Research Topics
Species | E SavaskanSummaryAffiliation: University of Basel Country: Switzerland Publications
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Detail Information
Publications
Distribution of melatonin MT1 receptor immunoreactivity in human retinaEgemen Savaskan
Department of Gerontopsychiatry, Psychiatric University Clinic, University of Basel, Wilhelm Klein Strasse 27, CH 4025 Basel, Switzerland
J Histochem Cytochem 50:519-26. 2002..In AD cases photoreceptor cells were degenerated and showed low MT1 expression...- The role of the brain renin-angiotensin system in neurodegenerative disordersEgemen Savaskan
Psychiatric University Clinic, Wilhelm Klein Str 27, CH 4025 Basel, Switzerland
Curr Alzheimer Res 2:29-35. 2005..The aim of this brief review is to summarize the current state of research in this field with emphasis on RAS-related alterations during the course of neurodegenerative disorders... - Alterations in trk A, trk B and trk C receptor immunoreactivities in parietal cortex and cerebellum in Alzheimer's diseaseE Savaskan
Department of Psychiatry, University of Basel, Switzerland
Eur Neurol 44:172-80. 2000..In addition, cerebellar Purkinje cells revealed a distinct immunoreactivity for trk C both in control and AD cases, suggesting trk C may be important in the maintenance of these cells in the aged brain... - Immunohistochemical Localization of Fas-associated phosphatase-1 (FAP-1) in Alzheimer disease hippocampusEgemen Savaskan
Psychiatric Clinic, University of Basel, Wilhelm Klein Str 27, Basel, Switzerland
Appl Immunohistochem Mol Morphol 13:190-3. 2005..Rather, these data may indicate a general role for FAP-1 in neuronal death both in adult CNS and during the course of neurodegenerative disorders... - Orexins and their receptors in the human retinaEgemen Savaskan
Psychiatric University Clinic, Basel, Switzerland
Pathobiology 71:211-6. 2004..In the human retina, however, immunohistochemical localization of orexins and their receptors, OX-R1 and OX-R2, has not been ascertained... - Red wine ingredient resveratrol protects from beta-amyloid neurotoxicityEgemen Savaskan
Psychiatric Clinic, University of Basel, Basel, Switzerland
Gerontology 49:380-3. 2003..Since a moderate wine intake correlates with a lower risk for Alzheimer disease (AD), an additional neuroprotective effect has been postulated for resveratrol... - Increased melatonin 1a-receptor immunoreactivity in the hippocampus of Alzheimer's disease patientsEgemen Savaskan
Psychiatric University Clinic, Basel, Switzerland
J Pineal Res 32:59-62. 2002..There was a distinct increase in staining intensity in all AD cases indicating an up-regulation of the receptor, possibly as a compensatory response to impaired melatonin levels in order to augment melatonin's neuroprotective effects... - Hippocampal estrogen beta-receptor immunoreactivity is increased in Alzheimer's diseaseE Savaskan
Department of Psychiatry, University of Basel, Wilhelm Klein Str 27, CH 4025 Basel, Switzerland
Brain Res 908:113-9. 2001..This study provides the first demonstration of ER beta in human hippocampus in aged controls compared to AD cases... - Cortical alterations of angiotensin converting enzyme, angiotensin II and AT1 receptor in Alzheimer's dementiaE Savaskan
Department of Psychiatry, University of Basel, Wilhelm Klein Str 27, CH 4054, Basel, Switzerland
Neurobiol Aging 22:541-6. 2001..In addition, a prominent perivascular ACE and angiotensin II immunoreactivity surrounding some cortical vessels in aged controls and AD patients points to an underlying microvascular pathology in the process of neurodegeneration... - Cerebrovascular melatonin MT1-receptor alterations in patients with Alzheimer's diseaseE Savaskan
Department of Psychiatry, University of Basel, Wilhelm Klein Str 27, CH 4025, Basel, Switzerland
Neurosci Lett 308:9-12. 2001..The increased MT1 in AD may indicate a regulatory response to impaired melatonin levels in those patients, contributing to the regulation of cerebral circulation... - Melatonin protects SHSY5Y neuroblastoma cells from cobalt-induced oxidative stress, neurotoxicity and increased beta-amyloid secretionG Olivieri
Neurobiology Laboratory, Psychiatric University Hospital, CH 4025 Basel, Switzerland
J Pineal Res 31:320-5. 2001..These findings are significant as cobalt is an essential nutritional requirement, usually bound to cobalamin (vitamin B12), for all animals which in the unbound form could lead to neurotoxicity... - Oxidative stress modulates tyrosine kinase receptor A and p75 receptor (low-affinity nerve growth factor receptor) expression in SHSY5Y neuroblastoma cellsG Olivieri
Neurobiology Laboratory, Psychiatric University Hospital, Basel, Switzerland
Neurol Clin Neurophysiol 2002:2-10. 2002..These results are significant, as they can help in the planning and implementation of AD treatment strategies involving neurotrophins... - The effects of beta-estradiol on SHSY5Y neuroblastoma cells during heavy metal induced oxidative stress, neurotoxicity and beta-amyloid secretionG Olivieri
Neurobiology Laboratory, Psychiatric University Hospital, CH 4025 Basel, Switzerland
