N M Probst-Hensch

Summary

Affiliation: University of Basel
Country: Switzerland

Publications

  1. pmc Causal and synthetic associations of variants in the SERPINA gene cluster with alpha1-antitrypsin serum levels
    Gian Andri Thun
    Swiss Tropical and Public Health Institute, Basel, Switzerland
    PLoS Genet 9:e1003585. 2013
  2. pmc SERPINA1 PiZ and PiS heterozygotes and lung function decline in the SAPALDIA cohort
    Gian Andri Thun
    Swiss Tropical and Public Health Institute, Basel, Switzerland
    PLoS ONE 7:e42728. 2012
  3. pmc Different genes interact with particulate matter and tobacco smoke exposure in affecting lung function decline in the general population
    Ivan Curjuric
    Department of Epidemiology and Public Health, Swiss Tropical and Public Health Institute SwissTPH, Basel, Switzerland
    PLoS ONE 7:e40175. 2012
  4. doi request reprint [New genetic tests and their clinical utility for cancer screening]
    Nicole M Probst-Hensch
    Swiss Tropical and Public Health Institute, Associated Institute of the University of Basel
    Ther Umsch 70:251-4; discussion 255-6. 2013
  5. doi request reprint IGFBP2 and IGFBP3 protein expressions in human breast cancer: association with hormonal factors and obesity
    Nicole M Probst-Hensch
    Institute of Social and Preventive Medicine, University of Zurich, Zurich
    Clin Cancer Res 16:1025-32. 2010
  6. ncbi request reprint Chronic age-related diseases share risk factors: do they share pathophysiological mechanisms and why does that matter?
    N M Probst-Hensch
    Department of Epidemiology and Public Health, Swiss Tropical and Public Health Institute, 4002 Basel, Switzerland
    Swiss Med Wkly 140:w13072. 2010
  7. doi request reprint Prevention--a cost-effective way to fight the non-communicable disease epidemic: an academic perspective of the United Nations High-level NCD Meeting
    Nicole Probst-Hensch
    Department of Epidemiology and Public Health, Swiss Tropical and Public Health Institute, Socinstrasse 57, 4002 Basel, CH, Switzerland
    Swiss Med Wkly 141:w13266. 2011
  8. doi request reprint HMOX1 and GST variants modify attenuation of FEF25-75% decline due to PM10 reduction
    I Curjuric
    Chronic Disease Epidemiology, Institute of Social and Preventive Medicine, University of Zurich
    Eur Respir J 35:505-14. 2010
  9. ncbi request reprint The common G-allele of interleukin-18 single-nucleotide polymorphism is a genetic risk factor for atopic asthma. The SAPALDIA Cohort Study
    M Imboden
    Molecular Epidemiology Cancer Registry, Institutes of Social and Preventive Medicine and Clinical Pathology, Zurich, Switzerland
    Clin Exp Allergy 36:211-8. 2006
  10. pmc Decreased PM10 exposure attenuates age-related lung function decline: genetic variants in p53, p21, and CCND1 modify this effect
    Medea Imboden
    Department of Chronic Disease Epidemiology, Institute of Social and Preventive Medicine, University of Zurich, Sumatrastrasse 30, Zurich, Switzerland
    Environ Health Perspect 117:1420-7. 2009

