Affiliation: University of Geneva
- Cyclic stretch of human lung cells induces an acidification and promotes bacterial growthJerome Pugin
Soins Intensifs, Hopitaux Universitaires de Geneve, 1211 Geneve 14, Switzerland
Am J Respir Cell Mol Biol 38:362-70. 2008..This novel metabolic pathway stimulated by cyclic stretch may represent an important pathogenic mechanism of VAP. Alkalinization of the airways may represent a promising preventive strategy in ventilated critically ill patients...
- Soluble MD-2 activity in plasma from patients with severe sepsis and septic shockJerome Pugin
Laboratory of the Division of Intensive Care, Department of Internal Medicine, University Hospital of Geneva, 24, Rue Micheli du Crest, 1211 Geneva 14, Switzerland
Blood 104:4071-9. 2004..We therefore propose that soluble MD-2 is an important mediator of organ inflammation during sepsis...
- Use of procalcitonin to shorten antibiotic treatment duration in septic patients: a randomized trialVandack Nobre
Intensive Care, University Hospital of Geneva, 24, Micheli du Crest, 1211 Geneva 14, Switzerland
Am J Respir Crit Care Med 177:498-505. 2008..The duration of antibiotic therapy in critically ill patients with sepsis can result in antibiotic overuse, increasing the risk of developing bacterial resistance...
- Immune monitoring of patients with septic shock by measurement of intraleukocyte cytokinesThierry Fumeaux
Department of Internal Medicine, University Hospital and Faculty of Medicine, 24 Rue Micheli du Crest, 1211 Geneva 14, Switzerland
Intensive Care Med 30:2028-37. 2004..To assess the immune competence of patients presenting with septic shock by measuring on-line the production of intracellular cytokines by circulating leukocytes...
- Soluble MD-2 is an acute-phase protein and an opsonin for Gram-negative bacteriaPierre Tissieres
Intensive Care, Department of Anesthesiology, Pharmacology and Intensive Care, University Hospitals of Geneva, Switzerland
Blood 111:2122-31. 2008..This suggests that sMD-2 plays a key role in the host innate immune response to Gram-negative infections...
- Role of interleukin-10 in the intracellular sequestration of human leukocyte antigen-DR in monocytes during septic shockThierry Fumeaux
Department of Internal Medicine, Division of Medical Intensive Care, and Faculty of Medicine, University Hospital of Geneva, Switzerland
Am J Respir Crit Care Med 166:1475-82. 2002..IL-10 may represent a future target for immunomodulating patients with the sepsis syndrome or critically ill patients at risk of developing infections...
- Toll-like receptor activation of human cells by synthetic triacylated lipid A-like moleculesIrene Dunn-Siegrist
Intensive Care Laboratory and Department of Microbiology and Molecular Medicine, Faculty of Medicine, University of Geneva, 1211 Geneva 14, Switzerland
J Biol Chem 287:16121-31. 2012..Not only do they block human cell responses to LPS but also to whole gram-negative bacteria, and they inhibit the phagocytosis of gram-negative bacteria. These compounds may represent promising immunomodulatory agents...
- Cooperation between PU.1 and CAAT/enhancer-binding protein beta is necessary to induce the expression of the MD-2 genePierre Tissieres
Intensive Care, University Hospitals of Geneva, Geneva 14, Switzerland
J Biol Chem 284:26261-72. 2009..Herein, we show that it also participates in the regulation of an acute phase protein, MD-2, in nonmyeloid cells cooperatively with C/EBPbeta, a classical IL-6-inducible TF...
- The role of MD-2 in the opsonophagocytosis of Gram-negative bacteriaPierre Tissieres
Intensive Care, University Hospitals of Geneva, Switzerland
Curr Opin Infect Dis 22:286-91. 2009....
- Role of MAP kinase activation in interleukin-8 production by human BEAS-2B bronchial epithelial cells submitted to cyclic stretchSéverine Oudin
Division of Medical Intensive Care, Department of Internal Medicine, University of Geneva, Switzerland
Am J Respir Cell Mol Biol 27:107-14. 2002..Pharmacologic inhibition of the p38 pathway holds promise as a new therapeutic avenue in ventilated patients...
- Immunostimulation is a rational therapeutic strategy in sepsisJerome Pugin
Intensive Care, University Hospital of Geneva, 1211 Geneva 14, Switzerland
Novartis Found Symp 280:21-7; discussion 27-36, 160-4. 2007..As a word of caution, one should not induce deleterious overwhelming inflammatory reactions, and therefore close monitoring of immune and inflammatory responses during immune stimulation therapy is necessary...