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Genomes and Genes | R RizzoliSummaryAffiliation: University of Geneva Country: Switzerland Publications
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Publications
Effects of strontium ranelate and alendronate on bone microstructure in women with osteoporosis. Results of a 2-year studyR Rizzoli
Division of Bone Diseases, Department of Medical Specialties, Geneva University Hospitals and Faculty of Medicine, 1211 Geneva 14, Switzerland
Osteoporos Int 23:305-15. 2012....- Vitamin D supplementation in elderly or postmenopausal women: a 2013 update of the 2008 recommendations from the European Society for Clinical and Economic Aspects of Osteoporosis and Osteoarthritis (ESCEO)R Rizzoli
Division of Bone Diseases, Geneva University Hospitals and Faculty of Medicine, Geneva, Switzerland
Curr Med Res Opin 29:305-13. 2013..Vitamin D insufficiency has deleterious consequences on health outcomes. In elderly or postmenopausal women, it may exacerbate osteoporosis... - Antidepressant medications and osteoporosisR Rizzoli
Division of Bone Diseases, Department of Medical Specialties, Geneva University Hospitals and Faculty of Medicine, Geneva, Switzerland
Bone 51:606-13. 2012..The body of evidence suggests that SSRIs should be considered in the list of medications that are risk factors for osteoporotic fractures... - Management of glucocorticoid-induced osteoporosisR Rizzoli
Service of Bone Diseases, Geneva University Hospitals, Geneva, Switzerland
Calcif Tissue Int 91:225-43. 2012.... - [Bisphosphonates treatment in patients with osteoporosis]Rene Rizzoli
Abteilung für Knochenerkrankungen, Departement Medizinischer Spezialitäten, Universitätsspital und Medizinische Fakultät, Genf
Ther Umsch 69:173-81. 2012..Bisphosphonates have been associated with a number of side effects, with a well-documented association between gastrointestinal adverse events and oral administration, and between acute phase reactions and intravenous administration... 
Strontium ranelate and alendronate have differing effects on distal tibia bone microstructure in women with osteoporosisRene Rizzoli
Division of Bone Diseases, Department of Rehabilitation and Geriatrics, Geneva University Hospitals and Faculty of Medicine, 1211, Geneva 14, Switzerland
Rheumatol Int 30:1341-8. 2010....- Subtrochanteric fractures after long-term treatment with bisphosphonates: a European Society on Clinical and Economic Aspects of Osteoporosis and Osteoarthritis, and International Osteoporosis Foundation Working Group ReportR Rizzoli
Division of Bone Diseases, Department of Rehabilitation and Geriatrics, University Hospitals and Faculty of Medicine of Geneva, 1211, Geneva 14, Switzerland
Osteoporos Int 22:373-90. 2011..Bisphosphonate use may be associated with atypical subtrochanteric fractures, but the case is yet unproven... - Maximizing bone mineral mass gain during growth for the prevention of fractures in the adolescents and the elderlyRene Rizzoli
Division of Bone Diseases, Department of Rehabilitation and Geriatrics, Geneva University Hospitals and Faculty of Medicine, Geneva, Switzerland
Bone 46:294-305. 2010..Optimizing PBM acquisition through dietary and physical exercise measures may represent a valuable primary method for the prevention of fractures... - Bisphosphonates for post-menopausal osteoporosis: are they all the same?R Rizzoli
Faculty of Medicine of Geneva, Division of Bone Diseases, Department of Rehabilitation and Geriatrics, University Hospitals, CH_1211 Geneva 14, Switzerland
QJM 104:281-300. 2011..Ultimately, selection of a specific bisphosphonate for treatment of PMO should be based on efficacy, risk profile, cost-effectiveness and patient preference... - Indications to teriparatide treatment in patients with osteoporosisR Rizzoli
Service of Bone Diseases, Department of Rehabilitation and Geriatrics, Geneva University Hospitals, Switzerland
Swiss Med Wkly 141:w13297. 2011..Teriparatide should thus be considered as first line treatment for postmenopausal women and for men with severe osteoporosis... - Management of osteoporosis in the elderlyR Rizzoli
Division of Bone Diseases, Department of Rehabilitation and Geriatrics, Geneva University Hospitals and Faculty of Medicine, Rue Micheli du Crest 24, 1211, Geneva 14, Switzerland
Curr Med Res Opin 25:2373-87. 2009..Osteoporotic fracture risk is multifactorial, and often involves the balance between bone strength and propensity for falling... 
