Uwe Rudolph

Summary

Affiliation: University of Zurich
Country: Switzerland

Publications

  1. ncbi request reprint Genetically modified animals in pharmacological research: future trends
    U Rudolph
    Institute of Pharmacology, Swiss Federal Institute of Technology ETH, University of Zurich
    Eur J Pharmacol 375:327-37. 1999
  2. ncbi request reprint Molecular and neuronal substrates for general anaesthetics
    Uwe Rudolph
    Institute of Pharmacology and Toxicology, University of Zurich, Winterthurerstrasse 190, CH 8057 Zurich, Switzerland
    Nat Rev Neurosci 5:709-20. 2004
  3. ncbi request reprint Identification of molecular substrate for the attenuation of anxiety: a step toward the development of better anti-anxiety drugs
    U Rudolph
    Institute of Pharmacology and Toxicology, University of Zurich
    ScientificWorldJournal 1:192-3. 2001
  4. ncbi request reprint Analysis of GABAA receptor function and dissection of the pharmacology of benzodiazepines and general anesthetics through mouse genetics
    Uwe Rudolph
    Institute of Pharmacology and Toxicology, University of Zurich, Winterthurerstrasse 190, CH 8057 Zurich
    Annu Rev Pharmacol Toxicol 44:475-98. 2004
  5. ncbi request reprint GABA(A) receptor subtypes: dissecting their pharmacological functions
    U Rudolph
    Institute of Pharmacology and Toxicology, University of Zürich and Swiss Federal Institut of Technology ETH Zürich, Winterthurerstrasse 190, CH 8057, Zurich, Switzerland
    Trends Pharmacol Sci 22:188-94. 2001
  6. ncbi request reprint Benzodiazepine actions mediated by specific gamma-aminobutyric acid(A) receptor subtypes
    U Rudolph
    Institute of Pharmacology, University of Zurich, Switzerland
    Nature 401:796-800. 1999
  7. pmc Mapping the contribution of beta3-containing GABAA receptors to volatile and intravenous general anesthetic actions
    Anja Zeller
    Institute of Pharmacology and Toxicology, University of Zurich, Winterthurerstr, 190, CH 8057 Switzerland
    BMC Pharmacol 7:2. 2007
  8. ncbi request reprint Specific subtypes of GABAA receptors mediate phasic and tonic forms of inhibition in hippocampal pyramidal neurons
    George A Prenosil
    University of Zurich, Institute of Pharmacology and Toxicology, Zurich, Switzerland
    J Neurophysiol 96:846-57. 2006
  9. doi request reprint The alpha5(H105R) mutation impairs alpha5 selective binding properties by altered positioning of the alpha5 subunit in GABAA receptors containing two distinct types of alpha subunits
    Ela Balic
    Institute of Pharmacology and Toxicology, University of Zurich, Winterhurerstrasse, Zurich, Switzerland
    J Neurochem 110:244-54. 2009
  10. ncbi request reprint Requirement of alpha5-GABAA receptors for the development of tolerance to the sedative action of diazepam in mice
    Carolien van Rijnsoever
    Institute of Pharmacology and Toxicology, University of Zurich, 8057 Zurich, Switzerland
    J Neurosci 24:6785-90. 2004

Collaborators

Detail Information

Publications47

  1. ncbi request reprint Genetically modified animals in pharmacological research: future trends
    U Rudolph
    Institute of Pharmacology, Swiss Federal Institute of Technology ETH, University of Zurich
    Eur J Pharmacol 375:327-37. 1999
    ..Techniques which permit the time- and tissue-specific inducible regulation of gene expression present an important methodological advance...
  2. ncbi request reprint Molecular and neuronal substrates for general anaesthetics
    Uwe Rudolph
    Institute of Pharmacology and Toxicology, University of Zurich, Winterthurerstrasse 190, CH 8057 Zurich, Switzerland
    Nat Rev Neurosci 5:709-20. 2004
    ....
