Jürgen Roth

Summary

Affiliation: University Hospital
Country: Switzerland

Publications

  1. ncbi Tubules of the trans Golgi apparatus visualized by immunoelectron microscopy
    J Roth
    Department of Pathology, University of Zurich, Switzerland
    Histochem Cell Biol 109:545-53. 1998
  2. ncbi Protein N-glycosylation along the secretory pathway: relationship to organelle topography and function, protein quality control, and cell interactions
    Jürgen Roth
    Division of Cell and Molecular Pathology, Department of Pathology, University of Zurich, CH 8091 Zurich, Switzerland
    Chem Rev 102:285-303. 2002
  3. ncbi The importance of trimming reactions on asparagine-linked oligosaccharides for protein quality control
    Jürgen Roth
    Division of Cell and Molecular Pathology, Department of Pathology, University of Zurich, Schmelzbergstrasse 12, 8091 Zurich, Switzerland
    Histochem Cell Biol 117:159-69. 2002
  4. ncbi Sodium 4-phenylbutyrate acts as a chemical chaperone on misfolded myocilin to rescue cells from endoplasmic reticulum stress and apoptosis
    Gary Hin Fai Yam
    Division of Cell and Molecular Pathology, Department of Pathology, University of Zurich, Schmelzbergstrasse 12, CH 8091 Zurich, Switzerland
    Invest Ophthalmol Vis Sci 48:1683-90. 2007
  5. ncbi Protein quality control: the who's who, the where's and therapeutic escapes
    Jürgen Roth
    Division of Cell and Molecular Pathology, Department of Pathology, University of Zurich, 8091 Zurich, Switzerland
    Histochem Cell Biol 129:163-77. 2008
  6. ncbi Expression of mutant Ins2C96Y results in enhanced tubule formation causing enlargement of pre-Golgi intermediates of CHO cells
    Jing Yu Fan
    Division of Cell and Molecular Pathology, Department of Pathology, University of Zurich, CH 8091, Zurich, Switzerland
    Histochem Cell Biol 128:161-73. 2007
  7. ncbi 4-Phenylbutyrate rescues trafficking incompetent mutant alpha-galactosidase A without restoring its functionality
    Gary Hin Fai Yam
    Division of Cell and Molecular Pathology, Department of Pathology, University of Zurich, CH 8091 Zurich, Switzerland
    Biochem Biophys Res Commun 360:375-80. 2007
  8. ncbi Endomannosidase undergoes phosphorylation in the Golgi apparatus
    Tania Torossi
    Division of Cell and Molecular Pathology, Department of Pathology, University of Zurich, CH 8091 Zurich, Switzerland
    Glycobiology 20:55-61. 2010
  9. ncbi Pharmacological chaperone corrects lysosomal storage in Fabry disease caused by trafficking-incompetent variants
    Gary Hin Fai Yam
    Division of Cell and Molecular Pathology, Department of Pathology, University of Zurich, CH 8091 Zurich, Switzerland
    Am J Physiol Cell Physiol 290:C1076-82. 2006
  10. ncbi The role of glucosidase II and endomannosidase in glucose trimming of asparagine-linked oligosaccharides
    Jürgen Roth
    Division of Cell and Molecular Pathology, Department of Pathology, University of Zurich, Switzerland
    Biochimie 85:287-94. 2003

