M A Ruegg

Summary

Affiliation: University of Basel
Country: Switzerland

Publications

  1. ncbi Differential response of skeletal muscles to mTORC1 signaling during atrophy and hypertrophy
    C Florian Bentzinger
    Biozentrum, University of Basel, Basel, CH 4056, Switzerland
    Skelet Muscle 3:6. 2013
  2. ncbi Angiotensin II type 1 receptor antagonists alleviate muscle pathology in the mouse model for laminin-α2-deficient congenital muscular dystrophy (MDC1A)
    Sarina Meinen
    Biozentrum, University of Basel, Basel, Switzerland
    Skelet Muscle 2:18. 2012
  3. ncbi Tyrosine phosphatases such as SHP-2 act in a balance with Src-family kinases in stabilization of postsynaptic clusters of acetylcholine receptors
    Alain A Camilleri
    Brain Research Institute, University of Zurich, Zurich, Switzerland
    BMC Neurosci 8:46. 2007
  4. ncbi Molecular mechanisms and treatment options for muscle wasting diseases
    Markus A Ruegg
    Biozentrum, University of Basel, Switzerland
    Annu Rev Pharmacol Toxicol 51:373-95. 2011
  5. ncbi Molecules involved in the formation of synaptic connections in muscle and brain
    M A Ruegg
    Department of Pharmacology Neurobiology, Biozentrum, University of Basel, Klingelbergstrasse 70, CH 4056, Basel, Switzerland
    Matrix Biol 20:3-12. 2001
  6. ncbi Apoptosis inhibitors and mini-agrin have additive benefits in congenital muscular dystrophy mice
    Sarina Meinen
    Biozentrum, University of Basel, Switzerland
    EMBO Mol Med 3:465-79. 2011
  7. ncbi A minigene of neural agrin encoding the laminin-binding and acetylcholine receptor-aggregating domains is sufficient to induce postsynaptic differentiation in muscle fibres
    T Meier
    Institute of Physiology, University of Basel, Switzerland
    Eur J Neurosci 10:3141-52. 1998
  8. ncbi Alternative splicing of agrin alters its binding to heparin, dystroglycan, and the putative agrin receptor
    M Gesemann
    Department of Pharmacology, University of Basel, Switzerland
    Neuron 16:755-67. 1996
  9. ncbi Agrin is a high-affinity binding protein of dystroglycan in non-muscle tissue
    M Gesemann
    Department of Pharmacology, Biozentrum, University of Basel, Klingelbergstrasse 70, CH 4056 Basel, Switzerland
    J Biol Chem 273:600-5. 1998
  10. ncbi Agrin binds to the nerve-muscle basal lamina via laminin
    A J Denzer
    Department of Pharmacology, Biozentrum, University of Basel, Switzerland
    J Cell Biol 137:671-83. 1997

Collaborators

  • G Bezakova
  • B Schumacher
  • A Brancaccio
  • Jörg Stetefeld
  • J Moll
  • M Chiquet
  • Christoph Handschin
  • S Frank
  • S Lin
  • Thomas Meier
  • U Muller
  • David J Glass
  • A Probst
  • Bernhard Bettler
  • Sarina Meinen
  • C Florian Bentzinger
  • Patrizia Barzaghi
  • Raffaella Willmann
  • Michael N Hall
  • Pankaj Shende
  • M Gesemann
  • Alain A Camilleri
  • Iwona Ksiazek
  • Patrick Scotton
  • A J Denzer
  • Xian Chu Kong
  • Alexander Eusebio
  • Maitea Guridi
  • Serge Summermatter
  • Klaas Romanino
  • Perrine Castets
  • Lionel A Tintignac
  • F R Neumann
  • Christian Morandi
  • Thierry Pedrazzini
  • Rene Lerch
  • Francesco Zorzato
  • Jaya Krishnan
  • Corinne Berthonneche
  • Isabelle Plaisance
  • Michael Erb
  • Marijke Brink
  • Raphael Thurnherr
  • Corinne Pellieux
  • B Sommer
  • Judith Dubach-Powell
  • Stefanie Possekel
  • Christian Fuhrer
  • Gayathri Sadasivam
  • Silvia Arber
  • Marcin Maj
  • Riad Seddik
  • Matthias Gesemann
  • Pico Caroni
  • Constanze Burkhardt
  • Joshua R Sanes
  • Mathias Jucker
  • Hanns Lochmuller
  • Francesca Sciandra
  • Dorothee Bleckmann
  • Michael Stebler
  • Filippo Oliveri
  • M Annies
  • G Bittcher
  • K Hofele
  • W Spooren
  • - van der Putten H
  • C Mistl
  • G Bilbe
  • S Danner
  • S Kauffmann
  • K Wiederhold
  • S Barbieri
  • P Caromi
  • M Tolnay
  • S Kafmann
  • R Brandenberger
  • V Cavalli