Adverse drug reactions to osteoporosis treatmentsRene Rizzoli
Division of Bone Diseases, Department of Medical Specialties, Geneva University Hospitals and Faculty of Medicine, Geneva, Switzerland
Expert Rev Clin Pharmacol 4:593-604. 2011..The management of osteoporosis should entail weighing the probability of adverse reactions against the benefits of therapy--that is, reduction of fracture risk...- Fractures during childhood and adolescence in healthy boys: relation with bone mass, microstructure, and strengthT Chevalley
Division of Bone Diseases, University Hospitals and Faculty of Medicine, CH 1211 Geneva 14, Switzerland
J Clin Endocrinol Metab 96:3134-42. 2011..In healthy boys, fractures result from trauma of various severity, suggesting contribution of an intrinsic biomechanical fragility... - Arginine increases insulin-like growth factor-I production and collagen synthesis in osteoblast-like cellsT Chevalley
WHO Collaborating Center for Osteoporosis and Bone Diseases, Department of Internal Medicine, University Hospital, Geneva, Switzerland
Bone 23:103-9. 1998..02). In conclusion, Arg stimulated IGF-I production and collagen synthesis in osteoblast-like cells. Thus, Arg may influence bone formation by enhancing local IGF-I production... - Skeletal site selectivity in the effects of calcium supplementation on areal bone mineral density gain: a randomized, double-blind, placebo-controlled trial in prepubertal boysT Chevalley
Service of Bone Diseases, Department of Rehabilitation and Geriatrics, University Hospitals of Geneva, CH 1211 Geneva 14, Switzerland
J Clin Endocrinol Metab 90:3342-9. 2005..Calcium supplementation during childhood and adolescence is considered an early means of preventing osteoporosis in adults. Prepuberty is an opportune time for detecting the benefits of calcium in girls... - Reversal of the hip fracture secular trend is related to a decrease in the incidence in institution-dwelling elderly womenE Guilley
Centre for Interdisciplinary Gerontology, University of Geneva, Geneva, Switzerland
Osteoporos Int 19:1741-7. 2008..3% per year reduction in the standardized incidence of hip fracture in women but not in men. This decrease was mainly due to changes in the standardized incidence of hip fracture in institution-dwelling women... - Zinc increases the effects of essential amino acids-whey protein supplements in frail elderlyA Rodondi
Division of Bone Diseases, Department of Rehabilitation and Geriatrics, University Hospitals and Faculty of Medicine of Geneva, CH 1211 Geneva 14, Switzerland
J Nutr Health Aging 13:491-7. 2009..Protein undernutrition is frequent in the elderly. It contributes to the development of osteoporosis, possibly via lower IGF-I. Dietary zinc can influence IGF-I production... - Socioeconomic and living conditions are determinants of hip fracture incidence and age occurrence among community-dwelling elderlyE Guilley
Centre for Interdisciplinary Gerontology, University of Geneva, Geneva, Switzerland
Osteoporos Int 22:647-53. 2011..Age at hip fracture also depended of marital status but in a gender-specific way... - Allogeneic bone marrow transplantation is associated with a preferential femoral neck bone lossN Buchs
Division of Bone Diseases (World Health Organization Collaborating Center for Osteoporosis and Bone Diseases, University Hospital, Geneva, Switzerland
Osteoporos Int 12:880-6. 2001.... - Protein intake and bone disorders in the elderlyR Rizzoli
Centre Collaborateur de l OMS pour l ostéoporose et les Maladies Osseuses, Departement de Medecine Interne, Hopital Cantonal Universitaire, Geneva, Switzerland
Joint Bone Spine 68:383-92. 2001..Supplemental protein also significantly reduces the length of inpatient rehabilitation care. These data emphasize the importance of adequate nutrient intake in the prevention and treatment of osteoporotic fractures... - Vitamin D supplementation during infancy is associated with higher bone mineral mass in prepubertal girlsS A Zamora
Department of Pediatrics, University Hospital, Geneva, Switzerland
J Clin Endocrinol Metab 84:4541-4. 1999..045 g/cm2 in the supplemented group (P = 0.02). Vitamin D supplementation in infancy was found to be associated with increased aBMD at specific skeletal sites later in childhood in prepubertal Caucasian girls... - Dietary essential amino acid supplements increase bone strength by influencing bone mass and bone microarchitecture in ovariectomized adult rats fed an isocaloric low-protein dietP Ammann
Department of Internal Medicine, University Hospital, Geneva, Switzerland
J Bone Miner Res 17:1264-72. 2002..In conclusion, dietary essential amino acid supplements increased bone strength through modifications of BMD, trabecular architecture, and cortical thickness possibly by an IGF-I-mediated process... - Effects of oral clodronate on bone mineral density in patients with relapsing breast cancerR Rizzoli
Division of Clinical Pathophysiology, World Health Organization Collaborating Center for Osteoporosis and Bone Disease, Geneva, Switzerland
Bone 18:531-7. 1996..These results indicate that clodronate treatment decreased bone turnover and attenuated cancer-related bone morbidity. In addition, clodronate increased LS BMD in apparently unaffected bone of women with relapsing breast cancer... - Osteoporosis, genetics and hormonesR Rizzoli
