Laura Rubbia-Brandt

Summary

Affiliation: University Hospital
Country: Switzerland

Publications

  1. ncbi request reprint Fibrinogen gamma375 arg-->trp mutation (fibrinogen aguadilla) causes hereditary hypofibrinogenemia, hepatic endoplasmic reticulum storage disease and cirrhosis
    Laura Rubbia-Brandt
    Gastrointestinal and Liver Pathology Unit, University Hospital, 24 Rue Micheli du Crest, 1211 Geneva 14, Switzerland
    Am J Surg Pathol 30:906-11. 2006
  2. ncbi request reprint Liver steatosis in chronic hepatitis C: a morphological sign suggesting infection with HCV genotype 3
    L Rubbia-Brandt
    Division of Clinical Pathology, University Hospital, 1 rue Michel Servet, 1211 Geneva, Switzerland
    Histopathology 39:119-24. 2001
  3. doi request reprint Gene expression profiling provides insights into pathways of oxaliplatin-related sinusoidal obstruction syndrome in humans
    Laura Rubbia-Brandt
    Service de pathologie clinique, Hopitaux Universitaires de Geneve, 1211 Geneva, Switzerland
    Mol Cancer Ther 10:687-96. 2011
  4. ncbi request reprint Lymphatic vessel density and vascular endothelial growth factor-C expression correlate with malignant behavior in human pancreatic endocrine tumors
    Laura Rubbia-Brandt
    Services of Clinical Pathology, Gastroenterology and Hepatology, and Digestive Surgery, Geneva University Hospital, Geneva, Switzerland
    Clin Cancer Res 10:6919-28. 2004
  5. ncbi request reprint Severe hepatic sinusoidal obstruction associated with oxaliplatin-based chemotherapy in patients with metastatic colorectal cancer
    L Rubbia-Brandt
    Division of Clinical Pathology, University Hospital, Geneva, Switzerland
    Ann Oncol 15:460-6. 2004
  6. doi request reprint [Hepatic lesions induced by systemic chemotherapy for digestive cancer]
    Laura Rubbia-Brandt
    Hopitaux Universitaires de Geneve, Suisse
    Ann Pathol 30:421-5. 2010
  7. doi request reprint Sinusoidal obstruction syndrome
    Laura Rubbia-Brandt
    Division of Clinical Pathology of University Hospital, Geneva, Switzerland
    Clin Liver Dis 14:651-68. 2010
  8. ncbi request reprint Sinusoidal obstruction syndrome and nodular regenerative hyperplasia are frequent oxaliplatin-associated liver lesions and partially prevented by bevacizumab in patients with hepatic colorectal metastasis
    Laura Rubbia-Brandt
    Division of Pathology, Geneva University Hospital, Geneva, Switzerland
    Histopathology 56:430-9. 2010
  9. doi request reprint Neoadjuvant chemotherapy in patients with stage IV colorectal cancer: a comparison of histological response in liver metastases, primary tumors, and regional lymph nodes
    Pascal Gervaz
    Department of Surgery, University Hospital Geneva, Geneva, Switzerland
    Ann Surg Oncol 17:2714-9. 2010
  10. doi request reprint Liver resection for colorectal metastases after chemotherapy: impact of chemotherapy-related liver injuries, pathological tumor response, and micrometastases on long-term survival
    Luca Vigano
    Departments of HPB and Digestive Surgery and Pathology, Ospedale Mauriziano Umberto I, Torino, Italy and Departments of Visceral and Transplantation Surgery and Clinical Pathology, University Hospitals, Geneva, Switzerland
    Ann Surg 258:731-40; discussion 741-2. 2013

Detail Information

Publications66

  1. ncbi request reprint Fibrinogen gamma375 arg-->trp mutation (fibrinogen aguadilla) causes hereditary hypofibrinogenemia, hepatic endoplasmic reticulum storage disease and cirrhosis
    Laura Rubbia-Brandt
    Gastrointestinal and Liver Pathology Unit, University Hospital, 24 Rue Micheli du Crest, 1211 Geneva 14, Switzerland
    Am J Surg Pathol 30:906-11. 2006
    ..Our results suggest that familial hypofibrinogenemia should be considered in the differential diagnosis of a progressive liver disease associated to hepatocellular intracytoplasmic globular inclusions...