Detail Information

Publications32

  1. ncbi Differential response of skeletal muscles to mTORC1 signaling during atrophy and hypertrophy
    C Florian Bentzinger
    Biozentrum, University of Basel, Basel, CH 4056, Switzerland
    Skelet Muscle 3:6. 2013
    ..Here, we tested this hypothesis by deletion of the mTORC1 inhibitor tuberous sclerosis complex (TSC) in muscle fibers...
  2. ncbi Angiotensin II type 1 receptor antagonists alleviate muscle pathology in the mouse model for laminin-α2-deficient congenital muscular dystrophy (MDC1A)
    Sarina Meinen
    Biozentrum, University of Basel, Basel, Switzerland
    Skelet Muscle 2:18. 2012
    ....
  3. ncbi Tyrosine phosphatases such as SHP-2 act in a balance with Src-family kinases in stabilization of postsynaptic clusters of acetylcholine receptors
    Alain A Camilleri
    Brain Research Institute, University of Zurich, Zurich, Switzerland
    BMC Neurosci 8:46. 2007
    ..This suggests that a balance between protein tyrosine phosphatases (PTPs) and protein tyrosine kinases (PTKs) such as those of the Src-family may be essential in stabilizing clusters of AChRs...
  4. ncbi Molecular mechanisms and treatment options for muscle wasting diseases
    Markus A Ruegg
    Biozentrum, University of Basel, Switzerland
    Annu Rev Pharmacol Toxicol 51:373-95. 2011
    ....
  5. ncbi Molecules involved in the formation of synaptic connections in muscle and brain
    M A Ruegg
    Department of Pharmacology Neurobiology, Biozentrum, University of Basel, Klingelbergstrasse 70, CH 4056, Basel, Switzerland
    Matrix Biol 20:3-12. 2001
    ..This review focuses on the molecular mechanisms involved in the formation and the function of synapses...
  6. ncbi Apoptosis inhibitors and mini-agrin have additive benefits in congenital muscular dystrophy mice
    Sarina Meinen
    Biozentrum, University of Basel, Switzerland
    EMBO Mol Med 3:465-79. 2011
    ....
  7. ncbi A minigene of neural agrin encoding the laminin-binding and acetylcholine receptor-aggregating domains is sufficient to induce postsynaptic differentiation in muscle fibres
    T Meier
    Institute of Physiology, University of Basel, Switzerland
    Eur J Neurosci 10:3141-52. 1998
    ....
  8. ncbi Alternative splicing of agrin alters its binding to heparin, dystroglycan, and the putative agrin receptor
    M Gesemann
    Department of Pharmacology, University of Basel, Switzerland
    Neuron 16:755-67. 1996
    ..Its binding is completed only by agrin isoforms that are active in AChR aggregation, and therefore this binding site is likely to represent the receptor that initiates AChR clustering...
  9. ncbi Agrin is a high-affinity binding protein of dystroglycan in non-muscle tissue
    M Gesemann
    Department of Pharmacology, Biozentrum, University of Basel, Klingelbergstrasse 70, CH 4056 Basel, Switzerland
    J Biol Chem 273:600-5. 1998
    ....
  10. ncbi Agrin binds to the nerve-muscle basal lamina via laminin
    A J Denzer
    Department of Pharmacology, Biozentrum, University of Basel, Switzerland
    J Cell Biol 137:671-83. 1997
    ..These data strongly suggest that binding of agrin to laminin provides the basis of its localization to synaptic basal lamina and other basement membranes...
  11. ncbi An agrin minigene rescues dystrophic symptoms in a mouse model for congenital muscular dystrophy
    J Moll
    Department of Pharmacology Neurobiology, Biozentrum, University of Basel, Klingelbergstrasse 70, CH 4056 Basel, Switzerland
    Nature 413:302-7. 2001
    ..Our data provides in vivo evidence that a non-homologous protein in combination with rational protein design can be used to devise therapeutic tools that may restore muscle function in human muscular dystrophies...
  12. ncbi The laminin-binding domain of agrin is structurally related to N-TIMP-1
    J Stetefeld
    Department of Biophysical Chemistry, Biozentrum, University of Basel, Klingelbergstrasse 70, CH 4056 Basel, Switzerland
    Nat Struct Biol 8:705-9. 2001
