E Savaskan

Summary

Affiliation: University of Basel
Country: Switzerland

Publications

  1. ncbi request reprint Distribution of melatonin MT1 receptor immunoreactivity in human retina
    Egemen Savaskan
    Department of Gerontopsychiatry, Psychiatric University Clinic, University of Basel, Wilhelm Klein Strasse 27, CH 4025 Basel, Switzerland
    J Histochem Cytochem 50:519-26. 2002
  2. ncbi request reprint The role of the brain renin-angiotensin system in neurodegenerative disorders
    Egemen Savaskan
    Psychiatric University Clinic, Wilhelm Klein Str 27, CH 4025 Basel, Switzerland
    Curr Alzheimer Res 2:29-35. 2005
  3. ncbi request reprint Alterations in trk A, trk B and trk C receptor immunoreactivities in parietal cortex and cerebellum in Alzheimer's disease
    E Savaskan
    Department of Psychiatry, University of Basel, Switzerland
    Eur Neurol 44:172-80. 2000
  4. ncbi request reprint Immunohistochemical Localization of Fas-associated phosphatase-1 (FAP-1) in Alzheimer disease hippocampus
    Egemen Savaskan
    Psychiatric Clinic, University of Basel, Wilhelm Klein Str 27, Basel, Switzerland
    Appl Immunohistochem Mol Morphol 13:190-3. 2005
  5. ncbi request reprint Orexins and their receptors in the human retina
    Egemen Savaskan
    Psychiatric University Clinic, Basel, Switzerland
    Pathobiology 71:211-6. 2004
  6. ncbi request reprint Red wine ingredient resveratrol protects from beta-amyloid neurotoxicity
    Egemen Savaskan
    Psychiatric Clinic, University of Basel, Basel, Switzerland
    Gerontology 49:380-3. 2003
  7. ncbi request reprint Increased melatonin 1a-receptor immunoreactivity in the hippocampus of Alzheimer's disease patients
    Egemen Savaskan
    Psychiatric University Clinic, Basel, Switzerland
    J Pineal Res 32:59-62. 2002
  8. ncbi request reprint Hippocampal estrogen beta-receptor immunoreactivity is increased in Alzheimer's disease
    E Savaskan
    Department of Psychiatry, University of Basel, Wilhelm Klein Str 27, CH 4025 Basel, Switzerland
    Brain Res 908:113-9. 2001
  9. ncbi request reprint Cortical alterations of angiotensin converting enzyme, angiotensin II and AT1 receptor in Alzheimer's dementia
    E Savaskan
    Department of Psychiatry, University of Basel, Wilhelm Klein Str 27, CH 4054, Basel, Switzerland
    Neurobiol Aging 22:541-6. 2001
  10. ncbi request reprint Cerebrovascular melatonin MT1-receptor alterations in patients with Alzheimer's disease
    E Savaskan
    Department of Psychiatry, University of Basel, Wilhelm Klein Str 27, CH 4025, Basel, Switzerland
    Neurosci Lett 308:9-12. 2001

