Research Topics
Species | Andri RauchSummaryAffiliation: University Hospital Country: Switzerland Publications
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Publications
The recent breakthroughs in the understanding of host genomics in hepatitis CAndri Rauch
University Clinic of Infectious Diseases, University Hospital Bern and University of Bern, Bern, Switzerland
Eur J Clin Invest 40:950-9. 2010..In those who progress to chronic hepatitis C, HCV therapy permanently eradicates infection in about 40% of cases. It has long been suspected that host genetic factors are key determinants for the control of HCV infection...
Genetic variation in IL28B is associated with chronic hepatitis C and treatment failure: a genome-wide association studyAndri Rauch
University Clinic of Infectious Diseases, University Hospital Bern and University of Bern, Bern, Switzerland
Gastroenterology 138:1338-45, 1345.e1-7. 2010..We performed a genome-wide association study to screen for host genetic determinants of HCV persistence and response to therapy...
Host genetic determinants of spontaneous hepatitis C clearanceAndri Rauch
University Clinic of Infectious Diseases, University Hospital Bern and University of Bern, Inselspital PKT2B, 3010 Bern, Switzerland
Pharmacogenomics 10:1819-37. 2009....
Refining abacavir hypersensitivity diagnoses using a structured clinical assessment and genetic testing in the Swiss HIV Cohort StudyAndri Rauch
Department of Infectious Diseases, University Hospital Inselspital and University of Bern, Bern, Switzerland
Antivir Ther 13:1019-28. 2008..We aimed to assess the value of a structured clinical assessment and genetic testing for refining the diagnosis of abacavir hypersensitivity reactions (ABC-HSRs) in a routine clinical setting...
Low current and nadir CD4+ T-cell counts are associated with higher hepatitis C virus RNA levels in the Swiss HIV cohort studyAndri Rauch
Division of Infectious Diseases, University Hospital Bern and University of Bern, Switzerland
Antivir Ther 13:455-60. 2008..The aim of this study was to evaluate the effect of CD4+ T-cell counts and other characteristics of HIV-infected individuals on hepatitis C virus (HCV) RNA levels...
HLA-Bw4 homozygosity is associated with an impaired CD4 T cell recovery after initiation of antiretroviral therapyAndri Rauch
Division of Infectious Diseases, University Hospital Bern and University of Bern, Switzerland
Clin Infect Dis 46:1921-5. 2008..01, compared with HLA-Bw4 homozygotes). HLA-Bw4 homozygosity appears to predict an impaired CD4 T cell recovery after initiation of combination antiretroviral therapy...
A randomized cross-over study to compare raltegravir and efavirenz (SWITCH-ER study)Alain Nguyen
University Clinic of Infectious Diseases, University Hospital of Geneva, Switzerland
AIDS 25:1481-7. 2011..We investigated the effect of replacing EFV with raltegravir (RAL) on patient preference, daytime sleepiness, sleep quality, anxiety, and lipid levels...
Cellular immune responses to HCV core increase and HCV RNA levels decrease during successful antiretroviral therapyJanine Rohrbach
Klinik und Poliklinik für Infektiologie, University Hospital Berne and University of Berne, Inselspital PKT2B, 3010 Bern, Switzerland
Gut 59:1252-8. 2010..Hepatitis C virus (HCV) infection is a major cause of morbidity in HIV infected individuals. Coinfection with HIV is associated with diminished HCV-specific immune responses and higher HCV RNA levels...
Tenofovir use is associated with an increase in serum alkaline phosphatase in the Swiss HIV Cohort StudyChristoph A Fux
Division of Infectious Diseases, University Hospital Berne and University of Berne, Berne, Switzerland
Antivir Ther 13:1077-82. 2008..A few small studies have reported a positive correlation between renal phosphate losses, increased bone turnover and sAP...
Divergent adaptation of hepatitis C virus genotypes 1 and 3 to human leukocyte antigen-restricted immune pressureAndri Rauch
University Clinic of Infectious Diseases, University Hospital Bern and University of Bern, Bern, Switzerland
Hepatology 50:1017-29. 2009..These findings have implications for future therapeutic strategies to combat HCV infection, including vaccine design...
Unsafe sex and increased incidence of hepatitis C virus infection among HIV-infected men who have sex with men: the Swiss HIV Cohort StudyAndri Rauch
Division of Infectious Diseases, University Hospital Berne, Switzerland
Clin Infect Dis 41:395-402. 2005..CONCLUSIONS: HCV infection incidence in the Swiss HIV Cohort Study was mainly associated with IDU. In HIV-infected MSM, HCV infection was associated with unsafe sex...
A randomized crossover study to compare efavirenz and etravirine treatmentAlain Nguyen
University Clinic of Infectious Diseases, University Hospital of Geneva, Switzerland
AIDS 25:57-63. 2011..Efavirenz (EFV) causes neuropsychiatric side-effects and an unfavourable blood lipid profile. We investigated the effect of replacing EFV with etravirine (ETR) on patient preference, sleep, anxiety and lipid levels...
Hepatitis C virus infections in the Swiss HIV Cohort Study: a rapidly evolving epidemicGilles Wandeler
Department of Infectious Diseases, Bern University Hospital and University of Bern, Switzerland
Clin Infect Dis 55:1408-16. 2012..We assessed trends in HCV incidence in the different HIV transmission groups in the Swiss HIV Cohort Study (SHCS)...
The HCP5 single-nucleotide polymorphism: a simple screening tool for prediction of hypersensitivity reaction to abacavirSara Colombo
Institute of Microbiology, University Hospital Center and University of Lausanne, Lausanne, Switzerland
J Infect Dis 198:864-7. 2008..2%, respectively; P < .0001). Therefore, HCP5 genotyping could serve as a simple screening tool for ABC-HSR, particularly in settings where sequence-based HLA typing is not available...
Evidence of viral adaptation to HLA class I-restricted immune pressure in chronic hepatitis C virus infectionSilvana Gaudieri
Centre for Clinical Immunology and Biomedical Statistics, Level 2, North Block, Royal Perth Hospital, Wellington St, Perth, Western Australia 6000, Australia
J Virol 80:11094-104. 2006..This analysis of host-virus interaction reveals evidence of HCV adaptation to HLA class I-restricted immune pressure and identifies in vivo targets of cellular immune responses at the population level...
Chronic hepatitis C in HIV-infected patients: low eligibility and applicability of therapy with pegylated interferon-alpha plus ribavirinAndri Rauch
J Acquir Immune Defic Syndr 38:238-40. 2005
