Jürgen Roth

Summary

Affiliation: University Hospital
Country: Switzerland

Publications

  1. ncbi request reprint Tubules of the trans Golgi apparatus visualized by immunoelectron microscopy
    J Roth
    Department of Pathology, University of Zurich, Switzerland
    Histochem Cell Biol 109:545-53. 1998
  2. ncbi request reprint Protein N-glycosylation along the secretory pathway: relationship to organelle topography and function, protein quality control, and cell interactions
    Jürgen Roth
    Division of Cell and Molecular Pathology, Department of Pathology, University of Zurich, CH 8091 Zurich, Switzerland
    Chem Rev 102:285-303. 2002
  3. ncbi request reprint The importance of trimming reactions on asparagine-linked oligosaccharides for protein quality control
    Jürgen Roth
    Division of Cell and Molecular Pathology, Department of Pathology, University of Zurich, Schmelzbergstrasse 12, 8091 Zurich, Switzerland
    Histochem Cell Biol 117:159-69. 2002
  4. ncbi request reprint Sodium 4-phenylbutyrate acts as a chemical chaperone on misfolded myocilin to rescue cells from endoplasmic reticulum stress and apoptosis
    Gary Hin Fai Yam
    Division of Cell and Molecular Pathology, Department of Pathology, University of Zurich, Schmelzbergstrasse 12, CH 8091 Zurich, Switzerland
    Invest Ophthalmol Vis Sci 48:1683-90. 2007
  5. pmc Protein quality control: the who's who, the where's and therapeutic escapes
    Jürgen Roth
    Division of Cell and Molecular Pathology, Department of Pathology, University of Zurich, 8091 Zurich, Switzerland
    Histochem Cell Biol 129:163-77. 2008
  6. doi request reprint Endomannosidase undergoes phosphorylation in the Golgi apparatus
    Tania Torossi
    Division of Cell and Molecular Pathology, Department of Pathology, University of Zurich, CH 8091 Zurich, Switzerland
    Glycobiology 20:55-61. 2010
  7. ncbi request reprint Expression of mutant Ins2C96Y results in enhanced tubule formation causing enlargement of pre-Golgi intermediates of CHO cells
    Jing Yu Fan
    Division of Cell and Molecular Pathology, Department of Pathology, University of Zurich, CH 8091, Zurich, Switzerland
    Histochem Cell Biol 128:161-73. 2007
  8. ncbi request reprint 4-Phenylbutyrate rescues trafficking incompetent mutant alpha-galactosidase A without restoring its functionality
    Gary Hin Fai Yam
    Division of Cell and Molecular Pathology, Department of Pathology, University of Zurich, CH 8091 Zurich, Switzerland
    Biochem Biophys Res Commun 360:375-80. 2007
  9. ncbi request reprint Expression of a mutant ER-retained polytope membrane protein in cultured rat hepatocytes results in Mallory body formation
    Kiyoko Hirano
    Division of Cell and Molecular Pathology, Department of Pathology, University of Zurich, Schmelzbergstrasse 12, 8091 Zurich, Switzerland
    Histochem Cell Biol 117:41-53. 2002
  10. doi request reprint Large protein complexes retained in the ER are dislocated by non-COPII vesicles and degraded by selective autophagy
    Valerie Le Fourn
    Division of Cell and Molecular Pathology, Department of Pathology, University of Zurich, 8091 Zurich, Switzerland
    Cell Mol Life Sci 70:1985-2002. 2013