Collaborators

Detail Information

Publications26

  1. ncbi request reprint Distribution of melatonin MT1 receptor immunoreactivity in human retina
    Egemen Savaskan
    Department of Gerontopsychiatry, Psychiatric University Clinic, University of Basel, Wilhelm Klein Strasse 27, CH 4025 Basel, Switzerland
    J Histochem Cytochem 50:519-26. 2002
    ..In AD cases photoreceptor cells were degenerated and showed low MT1 expression...
  2. ncbi request reprint The role of the brain renin-angiotensin system in neurodegenerative disorders
    Egemen Savaskan
    Psychiatric University Clinic, Wilhelm Klein Str 27, CH 4025 Basel, Switzerland
    Curr Alzheimer Res 2:29-35. 2005
    ..The aim of this brief review is to summarize the current state of research in this field with emphasis on RAS-related alterations during the course of neurodegenerative disorders...
  3. ncbi request reprint Alterations in trk A, trk B and trk C receptor immunoreactivities in parietal cortex and cerebellum in Alzheimer's disease
    E Savaskan
    Department of Psychiatry, University of Basel, Switzerland
    Eur Neurol 44:172-80. 2000
    ..In addition, cerebellar Purkinje cells revealed a distinct immunoreactivity for trk C both in control and AD cases, suggesting trk C may be important in the maintenance of these cells in the aged brain...
  4. ncbi request reprint Immunohistochemical Localization of Fas-associated phosphatase-1 (FAP-1) in Alzheimer disease hippocampus
    Egemen Savaskan
    Psychiatric Clinic, University of Basel, Wilhelm Klein Str 27, Basel, Switzerland
    Appl Immunohistochem Mol Morphol 13:190-3. 2005
    ..Rather, these data may indicate a general role for FAP-1 in neuronal death both in adult CNS and during the course of neurodegenerative disorders...
  5. ncbi request reprint Orexins and their receptors in the human retina
    Egemen Savaskan
    Psychiatric University Clinic, Basel, Switzerland
    Pathobiology 71:211-6. 2004
    ..In the human retina, however, immunohistochemical localization of orexins and their receptors, OX-R1 and OX-R2, has not been ascertained...
  6. ncbi request reprint Red wine ingredient resveratrol protects from beta-amyloid neurotoxicity
    Egemen Savaskan
    Psychiatric Clinic, University of Basel, Basel, Switzerland
    Gerontology 49:380-3. 2003
    ..Since a moderate wine intake correlates with a lower risk for Alzheimer disease (AD), an additional neuroprotective effect has been postulated for resveratrol...
  7. ncbi request reprint Increased melatonin 1a-receptor immunoreactivity in the hippocampus of Alzheimer's disease patients
    Egemen Savaskan
    Psychiatric University Clinic, Basel, Switzerland
    J Pineal Res 32:59-62. 2002
    ..There was a distinct increase in staining intensity in all AD cases indicating an up-regulation of the receptor, possibly as a compensatory response to impaired melatonin levels in order to augment melatonin's neuroprotective effects...
  8. ncbi request reprint Hippocampal estrogen beta-receptor immunoreactivity is increased in Alzheimer's disease
    E Savaskan
    Department of Psychiatry, University of Basel, Wilhelm Klein Str 27, CH 4025 Basel, Switzerland
    Brain Res 908:113-9. 2001
    ..This study provides the first demonstration of ER beta in human hippocampus in aged controls compared to AD cases...
  9. ncbi request reprint Cortical alterations of angiotensin converting enzyme, angiotensin II and AT1 receptor in Alzheimer's dementia
    E Savaskan
    Department of Psychiatry, University of Basel, Wilhelm Klein Str 27, CH 4054, Basel, Switzerland
    Neurobiol Aging 22:541-6. 2001
    ..In addition, a prominent perivascular ACE and angiotensin II immunoreactivity surrounding some cortical vessels in aged controls and AD patients points to an underlying microvascular pathology in the process of neurodegeneration...
  10. ncbi request reprint Cerebrovascular melatonin MT1-receptor alterations in patients with Alzheimer's disease
    E Savaskan
    Department of Psychiatry, University of Basel, Wilhelm Klein Str 27, CH 4025, Basel, Switzerland
    Neurosci Lett 308:9-12. 2001
    ..The increased MT1 in AD may indicate a regulatory response to impaired melatonin levels in those patients, contributing to the regulation of cerebral circulation...
  11. ncbi request reprint Melatonin protects SHSY5Y neuroblastoma cells from cobalt-induced oxidative stress, neurotoxicity and increased beta-amyloid secretion
    G Olivieri
    Neurobiology Laboratory, Psychiatric University Hospital, CH 4025 Basel, Switzerland
    J Pineal Res 31:320-5. 2001
    ..These findings are significant as cobalt is an essential nutritional requirement, usually bound to cobalamin (vitamin B12), for all animals which in the unbound form could lead to neurotoxicity...
  12. ncbi request reprint Oxidative stress modulates tyrosine kinase receptor A and p75 receptor (low-affinity nerve growth factor receptor) expression in SHSY5Y neuroblastoma cells
    G Olivieri
    Neurobiology Laboratory, Psychiatric University Hospital, Basel, Switzerland
    Neurol Clin Neurophysiol 2002:2-10. 2002
    ..These results are significant, as they can help in the planning and implementation of AD treatment strategies involving neurotrophins...
  13. ncbi request reprint The effects of beta-estradiol on SHSY5Y neuroblastoma cells during heavy metal induced oxidative stress, neurotoxicity and beta-amyloid secretion
    G Olivieri
    Neurobiology Laboratory, Psychiatric University Hospital, CH 4025 Basel, Switzerland
    Neuroscience 113:849-55. 2002
    ..Our results are significant as they contribute to a better understanding of the mode of action of estrogen with relevance to its use in the treatment of neurodegenerative disorders...