    ..A high structural similarity of NtA with the protease inhibition domain in tissue inhibitor of metalloproteinases-1 (TIMP-1) supports the idea of additional functions of agrin besides synaptogenic activity...
  13. ncbi An alternative amino-terminus expressed in the central nervous system converts agrin to a type II transmembrane protein
    F R Neumann
    Department of Pharmacology/Neurobiology, Biozentrum, University of Basel, Klingelbergstrasse 70, Basel, CH-4056, Switzerland
    Mol Cell Neurosci 17:208-25. 2001
    ..Agrin transcripts encoding this form are enriched in the embryonic brain, particularly in neurons. To our knowledge, this is the first example of a molecule that is synthesized both as a basal lamina and a plasma membrane protein...
  14. ncbi Neural agrin induces ectopic postsynaptic specializations in innervated muscle fibers
    T Meier
    Institute of Physiology, University of Basel, CH 4051 Basel, Switzerland
    J Neurosci 17:6534-44. 1997
    ..Thus, a motor neuron-specific agrin isoform is sufficient to induce a full ectopic postsynaptic apparatus in muscle fibers kept electrically active at their original endplate sites...
  15. ncbi Agrin, laminin beta 2 (s-laminin) and ARIA: their role in neuromuscular development
    M A Ruegg
    Department of Pharmacology, Biozentrum, University of Basel, Switzerland
    Curr Opin Neurobiol 6:97-103. 1996
    ....
  16. ncbi Cardiac raptor ablation impairs adaptive hypertrophy, alters metabolic gene expression, and causes heart failure in mice
    Pankaj Shende
    Department of Biomedicine, University of Basel and University Hospital Basel, Hebelstrasse 20, CH 4031 Basel, Switzerland
    Circulation 123:1073-82. 2011
    ..It is found in 2 structurally and functionally distinct multiprotein complexes called mTOR complex (mTORC) 1 and mTORC2. The role of each of these branches of mTOR signaling in the adult heart is currently unknown...
  17. ncbi Structural and functional diversity generated by alternative mRNA splicing
    Jörg Stetefeld
    Biozentrum, University Basel, Klingelbergstrasse 70, CH 4056 Basel, Switzerland
    Trends Biochem Sci 30:515-21. 2005
    ..It is only recently that structures of alternatively spliced proteins have been solved. These studies have shown that alternative splicing affects the structure not only in the vicinity of the splice site but also at long distance...
  18. ncbi Organization of synaptic myonuclei by Syne proteins and their role during the formation of the nerve-muscle synapse
    Markus A Ruegg
    Biozentrum, University of Basel, Klingelbergstrasse 70, CH-4056 Basel, Switzerland
    Proc Natl Acad Sci U S A 102:5643-4. 2005
  19. ncbi Modulation of agrin function by alternative splicing and Ca2+ binding
    Jörg Stetefeld
    Department of Biophysical Chemistry, University of Basel, Klingelbergstrasse 70, CH 4056 Basel, Switzerland
    Structure 12:503-15. 2004
    ..The plasticity of the interaction interface could enable different splice forms of agrin to select between multiple binding partners...
  20. ncbi Activation of muscle-specific receptor tyrosine kinase and binding to dystroglycan are regulated by alternative mRNA splicing of agrin
    Patrick Scotton
    Biozentrum, University of Basel, Klingelbergstrasse 70, CH 4056 Basel, Switzerland
    J Biol Chem 281:36835-45. 2006
    ..We also show that binding to alpha-dystroglycan requires at least two LG domains and that amino acid inserts at the A and the B splice sites negatively affect binding...
  21. ncbi Linker molecules between laminins and dystroglycan ameliorate laminin-alpha2-deficient muscular dystrophy at all disease stages
    Sarina Meinen
    Biozentrum, University of Basel, CH 4056 Basel, Switzerland
    J Cell Biol 176:979-93. 2007
    ....
  22. ncbi The role of nerve- versus muscle-derived factors in mammalian neuromuscular junction formation
    Shuo Lin
    Biozentrum, University of Basel, CH 4056 Basel, Switzerland
    J Neurosci 28:3333-40. 2008
