Sylvain Pradervand

Summary

Affiliation: University of Lausanne
Country: Switzerland

Publications

  1. doi request reprint Affymetrix Whole-Transcript Human Gene 1.0 ST array is highly concordant with standard 3' expression arrays
    Sylvain Pradervand
    DNA Array Facility, Center for Integrative Genomics, University of Lausanne, Lausanne, Switzerland
    Biotechniques 44:759-62. 2008
  2. pmc Impact of normalization on miRNA microarray expression profiling
    Sylvain Pradervand
    Lausanne DNA Array Facility, Center for Integrative Genomics, University of Lausanne, CH 1015 Lausanne, Switzerland
    RNA 15:493-501. 2009
  3. doi request reprint Concordance among digital gene expression, microarrays, and qPCR when measuring differential expression of microRNAs
    Sylvain Pradervand
    Genomic Technologies Facility, Center for Integrative Genomics, University of Lausanne, Genopode Building, Lausanne, Switzerland
    Biotechniques 48:219-22. 2010
  4. doi request reprint Phytochrome interacting factors 4 and 5 control seedling growth in changing light conditions by directly controlling auxin signaling
    Patricia Hornitschek
    Center for Integrative Genomics, Faculty of Biology and Medicine, University of Lausanne, CH 1015 Lausanne, Switzerland
    Plant J 71:699-711. 2012
  5. pmc Copy number variation modifies expression time courses
    Evelyne Chaignat
    Center for Integrative Genomics, University of Lausanne, 1015 Lausanne, Switzerland
    Genome Res 21:106-13. 2011
  6. pmc Context-dependent dual role of SKI8 homologs in mRNA synthesis and turnover
    Eavan Dorcey
    Department of Plant Molecular Biology, University of Lausanne, Lausanne, Switzerland
    PLoS Genet 8:e1002652. 2012
  7. pmc The circadian clock modulates renal sodium handling
    Svetlana Nikolaeva
    Department of Pharmacology and Toxicology, University of Lausanne, 27 rue du Bugnon, Lausanne, Switzerland
    J Am Soc Nephrol 23:1019-26. 2012
  8. ncbi request reprint Identification of multiple mechanisms of resistance to vemurafenib in a patient with BRAFV600E-mutated cutaneous melanoma successfully rechallenged after progression
    Emanuela Romano
    Authors Affiliations Department of Oncology, University Hospital of Lausanne Genomic Technologies Facility GTF, Center for Integrative Genomics, University of Lausanne Vital IT, Swiss Institute of Bioinformatics, and the Ludwig Center for Cancer Research of the University of Lausanne, Lausanne, Switzerland
    Clin Cancer Res 19:5749-57. 2013
  9. pmc Sumoylated PPARalpha mediates sex-specific gene repression and protects the liver from estrogen-induced toxicity in mice
    Nicolas Leuenberger
    Center for Integrative Genomics, National Research Center Frontiers in Genetics, Switzerland
    J Clin Invest 119:3138-48. 2009
  10. doi request reprint A comprehensive analysis of gene expression profiles in distal parts of the mouse renal tubule
    Sylvain Pradervand
    Lausanne Genomic Technologies Facility, Center for Integrative Genomics, University of Lausanne, 1015 Lausanne, Switzerland
    Pflugers Arch 460:925-52. 2010