  2. ncbi request reprint Liver steatosis in chronic hepatitis C: a morphological sign suggesting infection with HCV genotype 3
    L Rubbia-Brandt
    Division of Clinical Pathology, University Hospital, 1 rue Michel Servet, 1211 Geneva, Switzerland
    Histopathology 39:119-24. 2001
    ..To identify factors associated with liver steatosis in chronic hepatitis C...
  3. doi request reprint Gene expression profiling provides insights into pathways of oxaliplatin-related sinusoidal obstruction syndrome in humans
    Laura Rubbia-Brandt
    Service de pathologie clinique, Hopitaux Universitaires de Geneve, 1211 Geneva, Switzerland
    Mol Cancer Ther 10:687-96. 2011
    ..Activation of VEGF and coagulation (vWF) pathways could partially explain at a molecular level the clinical observations that bevacizumab and aspirin have a preventive effect in SOS...
  4. ncbi request reprint Lymphatic vessel density and vascular endothelial growth factor-C expression correlate with malignant behavior in human pancreatic endocrine tumors
    Laura Rubbia-Brandt
    Services of Clinical Pathology, Gastroenterology and Hepatology, and Digestive Surgery, Geneva University Hospital, Geneva, Switzerland
    Clin Cancer Res 10:6919-28. 2004
    ..These findings strongly suggest that lymphangiogenesis occurs in pancreatic endocrine tumors and that lymphatic invasion and the development of metastases are associated with VEGF-C expression...
  5. ncbi request reprint Severe hepatic sinusoidal obstruction associated with oxaliplatin-based chemotherapy in patients with metastatic colorectal cancer
    L Rubbia-Brandt
    Division of Clinical Pathology, University Hospital, Geneva, Switzerland
    Ann Oncol 15:460-6. 2004
    ..The objective of this study was to assess the effects of preoperative systemic chemotherapy on the morphology of non-tumoral liver...
  6. doi request reprint [Hepatic lesions induced by systemic chemotherapy for digestive cancer]
    Laura Rubbia-Brandt
    Hopitaux Universitaires de Geneve, Suisse
    Ann Pathol 30:421-5. 2010
    ..The new targeted molecules do not seem to modify the postoperative course. Hepatic injury and postoperative complications associated with chemotherapies used in the treatment of digestive cancers are summarized in this review...
  7. doi request reprint Sinusoidal obstruction syndrome
    Laura Rubbia-Brandt
    Division of Clinical Pathology of University Hospital, Geneva, Switzerland
    Clin Liver Dis 14:651-68. 2010
    ....
  8. ncbi request reprint Sinusoidal obstruction syndrome and nodular regenerative hyperplasia are frequent oxaliplatin-associated liver lesions and partially prevented by bevacizumab in patients with hepatic colorectal metastasis
    Laura Rubbia-Brandt
    Division of Pathology, Geneva University Hospital, Geneva, Switzerland
    Histopathology 56:430-9. 2010
    ....
  9. doi request reprint Neoadjuvant chemotherapy in patients with stage IV colorectal cancer: a comparison of histological response in liver metastases, primary tumors, and regional lymph nodes
    Pascal Gervaz
    Department of Surgery, University Hospital Geneva, Geneva, Switzerland
    Ann Surg Oncol 17:2714-9. 2010
    ..This study was designed to compare the response to chemotherapy in liver metastases, primary tumors, and locoregional lymph nodes...
  10. doi request reprint Liver resection for colorectal metastases after chemotherapy: impact of chemotherapy-related liver injuries, pathological tumor response, and micrometastases on long-term survival
    Luca Vigano
    Departments of HPB and Digestive Surgery and Pathology, Ospedale Mauriziano Umberto I, Torino, Italy and Departments of Visceral and Transplantation Surgery and Clinical Pathology, University Hospitals, Geneva, Switzerland
    Ann Surg 258:731-40; discussion 741-2. 2013
    ....