  3. ncbi request reprint Identification of molecular substrate for the attenuation of anxiety: a step toward the development of better anti-anxiety drugs
    U Rudolph
    Institute of Pharmacology and Toxicology, University of Zurich
    ScientificWorldJournal 1:192-3. 2001
    ..Benzodiazepines like diazepam bind to GABA(A) receptors containing the alpha subunits alpha 1, alpha 2, alpha 3, or alpha 5, most likely in alphabetagamma combinations...
  4. ncbi request reprint Analysis of GABAA receptor function and dissection of the pharmacology of benzodiazepines and general anesthetics through mouse genetics
    Uwe Rudolph
    Institute of Pharmacology and Toxicology, University of Zurich, Winterthurerstrasse 190, CH 8057 Zurich
    Annu Rev Pharmacol Toxicol 44:475-98. 2004
    ....
  5. ncbi request reprint GABA(A) receptor subtypes: dissecting their pharmacological functions
    U Rudolph
    Institute of Pharmacology and Toxicology, University of Zürich and Swiss Federal Institut of Technology ETH Zürich, Winterthurerstrasse 190, CH 8057, Zurich, Switzerland
    Trends Pharmacol Sci 22:188-94. 2001
    ..Such discoveries could open up new avenues for drug development...
  6. ncbi request reprint Benzodiazepine actions mediated by specific gamma-aminobutyric acid(A) receptor subtypes
    U Rudolph
    Institute of Pharmacology, University of Zurich, Switzerland
    Nature 401:796-800. 1999
    ..Thus, benzodiazepine-induced behavioural responses are mediated by specific GABA(A) receptor subtypes in distinct neuronal circuits, which is of interest for drug design...
  7. pmc Mapping the contribution of beta3-containing GABAA receptors to volatile and intravenous general anesthetic actions
    Anja Zeller
    Institute of Pharmacology and Toxicology, University of Zurich, Winterthurerstr, 190, CH 8057 Switzerland
    BMC Pharmacol 7:2. 2007
    ..In this communication, we analyzed the contribution of beta3-containing GABAA receptors to the pharmacological actions of isoflurane, etomidate and propofol by means of beta3(N265M) mice...
  8. ncbi request reprint Specific subtypes of GABAA receptors mediate phasic and tonic forms of inhibition in hippocampal pyramidal neurons
    George A Prenosil
    University of Zurich, Institute of Pharmacology and Toxicology, Zurich, Switzerland
    J Neurophysiol 96:846-57. 2006
    ..These results show that the major forms of inhibitory neurotransmission in hippocampal pyramidal cells are mediated by distinct GABA(A)Rs subtypes...
  9. doi request reprint The alpha5(H105R) mutation impairs alpha5 selective binding properties by altered positioning of the alpha5 subunit in GABAA receptors containing two distinct types of alpha subunits
    Ela Balic
    Institute of Pharmacology and Toxicology, University of Zurich, Winterhurerstrasse, Zurich, Switzerland
    J Neurochem 110:244-54. 2009
    ..These findings imply an important role of histidine 105 in determining the position of the alpha5 subunit within the receptor complex by determining the affinity for assembly with the gamma2 subunit...
  10. ncbi request reprint Requirement of alpha5-GABAA receptors for the development of tolerance to the sedative action of diazepam in mice
    Carolien van Rijnsoever
    Institute of Pharmacology and Toxicology, University of Zurich, 8057 Zurich, Switzerland
    J Neurosci 24:6785-90. 2004
    ..Thus, the chronic activation of alpha(5)-GABA(A) receptors is crucial for the normal development of sedative tolerance to diazepam, which manifests itself in conjunction with alpha1-GABA(A) receptors...
  11. pmc Mutational analysis of molecular requirements for the actions of general anaesthetics at the gamma-aminobutyric acidA receptor subtype, alpha1beta2gamma2
    Roberta Siegwart
    Institute of Pharmacology and Toxicology, University of Zurich, Winterthurerstrasse 190, CH 8057 Zurich, Switzerland
    BMC Pharmacol 3:13. 2003
    ..We have now characterized the phenotypic effect of two beta subunit mutations in the most abundant GABA(A) receptor subtype, alpha1beta2gamma2...