Division of Bone Diseases, WHO Collaborating Center for Osteoporosis and Bone Diseases, Department of Internal Medicine, University Hospital, 1211 Geneva 14, Switzerland
J Mol Endocrinol 26:79-94. 2001..1)... - A new selective estrogen receptor modulator HMR-3339 fully corrects bone alterations induced by ovariectomy in adult ratsP Ammann
Department of Rehabilitation and Geriatrics, Service of Bone Diseases WHO Collaborating Center for Osteoporosis Prevention, University Hospital, CH 1211 Geneva 14, Switzerland
Bone 35:153-61. 2004..In contrast to raloxifene, HMR-3339 also influenced skeletal sites predominantly formed of cortical bone... - Pamidronate prevents bone loss and decreased bone strength in adult female and male rats fed an isocaloric low-protein dietSamia Mekraldi
Service of Bone Diseases WHO Collaborating Center for Osteoporosis Prevention, Department of Rehabilitation and Geriatrics, University Hospital of Geneva, Geneva, Switzerland
J Bone Miner Res 20:1365-71. 2005..CONCLUSION: In conclusion, inhibition of increased bone resorption in rats fed an isocaloric low-protein diet fully prevents bone loss and alteration of bone strength... - Fractures in healthy females followed from childhood to early adulthood are associated with later menarcheal age and with impaired bone microstructure at peak bone massT Chevalley
Division of Bone Diseases, Geneva University Hospitals and Faculty of Medicine, Rue Gabrielle Perret Gentil 4, CH 1211 Geneva 14, Switzerland
J Clin Endocrinol Metab 97:4174-81. 2012..Considering the importance of pubertal timing in bone development, we also quantified the fracture risk related to later menarcheal age (MENA)... - Lower femoral neck bone mineral density in prepubertal former preterm girlsS A Zamora
Gastroenterology Unit, Department of Paediatrics, University Hospital, Geneva, Switzerland
Bone 29:424-7. 2001..Preterm girls had similar aBMD results compared with controls at sites with predominantly cortical bone (radial and femoral diaphysis), which are known to be more sensitive to calcium intake... - Decreased bone turnover in children and adolescents with well controlled type 1 diabetesA B R Maggio
Pediatric Cardiology Unit, Department of Child and Adolescent, University Hospitals of Geneva and University of Geneva, Geneva, Switzerland
J Pediatr Endocrinol Metab 23:697-707. 2010..Osteoporosis is a common long-term complication of type 1 diabetes (T1DM). We aimed to determine whether bone mineral density (BMD) and turnover are already altered during childhood... - Pubertal timing and body mass index gain from birth to maturity in relation with femoral neck BMD and distal tibia microstructure in healthy female subjectsT Chevalley
Division of Bone Diseases, Department of Rehabilitation and Geriatrics, Geneva University Hospitals and Faculty of Medicine, Rue Micheli du Crest 24, CH 1211, Geneva 14, Switzerland
Osteoporos Int 22:2689-98. 2011..This study underscores the importance of pubertal timing in age-related fragility fracture risk... - Protein intake and bone growthJ P Bonjour
Division of Bone Diseases, WHO Collaborating Center for Osteoporosis and Bone Diseases, Department of Internal Medicine, University Hospital, Geneva, Switzerland
Can J Appl Physiol 26:S153-66. 2001..This suggests that, like for the bone response to either the intake of calcium or weight-bearing exercise, the skeleton would be particularly responsive to the protein intake during the years preceding the onset of pubertal maturation... - Osteoporosis: non-hormonal treatmentR Rizzoli
Division of Bone Diseases World Health Organization Collaborating Center for Osteoporosis Prevention, Department of Rehabilitation and Geriatrics, University Hospitals, Geneva, Switzerland
Climacteric 10:74-8. 2007..Spine, hip and forearm bone mineral density increased, to an extent slightly higher than with the weekly administration of 70 mg alendronate... - The role of calcium and vitamin D in the management of osteoporosisR Rizzoli
Division of Bone Diseases, World Health Organization Collaborating Center for Osteoporosis Prevention, Department of Rehabilitation and Geriatrics, University Hospitals and Faculty of Medicine, 1211 Geneva 14, Switzerland
Bone 42:246-9. 2008..The combination of vitamin D with calcium may be beneficial in terms of efficacy and, perhaps, for optimising adherence... - The influence of pubertal timing on bone mass acquisition: a predetermined trajectory detectable five years before menarcheT Chevalley
Division of Bone Diseases, Department of Rehabilitation and Geriatrics, Geneva University Hospitals and Faculty of Medicine, Rue Gabrielle Perret Gentil 4, CH 1211 Geneva 14, Switzerland
J Clin Endocrinol Metab 94:3424-31. 2009..It is associated with low peak bone mass (PBM). Like PBM, MENA is under strong genetic influence. We hypothesized that MENA-related bone mass differences could be predetermined before puberty... - Incidence of hip fracture over a 10-year period (1991-2000): reversal of a secular trendT Chevalley
Service of Bone Diseases and Geriatric Evaluation Unit, Department of Rehabilitation and Geriatrics, University Hospitals of Geneva, CH 1211 Geneva 14, Switzerland