  11. pmc Early liver biopsy, intraparenchymal cholestasis, and prognosis in patients with alcoholic steatohepatitis
    Laurent Spahr
    Gastroenterology and Hepatology, Specialities Department, University Hospitals of Geneva, 4, rue Gabrielle Perret Gentil, CH 1211 Geneva, Switzerland
    BMC Gastroenterol 11:115. 2011
    ..Whether these lesions, in addition to other histological features observed in liver tissue specimens, have prognostic significance is unclear...
  12. ncbi request reprint Severe acute pancreatitis and reduced acinar cell apoptosis in the exocrine pancreas of mice deficient for the Cx32 gene
    Jean Louis Frossard
    Divisions of Gastroenterology, University Hospitals, Geneva, Switzerland
    Gastroenterology 124:481-93. 2003
    ....
  13. doi request reprint Intrahepatic mRNA levels of SOCS1 and SOCS3 are associated with cirrhosis but do not predict virological response to therapy in chronic hepatitis C
    Stéphanie Pascarella
    Department of Pathology and Immunology, University of Geneva, Geneva, Switzerland
    Liver Int 33:94-103. 2013
    ..The suppressor of cytokine signalling (SOCS) family members have been suggested to affect the rate of virological response to therapy, but the published evidence is conflicting...
  14. pmc Autologous bone marrow mononuclear cell transplantation in patients with decompensated alcoholic liver disease: a randomized controlled trial
    Laurent Spahr
    Division of Gastroenterology and Hepatology, University Hospitals and Faculty of Medicine, Geneva, Switzerland
    PLoS ONE 8:e53719. 2013
    ..We assessed whether autologous bone marrow mononuclear cell transplantation (BMMCT) improved liver function in decompensated ALD...
  15. ncbi request reprint Lack of in vivo blockade of Fas- and TNFR1-mediated hepatocyte apoptosis by the hepatitis C virus
    Laura Rubbia-Brandt
    Division of Clinical Pathology, University Hospital, 1211 Geneva, Switzerland
    J Pathol 197:617-23. 2002
    ..In conclusion, an HCV-mediated, in vivo blockade of hepatocyte apoptosis via the Fas- or TNFR1-dependent pathways seems unlikely...
  16. doi request reprint Hepatic regeneration is decreased in a rat model of sinusoidal obstruction syndrome
    Eduardo Schiffer
    Laboratoire de Physiopathologie Hépatique et Imagerie Moléculaire, Hopitaux Universitaires de Geneve, Geneva 1205, Switzerland
    J Surg Oncol 99:439-46. 2009
    ..However, the drug may severely injure hepatic sinusoids, inducing a sinusoidal obstruction syndrome in non-tumoral parenchyma with a risk of decreased regeneration in the remnant liver following partial hepatectomy...
  17. doi request reprint Down-regulation of phosphatase and tensin homolog by hepatitis C virus core 3a in hepatocytes triggers the formation of large lipid droplets
    Sophie Clement
    Division of Clinical Pathology, University Hospital, Geneva, Switzerland
    Hepatology 54:38-49. 2011
    ..However, IRS1 knockdown per se did not alter the morphology of lipid droplets, and this suggests that other PTEN-dependent mechanisms are involved in this process...
  18. ncbi request reprint Soluble TNF-R1, but not tumor necrosis factor alpha, predicts the 3-month mortality in patients with alcoholic hepatitis
    Laurent Spahr
    Gastroenterology and Hepatology, University Hospital, Geneva, Switzerland
    J Hepatol 41:229-34. 2004
    ..In patients with AH, we determined the prognostic value of TNF alpha, sTNF-R1, and lipopolysaccharide binding protein (LBP) and CD14, both involved in endotoxemia-associated inflammation...
  19. doi request reprint 'Liver first' approach in the treatment of colorectal cancer with synchronous liver metastases
    Gilles Mentha
    Department of Surgery, University Hospitals of Geneva, Geneva, Switzerland
    Dig Surg 25:430-5. 2008
    ..The present series updates on a previously reported pilot experience...
