Affiliation: University of Basel
- 2D QSAR of PPARgamma agonist binding and transactivationChristoph Rücker
Biocenter, University of Basel, Klingelbergstrasse 50 70, CH 4056 Basel, Switzerland
Bioorg Med Chem 14:5178-95. 2006..For gene transactivation, the functional activity of the agonists, a corresponding model for a similarly diverse compound set is of somewhat lower statistical quality...
- Sulfonylureas and glinides exhibit peroxisome proliferator-activated receptor gamma activity: a combined virtual screening and biological assay approachMarco Scarsi
Biozentrum, University of Basel, Klingelbergstr 50 70, CH 4056 Basel, Switzerland
Mol Pharmacol 71:398-406. 2007..In addition, we provide a unified concept of the PPARgamma binding ability of seemingly disparate compound classes...
- y-Randomization and its variants in QSPR/QSARChristoph Rücker
Biozentrum, University of Basel, 4056 Basel, Switzerland
J Chem Inf Model 47:2345-57. 2007..Some progress also is reported toward the aim of obtaining the mean highest r2 of random pseudomodels by calculation rather than by tedious multiple simulations on random number variables...