  12. doi request reprint GABA A receptors as in vivo substrate for the anxiolytic action of valerenic acid, a major constituent of valerian root extracts
    Dietmar Benke
    Institute of Pharmacology and Toxicology, University of Zurich, Winterthurerstrasse 190, CH 8057 Zurich, Switzerland
    Neuropharmacology 56:174-81. 2009
    ..In beta3 (N265M) point-mutated mice the anxiolytic activity of valerenic acid was absent. Thus, neurons expressing beta3 containing GABA(A) receptors are a major cellular substrate for the anxiolytic action of valerian extracts...
  13. doi request reprint Genuine antihyperalgesia by systemic diazepam revealed by experiments in GABAA receptor point-mutated mice
    Julia Knabl
    Institute of Pharmacology and Toxicology, University of Zurich, Winterthurerstrasse 190, CH 8057 Zurich, Switzerland
    Pain 141:233-8. 2009
    ..We conclude that systemic diazepam exerts a genuine antihyperalgesic effect, which depends on spinal GABA(A) receptors containing alpha2 and/or alpha3 subunits...
  14. doi request reprint Spatiotemporal specificity of GABAA receptor-mediated regulation of adult hippocampal neurogenesis
    Venceslas Duveau
    Institute of Pharmacology and Toxicology, University of Zurich, Winterthurerstrasse 190, 8057 Zurich, Switzerland
    Eur J Neurosci 34:362-73. 2011
    ..Taken together, the availability of distinct GABA(A) R subtypes provides a molecular mechanism endowing spatiotemporal specificity to GABAergic control of neuronal maturation in adult brain...
  15. ncbi request reprint Isoflurane-induced surgical tolerance mediated only in part by beta3-containing GABA(A) receptors
    Sachar Lambert
    Institute of Pharmacology and Toxicology, University of Zurich, Winterthurerstrasse 190, CH 8057 Zurich, Switzerland
    Eur J Pharmacol 516:23-7. 2005
    ..At high concentrations isoflurane also immobilizes beta3(N265M) mice, indicating that other targets also mediate immobility. Thus, our findings support a multisite model for the immobilizing action of isoflurane...
  16. ncbi request reprint Distinct molecular targets for the central respiratory and cardiac actions of the general anesthetics etomidate and propofol
    Anja Zeller
    Institute of Pharmacology and Toxicology, University of Zurich, Switzerland
    FASEB J 19:1677-9. 2005
    ....
  17. ncbi request reprint alpha2-gamma-Aminobutyric acid (GABA)A receptors are the molecular substrates mediating precipitation of narcosis but not of sedation by the combined use of diazepam and alcohol in vivo
    Marcus Täuber
    Institut of Pharmacology and Toxicology, University of Zurich, Winterthurerstrasse 190, CH 8057 Zurich, Switzerland
    Eur J Neurosci 18:2599-604. 2003
    ....
  18. ncbi request reprint Alteration of GABAergic synapses and gephyrin clusters in the thalamic reticular nucleus of GABAA receptor alpha3 subunit-null mice
    Remo Studer
    Institute of Pharmacology and Toxicology, University of Zurich, Winterthurerstrasse 190, CH 8057 Zurich, Switzerland
    Eur J Neurosci 24:1307-15. 2006
    ..The absence of GABAA-mediated transmission in the nRT may have a significant impact on the function of the thalamo-cortical loop of alpha3(0/0) mice...
  19. doi request reprint Dissecting the role of diazepam-sensitive γ-aminobutyric acid type A receptors in defensive behavioral reactivity to mild threat
    Christina Koester
    Institute of Pharmacology and Toxicology, University of Zurich, Winterthurerstrasse 190, 8057 Zurich, Switzerland
    Pharmacol Biochem Behav 103:541-9. 2013
    ..In the absence of these receptors, diazepam through activation of α1-GABA(A)Rs remains effective in reducing risk assessment, but not behavioral aversion...
  20. ncbi request reprint Identification of a molecular target mediating the general anesthetic actions of pentobarbital
    Anja Zeller
    Institute of Pharmacology and Toxicology, University of Zurich, Switzerland
    Mol Pharmacol 71:852-9. 2007
    ..In summary, we show a clear pharmacological dissociation of the immobilizing/hypnotic and respiratory/cardiovascular actions of pentobarbital...