Bone 40:1284-9. 2007..We specifically examined secular changes in the incidence of hip fracture in women and men aged 50 years and over in the well-defined area of Geneva, Switzerland... - Sequence and activity of parathyroid hormone/parathyroid hormone-related protein receptor promoter region in human osteoblast-like cellsD Manen
Division of Bone Diseases, Department of Internal Medicine, University Hospital, 1211, Geneva 14, Switzerland
Gene 218:49-56. 1998..The activities of P2 and P3 were not additive. These results provide important information on the structure of the 5' flanking region of the human PTH/PTHrP gene receptor... - Gain in bone mineral mass in prepubertal girls 3.5 years after discontinuation of calcium supplementation: a follow-up studyJ P Bonjour
Division of Bone Diseases WHO Collaborating Centre for Osteoporosis and Bone Diseases, Department of Internal Medicine, University Hospital, Geneva, Switzerland
Lancet 358:1208-12. 2001..We now report the results of a follow-up study undertaken more than 3 years after the end of calcium supplementation... - An osteoporosis clinical pathway for the medical management of patients with low-trauma fractureT Chevalley
Division of Bone Diseases, WHO Collaborating Center for Osteoporosis and Bone Diseases, Department of Internal Medicine, University Hospitals of Geneva, Switzerland
Osteoporos Int 13:450-5. 2002.... - Two-year results of once-weekly administration of alendronate 70 mg for the treatment of postmenopausal osteoporosisR Rizzoli
Department of Internal Medicine, , Geneva, Switzerland
J Bone Miner Res 17:1988-96. 2002.... - Bone strength and its determinantsP Ammann
Division of Bone Diseases, WHO Collaborating Center for Osteoporosis and Bone Disease, University Hospital of Geneva, Geneva, Switzerland
Osteoporos Int 14:S13-8. 2003..The careful investigation of all the determinants of bone strength (bone tissue included) should be considered in the pathophysiology of osteoporosis and in the mechanisms of action of antiosteoporotic drugs... - Oligo-amenorrheic long-distance runners may lose more bone in spine than in femurG Gremion
Department of Clinical Neurosciences, University Hospital, Geneva, Switzerland
Med Sci Sports Exerc 33:15-21. 2001..CONCLUSIONS: Oligo-amenorrhea in long-distance runners, with adequate dietary intakes, was associated with a decrease in BMD affecting more the lumbar spine than the proximal and midshaft femur during a 1-yr follow-up... - Selective modification of bone quality by PTH, pamidronate, or raloxifeneTara C Brennan
Division of Bone Diseases WHO Collaborating Centre for Osteoporosis Prevention, Department of Rehabilitation and Geriatrics, Geneva University Hospital and Faculty of Medicine, Geneva, Switzerland
J Bone Miner Res 24:800-8. 2009..PTH influences microarchitecture, whereas bisphosphonates alter material-level bone properties, with probable opposite effects on remodeling space. Raloxifene primarily improved the material stiffness at the cortical level... - Alterations of bone microstructure and strength in end-stage renal failureA Trombetti
Bone Diseases Service, Department of Internal Medicine Specialties, Geneva University Hospitals and Faculty of Medicine, Rue Gabrielle Perret Gentil 4, 1211, Geneva 14, Switzerland
Osteoporos Int 24:1721-32. 2013..We observed an alteration of cortical and trabecular bone microstructure and of bone strength and stiffness in ESRD patients... - Survival and potential years of life lost after hip fracture in men and age-matched womenA Trombetti
Division of Bone Diseases [WHO Collaborating Center for Osteoporosis and Bone Diseases, Department of Internal Medicine, University Hospital of Geneva, 1211 Geneva 14, Switzerland
Osteoporos Int 13:731-7. 2002.... - Longitudinal follow-up of body composition in hematopoietic stem cell transplant patientsU G Kyle
Division of Clinical Nutrition, Geneva University Hospital, Geneva, Switzerland
Bone Marrow Transplant 35:1171-7. 2005..7, CI 1.3-5.9, P=0.01). Patients were more likely to have low LBMI than volunteers. Chronic GVHD and low performance status were associated with low LBMI; thus, complications and/or treatment increase the likelihood of low LBMI... - Targeted education improves the very low recognition of vertebral fractures and osteoporosis management by general internistsP Casez
Service of Bone Diseases (WHO Collaborating Centre for Osteoporosis Prevention, Department of Rehabilitation and Geriatrics, Geneva University Hospitals, 24 rue Micheli-du-Crest, 1211 Geneva 14, Switzerland
Osteoporos Int 17:965-70. 2006.... - Osteoporosis in menR Rizzoli
Division of Bone Diseases WHO Collaborating Center for Osteoporosis and Bone Diseases, Department of Internal Medicine, University Hospital, Geneva, Switzerland
Nurs Clin North Am 36:467-79, ix. 2001..In the management of the disease, the nurse plays a major role in the education and management of men with osteoporosis... - PTH improves titanium implant fixation more than pamidronate or renutrition in osteopenic rats chronically fed a low protein dietR Dayer
Division of Bone Diseases, Department of Rehabilitation and Geriatrics, Faculty of Medicine, Geneva University Hospitals, WHO Collaborating Center for Osteoporosis Prevention, 1211 Geneva 14, Switzerland