Detail Information

Publications34

  1. doi request reprint Affymetrix Whole-Transcript Human Gene 1.0 ST array is highly concordant with standard 3' expression arrays
    Sylvain Pradervand
    DNA Array Facility, Center for Integrative Genomics, University of Lausanne, Lausanne, Switzerland
    Biotechniques 44:759-62. 2008
    ..This may reflect the impact of the target type. Overall, the high degree of correspondence provides strong evidence for the reliability of the Gene 1.0 ST array...
  2. pmc Impact of normalization on miRNA microarray expression profiling
    Sylvain Pradervand
    Lausanne DNA Array Facility, Center for Integrative Genomics, University of Lausanne, CH 1015 Lausanne, Switzerland
    RNA 15:493-501. 2009
    ....
  3. doi request reprint Concordance among digital gene expression, microarrays, and qPCR when measuring differential expression of microRNAs
    Sylvain Pradervand
    Genomic Technologies Facility, Center for Integrative Genomics, University of Lausanne, Genopode Building, Lausanne, Switzerland
    Biotechniques 48:219-22. 2010
    ....
  4. doi request reprint Phytochrome interacting factors 4 and 5 control seedling growth in changing light conditions by directly controlling auxin signaling
    Patricia Hornitschek
    Center for Integrative Genomics, Faculty of Biology and Medicine, University of Lausanne, CH 1015 Lausanne, Switzerland
    Plant J 71:699-711. 2012
    ..Moreover our study suggests that PIF4 and PIF5 regulate elongation growth by controlling directly the expression of genes that code for auxin biosynthesis and auxin signaling components...
  5. pmc Copy number variation modifies expression time courses
    Evelyne Chaignat
    Center for Integrative Genomics, University of Lausanne, 1015 Lausanne, Switzerland
    Genome Res 21:106-13. 2011
    ..Thus, modifying the copy number of a gene may potentially alter not only its expression level, but also the timing of its expression...
  6. pmc Context-dependent dual role of SKI8 homologs in mRNA synthesis and turnover
    Eavan Dorcey
    Department of Plant Molecular Biology, University of Lausanne, Lausanne, Switzerland
    PLoS Genet 8:e1002652. 2012
    ..Surprisingly then, transgenic ScSKI8 rescued all aspects of the vip3 phenotype, suggesting that the dual role of SKI8 depends on species-specific cellular context...
  7. pmc The circadian clock modulates renal sodium handling
    Svetlana Nikolaeva
    Department of Pharmacology and Toxicology, University of Lausanne, 27 rue du Bugnon, Lausanne, Switzerland
    J Am Soc Nephrol 23:1019-26. 2012
    ..It also suggests that the circadian clock affects BP, at least in part, by exerting dynamic control over renal sodium handling...
  8. ncbi request reprint Identification of multiple mechanisms of resistance to vemurafenib in a patient with BRAFV600E-mutated cutaneous melanoma successfully rechallenged after progression
    Emanuela Romano
    Authors Affiliations Department of Oncology, University Hospital of Lausanne Genomic Technologies Facility GTF, Center for Integrative Genomics, University of Lausanne Vital IT, Swiss Institute of Bioinformatics, and the Ludwig Center for Cancer Research of the University of Lausanne, Lausanne, Switzerland
    Clin Cancer Res 19:5749-57. 2013
    ....
  9. pmc Sumoylated PPARalpha mediates sex-specific gene repression and protects the liver from estrogen-induced toxicity in mice
    Nicolas Leuenberger
    Center for Integrative Genomics, National Research Center Frontiers in Genetics, Switzerland
    J Clin Invest 119:3138-48. 2009
    ..Physiologically, this repression conferred on female mice protection against estrogen-induced intrahepatic cholestasis, the most common hepatic disease during pregnancy, suggesting a therapeutic target for prevention of this disease...
  10. doi request reprint A comprehensive analysis of gene expression profiles in distal parts of the mouse renal tubule
    Sylvain Pradervand
    Lausanne Genomic Technologies Facility, Center for Integrative Genomics, University of Lausanne, 1015 Lausanne, Switzerland
    Pflugers Arch 460:925-52. 2010
    ..Collectively, this in silico analysis provides comprehensive information about relative abundance and tissue specificity of the DCT/CNT and the CCD expressed transcripts and identifies new candidate genes for renal homeostasis...
  11. ncbi request reprint Key electrophysiological, molecular, and metabolic signatures of sleep and wakefulness revealed in primary cortical cultures
    Valérie Hinard
    Center for Integrative Genomics, University of Lausanne, CH 1015 Lausanne, Switzerland