  21. doi request reprint Tonic inhibition in principal cells of the amygdala: a central role for α3 subunit-containing GABAA receptors
    Anne Marowsky
    Institute of Pharmacology and Toxicology, University of Zurich, CH 8057 Zurich, Switzerland
    J Neurosci 32:8611-9. 2012
    ....
  22. pmc Presynaptic alpha2-GABAA receptors in primary afferent depolarization and spinal pain control
    Robert Witschi
    Institute of Pharmacology and Toxicology, University of Zurich, CH 8057 Zurich, Switzerland
    J Neurosci 31:8134-42. 2011
    ..Our results thus show that part of the antihyperalgesic action of spinally applied DZP occurs through facilitated activation of GABA(A) receptors residing on primary nociceptors...
  23. doi request reprint Regulation of cognition and symptoms of psychosis: focus on GABA(A) receptors and glycine transporter 1
    Hanns Mohler
    University of Zurich and Swiss Federal Institute of Technology, Zurich, Institute of Pharmacology, Winterthurerstrasse 190, CH 8057 Zurich, Switzerland
    Pharmacol Biochem Behav 90:58-64. 2008
    ..Taken together, these results qualify distinct GABA-A receptor subtypes and GlyT1 as molecular targets for the development of a new pharmacology in the treatment of cognitive decline and psychotic symptoms...
  24. ncbi request reprint Analysis of the presence and abundance of GABAA receptors containing two different types of alpha subunits in murine brain using point-mutated alpha subunits
    Dietmar Benke
    Institute of Pharmacology and Toxicology, University of Zurich, Winterthurerstrasse 190, CH 8057, Switzerland
    J Biol Chem 279:43654-60. 2004
    ..This experimental approach provides the basis for a detailed analysis of the abundance of GABAA receptors containing heterologous alpha subunits on a brain regional level...
  25. ncbi request reprint General anesthetic actions in vivo strongly attenuated by a point mutation in the GABA(A) receptor beta3 subunit
    Rachel Jurd
    Institute of Pharmacology and Toxicology, University of Zurich, CH 8057 Zurich, Switzerland
    FASEB J 17:250-2. 2003
    ....
  26. ncbi request reprint Diazepam-induced adaptive plasticity revealed by alpha1 GABAA receptor-specific expression profiling
    Laura Huopaniemi
    Institute of Pharmacology and Toxicology, University of Zurich, Zurich, Switzerland
    J Neurochem 88:1059-67. 2004
    ..This long-term alteration is likely to contribute to the resetting of the neuronal responsiveness, which may be involved in rebound phenomena and, under chronic treatment, in the development of tolerance and dependence...
  27. ncbi request reprint GABA-based therapeutic approaches: GABAA receptor subtype functions
    Uwe Rudolph
    Institute of Pharmacology and Toxicology, University of Zurich, Winterthurerstrasse 190, CH 8057 Zurich, Switzerland, and Laboratory of Genetic Neuropharmacology, McLean Hospital, Harvard Medical School, Belmont, MA 02478, USA
    Curr Opin Pharmacol 6:18-23. 2006
    ..Thus, a new pharmacology based on GABAA receptor subtype-specific actions is emerging...
  28. pmc Antihyperalgesia by α2-GABAA Receptors Occurs Via a Genuine Spinal Action and Does Not Involve Supraspinal Sites
    Jolly Paul
    1 Institute of Pharmacology and Toxicology, University of Zurich, Zurich, Switzerland 2 Zurich Neuroscience Center ZNZ, Zurich, Switzerland
    Neuropsychopharmacology 39:477-87. 2014
    ..Such drugs may therefore be well-suited for the systemic treatment of different chronic pain conditions. ..
  29. ncbi request reprint Molecular determinants for the action of general anesthetics at recombinant alpha(2)beta(3)gamma(2)gamma-aminobutyric acid(A) receptors
    Roberta Siegwart
    Institute of Pharmacology and Toxicology, University of Zurich, Zurich, Switzerland
    J Neurochem 80:140-8. 2002
    ..The molecular switches induced by these mutations can be exploited to identify the molecular determinants for the action of general anesthetics...