    ..A model is proposed that explains either the neurocentric or the myocentric mode of NMJ formation depending on a balance between the levels of MuSK expression and the availability of nerve-released agrin...
  23. ncbi Muscle-wide secretion of a miniaturized form of neural agrin rescues focal neuromuscular innervation in agrin mutant mice
    Shuo Lin
    Biozentrum and Institute of Physiology, Department of Biomedicine, University of Basel, Klingelbergstrasse 70, 4056 Basel, Switzerland
    Proc Natl Acad Sci U S A 105:11406-11. 2008
    ..Finally, they suggest a novel local function of ACh in stabilizing postsynaptic structures...
  24. ncbi New insights into the roles of agrin
    Gabriela Bezakova
    Department of Pharmacology/Neurobiology, Biozentrum, University of Basel, Klingelbergstrasse 70, CH-4056 Basel, Switzerland
    Nat Rev Mol Cell Biol 4:295-308. 2003
    ..So the activities of agrin might be of broader significance than previously anticipated...
  25. ncbi Cloning and sequencing of mouse skeletal muscle alpha-dystroglycan
    A Brancaccio
    Department of Biophysical Chemistry, University of Basel, Switzerland
    Matrix Biol 14:681-5. 1995
    ..The results demonstrate the usefulness of this approach and the high degree of conservation of alpha-dystroglycan between different species, and they provide the basis for additional work with the murine species...
  26. ncbi An amino-terminal extension is required for the secretion of chick agrin and its binding to extracellular matrix
    A J Denzer
    Department of Pharmacology, University of Basel, Switzerland
    J Cell Biol 131:1547-60. 1995
    ..In conclusion, the cDNAs described here code for chick agrin that has all the characteristics previously allocated to endogenous agrin...
  27. ncbi Synapse loss in cortex of agrin-deficient mice after genetic rescue of perinatal death
    Iwona Ksiazek
    Biozentrum, University of Basel, CH 4056 Basel, Switzerland
    J Neurosci 27:7183-95. 2007
    ..In summary, our results provide strong evidence that agrin plays an important role in the formation and/or the maintenance of excitatory synapses in the brain, and we provide evidence that this function involves MAP kinase signaling...
  28. ncbi Inhibition of synapse assembly in mammalian muscle in vivo by RNA interference
    Xian Chu Kong
    Biozentrum, University of Basel, Basel, Switzerland
    EMBO Rep 5:183-8. 2004
    ..Moreover, they show that MuSK is also required for the maintenance of the NMJ, offering a mechanistic explanation for the myasthenia gravis caused by auto-antibodies to MuSK...
  29. ncbi Overexpression of mini-agrin in skeletal muscle increases muscle integrity and regenerative capacity in laminin-alpha2-deficient mice
    C Florian Bentzinger
    Biozentrum, University of Basel, Basel, Switzerland
    FASEB J 19:934-42. 2005
    ..Our findings thus suggest that treatment with mini-agrin might be beneficial over the entire spectrum of the MDC1A disease, whose severity inversely correlates with expression levels and the size of the truncation in laminin-alpha2...
  30. ncbi Mouse models of alpha-synucleinopathy and Lewy pathology
    B Sommer
    Nervous System Research, Novartis Pharma Inc, CH 4002, Basel, Switzerland
    Exp Gerontol 35:1389-403. 2000
    ..The mouse models provide means to address fundamental aspects of alpha-synucleinopathy and to test therapeutic strategies...
  31. ncbi Mammalian animal models for Duchenne muscular dystrophy
    Raffaella Willmann
    Biozentrum, University of Basel, Klingelbergstrasse 70, CH 4056 Basel, Switzerland
    Neuromuscul Disord 19:241-9. 2009
    ....
  32. ncbi Expression of mouse agrin in normal, denervated and dystrophic muscle
    Alexander Eusebio
    Department of Pharmacology Neurobiology, Biozentrum, University of Basel, Klingelbergstrasse 70, CH 4056 Basel, Switzerland
    Neuromuscul Disord 13:408-15. 2003
    ..We find that expression of agrin in non-synaptic region varies greatly between different muscles in wild-type mice and that its levels are altered in dystrophic muscle...