Neuroscience 113:849-55. 2002..Our results are significant as they contribute to a better understanding of the mode of action of estrogen with relevance to its use in the treatment of neurodegenerative disorders... - Pineal and cortical melatonin receptors MT1 and MT2 are decreased in Alzheimer's diseaseP Brunner
Psychiatric University Clinics, Basel, Switzerland
Eur J Histochem 50:311-6. 2006..In line with our previous findings, melatonin receptor expression in AD is impaired in two additional brain areas, and may contribute to disease pathology... - Haloperidol disrupts, clozapine reinstates the circadian rest-activity cycle in a patient with early-onset Alzheimer diseaseA Wirz-Justice
Chronobiology and Sleep Laboratory, Psychiatric University Clinic, Basel, Switzerland
Alzheimer Dis Assoc Disord 14:212-5. 2000..Similar observations in schizophrenic patients indicate that this chronobiological finding is drug- and not illness-related... - Are G protein-coupled receptor heterodimers of physiological relevance?--Focus on melatonin receptorsAngelique Levoye
Department of Cell Biology, Institut Cochin, Universite Paris Descartes, Faculte de Medecine, France
Chronobiol Int 23:419-26. 2006.... - The MT2 melatonin receptor subtype is present in human retina and decreases in Alzheimer's diseaseEgemen Savaskan
Psychiatric University Clinic, Basel, Switzerland
Curr Alzheimer Res 4:47-51. 2007..Since our previous results showed an increase in MT(1) expression in AD retina, the two melatonin receptor subtypes appear to be differentially affected by the course of the neurodegenerative disorder... - Detection of the human GPR50 orphan seven transmembrane protein by polyclonal antibodies mapping different epitopesHassina Ould Hamouda
Institut Cochin, Department of Cell Biology, Paris, France
J Pineal Res 43:10-5. 2007..In conclusion, we successfully produced antibodies against the orphan GPR50 protein that will become valuable tools for functional studies of this protein... - Humour therapy in patients with late-life depression or Alzheimer's disease: a pilot studyMarc Walter
Psychiatric University Clinics, University of Basel, Basel, Switzerland
Int J Geriatr Psychiatry 22:77-83. 2007..Therefore non-pharmacological treatment strategies are of great importance. The aim of the present study was to investigate the impact of humour therapy on quality of life in patients with depression or AD... - Treatment of behavioural, cognitive and circadian rest-activity cycle disturbances in Alzheimer's disease: haloperidol vs. quetiapineEgemen Savaskan
Geriatric Psychiatry, University Psychiatric Hospitals, CH 4025 Basel, Switzerland
Int J Neuropsychopharmacol 9:507-16. 2006..The study provides evidence that quetiapine at a moderate dose may be efficacious in treating behavioural disturbances in AD, with better tolerability than haloperidol... - Immunohistochemical localization of angiotensin-converting enzyme, angiotensin II and AT1 receptor in human ocular tissuesEgemen Savaskan
Psychiatric University Clinic, University of Basel, Basel, Switzerland
Ophthalmic Res 36:312-20. 2004..The manifold localization sites of the observed antigens point to rather generalized functions of the RAS in human ocular tissues, such as regulatory effects on neuronal cells, vessels and vitreous humor homeostasis... - Reduced hippocampal MT2 melatonin receptor expression in Alzheimer's diseaseEgemen Savaskan
Psychiatric University Clinic, University of Basel, Basel, Switzerland
J Pineal Res 38:10-6. 2005..The results indicate that MT2 may be involved in mediating the effects of melatonin in the human hippocampus, and this mechanism may be heavily impaired in AD... - Colour vision deficiencies in Alzheimer's diseaseMona Pache
University Eye Clinic, Mittlere Strasse 91, CH-4012 Basel, Switzerland
Age Ageing 32:422-6. 2003..0008) than the controls. No relation between test performance and severity of Alzheimer's disease was found. CONCLUSIONS: Alzheimer's disease patients have an unspecific colour vision deficiency independent of the severity of the disease... - Dawn-dusk simulation light therapy of disturbed circadian rest-activity cycles in demented elderlyPaola Fontana Gasio
Centre for Chronobiology, Psychiatric University Clinic, Basel, Switzerland
Exp Gerontol 38:207-16. 2003..Increasing zeitgeber strength is an important strategy for improving sleep quality and timing in dementia, and DDS light therapy may provide one of the appropriate means to do so... - Skill learning in patients with moderate Alzheimer's disease: a prospective pilot-study of waltz-lessonsAlexander Rösler
Department of Neurology, Johann Wolfgang Goethe Universitat Frankfurt, Frankfurt, Germany
Int J Geriatr Psychiatry 17:1155-6. 2002..Patients with AD showed a significant effect in procedural learning whereas depressed patients did not. These findings suggest potential implications for therapeutic interventions in patients with moderate AD... 
Melatonin reduces arousal and startle responsiveness without influencing startle habituation or affective startle modulation in young womenHartmut Schachinger
Clinical Physiology, Graduate School of Psychobiology, University of Trier, Johanniterufer 15, D 54290 Trier, Germany
Horm Behav 54:258-62. 2008..We conclude that melatonin reduces arousal and startle responsiveness. However, no evidence for a direct emotion-modulating effect of melatonin was found in this healthy cohort...