  30. ncbi request reprint Sleep EEG changes after zolpidem in mice
    Caroline Kopp
    Institute of Pharmacology and Toxicology, University of Zurich, Winterthurerstrasse 190, CH 8057 Zurich, Switzerland
    Neuroreport 15:2299-302. 2004
    ..We conclude that the effects of zolpidem on the sleep EEG in mice are distinct from the changes typically induced by benzodiazepines, and are primarily mediated by alpha1GABAA receptors...
  31. ncbi request reprint Amino acid composition of brain cysts: levels of excitatory amino acids in cyst fluid fail to predict seizures
    Heinz Gregor Wieser
    Department of Neurology, University Hospital, University of Zurich, Frauenklinikstrasse 26, CH 8091 Zurich, Switzerland
    Epilepsy Res 55:191-9. 2003
    ..In summary, there is no evidence for a close correlation between excitatory amino acids in brain cysts and the occurrence of seizures...
  32. doi request reprint Reversal of pathological pain through specific spinal GABAA receptor subtypes
    Julia Knabl
    Institute of Experimental and Clinical Pharmacology and Toxicology, University of Erlangen Nurnberg, D 91054 Erlangen, Germany
    Nature 451:330-4. 2008
    ..These results provide a rational basis for the development of subtype-selective GABAergic drugs for the treatment of chronic pain, which is often refractory to classical analgesics...
  33. ncbi request reprint Etomidate and propofol-hyposensitive GABAA receptor beta3(N265M) mice show little changes in acute alcohol sensitivity but enhanced tolerance and withdrawal
    Carles Sanchis-Segura
    Department of Psychopharmacology, Central Institute of Mental Health, Mannheim, Germany
    Neurosci Lett 416:275-8. 2007
    ..The results of the present study suggest that the alcohol effects abolished by the beta3(N265M) mutation do not play a dominant role in acute alcohol intoxication but influence ethanol tolerance and withdrawal...
  34. ncbi request reprint Giant spontaneous depolarizing potentials in the developing thalamic reticular nucleus
    Susanne Pangratz-Fuehrer
    Department of Neurology and Neurological Sciences, Stanford University School of Medicine, Stanford, CA 94305, USA
    J Neurophysiol 97:2364-72. 2007
    ..Taken together, these data suggest that in immature nRt, long-lasting depolarizing responses mediated by GABA receptors could trigger Ca(2+) entry and play a role in functional development of the spindle-generating circuitry...
  35. ncbi request reprint Dual actions of enflurane on postsynaptic currents abolished by the gamma-aminobutyric acid type A receptor beta3(N265M) point mutation
    Berthold Drexler
    Department of Anesthesiology, Experimental Anesthesiology Section, University of Tuebingen, Germany
    Anesthesiology 105:297-304. 2006
    ..Furthermore, the role of the beta3 subunit in producing the depressant actions of enflurane on neocortical neurons was elucidated...
  36. ncbi request reprint Diminished GABA(A) receptor-binding capacity and a DNA base substitution in a patient with treatment-resistant depression and anxiety
    Markus Kosel
    Psychiatric Neuroimaging Group of the Department of Psychiatry, University Hospital, Bern, Switzerland
    Neuropsychopharmacology 29:347-50. 2004
    ..No conclusion can, however, be made about casual links in this single case [corrected]...
  37. ncbi request reprint Specific GABAA circuits for visual cortical plasticity
    Michela Fagiolini
    Laboratory for Neuronal Circuit Development, RIKEN Brain Science Institute, 2 1 Hirosawa, Wako Shi, Saitama, 351 0198 Japan
    Science 303:1681-3. 2004
    ..This dissociation carries implications for models of brain development and the safe design of benzodiazepines for use in infants...
  38. ncbi request reprint Major differences in inhibitory synaptic transmission onto two neocortical interneuron subclasses
    Alberto Bacci
    Department of Neurology and Neurological Sciences, Stanford University School of Medicine, Stanford, California 94305, USA
    J Neurosci 23:9664-74. 2003
    ..Moreover, selective pharmacological manipulation of distinct inhibitory circuits might allow regulation of pyramidal cell activities under specific physiological and pathophysiological conditions...
