 1 (TBK
    Holger Buss
    Institute of Pharmacology, Medical School Hannover, Carl Neuberg Strasse 1, D 30625 Hannover, Germany
    J Biol Chem 279:55633-43. 2004
    ....
  35. doi request reprint NIK and Cot cooperate to trigger NF-kappaB p65 phosphorylation
    Tobias Wittwer
    Institute of Biochemistry, Medical Faculty, Friedrichstrasse 24, Justus Liebig University, D 35392 Giessen, Germany
    Biochem Biophys Res Commun 371:294-7. 2008
    ..Also the C-terminally truncated, oncogenic form of Cot is able to trigger p65 phosphorylation. In vitro kinase assays and dominant negative mutants revealed that NIK functions downstream of Cot to mediate p65 phosphorylation...