Detail Information

Publications22

  1. pmc Causal and synthetic associations of variants in the SERPINA gene cluster with alpha1-antitrypsin serum levels
    Gian Andri Thun
    Swiss Tropical and Public Health Institute, Basel, Switzerland
    PLoS Genet 9:e1003585. 2013
    ..Overall, our meta-analysis of lung function in ever-smokers does not support a functional role of common SNPs in the SERPINA gene cluster in the general population...
  2. pmc SERPINA1 PiZ and PiS heterozygotes and lung function decline in the SAPALDIA cohort
    Gian Andri Thun
    Swiss Tropical and Public Health Institute, Basel, Switzerland
    PLoS ONE 7:e42728. 2012
    ..Therefore, we tested the effect of the presence of a protease inhibitor (Pi) S or Z allele (PiMS and PiMZ) on the change in lung function in different inflammation-exposed subgroups of a large, population-based cohort study...
  3. pmc Different genes interact with particulate matter and tobacco smoke exposure in affecting lung function decline in the general population
    Ivan Curjuric
    Department of Epidemiology and Public Health, Swiss Tropical and Public Health Institute SwissTPH, Basel, Switzerland
    PLoS ONE 7:e40175. 2012
    ..Oxidative stress related genes modify the effects of ambient air pollution or tobacco smoking on lung function decline. The impact of interactions might be substantial, but previous studies mostly focused on main effects of single genes...
  4. doi request reprint [New genetic tests and their clinical utility for cancer screening]
    Nicole M Probst-Hensch
    Swiss Tropical and Public Health Institute, Associated Institute of the University of Basel
    Ther Umsch 70:251-4; discussion 255-6. 2013
    ....
  5. doi request reprint IGFBP2 and IGFBP3 protein expressions in human breast cancer: association with hormonal factors and obesity
    Nicole M Probst-Hensch
    Institute of Social and Preventive Medicine, University of Zurich, Zurich
    Clin Cancer Res 16:1025-32. 2010
    ..The prognostic relevance of tumor expression patterns of IGFI-related proteins remains poorly understood. This study associates the expression of selected IGF proteins with breast tumor and patient characteristics...
  6. ncbi request reprint Chronic age-related diseases share risk factors: do they share pathophysiological mechanisms and why does that matter?
    N M Probst-Hensch
    Department of Epidemiology and Public Health, Swiss Tropical and Public Health Institute, 4002 Basel, Switzerland
    Swiss Med Wkly 140:w13072. 2010
    ..Understanding the causality of exposure disease associations and differences in susceptibilities to environment and lifestyle is an important aspect for effective prevention...
  7. doi request reprint Prevention--a cost-effective way to fight the non-communicable disease epidemic: an academic perspective of the United Nations High-level NCD Meeting
    Nicole Probst-Hensch
    Department of Epidemiology and Public Health, Swiss Tropical and Public Health Institute, Socinstrasse 57, 4002 Basel, CH, Switzerland
    Swiss Med Wkly 141:w13266. 2011
    ..Switzerland has a track record in research and development against diseases of poverty on a global scale that now needs to be applied to NCDs...
  8. doi request reprint HMOX1 and GST variants modify attenuation of FEF25-75% decline due to PM10 reduction
    I Curjuric
    Chronic Disease Epidemiology, Institute of Social and Preventive Medicine, University of Zurich
    Eur Respir J 35:505-14. 2010
    ..s(-1) and 27.3 mL.s(-1) respectively) than non-carriers. Benefits of a reduction in PM(10) exposure are not equally distributed across the population but are modified by the individual genetic make-up determining oxidative stress defence...
  9. ncbi request reprint The common G-allele of interleukin-18 single-nucleotide polymorphism is a genetic risk factor for atopic asthma. The SAPALDIA Cohort Study
    M Imboden
    Molecular Epidemiology Cancer Registry, Institutes of Social and Preventive Medicine and Clinical Pathology, Zurich, Switzerland
    Clin Exp Allergy 36:211-8. 2006
    ..IL-18 is a pleiotrophic cytokine involved in both, T-helper type 1 (Th1) and Th2 differentiation. Recently genetic variants in the IL-18 gene have been associated with increased risk of atopy and asthma...
  10. pmc Decreased PM10 exposure attenuates age-related lung function decline: genetic variants in p53, p21, and CCND1 modify this effect
    Medea Imboden
    Department of Chronic Disease Epidemiology, Institute of Social and Preventive Medicine, University of Zurich, Sumatrastrasse 30, Zurich, Switzerland
    Environ Health Perspect 117:1420-7. 2009
    ..Recent evidence points to the involvement of the genes p53 and p21 and of the cell cycle control gene cyclin D1 (CCND1) in the response of bronchial cells to air pollution...
  11. doi request reprint Longitudinal change of prebronchodilator spirometric obstruction and health outcomes: results from the SAPALDIA cohort
    N M Probst-Hensch
    Institute of Social and Preventive Medicine, Chronic Disease Epidemiology, University of Zurich, Sumatrastr 30, CH 8091 Zurich, Switzerland
    Thorax 65:150-6. 2010
    ..In the SAPALDIA (Swiss Study on Air Pollution and Lung Disease in Adults) cohort, time course, clinical relevance and determinants of severity stages of obstruction were investigated using prebronchodilator spirometry...