  14. ncbi request reprint Pineal and cortical melatonin receptors MT1 and MT2 are decreased in Alzheimer's disease
    P Brunner
    Psychiatric University Clinics, Basel, Switzerland
    Eur J Histochem 50:311-6. 2006
    ..In line with our previous findings, melatonin receptor expression in AD is impaired in two additional brain areas, and may contribute to disease pathology...
  15. ncbi request reprint Haloperidol disrupts, clozapine reinstates the circadian rest-activity cycle in a patient with early-onset Alzheimer disease
    A Wirz-Justice
    Chronobiology and Sleep Laboratory, Psychiatric University Clinic, Basel, Switzerland
    Alzheimer Dis Assoc Disord 14:212-5. 2000
    ..Similar observations in schizophrenic patients indicate that this chronobiological finding is drug- and not illness-related...
  16. ncbi request reprint Are G protein-coupled receptor heterodimers of physiological relevance?--Focus on melatonin receptors
    Angelique Levoye
    Department of Cell Biology, Institut Cochin, Universite Paris Descartes, Faculte de Medecine, France
    Chronobiol Int 23:419-26. 2006
    ....
  17. ncbi request reprint The MT2 melatonin receptor subtype is present in human retina and decreases in Alzheimer's disease
    Egemen Savaskan
    Psychiatric University Clinic, Basel, Switzerland
    Curr Alzheimer Res 4:47-51. 2007
    ..Since our previous results showed an increase in MT(1) expression in AD retina, the two melatonin receptor subtypes appear to be differentially affected by the course of the neurodegenerative disorder...
  18. ncbi request reprint Detection of the human GPR50 orphan seven transmembrane protein by polyclonal antibodies mapping different epitopes
    Hassina Ould Hamouda
    Institut Cochin, Department of Cell Biology, Paris, France
    J Pineal Res 43:10-5. 2007
    ..In conclusion, we successfully produced antibodies against the orphan GPR50 protein that will become valuable tools for functional studies of this protein...
  19. ncbi request reprint Humour therapy in patients with late-life depression or Alzheimer's disease: a pilot study
    Marc Walter
    Psychiatric University Clinics, University of Basel, Basel, Switzerland
    Int J Geriatr Psychiatry 22:77-83. 2007
    ..Therefore non-pharmacological treatment strategies are of great importance. The aim of the present study was to investigate the impact of humour therapy on quality of life in patients with depression or AD...
  20. ncbi request reprint Treatment of behavioural, cognitive and circadian rest-activity cycle disturbances in Alzheimer's disease: haloperidol vs. quetiapine
    Egemen Savaskan
    Geriatric Psychiatry, University Psychiatric Hospitals, CH 4025 Basel, Switzerland
    Int J Neuropsychopharmacol 9:507-16. 2006
    ..The study provides evidence that quetiapine at a moderate dose may be efficacious in treating behavioural disturbances in AD, with better tolerability than haloperidol...
  21. ncbi request reprint Immunohistochemical localization of angiotensin-converting enzyme, angiotensin II and AT1 receptor in human ocular tissues
    Egemen Savaskan
    Psychiatric University Clinic, University of Basel, Basel, Switzerland
    Ophthalmic Res 36:312-20. 2004
    ..The manifold localization sites of the observed antigens point to rather generalized functions of the RAS in human ocular tissues, such as regulatory effects on neuronal cells, vessels and vitreous humor homeostasis...
  22. ncbi request reprint Reduced hippocampal MT2 melatonin receptor expression in Alzheimer's disease
    Egemen Savaskan
    Psychiatric University Clinic, University of Basel, Basel, Switzerland
    J Pineal Res 38:10-6. 2005
    ..The results indicate that MT2 may be involved in mediating the effects of melatonin in the human hippocampus, and this mechanism may be heavily impaired in AD...
  23. ncbi request reprint Colour vision deficiencies in Alzheimer's disease
    Mona Pache
    University Eye Clinic, Mittlere Strasse 91, CH 4012 Basel, Switzerland
    Age Ageing 32:422-6. 2003
    ..In this study, colour vision of Alzheimer's disease patients was tested using the Ishihara test and the PV-16 choice test. The latter test, primarily designed for children, was chosen in order to avoid problems due to cognitive decline...
  24. ncbi request reprint Dawn-dusk simulation light therapy of disturbed circadian rest-activity cycles in demented elderly
    Paola Fontana Gasio
    Centre for Chronobiology, Psychiatric University Clinic, Basel, Switzerland
    Exp Gerontol 38:207-16. 2003
    ..Increasing zeitgeber strength is an important strategy for improving sleep quality and timing in dementia, and DDS light therapy may provide one of the appropriate means to do so...
  25. ncbi request reprint Skill learning in patients with moderate Alzheimer's disease: a prospective pilot-study of waltz-lessons
    Alexander Rösler
    Department of Neurology, Johann Wolfgang Goethe Universitat Frankfurt, Frankfurt, Germany
    Int J Geriatr Psychiatry 17:1155-6. 2002
    ..Patients with AD showed a significant effect in procedural learning whereas depressed patients did not. These findings suggest potential implications for therapeutic interventions in patients with moderate AD...
  26. doi request reprint Melatonin reduces arousal and startle responsiveness without influencing startle habituation or affective startle modulation in young women
    Hartmut Schachinger
    Clinical Physiology, Graduate School of Psychobiology, University of Trier, Johanniterufer 15, D 54290 Trier, Germany
    Horm Behav 54:258-62. 2008
    ..We conclude that melatonin reduces arousal and startle responsiveness. However, no evidence for a direct emotion-modulating effect of melatonin was found in this healthy cohort...