Margret Schlumpf

Summary

Affiliation: University of Zurich
Country: Switzerland

Publications

  1. ncbi request reprint Endocrine activity and developmental toxicity of cosmetic UV filters--an update
    Margret Schlumpf
    Institute of Pharmacology and Toxicology, University of Zurich, Winterthurerstrasse 190, CH 8057 Zurich, Switzerland
    Toxicology 205:113-22. 2004
  2. doi request reprint Female sexual behavior, estrous cycle and gene expression in sexually dimorphic brain regions after pre- and postnatal exposure to endocrine active UV filters
    Oliver Faass
    GREEN Tox and Institute of Anatomy, University of Zurich, Zurich, Switzerland
    Neurotoxicology 30:249-60. 2009
  3. ncbi request reprint Sexually dimorphic gene regulation in brain as a target for endocrine disrupters: developmental exposure of rats to 4-methylbenzylidene camphor
    Kirsten Maerkel
    Institute of Pharmacology and Toxicology and GREEN Tox, University of Zurich, CH 8057 Zurich, Switzerland
    Toxicol Appl Pharmacol 218:152-65. 2007
  4. pmc Estrogen sensitivity of target genes and expression of nuclear receptor co-regulators in rat prostate after pre- and postnatal exposure to the ultraviolet filter 4-methylbenzylidene camphor
    Stefan Durrer
    Institute of Pharmacology and Toxicology and GREEN Tox, University of Zurich, Zurich, Switzerland
    Environ Health Perspect 115:42-50. 2007
  5. doi request reprint Developmental toxicity of UV filters and environmental exposure: a review
    Margret Schlumpf
    GREEN Tox and Institute of Anatomy, University of Zurich, Zurich, Switzerland
    Int J Androl 31:144-51. 2008
  6. ncbi request reprint Estrogen target gene regulation and coactivator expression in rat uterus after developmental exposure to the ultraviolet filter 4-methylbenzylidene camphor
    Stefan Durrer
    Institute of Pharmacology and Toxicology, University of Zurich, Switzerland
    Endocrinology 146:2130-9. 2005
  7. ncbi request reprint Gene expression and estrogen sensitivity in rat uterus after developmental exposure to the polybrominated diphenylether PBDE 99 and PCB
    Raffaella Ceccatelli
    GREEN Tox and Institute of Pharmacology and Toxicology, University of Zurich, Winterthurerstrasse 190, CH 8057 Zurich, Switzerland
    Toxicology 220:104-16. 2006
  8. doi request reprint Developmental effects of perinatal exposure to PBDE and PCB on gene expression in sexually dimorphic rat brain regions and female sexual behavior
    Oliver Faass
    GREEN Tox and Institute of Anatomy, University of Zurich, Winterthurerstrasse 190, Zurich, Switzerland
    Gen Comp Endocrinol 188:232-41. 2013
  9. pmc Salbutamol exhibits androgenic activity in vitro
    Andre O Von Bueren
    Institute of Pharmacology and Toxicology, University of Zurich, Switzerland
    Br J Sports Med 41:874-8; discussion 878. 2007
  10. ncbi request reprint Estrogenic activity and estrogen receptor beta binding of the UV filter 3-benzylidene camphor. Comparison with 4-methylbenzylidene camphor
    Margret Schlumpf
    Institute of Pharmacology and Toxicology, University of Zurich, Winterthurerstrasse 190, CH 8057 Zurich, Switzerland
    Toxicology 199:109-20. 2004

