Dominik J Schaer

Summary

Affiliation: University Hospital
Country: Switzerland

Publications

  1. pmc Mechanisms of haptoglobin protection against hemoglobin peroxidation triggered endothelial damage
    C A Schaer
    Institute of Anesthesiology, University Hospital, Zurich, Switzerland
    Cell Death Differ 20:1569-79. 2013
  2. pmc Persistent fever, neck swelling, and small vessel vasculitis following tonsillectomy in a patient with Behçet's disease: a case report
    Claudia Wagner
    University Hospital of Zurich, Clinic of Internal Medicine, Zurich, Switzerland
    J Med Case Rep 6:371. 2012
  3. ncbi request reprint CD163 is the macrophage scavenger receptor for native and chemically modified hemoglobins in the absence of haptoglobin
    Dominik J Schaer
    Medical Clinic B Research Unit, University Hospital, CH 8091 Zurich, Switzerland
    Blood 107:373-80. 2006
  4. pmc Hemolysis and free hemoglobin revisited: exploring hemoglobin and hemin scavengers as a novel class of therapeutic proteins
    Dominik J Schaer
    Division of Internal Medicine, University Hospital, Zurich, Switzerland
    Blood 121:1276-84. 2013
  5. pmc Hemophagocytic macrophages constitute a major compartment of heme oxygenase expression in sepsis
    Dominik J Schaer
    Department of Medicine, University Hospital, Zurich, Switzerland
    Eur J Haematol 77:432-6. 2006
  6. ncbi request reprint Heme carrier protein (HCP-1) spatially interacts with the CD163 hemoglobin uptake pathway and is a target of inflammatory macrophage activation
    Christian A Schaer
    Department of Medicine, University Hospital, CH 8091 Zurich, Switzerland
    J Leukoc Biol 83:325-33. 2008
  7. doi request reprint The reaction of hydrogen peroxide with hemoglobin induces extensive alpha-globin crosslinking and impairs the interaction of hemoglobin with endogenous scavenger pathways
    Florence Vallelian
    Internal Medicine Research Unit, University of Zurich, Zurich, Switzerland
    Free Radic Biol Med 45:1150-8. 2008
  8. ncbi request reprint CD163-expressing monocytes constitute an endotoxin-sensitive Hb clearance compartment within the vascular system
    Christian A Schaer
    Department of Medicine, University Hospital, CH 8091 Zurich, Switzerland
    J Leukoc Biol 82:106-10. 2007
  9. ncbi request reprint Constitutive endocytosis of CD163 mediates hemoglobin-heme uptake and determines the noninflammatory and protective transcriptional response of macrophages to hemoglobin
    Christian A Schaer
    Department of Medicine, University Hospital, Zurich, Switzerland
    Circ Res 99:943-50. 2006
  10. doi request reprint Hemoglobin can attenuate hydrogen peroxide-induced oxidative stress by acting as an antioxidative peroxidase
    Corinne C Widmer
    Division of Internal Medicine, University Hospital, Zurich, Switzerland
    Antioxid Redox Signal 12:185-98. 2010