  20. ncbi request reprint Impaired hepatic mitochondrial oxidation using the 13C-methionine breath test in patients with macrovesicular steatosis and patients with cirrhosis
    Laurent Spahr
    Division of Gastroenterology and Hepatology, University Hospital, Geneva, Switzerland
    Med Sci Monit 9:CR6-11. 2003
    ..In human steatosis, ultrastructural changes are reported in the absence of ethanol. Routine evaluation of mitochondrial function is difficult. We used a breath test to explore hepatic mitochondrial oxidation in vivo...
  21. ncbi request reprint Combination of steroids with infliximab or placebo in severe alcoholic hepatitis: a randomized controlled pilot study
    Laurent Spahr
    Gastroenterology and Hepatology, University Hospital, 24 Rue Micheli du Crest, 1211, Geneva, Switzerland
    J Hepatol 37:448-55. 2002
    ..The aim of this study is to evaluate the tolerance and effects of infliximab combined with steroids in severe alcoholic hepatitis (AH)...
  22. ncbi request reprint An in vitro model of hepatitis C virus genotype 3a-associated triglycerides accumulation
    Karim Abid
    Division of Gastroenterology and Hepatology, University Hospital, 24 Rue Micheli du Crest, CH 1211 Geneva, Switzerland
    J Hepatol 42:744-51. 2005
    ..To extend these observations, we established an in vitro model expressing the HCV core of different genotypes...
  23. ncbi request reprint Fat diet and alcohol-induced steatohepatitis after LPS challenge in mice: role of bioactive TNF and Th1 type cytokines
    Maria L Olleros
    Department of Pathology and Immunology, Centre Medical Universitaire, 1 rue Michel Servet, CH 1211 Geneva 4, Switzerland
    Cytokine 44:118-25. 2008
    ..In this model, changes in the regulation of TNF are associated with increased expression of IL-6, IFN-gamma, and iNOS...
  24. doi request reprint Granulocyte-colony stimulating factor induces proliferation of hepatic progenitors in alcoholic steatohepatitis: a randomized trial
    Laurent Spahr
    Department of Gastroenterology and Hepatology, University Hospital, Geneva, Switzerland
    Hepatology 48:221-9. 2008
    ..003). Changes in Ki67+/cytokeratin 7+ cells correlated with changes in CD34+ cells (r = 0.65, P < 0.03). Neutrophils and histological changes were similar in both groups...
  25. pmc Complete pathological response (ypT0N0M0) after preoperative chemotherapy alone for stage IV rectal cancer
    Surennaidoo P Naiken
    Services de chirurgie viscérale et transplantation, Departement de Chirurgie, Hopitaux Universitaires de Geneve, Rue Gabrielle Perret Gentil 4, Genève 14 1211, Suisse
    BMC Surg 14:4. 2014
    ..The possibility that complete pathological response of rectal cancer can also occur with neoadjuvant chemotherapy alone (without radiation) is an intriguing hypothesis...
  26. pmc Expression of the bile acid receptor FXR in Barrett's esophagus and enhancement of apoptosis by guggulsterone in vitro
    Andrea De Gottardi
    Division of Gastroenterology, University Hospital, Micheli du Crest 24, 1205 Geneva, Switzerland
    Mol Cancer 5:48. 2006
    ..The aim of this study was to assess the expression of bile acid receptors in the esophagus (normal, esophagitis, Barrett's esophagus and adenocarcinoma) and to investigate their possible function...
  27. doi request reprint Herpes simplex virus load to monitor antiviral treatment after liver transplantation for acute herpetic hepatitis
    Juan Ambrosioni
    Service of Infectious Diseases, Department of Medical Specialities, University Hospitals of Geneva, Geneva, Switzerland
    Antivir Ther 17:401-4. 2012
    ..We present a case of ALF complicating a primary HSV-1 infection in an immunocompetent host, who required emergency LT. We further discuss the value of measuring serial HSV DNA plasma loads to monitor antiviral therapy...