Osteoporos Int 21:957-67. 2010..PTH improved mechanical fixation, microarchitecture, and increased pull-out strength. Pamidronate or renutrition had lesser effects. PTH can thus improve implant osseointegration in protein-malnourished rats... - Importance of preclinical studies in the development of drugs for treatment of osteoporosis: a review related to the 1998 WHO guidelinesJ P Bonjour
Division of Bone Diseases, World Health Organization Collaborating Center for Osteoporosis and Bone Diseases, Department of Internal Medicine, University Hospital, Geneva, Switzerland
Osteoporos Int 9:379-93. 1999..Such a distribution of task assignment between preclinical and clinical programs should optimize the progress of research available to patients already suffering from or at risk of osteoporosis... - Is time since hip fracture influencing the discrimination between fractured and nonfractured subjects as assessed at the calcaneum by three technologically different quantitative ultrasound devices?D Hans
Department of Nuclear Medicine, Geneva University Hospital, Geneva, Switzerland
Calcif Tissue Int 71:485-92. 2002..As a result, it is advisable that such parameters would be taken into account when designing a study aimed to demonstrate the discriminatory ability of heel ultrasound between normal and hip-fractured patients... - A new treatment for post-menopausal osteoporosis: strontium ranelateR Rizzoli
Service of Bone Disease, WHO Collaborationg Center for Osteoporosis Prevention, University Hospitals, Geneva, Switzerland
J Endocrinol Invest 28:50-7. 2005.... - [Bisphosphonates and combined treatments osteoporosis]R Rizzoli
Centre collaborateur de I OMS pour la prevention de I ostéoporose, Service des maladies osseuses, Département de réhabilitation et gériatrie, HUG, 1211 Geneve
Rev Med Suisse 1:2266, 2269-71. 2005..Their efficacity has been shown in controlled trials up to 5 years, and their safety up to ten years. There is no proven benefit of combining two bone resorption inhibitors... - [Parathyroid hormone for osteroporsis: why and who to treat?]S Ferrari
Centre collaborateur de I OMS pour la prévention de I ostéoporose Service des maladies osseuses, HUG, 1211 Geneve
Rev Med Suisse 1:2272-4, 2276-7. 2005..However, the effects on PTH on cortical bone structure and its use in the context of anticatabolic treatments for osteoporosis remain complex... - Long-term use of bisphosphonates in osteoporosisRene Rizzoli
Service of Bone Diseases, WHO Collaborating Center for Osteoporosis Prevention, Department of Rehabilitation and Geriatrics, University Hospital, Rue Micheli du Crest 24CH 1211 Geneva 14, Switzerland
Womens Health (Lond Engl) 2:309-15. 2006..These drugs remain the cornerstone of osteoporosis treatment and appear to have favorable safety and efficacy profiles throughout long-term usage... - Low protein intake is associated with impaired titanium implant osseointegrationRomain Dayer
Service of Bone Diseases (WHO Collaborating Center for Osteoporosis Prevention, Department of Rehabilitation and Geriatrics, University Hospital of Geneva, Geneva, Switzerland
J Bone Miner Res 21:258-64. 2006..CONCLUSIONS: Isocaloric low protein intake impairs titanium implant osseointegration, with decreased strength needed to completely loosen the implant and altered bone microarchitecture in the vicinity of the implant... - Nutrition: its role in bone healthRene Rizzoli
Division of Bone Diseases, WHO Collaborating Center for Osteoporosis Prevention, Department of Rehabilitation and Geriatrics, Geneva University Hospitals and Faculty of Medicine, Geneva 14, Switzerland
Best Pract Res Clin Endocrinol Metab 22:813-29. 2008..Sufficient dietary calcium and protein are necessary for bone health during growth as well as in the elderly... - Beta-Arrestin2 regulates RANKL and ephrins gene expression in response to bone remodeling in miceDominique D Pierroz
Service of Bone Diseases, Department of Rehabilitation and Geriatrics, WHO Center for Osteoporosis Prevention, Geneva University Hospital and Faculty of Medicine, Geneva, Switzerland
J Bone Miner Res 24:775-84. 2009..As such, beta-arrestins should be considered an important mechanism for the control of bone remodeling in response to PTH and estrogen deprivation... - The importance and relevance of peak bone mass in the prevalence of osteoporosisJean Philippe Bonjour
Service of Bone Diseases, Department of Rehabilitation and Geriatrics, Geneva University Hospital, Geneva, Switzerland
Salud Publica Mex 51:S5-17. 2009..Prepuberty appears to be an opportune time to modify environmental factors that impinge on bone mineral mass acquisition... - [Duration of treatment against osteoporosis using bisphosphonate]Rene Rizzoli
Service des maladies osseuses Département de réhabilitation et gériatrie HUG
Rev Med Suisse Romande 124:105-7. 2004..Therapeutical controlled trials lasting up to 5 years are available. Beyond that duration, bisphosphonate treatment does not appear to be deleterious for bone... - Fibroblast growth factor-23 relationship to dietary phosphate and renal phosphate handling in healthy young menSerge L Ferrari
Service of Bone Diseases, Geneva University Hospital, 24 Rue Micheli du Crest, Geneva 1211, Switzerland
J Clin Endocrinol Metab 90:1519-24. 2005..These data suggest that FGF-23 may be implicated in the physiological regulation of Pi homeostasis in response to dietary phosphate changes, independent of PTH... - Osteonecrosis of the jaw and bisphosphonate treatment for osteoporosisRene Rizzoli