Collaborators

Detail Information

Publications27

  1. pmc Mechanisms of haptoglobin protection against hemoglobin peroxidation triggered endothelial damage
    C A Schaer
    Institute of Anesthesiology, University Hospital, Zurich, Switzerland
    Cell Death Differ 20:1569-79. 2013
    ..By these mechanisms, Hp shifts Hb's destructive pseudo-peroxidative reaction to a potential anti-oxidative function during peroxidative stress. ..
  2. pmc Persistent fever, neck swelling, and small vessel vasculitis following tonsillectomy in a patient with Behçet's disease: a case report
    Claudia Wagner
    University Hospital of Zurich, Clinic of Internal Medicine, Zurich, Switzerland
    J Med Case Rep 6:371. 2012
    ..abstract:..
  3. ncbi request reprint CD163 is the macrophage scavenger receptor for native and chemically modified hemoglobins in the absence of haptoglobin
    Dominik J Schaer
    Medical Clinic B Research Unit, University Hospital, CH 8091 Zurich, Switzerland
    Blood 107:373-80. 2006
    ..These results identify CD163 as a scavenger receptor for native Hb and small-molecular-weight Hb-based blood substitutes after Hp depletion...
  4. pmc Hemolysis and free hemoglobin revisited: exploring hemoglobin and hemin scavengers as a novel class of therapeutic proteins
    Dominik J Schaer
    Division of Internal Medicine, University Hospital, Zurich, Switzerland
    Blood 121:1276-84. 2013
    ....
  5. pmc Hemophagocytic macrophages constitute a major compartment of heme oxygenase expression in sepsis
    Dominik J Schaer
    Department of Medicine, University Hospital, Zurich, Switzerland
    Eur J Haematol 77:432-6. 2006
    ....
  6. ncbi request reprint Heme carrier protein (HCP-1) spatially interacts with the CD163 hemoglobin uptake pathway and is a target of inflammatory macrophage activation
    Christian A Schaer
    Department of Medicine, University Hospital, CH 8091 Zurich, Switzerland
    J Leukoc Biol 83:325-33. 2008
    ..Given the spatial relationship, we propose that the Hb scavenger receptor CD163 and HCP-1 constitute a linked pathway for Hb catabolism and heme-iron recycling in human macrophages...
  7. doi request reprint The reaction of hydrogen peroxide with hemoglobin induces extensive alpha-globin crosslinking and impairs the interaction of hemoglobin with endogenous scavenger pathways
    Florence Vallelian
    Internal Medicine Research Unit, University of Zurich, Zurich, Switzerland
    Free Radic Biol Med 45:1150-8. 2008
    ..Failed Hb clearance, inadequate HO-1 expression, and the subsequent accumulation of oxidatively damaged Hb species might thus contribute to pathologies related to oxidative stress...
  8. ncbi request reprint CD163-expressing monocytes constitute an endotoxin-sensitive Hb clearance compartment within the vascular system
    Christian A Schaer
    Department of Medicine, University Hospital, CH 8091 Zurich, Switzerland
    J Leukoc Biol 82:106-10. 2007
    ..Disruption of monocyte Hb-Hp clearance may increase Hb-Hp toxicity and contribute to the pathogenesis of systemic inflammatory diseases associated with reduced monocyte CD163 expression...
  9. ncbi request reprint Constitutive endocytosis of CD163 mediates hemoglobin-heme uptake and determines the noninflammatory and protective transcriptional response of macrophages to hemoglobin
    Christian A Schaer
    Department of Medicine, University Hospital, Zurich, Switzerland
    Circ Res 99:943-50. 2006
    ..Noninflammatory Hb clearance and intimately linked HO-1 expression may provide the long sought-after explanation for the antiinflammatory activity associated with CD163-positive macrophages...
  10. doi request reprint Hemoglobin can attenuate hydrogen peroxide-induced oxidative stress by acting as an antioxidative peroxidase
    Corinne C Widmer
    Division of Internal Medicine, University Hospital, Zurich, Switzerland
    Antioxid Redox Signal 12:185-98. 2010
    ..Our results suggest that complex interactions determine whether extracellular Hb, under certain circumstances, acts a protective or a damaging factor during peroxidative stress conditions...
  11. doi request reprint Glucocorticoid treatment skews human monocyte differentiation into a hemoglobin-clearance phenotype with enhanced heme-iron recycling and antioxidant capacity
    Florence Vallelian
    Internal Medicine, University Hospital, Zurich, Switzerland
    Blood 116:5347-56. 2010
    ..Therefore, stimulating Hb-endocytosis by CD163 and enhancing antioxidative homeostasis and iron recycling may be an essential activity of glucocorticoids that helps alleviate the adverse effects of extracellular Hb...
  12. doi request reprint Extracellular hemoglobin polarizes the macrophage proteome toward Hb-clearance, enhanced antioxidant capacity and suppressed HLA class 2 expression
    Theresa Kaempfer
    Internal Medicine, University Hospital, Zurich, Switzerland
    J Proteome Res 10:2397-408. 2011
    ..Enhanced Hb clearance and antioxidant capacity together with reduced antigen presentation might therefore be essential qualities of Hb polarized macrophages in wounded tissues and hemorrhage or atherosclerotic plaques...
  13. doi request reprint Wnt5A/CaMKII signaling contributes to the inflammatory response of macrophages and is a target for the antiinflammatory action of activated protein C and interleukin-10
    Claudia Pereira
    Molecular and Clinical Inflammation Research Unit, Medical Clinic, University Hospital of Zurich, Ramistrasse 100, CH 8091 Zurich, Switzerland
    Arterioscler Thromb Vasc Biol 28:504-10. 2008
    ..To identify targets for antiinflammatory intervention, we investigated the response of human macrophages to inflammatory and antiinflammatory mediators...
  14. ncbi request reprint Soluble hemoglobin-haptoglobin scavenger receptor CD163 as a lineage-specific marker in the reactive hemophagocytic syndrome