  28. doi request reprint Focal ischemic necrosis in advanced biliary atresia cirrhosis
    Barbara E Wildhaber
    Department of Pediatric Surgery, University Hospital of Geneva, Geneva, Switzerland
    Pediatr Transplant 12:487-91. 2008
    ..Because of precarious hepatic blood supply in such patients, close monitoring of portal and diastolic arterial flows is recommended...
  29. doi request reprint Operative management of colorectal liver metastases
    Gilles Mentha
    Divisions of Transplantation and Visceral Surgery, Department of Surgery, University Hospitals of Geneva, Switzerland
    Semin Liver Dis 33:262-72. 2013
    ..These rates would have been unimaginable only two decades ago. ..
  30. ncbi request reprint Liver progenitor cells and therapeutic potential of stem cells in human chronic liver diseases
    Nicolas Lanthier
    Gastroenterology and Hepatology, Specialities Department, University Hospitals of Geneva, Geneva, Switzerland
    Acta Gastroenterol Belg 76:3-9. 2013
    ..Present data on stem cell therapy are heterogeneous in terms of methods and endpoints; thus, results need to be carefully examined prior to drawing a conclusion on possible benefits...
  31. doi request reprint Echovirus 11 infection induces dramatic changes in the actin cytoskeleton of polarized Caco-2 cells
    Komla Sobo
    Department of Clinical Pathology, University of Geneva, 1 rue Michel Servet, 1211 Geneva 4, Switzerland
    J Gen Virol 93:475-87. 2012
    ....
  32. doi request reprint Mice deficient in hepatocyte-specific IL-1Ra show delayed resolution of concanavalin A-induced hepatitis
    Celine Lamacchia
    Division of Rheumatology, University Hospital and Department of Pathology and Immunology, University of Geneva School of Medicine, Geneva, Switzerland
    Eur J Immunol 42:1294-303. 2012
    ..In conclusion, our results show that the local production of IL-1Ra by hepatocytes contributes to the resolution of hepatitis...
  33. doi request reprint PTEN down-regulation by unsaturated fatty acids triggers hepatic steatosis via an NF-kappaBp65/mTOR-dependent mechanism
    Manlio Vinciguerra
    Department of Cell Physiology and Metabolism, Geneva Medical Faculty, Geneva University Hospital, Switzerland
    Gastroenterology 134:268-80. 2008
    ..Here, we investigated the pathophysiologic mechanisms regulating PTEN expression in the liver and the development of steatosis...
  34. ncbi request reprint Extensive biliary intraepithelial neoplasia (BilIN) and multifocal early intrahepatic cholangiocarcinoma in non-biliary cirrhosis
    Anne Laure Rougemont
    Division of Clinical Pathology, Geneva University Hospitals, Rue Gabrielle Perret Gentil 4, 1211, Geneva 14, Switzerland
    Virchows Arch 456:711-7. 2010
    ....
  35. ncbi request reprint Circulating concentrations of interleukin-18, interleukin-18 binding protein, and gamma interferon in patients with alcoholic hepatitis
    Laurent Spahr
    Gastroenterology and Hepatology Unit, Geneva, Switzerland
    Liver Int 24:582-7. 2004
    ....
  36. ncbi request reprint Management of hepatocellular adenoma: solitary-uncomplicated, multiple and ruptured tumors
    Christian Toso
    Abdominal and Transplant Surgery, University Hospital, 24, Rue Micheli du Crest, 1211 Geneva 14, Switzerland
    World J Gastroenterol 11:5691-5. 2005
    ..While hepatocellular adenomas (HAs) have often been studied as a unique entity, we aimed to better define current management of the various forms of HAs...
  37. ncbi request reprint Insulin resistance is associated with liver fibrosis in non-diabetic chronic hepatitis C patients
    Alba Muzzi
    Division of Gastroenterology and Hepatology, University Hospital, Geneva, Switzerland
    J Hepatol 42:41-6. 2005
    ..Liver steatosis is a frequent finding in chronic hepatitis C. An association has been suggested between steatosis and fibrosis progression rate, but the pathogenetic mechanisms linking fatty infiltration and collagen deposition are unknown...