Collaborators

Detail Information

Publications20

  1. ncbi Tubules of the trans Golgi apparatus visualized by immunoelectron microscopy
    J Roth
    Department of Pathology, University of Zurich, Switzerland
    Histochem Cell Biol 109:545-53. 1998
    ..These buds and vesicle are therefore involved in constitutive exocytosis...
  2. ncbi Protein N-glycosylation along the secretory pathway: relationship to organelle topography and function, protein quality control, and cell interactions
    Jürgen Roth
    Division of Cell and Molecular Pathology, Department of Pathology, University of Zurich, CH 8091 Zurich, Switzerland
    Chem Rev 102:285-303. 2002
  3. ncbi The importance of trimming reactions on asparagine-linked oligosaccharides for protein quality control
    Jürgen Roth
    Division of Cell and Molecular Pathology, Department of Pathology, University of Zurich, Schmelzbergstrasse 12, 8091 Zurich, Switzerland
    Histochem Cell Biol 117:159-69. 2002
    ....
  4. ncbi Sodium 4-phenylbutyrate acts as a chemical chaperone on misfolded myocilin to rescue cells from endoplasmic reticulum stress and apoptosis
    Gary Hin Fai Yam
    Division of Cell and Molecular Pathology, Department of Pathology, University of Zurich, Schmelzbergstrasse 12, CH 8091 Zurich, Switzerland
    Invest Ophthalmol Vis Sci 48:1683-90. 2007
    ....
  5. ncbi Protein quality control: the who's who, the where's and therapeutic escapes
    Jürgen Roth
    Division of Cell and Molecular Pathology, Department of Pathology, University of Zurich, 8091 Zurich, Switzerland
    Histochem Cell Biol 129:163-77. 2008
    ....
  6. ncbi Expression of mutant Ins2C96Y results in enhanced tubule formation causing enlargement of pre-Golgi intermediates of CHO cells
    Jing Yu Fan
    Division of Cell and Molecular Pathology, Department of Pathology, University of Zurich, CH 8091, Zurich, Switzerland
    Histochem Cell Biol 128:161-73. 2007
    ..We conclude that misfolded proinsulin causes enlargement of pre-Golgi intermediates which indicates their involvement in protein quality control...
  7. ncbi 4-Phenylbutyrate rescues trafficking incompetent mutant alpha-galactosidase A without restoring its functionality
    Gary Hin Fai Yam
    Division of Cell and Molecular Pathology, Department of Pathology, University of Zurich, CH 8091 Zurich, Switzerland
    Biochem Biophys Res Commun 360:375-80. 2007
    ..Because of lack of functionality of rescued mutant alpha-galactosidase A, 4-phenylbutyrate seems to be of limited use as a chemical chaperone for Fabry disease...
  8. ncbi Endomannosidase undergoes phosphorylation in the Golgi apparatus
    Tania Torossi
    Division of Cell and Molecular Pathology, Department of Pathology, University of Zurich, CH 8091 Zurich, Switzerland
    Glycobiology 20:55-61. 2010
    ..Treatment of cells with brefeldin A blocked the posttranslational modification of endomannosidase, suggesting that phosphorylation is occurring in the Golgi apparatus, the residence of endomannosidase...
  9. ncbi Pharmacological chaperone corrects lysosomal storage in Fabry disease caused by trafficking-incompetent variants
    Gary Hin Fai Yam
    Division of Cell and Molecular Pathology, Department of Pathology, University of Zurich, CH 8091 Zurich, Switzerland
    Am J Physiol Cell Physiol 290:C1076-82. 2006
    ..Pharmacological chaperones acting on misfolded, unstable mutant proteins that exhibit residual biological activity offer a convenient and cost-efficient therapeutic strategy...
  10. ncbi The role of glucosidase II and endomannosidase in glucose trimming of asparagine-linked oligosaccharides
    Jürgen Roth
    Division of Cell and Molecular Pathology, Department of Pathology, University of Zurich, Switzerland
    Biochimie 85:287-94. 2003
    ..The mutually exclusive subcellular distribution of glucosidase II and endomannosidase are discussed in terms of their significance for quality control of protein folding and N-glycosylation...
  11. ncbi EDEM1 reveals a quality control vesicular transport pathway out of the endoplasmic reticulum not involving the COPII exit sites
    Christian Zuber
    Division of Cell and Molecular Pathology, Department of Pathology, University of Zurich, CH 8091 Zurich, Switzerland
    Proc Natl Acad Sci U S A 104:4407-12. 2007
    ....
  12. ncbi A cell culture system for the induction of Mallory bodies: Mallory bodies and aggresomes represent different types of inclusion bodies
    Kiyoko Hirano
    Division of Cell and Molecular Pathology, Department of Pathology, University of Zurich, Schmelzbergstrasse 12, 8091, Zurich, Switzerland
    Histochem Cell Biol 132:293-304. 2009
    ..Thus, cultured clone 9 hepatocytes are a useful system to study further aspects of the pathobiology of MBs...
  13. ncbi Misfolded proinsulin accumulates in expanded pre-Golgi intermediates and endoplasmic reticulum subdomains in pancreatic beta cells of Akita mice
    Christian Zuber
    Division of Cell and Molecular Pathology, Department of Pathology, University of Zurich, Zurich, Switzerland
    FASEB J 18:917-9. 2004
    ....
  14. ncbi Aggregated myocilin induces russell bodies and causes apoptosis: implications for the pathogenesis of myocilin-caused primary open-angle glaucoma
    Gary Hin Fai Yam
    Division of Cell and Molecular Pathology, Department of Pathology, University of Zurich, CH 8091 Zurich, Switzerland
    Am J Pathol 170:100-9. 2007
    ....
  15. ncbi A synthetic chaperone corrects the trafficking defect and disease phenotype in a protein misfolding disorder
    Gary Hin Fai Yam
    Division of Cell and Molecular Pathology, Department of Pathology, University of Zurich, Zurich, Switzerland
    FASEB J 19:12-8. 2005
    ..Small molecule chemical chaperones will be therapeutically useful for various lysosomal storage disorders as well as for other genetic metabolic disorders caused by mutant but nonetheless catalytically active enzymes...
  16. ncbi Ceruloplasmin carries the anionic glycan oligo/poly alpha2,8 deaminoneuraminic acid
    Martin Ziak
    Division of Cell and Molecular Pathology, Department of Pathology, University of Zurich, Switzerland
    Biochem Biophys Res Commun 295:597-602. 2002
    ..Thus, ceruloplasmin, in addition to megalin, represents a glycoprotein carrying oligo/poly alpha2,8 KDN...
  17. ncbi Combined comparative genomic hybridization and genomic microarray for detection of gene amplifications in pulmonary artery intimal sarcomas and adrenocortical tumors
    Jianming Zhao
    Department of Pathology, University of Zurich, Zurich, Switzerland
    Genes Chromosomes Cancer 34:48-57. 2002
    ....
  18. ncbi Absence of somatic SDHD mutations in sporadic neuroendocrine tumors and detection of two germline variants in paraganglioma patients
    Aurel Perren
    Department of Pathology, University Hospital, 8091 Zurich, Switzerland
    Oncogene 21:7605-8. 2002
    ..However, LOH alone could lead to a complete loss of function since SDHD is an imprinted gene. Furthermore, we describe two germline variants possibly causing hereditary paragangliomas...
  19. ncbi The proteasome is involved in the degradation of different aquaporin-2 mutants causing nephrogenic diabetes insipidus
    Kiyoko Hirano
    Department of Pathology, Division of Cell and Molecular Pathology, University of Zurich, Zurich, Switzerland
    Am J Pathol 163:111-20. 2003
    ..This implies the involvement of different protein quality control processes in the processing of these AQP2 mutants...
  20. ncbi Recent progress in histochemistry
    Christian Zuber
    Division of Cell and Molecular Pathology, Department of Pathology, University of Zurich, CH 8091, Zurich, Switzerland
    Histochem Cell Biol 128:557-94. 2007
    ..This review will highlight some advancements made in these fields...