    Dominik J Schaer
    Department of Medicine, University Hospital, Zurich, Switzerland
    Eur J Haematol 74:6-10. 2005
    ..Our data suggests sCD163 to be a macrophage-specific marker in patients with disorders of inappropriate macrophage activation...
  15. pmc Transcriptome analysis revealed unique genes as targets for the anti-inflammatory action of activated protein C in human macrophages
    Claudia P Pereira
    Inflammation Research Unit, Division of Internal Medicine, University Hospital of Zurich and Zurich Center for Integrative Human Physiology ZIHP, University of Zurich, Zurich, Switzerland
    PLoS ONE 5:e15352. 2010
    ..In this study we investigated novel targets for the anti-inflammatory action of APC in human macrophages...
  16. ncbi request reprint Functional expression of the CD163 scavenger receptor on acute myeloid leukemia cells of monocytic lineage
    Esther B Bachli
    Department of Medicine, University Hospital of Zurich, CH 8091 Zurich, Switzerland
    J Leukoc Biol 79:312-8. 2006
    ....
  17. ncbi request reprint Gating the radical hemoglobin to macrophages: the anti-inflammatory role of CD163, a scavenger receptor
    Dominik J Schaer
    Medical Clinic B Research Unit, University of Zurich, Switzerland
    Antioxid Redox Signal 9:991-9. 2007
    ..Here, an overview and novel insights into the role of CD163 in Hb redox inactivation and clearance are provided...
  18. pmc Sequestration of extracellular hemoglobin within a haptoglobin complex decreases its hypertensive and oxidative effects in dogs and guinea pigs
    Felicitas S Boretti
    Clinic for Small Animals, Vetsuisse Faculty, University of Zurich, Zurich, Switzerland
    J Clin Invest 119:2271-80. 2009
    ....
  19. pmc Human Hp1-1 and Hp2-2 phenotype-specific haptoglobin therapeutics are both effective in vitro and in guinea pigs to attenuate hemoglobin toxicity
    Miriam Lipiski
    1 Division of Internal Medicine, University of Zurich, Zurich, Switzerland
    Antioxid Redox Signal 19:1619-33. 2013
    ..Epidemiologic studies demonstrate the phenotype heterogeneity of human Hp proteins and suggest differing vascular protective potential imparted by the dimeric Hp1-1 and the polymeric Hp2-2...
  20. doi request reprint Retinal microangiopathy and rapidly fatal cerebral edema in a patient with adult-onset Still's disease and concurrent macrophage activation syndrome
    Sara Gianella
    Department of Internal Medicine, University Hospital of Zurich, Zurich, Switzerland
    Am J Hematol 83:424-7. 2008
    ..In conclusion, even the slightest sign of mental decline in a patient with AOSD must be considered central nervous system MAS which can be rapidly fatal...
  21. pmc Chloroquine interference with hemoglobin endocytic trafficking suppresses adaptive heme and iron homeostasis in macrophages: the paradox of an antimalarial agent
    Christian A Schaer
    Department of Anesthesiology, University Hospital, 8091 Zurich, Switzerland
    Oxid Med Cell Longev 2013:870472. 2013
    ..A functional deficiency of Hb detoxification and heme-iron recycling may therefore be an adverse consequence of chloroquine treatment during hemolysis. ..
  22. doi request reprint Inhibition of meningitis-associated neutrophil apoptosis by TNF-α depends on functional PI3-kinase in monocytes
    Mike Recher
    Clinical Immunology, University Hospital, Zurich, Switzerland
    J Leukoc Biol 93:259-66. 2013
    ..We conclude that LPS-driven PI3K signaling in monocytes regulates neutrophil apoptosis and thereby, may be crucial in the initiation of secondary brain damage in bacterial meningitis...
  23. doi request reprint Characterization of high molecular weight multimeric states of human haptoglobin and hemoglobin-based oxygen carriers by high-mass MALDI MS
    Tatiana Pimenova
    Department of Chemistry and Applied Biosciences, ETH Zurich, Zurich, Switzerland
    J Sep Sci 32:1224-30. 2009
    ..These investigations are of clinical importance and contribute to the overall understanding of specific toxicity and clearance of HBOCs...
  24. doi request reprint Determinants of inter-individual cholesterol level variation in an unbiased young male sample
    Frank Jakobus Rühli
    Institute of Anatomy, University of Zurich, Zurich, Switzerland
    Swiss Med Wkly 138:286-91. 2008
    ..We present total cholesterol values and their possible aetiological factors of young Swiss conscripts. Particularly, we study varying impact of these factors depending on different levels of individual cholesterol...
  25. ncbi request reprint Proteinase-activated receptors induce nonoxidative, antimicrobial peptides and increased antimicrobial activity in human mononuclear phagocytes
    Nadine Lippuner
    Research Unit, Clinic for Internal Medicine, AW 9, University Hospital, CH 8091 Zurich, Switzerland
    J Leukoc Biol 81:465-73. 2007
    ..Taken together, these findings suggest that IFN-gamma and thrombin differentially regulate oxidative and nonoxidative killing systems of human monocytes...
  26. ncbi request reprint Neurological adverse events to voriconazole: evidence for therapeutic drug monitoring
    Alexander Imhof
    Department of Internal Medicine, University Hospital, Zurich, Switzerland
    Swiss Med Wkly 136:739-42. 2006
    ..Voriconazole shows a considerable interpatient variation of serum concentrations...
  27. ncbi request reprint Expression and secretion of procalcitonin and calcitonin gene-related peptide by adherent monocytes and by macrophage-activated adipocytes
    Philippe Linscheid
    Department of Research, Division of Endocrinology, Diabetology and Clinical Nutrition, University Hospital, Basel, Switzerland
    Crit Care Med 32:1715-21. 2004
    ..To explore the roles of peripheral blood mononuclear cells (PBMCs) and PBMC-derived macrophages in sepsis-related increased procalcitonin and calcitonin gene-related peptide (CGRP) I production...