  38. doi request reprint Cure of multifocal panhepatic hepatoblastoma: is liver transplantation always necessary?
    Reto Marc Baertschiger
    Pediatric Surgery Unit, University of Geneva Children s Hospital, 1211 Geneva 4, Switzerland
    J Pediatr Surg 45:1030-6. 2010
    ..This procedure is no longer recommended because of the risk of persistent viable tumor cells in the hepatic remnant. We report our experience with conservative surgery in such cases...
  39. ncbi request reprint Hepatocellular adenoma and polycystic ovary syndrome
    Christian Toso
    Clinique et Policlinique de Chirurgie Digestive, Departement de Chirurgie, Hôpitaux Universitaires Genève, Rue Michelidu Crest, 24 CH 1211, Geneve
    Liver Int 23:35-7. 2003
    ..In view of this complication, we recommend a close screening of patients with such hormonal imbalance, especially those who are treated with high doses of hormones, with repeated liver tests and ultrasonographies...
  40. ncbi request reprint [Biliary, pancreatic and systemic diseases associated with IgG4]
    Jean Louis Frossard
    Division de gastroentérologie et hépatologie, HUG, 1211 Geneve 14
    Rev Med Suisse 4:1856-8. 2008
    ..This paper is aimed at reviewing all new aspects of diseases associated with high levels of IgG4...
  41. pmc Alloimmune activation promotes anti-cancer cytotoxicity after rat liver transplantation
    Stéphanie Lacotte
    Department of Surgery, Geneva University Hospitals, University of Geneva, Geneva, Switzerland
    PLoS ONE 9:e91515. 2014
    ....
  42. doi request reprint Acoustic radiation force impulse (ARFI) elastography for the noninvasive diagnosis of liver fibrosis in children
    Sylviane Hanquinet
    Department of Pediatric Radiology, University Hospitals Geneva, Geneva, Switzerland
    Pediatr Radiol 43:545-51. 2013
    ..Acoustic radiation force impulse (ARFI) imaging) is correlated with histopathological findings using METAVIR and semiquantitative scoring system (SSS) criteria for liver fibrosis...
  43. pmc Acute partial Budd-Chiari syndrome and portal vein thrombosis in cytomegalovirus primary infection: a case report
    Laurent Spahr
    Gastroenterology and Hepatology, Ospedale Regionale, Lugano, Switzerland
    BMC Gastroenterol 6:10. 2006
    ..Acute cytomegalovirus infection is a rare cause of acquired venous thrombosis in the portal or mesenteric territory, but has never been described extending into a main hepatic vein...
  44. doi request reprint Humoral and cellular rejection after combined liver-kidney transplantation in low immunologic risk recipients
    Karine Hadaya
    Division of Nephrology, Geneva University Hospital, Geneva, Switzerland
    Transpl Int 22:242-6. 2009
    ..Indeed, the detection of C4d in the liver should be carefully followed after combined liver-kidney transplantation...
  45. ncbi request reprint An unusual case of gastric heterotopic pancreas
    Laura Rubbia-Brandt
    Division of Clinical Pathology, Clinic of Digestive Surgery, Geneva University Hospitals, Geneva, Switzerland
    JOP 5:484-7. 2004
    ..Submucosal lesions of the gastrointestinal tract represent a diagnostic challenge for the physician. Endoscopic ultrasonography may provide useful information before deciding on therapeutic strategy...
  46. ncbi request reprint Do eosinophil numbers differentiate eosinophilic esophagitis from gastroesophageal reflux disease?
    Muriel Genevay
    Department of Clinical Pathology, Geneva University Hospitals, Geneva, Switzerland
    Arch Pathol Lab Med 134:815-25. 2010
    ....
  47. ncbi request reprint Acute hepatitis due to brivudin: a case report
    Alexandre Mottu
    General Internal Medicine, University Hospitals, Geneva, Switzerland
    J Hepatol 51:967-9. 2009
    ..Brivudin is licensed in several European countries for the treatment of herpetic infections, and is considered safe (approximately 1% of patients with transient elevation of liver enzymes) in large multicenter trials...