University Hospital and Faculty of Medicine, Geneva, Switzerland
Bone 42:841-7. 2008..A majority of ONJ occurs after tooth extraction. Furthermore, the underlying risk of developing ONJ may be increased in osteoporotic patients by comorbid diseases. Treatment for ONJ is generally conservative... - Administration of growth hormone in selectively protein-deprived rats decreases BMD and bone strengthPatrick Ammann
Service of Bone Diseases, Department of Rehabilitation and Geriatrics, University Hospitals of Geneva, Switzerland
Bone 46:1574-81. 2010..It remains unclear whether administration of growth hormone (GH) corrects these alterations in bone metabolism... - Long-term outcome of weekly bisphosphonatesRene Rizzoli
Division of Bone Diseases WHO Collaborating Center for Osteoporosis Prevention, Department of Rehabilitation and Geriatrics, University Hospital, Geneva, Switzerland
Clin Orthop Relat Res 443:61-5. 2006..LEVEL OF EVIDENCE: Therapeutic study, Level V (expert opinion). See the Guidelines for Authors for a complete description of the levels of evidence... - Long-term strategy in the management of postmenopausal osteoporosisRene Rizzoli
Division of Bone Diseases, WHO Collaborating Center for Osteoporosis Prevention, Department of Rehabilitation and Geriatrics, Geneva University Hospitals, 24 Rue Micheli du Crest, CH 1211 Geneva 14, Switzerland
Joint Bone Spine 74:540-3. 2007..Several medications were effective in double-blind controlled trials in which the fracture incidence was the primary endpoint. Long-term data are available to confirm the good safety profile of these medications... - Gene-environment interactions in the skeletal response to nutrition and exercise during growthJean Philippe Bonjour
Division of Bone Diseases, WHO Collaborating Centre for Osteoporosis Prevention, Department of Rehabilitation and Geriatrics, University Hospitals of Geneva, Geneva 14, Switzerland
Med Sport Sci 51:64-80. 2007..Identifying the functionally implicated genes interacting with mechanical loading and/or specific nutrients represents a formidable but hopefully not intractable challenge... - Childhood fractures are associated with decreased bone mass gain during puberty: an early marker of persistent bone fragility?Serge L Ferrari
Service of Bone Diseases, WHO Collaborating Center for Osteoporosis Prevention, Department of Rehabilitation and Geriatrics, Geneva University Hospital, Geneva, Switzerland
J Bone Miner Res 21:501-7. 2006..Among those, BMC gain at multiple sites and vertebral bone size at pubertal maturity were significantly decreased. Hence, childhood fractures may be markers of low peak bone mass acquisition and persistent skeletal fragility... - Strontium ranelate treatment improves trabecular and cortical intrinsic bone tissue quality, a determinant of bone strengthPatrick Ammann
Division of Bone Diseases, WHO Collaborting Centre for Osteoporosis Prevention, Department of Rehabilitation and Geriatrics, University Hospitals, Geneva, Switzerland
J Bone Miner Res 22:1419-25. 2007.... - Different responsiveness of alveolar and tibial bone to bone loss stimuliAnestis Mavropoulos
Division of Bone Diseases, WHO Collaborating Center for Osteoporosis Prevention, Department of Rehabilitation and Geriatrics, University Hospitals of Geneva, Switzerland
J Bone Miner Res 22:403-10. 2007..We compared the effect of isocaloric protein undernutrition and/or ovariectomy on BMD and microstructure of mandibular alveolar and proximal tibia sites in adult rats. Mandibular bone was significantly less affected... - Calcitropic hormones and IGF-I are influenced by dietary proteinVictor Dubois-Ferrière
Division of Bone Diseases, Department of Rehabilitation and Geriatrics, University Hospital, CH 1211 Geneva 14, Switzerland
Endocrinology 152:1839-47. 2011..Blocking resorption resulted in further increases in PTH and improved microarchitecture and biomechanical properties, irrespective of vitamin D status or protein intake... - Effect of a multifactorial fall-and-fracture risk assessment and management program on gait and balance performances and disability in hospitalized older adults: a controlled studyA Trombetti
Division of Bone Diseases, Geneva University Hospitals and Faculty of Medicine, Rue Gabrielle Perret Gentil 4, CH 1211, Geneva 14, Switzerland
Osteoporos Int 24:867-76. 2013.... - Recovery of proximal tibia bone mineral density and strength, but not cancellous bone architecture, after long-term bisphosphonate or selective estrogen receptor modulator therapy in aged ratsS Bourrin
Division of Bone Diseases, WHO Collaborating Center for Osteoporosis and Bone Diseases, Department of Internal Medicine, University Hospital, Geneva, Switzerland
Bone 30:195-200. 2002.... - Positive and negative control of the expression of parathyroid hormone (PTH)/PTH-related protein receptor via proximal promoter P3 in human osteoblast-like cellsD Manen
WHO Collaborating Center for Osteoporosis and Bone Diseases, Department of Internal Medicine, University Hospital, Geneva, Switzerland
J Clin Endocrinol Metab 85:3376-82. 2000..This study provides new insights into PTH receptor expression in human osteoblast-like cells... - Evidences for a role of p38 MAP kinase in the stimulation of alkaline phosphatase and matrix mineralization induced by parathyroid hormone in osteoblastic cellsA Rey