Collaborators

Detail Information

Publications25

  1. ncbi request reprint Tubules of the trans Golgi apparatus visualized by immunoelectron microscopy
    J Roth
    Department of Pathology, University of Zurich, Switzerland
    Histochem Cell Biol 109:545-53. 1998
    ..These buds and vesicle are therefore involved in constitutive exocytosis...
  2. ncbi request reprint Protein N-glycosylation along the secretory pathway: relationship to organelle topography and function, protein quality control, and cell interactions
    Jürgen Roth
    Division of Cell and Molecular Pathology, Department of Pathology, University of Zurich, CH 8091 Zurich, Switzerland
    Chem Rev 102:285-303. 2002
  3. ncbi request reprint The importance of trimming reactions on asparagine-linked oligosaccharides for protein quality control
    Jürgen Roth
    Division of Cell and Molecular Pathology, Department of Pathology, University of Zurich, Schmelzbergstrasse 12, 8091 Zurich, Switzerland
    Histochem Cell Biol 117:159-69. 2002
    ....
  4. ncbi request reprint Sodium 4-phenylbutyrate acts as a chemical chaperone on misfolded myocilin to rescue cells from endoplasmic reticulum stress and apoptosis
    Gary Hin Fai Yam
    Division of Cell and Molecular Pathology, Department of Pathology, University of Zurich, Schmelzbergstrasse 12, CH 8091 Zurich, Switzerland
    Invest Ophthalmol Vis Sci 48:1683-90. 2007
    ....
  5. pmc Protein quality control: the who's who, the where's and therapeutic escapes
    Jürgen Roth
    Division of Cell and Molecular Pathology, Department of Pathology, University of Zurich, 8091 Zurich, Switzerland
    Histochem Cell Biol 129:163-77. 2008
    ....
  6. doi request reprint Endomannosidase undergoes phosphorylation in the Golgi apparatus
    Tania Torossi
    Division of Cell and Molecular Pathology, Department of Pathology, University of Zurich, CH 8091 Zurich, Switzerland
    Glycobiology 20:55-61. 2010
    ..Treatment of cells with brefeldin A blocked the posttranslational modification of endomannosidase, suggesting that phosphorylation is occurring in the Golgi apparatus, the residence of endomannosidase...
  7. ncbi request reprint Expression of mutant Ins2C96Y results in enhanced tubule formation causing enlargement of pre-Golgi intermediates of CHO cells
    Jing Yu Fan
    Division of Cell and Molecular Pathology, Department of Pathology, University of Zurich, CH 8091, Zurich, Switzerland
    Histochem Cell Biol 128:161-73. 2007
    ..We conclude that misfolded proinsulin causes enlargement of pre-Golgi intermediates which indicates their involvement in protein quality control...
  8. ncbi request reprint 4-Phenylbutyrate rescues trafficking incompetent mutant alpha-galactosidase A without restoring its functionality
    Gary Hin Fai Yam
    Division of Cell and Molecular Pathology, Department of Pathology, University of Zurich, CH 8091 Zurich, Switzerland
    Biochem Biophys Res Commun 360:375-80. 2007
    ..Because of lack of functionality of rescued mutant alpha-galactosidase A, 4-phenylbutyrate seems to be of limited use as a chemical chaperone for Fabry disease...
  9. ncbi request reprint Expression of a mutant ER-retained polytope membrane protein in cultured rat hepatocytes results in Mallory body formation
    Kiyoko Hirano
    Division of Cell and Molecular Pathology, Department of Pathology, University of Zurich, Schmelzbergstrasse 12, 8091 Zurich, Switzerland
    Histochem Cell Biol 117:41-53. 2002
    ..The here reported in vitro system will be useful in studies about the biogenesis and progression of Mallory bodies, their relationship to aggresomes, and the role of inclusion bodies in the pathogenesis of cell damage...
  10. doi request reprint Large protein complexes retained in the ER are dislocated by non-COPII vesicles and degraded by selective autophagy
    Valerie Le Fourn
    Division of Cell and Molecular Pathology, Department of Pathology, University of Zurich, 8091 Zurich, Switzerland
    Cell Mol Life Sci 70:1985-2002. 2013
    ..This implies that ER-associated protein degradation (ERAD) has a broader function in ER proteostasis and is not limited to the elimination of misfolded glycoproteins...
  11. ncbi request reprint Pharmacological chaperone corrects lysosomal storage in Fabry disease caused by trafficking-incompetent variants
    Gary Hin Fai Yam
    Division of Cell and Molecular Pathology, Department of Pathology, University of Zurich, CH 8091 Zurich, Switzerland
    Am J Physiol Cell Physiol 290:C1076-82. 2006
    ..Pharmacological chaperones acting on misfolded, unstable mutant proteins that exhibit residual biological activity offer a convenient and cost-efficient therapeutic strategy...
  12. ncbi request reprint Ultrastructural analysis of transitional endoplasmic reticulum and pre-Golgi intermediates: a highway for cars and trucks
    Jing Yu Fan
    Division of Cell and Molecular Pathology, Department of Pathology, University of Zurich, Schmelzbergstrasse 12, 8091 Zurich, Switzerland
    Histochem Cell Biol 120:455-63. 2003
    ..Immunogold labeling for proinsulin indicated that the large tubular elements contained cargo and thus appear to take part in ER-to-Golgi transport...