  12. doi request reprint Sensitisation to Ambrosia in Switzerland: a public health threat on the wait
    U Ackermann-Liebrich
    Institute of Social and Preventive Medicine, University of Basel, Basel, Switzerland
    Swiss Med Wkly 139:70-5. 2009
    ..The aim of this study is to describe Ambrosia sensitisation rates in the population-based SAPALDIA cohort (Swiss Study on Air Pollution And Lung Diseases In Adults) and to test whether an increase in these rates could be observed...
  13. pmc Differences in heart rate variability associated with long-term exposure to NO2
    Denise Felber Dietrich
    Institute of Social and Preventive Medicine, University of Basel, Basel, Switzerland
    Environ Health Perspect 116:1357-61. 2008
    ..Short-term studies have shown that subjects exposed to higher traffic-associated air pollutant levels have lower HRV...
  14. pmc Effect of physical activity on heart rate variability in normal weight, overweight and obese subjects: results from the SAPALDIA study
    Denise Felber Dietrich
    Institute of Social and Preventive Medicine, University of Basel, Steinengraben 49, 4051 Basel, Switzerland
    Eur J Appl Physiol 104:557-65. 2008
    ..Regular physical exercise has strong beneficial effects on cardiac autonomic nervous function and thus appears to offset the negative effect of obesity on HRV...
  15. ncbi request reprint Follow-up of the Swiss Cohort Study on Air Pollution and Lung Diseases in Adults (SAPALDIA 2) 1991-2003: methods and characterization of participants
    Ursula Ackermann-Liebrich
    Institute of Social and Preventive Medicine, University of Basel, Switzerland
    Soz Praventivmed 50:245-63. 2005
    ..The Swiss Cohort Study on Air Pollution and Lung Diseases in Adults (SAPALDIA) was designed to investigate the health effects from long-term exposure to air pollution...
  16. pmc IGF-1, IGF-2 and IGFBP-3 in prediagnostic serum: association with colorectal cancer in a cohort of Chinese men in Shanghai
    N M Probst Hensch
    Institute of Social and Preventive Medicine, University of Basel, Steinengraben 49, Basel, 4051, Switzerland
    Br J Cancer 85:1695-9. 2001
    ..67-4.50; 2-sided P for trend = 0.0008) and 2.85 (95% Cl = 1.69-4.81; 2-sided P for trend = 0.01), respectively. Our data thus suggest that circulating IGF-2 and IGFBP-3 can serve as early indicators of impending colorectal cancer...
  17. ncbi request reprint Glutathione S-transferase genotype increases risk of progression from bronchial hyperresponsiveness to asthma in adults
    M Imboden
    IInstitutes of Social and Preventive Medicine and Surgical Pathology, Cancer Registry Molecular Epidemiology, University of Zurich, Zurich, Switzerland
    Thorax 63:322-8. 2008
    ..Bronchial hyperresponsiveness (BHR) and variation in glutathione S-transferase (GST) genes have been associated with asthma risk. The relationship of these two risk factors with adult onset asthma in the general population was investigated...
  18. ncbi request reprint Reduced exposure to PM10 and attenuated age-related decline in lung function
    Sara H Downs
    Institute of Social and Preventive Medicine, University of Basel, Basel, Switzerland
    N Engl J Med 357:2338-47. 2007
    ..Air pollution has been associated with impaired health, including reduced lung function in adults. Moving to cleaner areas has been shown to attenuate adverse effects of air pollution on lung function in children but not in adults...
  19. pmc Circulating alpha1-antitrypsin in the general population: determinants and association with lung function
    Oliver Senn
    Molecular Epidemiology Cancer Registry, Institutes of Social and Preventive Medicine and Clinical Pathology, University of Zurich, Zurich, Switzerland
    Respir Res 9:35. 2008
    ..Less is known about the respiratory health impact of variation in AAT serum concentrations in the general population. We cross-sectionally investigated correlates of circulating AAT concentrations and its association with FEV1...
  20. ncbi request reprint NY-BR-1 protein expression in breast carcinoma: a mammary gland differentiation antigen as target for cancer immunotherapy
    Jean Philippe Theurillat
    Institute for Surgical Pathology, Department of Pathology, University Hospital Zurich, Schmelzbergstrasse 12, 8091, Zurich, Switzerland
    Cancer Immunol Immunother 56:1723-31. 2007
    ....
  21. ncbi request reprint Epidemiology and pathophysiology of obesity as cause of cancer
    Michela Ceschi
    Molecular Epidemiology, Institute of Social and Preventive Medicine, University of Zurich, University Hospital, Vogelsangstrasse 10, CH 8091 Zurich, Switzerland
    Swiss Med Wkly 137:50-6. 2007
    ..Since evidence is mounting that excess body weight can also adversely affect cancer prognosis, obesity is a primary target for cancer control programs...
  22. ncbi request reprint Chromosomal translocations t(4;14), t(11;14) and proliferation rate stratify patients with mature plasma cell myelomas into groups with different survival probabilities: a molecular epidemiologic study on tissue microarrays
    Marianne Tinguely
    Institute of Surgical Pathology, University Zurich, Zurich, Switzerland
    Am J Surg Pathol 31:690-6. 2007
    ..These findings demonstrate that a high proliferation rate and translocations involving the IgH locus can stratify mature PMs into groups with distinct survival probabilities...