Service of Bone Diseases, Department of Rehabilitation and Geriatrics, University Hospital of Geneva, CH 1211 Geneva 14, Switzerland
Bone 41:59-67. 2007..Activation of p38 is cAMP-PKA-dependent and mediates PTH-induced stimulation of ALP which plays a critical role for the calcification of the bone matrix... - Determinants of peak bone massR Rizzoli
Division of Bone Diseases (WHO Collaborating Center for Osteoporosis Prevention, Department of Rehabilitation and Geriatrics, University Hospital, 1211 Geneva 14, Switzerland
Ann Endocrinol (Paris) 67:114-5. 2006 - Combined treatment with a beta-blocker and intermittent PTH improves bone mass and microarchitecture in ovariectomized miceDominique D Pierroz
Service of Bone Diseases, WHO Collaborating Center for Osteoporosis Prevention, Department of Rehabilitation and Geriatrics, Geneva University Hospital, HUGs, 24, rue Micheli-du-Crest, 1211 Geneva 14, Switzerland
Bone 39:260-7. 2006..In turn, PRO exerted synergistic effects with intermittent PTH on bone mass and cancellous bone architecture. As such, combined therapy of beta-blockers and PTH may be of interest in the treatment of postmenopausal osteoporosis... - Early serum IGF-I response to oral protein supplements in elderly women with a recent hip fractureThierry Chevalley
Division of Bone Diseases, WHO Collaborating Centre for Osteoporosis and Bone Diseases, Department of Rehabilitation and Geriatrics, Geneva University Hospitals and Faculty of Medicine, University of Geneva, CH 1211 Geneva 14, Switzerland
Clin Nutr 29:78-83. 2010..Elevation of circulating IGF-I in response to a daily oral supplement of 20 g of casein was observed after 6 months. This study determined if the response to casein as compared to whey protein can be observed as early as after one week... - High-protein intake enhances the positive impact of physical activity on BMC in prepubertal boysThierry Chevalley
Division of Bone Diseases WHO Collaborating Centre for Osteoporosis Prevention, Department of Rehabilitation and Geriatrics, University Hospitals of Geneva, Geneva, Switzerland
J Bone Miner Res 23:131-42. 2008..In 232 healthy prepubertal boys, increased physical activity was associated with greater BMC at both axial and appendicular sites under high-protein intake... - Glucocorticoid-induced osteoporosis and its treatmentPietra Pennisi
Service of Bone Diseases, WHO Collaborating Center for Osteoporosis Prevention, Department of Rehabilitation and Geriatrics, University Hospital of Geneva, Geneva, Switzerland
Clin Orthop Relat Res 443:39-47. 2006..LEVEL OF EVIDENCE: Level V (expert opinion). See the Guidelines for Authors for a complete description of the levels of evidence... - Prevalence of vertebral fracture in oldest old nursing home residentsA Rodondi
Division of Bone Diseases, Department of Medical Specialties, Geneva University Hospitals and Faculty of Medicine, CH 1211 Geneva 14, Switzerland
Osteoporos Int 23:2601-6. 2012..Probably in relation with the prevailing influence of age and medical history of fracture, adding these information into FRAX did not markedly modify fracture probability... - Guidance for the prevention of bone loss and fractures in postmenopausal women treated with aromatase inhibitors for breast cancer: an ESCEO position paperR Rizzoli
Division of Bone Diseases, Geneva University Hospitals and Faculty of Medicine, Geneva, Switzerland
Osteoporos Int 23:2567-76. 2012..Based on available evidence and recommendations, an ESCEO working group proposes specific guidance for the prevention of AIs-induced bone loss and fragility fractures... - LRP5 gene polymorphisms and idiopathic osteoporosis in menS L Ferrari
Service of Bone Diseases, Department of Rehabilitation and Geriatrics, Geneva University Hospital, Geneva, Switzerland
Bone 37:770-5. 2005..In conclusion, these data indicate beyond a significant role for environmental factors, an association between LRP5 variants and idiopathic osteoporosis in males, pointing to a role of LRP5 in this disease... - Evaluation of the age-adjusted incidence of hip fractures between urban and rural areas: the difference is not related to the prevalence of institutions for the elderlyT Chevalley
Department of Geriatrics, WHO Collaborating Center for Osteoporosis and Bone Diseases, University Hospital, Geneva, Switzerland
Osteoporos Int 13:113-8. 2002..Since this difference is increased when patients living at home were analyzed separately, it indicates that the difference between urban and rural areas is not due to a preferential urban location of institutions for the elderly... - Risk factors for vitamin D inadequacy among women with osteoporosis: an international epidemiological studyR Rizzoli
Hopital Cantonal Universitaire de Geneve, Geneva, Switzerland
Int J Clin Pract 60:1013-9. 2006..Several modifiable risk factors are associated with vitamin D inadequacy worldwide, suggesting potentially simple ways to increase vitamin D and improve bone health in postmenopausal women... - Serum parathyroid hormone-related protein levels and response to bisphosphonate treatment in hypercalcemia of malignancyR Rizzoli
World Health Organization Collaborating Center for Osteoporosis and Bone Diseases, Department of Internal Medicine, University Hospital, Geneva, Switzerland