  48. ncbi request reprint Applications of mass spectrometry for quantitative protein analysis in formalin-fixed paraffin-embedded tissues
    Carine Steiner
    Division of Laboratory Medicine, Geneva University Hospital, Geneva, Switzerland Human Protein Sciences Department, University of Geneva, Geneva, Switzerland Translational Technologies and Bioinformatics, Pharma Research and Early Development, F Hoffmann La Roche AG, Basel, Switzerland
    Proteomics 14:441-51. 2014
    ..We also discuss the limitations and perspectives of the technique, particularly with regard to application in clinical diagnosis and drug discovery. ..
  49. pmc Management of a ruptured hydatid cyst involving the ribs: Dealing with a challenging case and review of the literature
    Theodoros Thomopoulos
    Department of Surgery, Clinics of Visceral and Transplantation Surgery, University Hospitals of Geneva HUG, 1211 Geneva 14, Geneva, Switzerland
    Int J Surg Case Rep 3:253-6. 2012
    ..Rarely, chest or abdominal wall involvement occurs that are challenging to manage. This case report and literature review describes the management of patients with chest wall and rib invasion...
  50. pmc Decay-accelerating factor binding determines the entry route of echovirus 11 in polarized epithelial cells
    Komla Sobo
    Department of Clinical Pathology, University of Geneva, 1 rue Michel Servet, 1211 Geneva 4, Switzerland
    J Virol 85:12376-86. 2011
    ..These data strongly indicate that in the case of infection of polarized epithelial cells by echovirus 11, DAF binding appears be a key determinant in the choice of entry pathway, at least in cell culture...
  51. ncbi request reprint Immunological and virological effects of ribavirin in hepatitis C after liver transplantation
    Rafael Quadri
    Division of Gastroenterology and Hepatology, University Hospital, 1211 Geneva, Switzerland
    Transplantation 73:373-8. 2002
    ..A better understanding of the mechanisms of action of drugs currently used to manage hepatitis C would be helpful...
  52. ncbi request reprint An unusual, presumably hepatic mass
    Axel Gamulin
    Clinic for Digestive and Transplant Surgery, Department of Surgery, University Hospital, 1211 Geneva, Switzerland
    Lancet 360:2066. 2002
  53. ncbi request reprint Role of macrophage inflammatory peptide-2 in cerulein-induced acute pancreatitis and pancreatitis-associated lung injury
    Catherine M Pastor
    Division of Gastroenterology and Hepatology, Geneva University Hospital, Geneva, Switzerland
    Lab Invest 83:471-8. 2003
    ..These results show that MIP-2 plays a key role in the pathophysiology of acute pancreatitis and that MIP-2 blockade may improve the outcome of the disease...
  54. doi request reprint Severe immune-mediated drug-induced liver injury linked to ibandronate: a case report
    Nicolas Goossens
    Division of Gastroenterology and Hepatology, Geneva University Hospital, Geneva, Switzerland Electronic address
    J Hepatol 59:1139-42. 2013
    ..We report the first case of ibandronate-related hepatotoxicity and, to our knowledge, the first case of immune-mediated drug-induced liver injury (DILI) related to bisphosphonates. ..
  55. pmc The prognostic value of expression of HIF1α, EGFR and VEGF-A, in localized prostate cancer for intermediate- and high-risk patients treated with radiation therapy with or without androgen deprivation therapy
    Damien C Weber
    Department of Radiation Oncology, Geneva University Hospital, Geneva, Switzerland
    Radiat Oncol 7:66. 2012
    ....
  56. ncbi request reprint Severe hemochromatosis in a Portuguese family associated with a new mutation in the 5'-UTR of the HAMP gene
    Thomas Matthes
    Division of Hematology, University Hospital, Geneva, Switzerland
    Blood 104:2181-3. 2004
    ..The decrease of hepcidin production would thus lead to increased iron absorption, resulting in iron deposition in parenchymal tissues. Phlebotomy therapy of the 2 patients resulted in impressive clinical improvement...