  39. ncbi request reprint Dynamic GABA(A) receptor subtype-specific modulation of the synchrony and duration of thalamic oscillations
    Vikaas S Sohal
    Department of Neurology and Neurological Sciences, Stanford University Medical Center, Stanford, California 94305 5122, USA
    J Neurosci 23:3649-57. 2003
    ..These results not only identify a particular anatomical and molecular target for anti-absence drug design, but also elucidate a specific dynamic mechanism by which inhibitory networks control neural oscillations...
  40. ncbi request reprint Beta3-containing gamma-aminobutyric acidA receptors are not major targets for the amnesic and immobilizing actions of isoflurane
    Mark Liao
    Department of Anesthesia and Perioperative Care, University of California, San Francisco, California 94143 0464, USA
    Anesth Analg 101:412-8, table of contents. 2005
    ....
  41. ncbi request reprint R (+) etomidate and the photoactivable R (+) azietomidate have comparable anesthetic activity in wild-type mice and comparably decreased activity in mice with a N265M point mutation in the gamma-aminobutyric acid receptor beta3 subunit
    Mark Liao
    Department of Anesthesia and Perioperative Care, S 455, University of California, San Francisco, CA 94143 0464, USA
    Anesth Analg 101:131-5, table of contents. 2005
    ..6 +/- 1.5 min and 7.2 +/- 1.8 min, respectively), emphasizing the contribution of this residue as a determinant of a behavioral response of azietomidate in mice...
  42. ncbi request reprint Propofol's effects on nociceptive behavior and spinal c-fos expression after intraplantar formalin injection in mice with a mutation in the gamma-aminobutyric acid-type(A) receptor beta3 subunit
    Austin W Merrill
    Section of Neurobiology, Physiology and Behavior, University of California, Davis, Davis, California 95616, USA
    Anesth Analg 103:478-83, table of contents. 2006
    ..These data indicate that although propofol produces anesthesia, it does not prevent the FLI that is associated with nociception, a finding consistent with propofol lacking analgesic properties...
  43. ncbi request reprint Modulation of presynaptic beta3-containing GABAA receptors limits the immobilizing actions of GABAergic anesthetics
    Christian Grasshoff
    Experimental Anesthesiology Section, Department of Anesthesiology and Intensive Care, Eberhard Karls University, Tuebingen, Germany
    Mol Pharmacol 72:780-7. 2007
    ....
  44. ncbi request reprint Intrinsic and synaptic dynamics interact to generate emergent patterns of rhythmic bursting in thalamocortical neurons
    Vikaas S Sohal
    Department of Neurology and Neurological Sciences, Stanford University Medical Center, Stanford, California 94305 5122, USA
    J Neurosci 26:4247-55. 2006
    ..These results demonstrate that rhythmic PIR activity is an emergent property of interactions between intrinsic and synaptic currents, not just a passive reflection of incoming synaptic inhibition...
  45. ncbi request reprint Opposing actions of etomidate on cortical theta oscillations are mediated by different gamma-aminobutyric acid type A receptor subtypes
    Berthold Drexler
    Department of Anesthesiology, Section of Experimental Anesthesiology, University of Tuebingen, Tuebingen, Germany
    Anesthesiology 102:346-52. 2005
    ..The authors ask how etomidate, acting predominantly via gamma-aminobutyric acid type A (GABAA) receptors containing beta2 or beta3 subunits, affects theta activity in vitro...
  46. ncbi request reprint GABA receptors containing the alpha5 subunit mediate the trace effect in aversive and appetitive conditioning and extinction of conditioned fear
    Benjamin K Yee
    Laboratory of Behavioural Neurobiology, Swiss Federal Institute of Technology Zurich, Schorenstrasse 16, CH 8603 Schwerzenbach, Switzerland
    Eur J Neurosci 20:1928-36. 2004
    ..Our results identify neuronal inhibition in the hippocampus mediated via alpha5 GABAA receptors as a critical control element in the regulation of the acquisition and expression of associative memory...
  47. ncbi request reprint Mouse gene knockout and knockin strategies in application to alpha subunits of Gi/Go family of G proteins
    Meisheng Jiang
    Department of Anesthesiology, School of Medicine, University of California, Los Angeles, California 90095, USA
    Methods Enzymol 344:277-98. 2002