    J Neurosci 32:12506-17. 2012
    ..With our in vitro model, the cellular and molecular consequences of sleep and wakefulness can now be investigated in a dish...
  12. pmc Meta-analysis of gene expression profiles in breast cancer: toward a unified understanding of breast cancer subtyping and prognosis signatures
    Pratyaksha Wirapati
    Swiss Institute of Bioinformatics, Batiment Genopode, University of Lausanne, 1015 Lausanne, Switzerland
    Breast Cancer Res 10:R65. 2008
    ....
  13. pmc Molecular clock is involved in predictive circadian adjustment of renal function
    Annie Mercier Zuber
    Department of Pharmacology and Toxicology, University of Lausanne, 1005 Lausanne, Switzerland
    Proc Natl Acad Sci U S A 106:16523-8. 2009
    ..Collectively, this study uncovers a major role of molecular clock in renal function...
  14. pmc Phenotypic consequences of copy number variation: insights from Smith-Magenis and Potocki-Lupski syndrome mouse models
    Guenola Ricard
    Center for Integrative Genomics, University of Lausanne, Lausanne, Switzerland
    PLoS Biol 8:e1000543. 2010
    ..Furthermore, structural change can cause the same perturbation in particular pathways regardless of gene dosage. Thus, the presence of a genomic structural change, as well as gene dosage imbalance, contributes to the ultimate phenotype...
  15. ncbi request reprint Epithelial sodium channel and the control of sodium balance: interaction between genetic and environmental factors
    Bernard C Rossier
    Institute of Pharmacology and Toxicology, University of Lausanne, Rue du Bugnon 27, Lausanne, CH 1005 Switzerland
    Annu Rev Physiol 64:877-97. 2002
    ..The role of single-nucleotide polymorphisms (SNPs) in determining salt sensitivity or salt resistance in general populations is one of the main challenges of the post-genomic era...
  16. doi request reprint Comprehensive expression analyses of neural cell-type-specific miRNAs identify new determinants of the specification and maintenance of neuronal phenotypes
    Ana Jovicic
    Laboratory of Functional Neurogenomics, Brain Mind Institute, Ecole Polytechnique Federale de Lausanne EPFL, Lausanne, Switzerland
    J Neurosci 33:5127-37. 2013
    ....
  17. pmc Substantial deletion overlap among divergent Arabidopsis genomes revealed by intersection of short reads and tiling arrays
    Luca Santuari
    Department of Plant Molecular Biology, University of Lausanne, Biophore Building, CH 1015 Lausanne, Switzerland
    Genome Biol 11:R4. 2010
    ..Interestingly, individual deletions were frequently observed in two or more of the accessions examined, suggesting that variation in gene content partly reflects a common history of deletion events...
  18. doi request reprint Drosophila intestinal response to bacterial infection: activation of host defense and stem cell proliferation
    Nicolas Buchon
    Global Health Institute, Ecole Polytechnique Federale de Lausanne, Lausanne, Switzerland
    Cell Host Microbe 5:200-11. 2009
    ..The Drosophila gut provides a powerful model to study the integration of stress and immunity with pathways associated with stem cell control, and this study should prove to be a useful resource for such further studies...
  19. doi request reprint Segmental copy number variation shapes tissue transcriptomes
    Charlotte N Henrichsen
    The Center for Integrative Genomics, University of Lausanne, Lausanne, Switzerland
    Nat Genet 41:424-9. 2009
    ..Dosage alterations of brain-expressed genes are less frequent than those of other genes and are buffered by tighter transcriptional regulation. Our study provides initial evidence that CNVs shape tissue transcriptomes on a global scale...
  20. pmc Circulating microRNAs as biomarkers for detection of autologous blood transfusion
    Nicolas Leuenberger
    Swiss Laboratory for Doping Analyses, University Center of Legal Medicine, Geneva and Lausanne, Centre Hospitalier Universitaire Vaudois and University of Lausanne, Lausanne, Switzerland
    PLoS ONE 8:e66309. 2013
    ..Therefore, our results lay the foundation for the development of miRNAs as novel blood-based biomarkers to detect autologous transfusion. ..
  21. pmc Identification and functional characterization of Rca1, a transcription factor involved in both antifungal susceptibility and host response in Candida albicans
    Patrick Vandeputte
    Institute of Microbiology, University of Lausanne and University Hospital Center, Lausanne, Switzerland
    Eukaryot Cell 11:916-31. 2012
    ....