  57. ncbi request reprint Peritoneal schistosomiasis: an unusual laparoscopic finding
    Virginie Masserey Spicher
    Department of Paediatrics, University Hospital, Geneva, Switzerland
    J Pediatr Surg 39:631-3. 2004
    ..This uncommon and rare presentation deserves to be reported, especially to physicians of nonendemic areas, in an era in which people travel extensively...
  58. ncbi request reprint Inhibition of inducible nitric oxide synthase protects against liver injury induced by mycobacterial infection and endotoxins
    Reto Guler
    Department of Pathology, CMU, Faculty of Medicine, University of Geneva, 1, rue Michel Servet, CH 1211 Geneva 4, Switzerland
    J Hepatol 41:773-81. 2004
    ..This work investigates the role of inducible nitric oxide synthase (iNOS) in liver damage induced by BCG and endotoxins in BCG-infected mice...
  59. ncbi request reprint Relationship between steatosis, inflammation, and fibrosis in chronic hepatitis C: a meta-analysis of individual patient data
    Gioacchino Leandro
    IRCSS de Bellis, Castellana Grotte, Italy
    Gastroenterology 130:1636-42. 2006
    ..We evaluated the association between steatosis and fibrosis and their common correlates in persons with CHC and in subgroup analyses according to hepatitis C virus (HCV) genotype and body mass index...
  60. ncbi request reprint Sinusoidal obstruction syndrome is a major feature of hepatic lesions associated with oxaliplatin neoadjuvant chemotherapy for liver colorectal metastases
    Laura Rubbia-Brandt
    J Am Coll Surg 202:199-200. 2006
  61. ncbi request reprint Improved long-term outcome of surgery for advanced colorectal liver metastases: reasons and implications for management on the basis of a severity score
    Axel Andres
    Unit of Visceral and Transplantation Surgery, University Hospitals of Geneva, 1211, Geneva 14, Switzerland
    Ann Surg Oncol 15:134-43. 2008
    ..To quantify this assumption and to understand its causes we analyzed a series of patients on the basis of a standardized severity score and changes in management occurring over the years...
  62. pmc Accumulation of hedgehog-responsive progenitors parallels alcoholic liver disease severity in mice and humans
    Youngmi Jung
    Department of Medicine, Duke University, Durham, North Carolina
    Gastroenterology 134:1532-43. 2008
    ..Hedgehog (Hh) pathway activation promotes expansion of progenitor populations in other tissues. We evaluated the hypothesis that chronic EtOH exposure activates Hh signaling in liver...
  63. ncbi request reprint In vivo evidence for the role of GM-CSF as a mediator in acute pancreatitis-associated lung injury
    Jean Louis Frossard
    Department of Surgery, Beth Israel Hospital Deaconess Medical Center, Harvard Medical School, Boston, Massachusetts 02115, USA
    Am J Physiol Lung Cell Mol Physiol 283:L541-8. 2002
    ..Our findings indicate that GM-CSF plays a critical role in coupling pancreatitis to ALI and suggest that GM-CSF may act indirectly by regulating the release of other proinflammatory factors including MIP-2...
  64. ncbi request reprint Hepatocellular carcinoma in a liver-cell adenoma within a non-cirrhotic liver
    Emanuel Burri
    Department of Gastroenterology, University Hospital Liestal, Switzerland
    Eur J Gastroenterol Hepatol 18:437-41. 2006
    ..Mechanisms of transformation remain unclear. The imaging findings as well as histological features are presented in detail and the literature is discussed...
  65. ncbi request reprint [Nonalcoholic fatty liver: does it have to be biopsed?]
    Laura Rubbia-Brandt
    Unité de pathologie gastro intestinale et hépatique, Département de pathologie clinique, HUG, 1211 Geneve 14
    Rev Med Suisse 1:2804-8. 2005
    ....
  66. ncbi request reprint Connective tissue growth factor, steatosis and fibrosis in patients with chronic hepatitis C
    Caroline Hora
    Department of Clinical Pharmacology, University of Bern, Bern, Switzerland
    Liver Int 28:370-6. 2008
    ..We hypothesized that CTGF may link steatosis, insulin resistance and fibrosis...