Collaborators

Detail Information

Publications15

  1. ncbi request reprint Endocrine activity and developmental toxicity of cosmetic UV filters--an update
    Margret Schlumpf
    Institute of Pharmacology and Toxicology, University of Zurich, Winterthurerstrasse 190, CH 8057 Zurich, Switzerland
    Toxicology 205:113-22. 2004
    ..Lowest effective doses were 0.24 mg/kg/day for 3-BC and 7 mg/kg/day for 4-MBC. Fat tissue levels at 7 mg/kg 4-MBC (GC-MS) approached the range of UV filters in fish (Nagtegaal et al., 1997; Balmer et al., 2004)...
  2. doi request reprint Female sexual behavior, estrous cycle and gene expression in sexually dimorphic brain regions after pre- and postnatal exposure to endocrine active UV filters
    Oliver Faass
    GREEN Tox and Institute of Anatomy, University of Zurich, Zurich, Switzerland
    Neurotoxicology 30:249-60. 2009
    ..4 and 7mg/kg bw/day 3-BC. Our data demonstrate that female sexual behavior represents a sensitive target of endocrine disrupters and point to an involvement of PR in VMH...
  3. ncbi request reprint Sexually dimorphic gene regulation in brain as a target for endocrine disrupters: developmental exposure of rats to 4-methylbenzylidene camphor
    Kirsten Maerkel
    Institute of Pharmacology and Toxicology and GREEN Tox, University of Zurich, CH 8057 Zurich, Switzerland
    Toxicol Appl Pharmacol 218:152-65. 2007
    ..The data indicate profound sex- and region-specific alterations in the regulation of estrogen target genes at brain level. Effect patterns in baseline and E2-induced gene expression differ from those in uterus and prostate...
  4. pmc Estrogen sensitivity of target genes and expression of nuclear receptor co-regulators in rat prostate after pre- and postnatal exposure to the ultraviolet filter 4-methylbenzylidene camphor
    Stefan Durrer
    Institute of Pharmacology and Toxicology and GREEN Tox, University of Zurich, Zurich, Switzerland
    Environ Health Perspect 115:42-50. 2007
    ..Here, we report effects on male development...
  5. doi request reprint Developmental toxicity of UV filters and environmental exposure: a review
    Margret Schlumpf
    GREEN Tox and Institute of Anatomy, University of Zurich, Zurich, Switzerland
    Int J Androl 31:144-51. 2008
    ..7 mg/kg for 4-MBC and 0.24/0.07 mg/kg for 3-BC. Molecular endpoints were affected by the lowest doses studied. Our data indicate that the potential risk posed by endocrine active UV filters warrants further investigations...
  6. ncbi request reprint Estrogen target gene regulation and coactivator expression in rat uterus after developmental exposure to the ultraviolet filter 4-methylbenzylidene camphor
    Stefan Durrer
    Institute of Pharmacology and Toxicology, University of Zurich, Switzerland
    Endocrinology 146:2130-9. 2005
    ..Our data indicate that developmental exposure to 4-MBC affects the regulation of estrogen target genes and the expression of nuclear receptor coregulators in uterus at mRNA and protein levels...
  7. ncbi request reprint Gene expression and estrogen sensitivity in rat uterus after developmental exposure to the polybrominated diphenylether PBDE 99 and PCB
    Raffaella Ceccatelli
    GREEN Tox and Institute of Pharmacology and Toxicology, University of Zurich, Winterthurerstrasse 190, CH 8057 Zurich, Switzerland
    Toxicology 220:104-16. 2006
    ..Since PBDE 99 was detected in blood and adipose tissue of adult offspring, these effects may result from interactions with developmental processes, adult functions, or a combination of both...
  8. doi request reprint Developmental effects of perinatal exposure to PBDE and PCB on gene expression in sexually dimorphic rat brain regions and female sexual behavior
    Oliver Faass
    GREEN Tox and Institute of Anatomy, University of Zurich, Winterthurerstrasse 190, Zurich, Switzerland
    Gen Comp Endocrinol 188:232-41. 2013
    ..Since PBDE99 was detected in blood and adipose tissue of adult offspring, these effects may result from interactions with developmental processes, with adult functions, or a combination of both...
  9. pmc Salbutamol exhibits androgenic activity in vitro
    Andre O Von Bueren
    Institute of Pharmacology and Toxicology, University of Zurich, Switzerland
    Br J Sports Med 41:874-8; discussion 878. 2007
    ..Salbutamol has been shown to mediate anabolic effects after intravenous administration. However, the mechanism responsible for the anabolic actions of salbutamol remains unknown...
  10. ncbi request reprint Estrogenic activity and estrogen receptor beta binding of the UV filter 3-benzylidene camphor. Comparison with 4-methylbenzylidene camphor
    Margret Schlumpf
    Institute of Pharmacology and Toxicology, University of Zurich, Winterthurerstrasse 190, CH 8057 Zurich, Switzerland
    Toxicology 199:109-20. 2004
    ..Their activity on immature rat uterus is not easily explained by ERbeta activation. It cannot be excluded that active metabolites with possibly different receptor binding characteristics are formed in vivo...
  11. doi request reprint Exposure patterns of UV filters, fragrances, parabens, phthalates, organochlor pesticides, PBDEs, and PCBs in human milk: correlation of UV filters with use of cosmetics
    Margret Schlumpf
    GREEN Tox and Institute of Anatomy, University of Zurich, Winterthurerstrasse 190, Zurich, Switzerland
    Chemosphere 81:1171-83. 2010
    ..Our data emphasize the need for analyses of complex mixtures to obtain more information on inter-individual and temporal variability of human exposure to different types of chemicals...
  12. ncbi request reprint UV filters with antagonistic action at androgen receptors in the MDA-kb2 cell transcriptional-activation assay
    Risheng Ma
    Institute of Pharmacology and Toxicology, University of Zurich, CH 8057, Zurich, Switzerland
    Toxicol Sci 74:43-50. 2003
    ..These data indicate that the UV filters Bp-3 and HMS possess antiandrogenic activity in vitro in addition to estrogenic activity...
  13. ncbi request reprint Adrenal-mediated rather than direct effects of nicotine as a basis of altered sex steroid synthesis in fetal and neonatal rat
    Alexander Sarasin
    Institute of Pharmacology and Toxicology, University of Zurich, Winterthurerstrasse 190, CH 8057, Zurich, Switzerland
    Reprod Toxicol 17:153-62. 2003
    ..POMC mRNA in anterior pituitary of nicotine-exposed GD 18 fetuses was reduced, probably as a result of corticosterone feedback. These data reveal a novel type of interaction of nicotine with the fetal gonadal axis involving the adrenal...
  14. pmc Region-specific growth effects in the developing rat prostate following fetal exposure to estrogenic ultraviolet filters
    Luke Hofkamp
    Division of Basic Biomedical Sciences, Sanford School of Medicine, University of South Dakota, Vermillion, South Dakota 57069, USA
    Environ Health Perspect 116:867-72. 2008
    ..We examined the effects of two UV filters, 4-methylbenzylidene camphor (4-MBC) and 3-benzylidene camphor (3-BC), in the developing prostate of the fetal rat...
  15. pmc Interlaboratory comparison of four in vitro assays for assessing androgenic and antiandrogenic activity of environmental chemicals
    Wolfgang Korner
    Bayerisches Landesamt für Umweltschutz, Augsburg, Germany
    Environ Health Perspect 112:695-702. 2004
    ..In summary, all assays proved sensitive screening tools to detect and quantify androgen receptor-mediated androgenic and antiandrogenic effects of these chemicals accurately, with coefficients of variation between 8 and 90%...