  13. pmc EDEM1 reveals a quality control vesicular transport pathway out of the endoplasmic reticulum not involving the COPII exit sites
    Christian Zuber
    Division of Cell and Molecular Pathology, Department of Pathology, University of Zurich, CH 8091 Zurich, Switzerland
    Proc Natl Acad Sci U S A 104:4407-12. 2007
    ....
  14. ncbi request reprint The role of glucosidase II and endomannosidase in glucose trimming of asparagine-linked oligosaccharides
    Jürgen Roth
    Division of Cell and Molecular Pathology, Department of Pathology, University of Zurich, Switzerland
    Biochimie 85:287-94. 2003
    ..The mutually exclusive subcellular distribution of glucosidase II and endomannosidase are discussed in terms of their significance for quality control of protein folding and N-glycosylation...
  15. ncbi request reprint Applications of immunogold labeling in ultrastructural pathology
    Christian Zuber
    Division of Cell and Molecular Pathology, Department of Pathology, University of Zurich, Zurich, Switzerland
    Ultrastruct Pathol 29:319-30. 2005
    ....
  16. doi request reprint A cell culture system for the induction of Mallory bodies: Mallory bodies and aggresomes represent different types of inclusion bodies
    Kiyoko Hirano
    Division of Cell and Molecular Pathology, Department of Pathology, University of Zurich, Schmelzbergstrasse 12, 8091, Zurich, Switzerland
    Histochem Cell Biol 132:293-304. 2009
    ..Thus, cultured clone 9 hepatocytes are a useful system to study further aspects of the pathobiology of MBs...
  17. ncbi request reprint Misfolded proinsulin accumulates in expanded pre-Golgi intermediates and endoplasmic reticulum subdomains in pancreatic beta cells of Akita mice
    Christian Zuber
    Division of Cell and Molecular Pathology, Department of Pathology, University of Zurich, Zurich, Switzerland
    FASEB J 18:917-9. 2004
    ....
  18. pmc Aggregated myocilin induces russell bodies and causes apoptosis: implications for the pathogenesis of myocilin-caused primary open-angle glaucoma
    Gary Hin Fai Yam
    Division of Cell and Molecular Pathology, Department of Pathology, University of Zurich, CH 8091 Zurich, Switzerland
    Am J Pathol 170:100-9. 2007
    ....
  19. ncbi request reprint A synthetic chaperone corrects the trafficking defect and disease phenotype in a protein misfolding disorder
    Gary Hin Fai Yam
    Division of Cell and Molecular Pathology, Department of Pathology, University of Zurich, Zurich, Switzerland
    FASEB J 19:12-8. 2005
    ..Small molecule chemical chaperones will be therapeutically useful for various lysosomal storage disorders as well as for other genetic metabolic disorders caused by mutant but nonetheless catalytically active enzymes...
  20. ncbi request reprint Absence of somatic SDHD mutations in sporadic neuroendocrine tumors and detection of two germline variants in paraganglioma patients
    Aurel Perren
    Department of Pathology, University Hospital, 8091 Zurich, Switzerland
    Oncogene 21:7605-8. 2002
    ..However, LOH alone could lead to a complete loss of function since SDHD is an imprinted gene. Furthermore, we describe two germline variants possibly causing hereditary paragangliomas...
  21. ncbi request reprint Ceruloplasmin carries the anionic glycan oligo/poly alpha2,8 deaminoneuraminic acid
    Martin Ziak
    Division of Cell and Molecular Pathology, Department of Pathology, University of Zurich, Switzerland
    Biochem Biophys Res Commun 295:597-602. 2002
    ..Thus, ceruloplasmin, in addition to megalin, represents a glycoprotein carrying oligo/poly alpha2,8 KDN...
  22. ncbi request reprint Combined comparative genomic hybridization and genomic microarray for detection of gene amplifications in pulmonary artery intimal sarcomas and adrenocortical tumors
    Jianming Zhao
    Department of Pathology, University of Zurich, Zurich, Switzerland
    Genes Chromosomes Cancer 34:48-57. 2002
    ....
  23. ncbi request reprint Spatiotemporal expression patterns of sialoglycoconjugates during nephron morphogenesis and their regional and cell type-specific distribution in adult rat kidney
    Christian Zuber
    Division of Cell and Molecular Pathology, Department of Pathology, University of Zurich, Schmelzbergstrasse 12, 8091 Zurich, Switzerland
    Histochem Cell Biol 120:143-60. 2003
    ..Thus, alpha2,6- and alpha2,3-linked sialic acids are differently expressed in embryonic anlagen and mesenchyme-derived early stages of nephron and show regional and cell type-specific differences in adult kidney...
  24. pmc The proteasome is involved in the degradation of different aquaporin-2 mutants causing nephrogenic diabetes insipidus
    Kiyoko Hirano
    Department of Pathology, Division of Cell and Molecular Pathology, University of Zurich, Zurich, Switzerland
    Am J Pathol 163:111-20. 2003
    ..This implies the involvement of different protein quality control processes in the processing of these AQP2 mutants...
  25. ncbi request reprint Recent progress in histochemistry
    Christian Zuber
    Division of Cell and Molecular Pathology, Department of Pathology, University of Zurich, CH 8091, Zurich, Switzerland
    Histochem Cell Biol 128:557-94. 2007
    ..This review will highlight some advancements made in these fields...