J Clin Endocrinol Metab 84:3545-50. 1999.... - Gene variants for osteoporosis and their pleiotropic effects in agingSerge L Ferrari
Service of Bone Diseases, WHO Collaborating Center for Osteoporosis Prevention, Department of Rehabilitation and Geriatrics, Geneva University Hospital, Switzerland
Mol Aspects Med 26:145-67. 2005.... - Does the mini nutritional assessment predict hospitalization outcomes in older people?M C Van Nes
Department of Geriatric Medicine, University Hospitals, Geneva, Switzerland
Age Ageing 30:221-6. 2001..the Mini Nutritional Assessment is a validated clinical tool for the assessment of nutritional status in older people. Moderate to severe malnutrition is common in elderly patients in hospital and is associated with a poor outcome... - Defective implant osseointegration under protein undernutrition: prevention by PTH or pamidronateRomain Dayer
Division of Bone Diseases WHO Collaborating Center for Osteoporosis Prevention, Department of Rehabilitation and Geriatrics, University Hospitals of Geneva, Geneva, Switzerland
J Bone Miner Res 22:1526-33. 2007..PTH or pamidronate prevented the deleterious effects of protein undernutrition on bone microarchitecture close to the implant and on mechanical fixation. PTH even significantly improved implant osseointegration... - Pamidronate and osteoporosis prevention in liver transplant recipientsPietra Pennisi
Service of Bone Diseases, WHO Collaborating Center for Osteoporosis Prevention, Department of Rehabilitation and Geriatrics, University Hospital of Geneva, 1211, Geneva 14, Switzerland
Rheumatol Int 27:251-6. 2007.... - Strontium ranelate improves implant osseointegrationLaurent Maimoun
Division of Bone Diseases WHO Collaborating Center for Osteoporosis Prevention, Department of Rehabilitation and Geriatrics and Faculty of Medicine, University Hospital of Geneva, Geneva 14, Switzerland
Bone 46:1436-41. 2010..Strontium ranelate, which acts on both resorption and formation, and improves biomaterial properties, is hypothesized to improve osseointegration and this hypothesis was tested here... - Bone mass in prepubertal boys is associated with a Gln223Arg amino acid substitution in the leptin receptorLaura Richert
Service of Bone Diseases, World Health Organization Collaborating Center for Osteoporosis Prevention, Department of Rehabilitation and Geriatrics, University Hospital of Geneva, 1211 Geneva 14, Switzerland
J Clin Endocrinol Metab 92:4380-6. 2007.... - Raloxifene treatment is associated with increased serum estradiol and decreased bone remodeling in healthy middle-aged men with low sex hormone levelsBrigitte Uebelhart
Service of Bone Diseases WHO Collaborating Center for Osteoporosis Prevention, Department of Rehabilitation and Geriatrics, University Hospital, Geneva 14 CH 1211, Switzerland
J Bone Miner Res 19:1518-24. 2004..In healthy middle-aged men, raloxifene treatment was associated with increased serum estradiol and decreased biochemical markers of bone turnover in subjects with estradiol levels below a threshold of 101.8 pM... - Interaction between calcium intake and menarcheal age on bone mass gain: an eight-year follow-up study from prepuberty to postmenarcheThierry Chevalley
Service of Bone Diseases WHO Collaborating Center for Osteoporosis Prevention, Department of Rehabilitation and Geriatrics, University Hospitals, CH 1211 Geneva 14, Switzerland
J Clin Endocrinol Metab 90:44-51. 2005..Thus, both determinants of early menarcheal age and high Ca intake may positively interact on bone mineral mass accrual... - A single bisphosphonate infusion is associated with improved functional capacity in elderly subjects with primary hyperparathyroidismPatrick Ammann
Bone Nutrition Unit, Department of Rehabilitation and Geriatrics, University Hospital, Thonex, Switzerland
Aging Clin Exp Res 15:500-4. 2003..To address this hypothesis, we investigated the effects of transient normalization of calcemia on functional capacity by the administration of a single infusion of the bone resorption inhibitors pamidronate or clodronate... - Increase in bone mineral density after successful parathyroidectomy for tertiary hyperparathyroidism after renal transplantationStéphane Collaud
Department of Thoracic and Endocrine Surgery, University Hospital of Geneva, Rue Micheli du Crest 24, 1211 Geneva, Switzerland
World J Surg 32:1795-801. 2008..Few studies have reported changes of bone mineral density (BMD) after parathyroidectomy in patients with persistent hyperparathyroidism after renal transplantation (3 HPT)... - Proline-rich motifs in the parathyroid hormone (PTH)/PTH-related protein receptor C terminus mediate scaffolding of c-Src with beta-arrestin2 for ERK1/2 activationAlexandre Rey
Service of Bone Diseases, Department of Rehabilitation and Geriatrics, University Hospital, 1211 Geneva 14, Switzerland
J Biol Chem 281:38181-8. 2006.... - A rapid self-administered food frequency questionnaire for the evaluation of dietary protein intakePatricia Morin
Service of Bone Diseases, WHO Collaborating Center for Osteoporosis Prevention, Department of Rehabilitation and Geriatrics, University Hospitals, Geneva, Switzerland
Clin Nutr 24:768-74. 2005..CONCLUSION: This rapid, self-administered food frequency questionnaire could be a useful tool for the evaluation of dietary protein intakes in groups of subjects...