  22. pmc The genome of the fire ant Solenopsis invicta
    Yannick Wurm
    Department of Ecology and Evolution, University of Lausanne, 1015 Lausanne, Switzerland
    Proc Natl Acad Sci U S A 108:5679-84. 2011
    ..Some of these and other unique aspects of the fire ant genome are likely linked to the complex social behavior of this species...
  23. pmc Separating the contribution of glucocorticoids and wakefulness to the molecular and electrophysiological correlates of sleep homeostasis
    Valérie Mongrain
    Center for Integrative Genomics, University of Lausanne, CH 1015 Lausanne, Switzerland
    Sleep 33:1147-57. 2010
    ..Because sleep deprivation also induces stress, we here determined the contribution of the corticosterone component of the stress response to the electrophysiological and molecular markers of sleep need in mice...
  24. pmc c-Cbl expression levels regulate the functional responses of human central and effector memory CD4 T cells
    Nicolò C Brembilla
    Division of Experimental Oncology, Multidisciplinary Oncology Center, Department of Medicine, Centre Hospitalier Universitaire Vaudois, University of Lausanne, Lausanne, Switzerland
    Blood 112:652-60. 2008
    ..Our study reports c-Cbl as a critical regulator of the functional responses of memory T cell subsets and identifies for the first time in humans a mechanism controlling the functional heterogeneity of memory CD4 cells...
  25. doi request reprint Phytochrome interacting factors 4 and 5 redundantly limit seedling de-etiolation in continuous far-red light
    Séverine Lorrain
    Center for Integrative Genomics, University of Lausanne, Genopode Building, CH 1015 Lausanne, Switzerland
    Plant J 60:449-61. 2009
    ..Our genetic analysis suggests that this is achieved through sequestration of these PIFs by the closely related bHLH transcription factor HFR1 (long hypocotyl in FR light)...
  26. ncbi request reprint Dysfunction of the epithelial sodium channel expressed in the kidney of a mouse model for Liddle syndrome
    Sylvain Pradervand
    Institut de Pharmacologie et de Toxicologie de l Université, Lausanne, Switzerland
    J Am Soc Nephrol 14:2219-28. 2003
    ..Aldosterone (5 x 10(-7)M for 3 h) further increased I(eq) from cultured L/L CCD. Thus, this study brings three independent lines of evidence for the constitutive hyperactivity of ENaC in CCD from mice harboring the Liddle mutation...
  27. ncbi request reprint Mineralocorticoid regulation of epithelial Na+ channels is maintained in a mouse model of Liddle's syndrome
    Anke Dahlmann
    Department of Physiology and Biophysics, Weill Medical College of Cornell Univ, 1300 York Ave, New York, NY 10021, USA
    Am J Physiol Renal Physiol 285:F310-8. 2003
    ..Analysis of spontaneous channel noise indicated that the open probability was similar in the two genotypes(WT: 0.77; L/L: 0.80). Thus the increase in whole cell current is attributed to a difference in the density of conducting channels...
  28. pmc Aldosterone responsiveness of the epithelial sodium channel (ENaC) in colon is increased in a mouse model for Liddle's syndrome
    Marko Bertog
    Institut fur Zellulare und Molekulare Physiologie, Waldstr 6, 91054 Erlangen, Germany
    J Physiol 586:459-75. 2008
    ..This may be pathophysiologically relevant in patients with Liddle's syndrome, in particular on a high salt diet, when suppression of P Aldo is likely to be insufficient to reduce Na+ absorption to an appropriate level...
  29. ncbi request reprint Systems biology of macrophages
    Mano Ram Maurya
    Department of Bioengineering, University of California at San Diego, La Jolla, CA 92093 0412, USA
    Adv Exp Med Biol 598:62-79. 2007
    ..macrophages? (3) How can we combine proteomic and other cellular measurements to characterize the repertoire of upstream signaling networks invoked by macrophages? (4) How do designed knockdowns of proteins influence cellular phenotypes?..
  30. pmc Small proline-rich protein 1A is a gp130 pathway- and stress-inducible cardioprotective protein
    Sylvain Pradervand
    UCSD Institute of Molecular Medicine, University of California, San Diego, La Jolla, CA, USA
    EMBO J 23:4517-25. 2004
    ..Thus, this study identifies SPRR1A as a novel stress-inducible downstream mediator of gp130 cytokines in cardiomyocytes and documents its cardioprotective effect against ischemic stress...
  31. ncbi request reprint Nkx2-5 pathways and congenital heart disease; loss of ventricular myocyte lineage specification leads to progressive cardiomyopathy and complete heart block
    Mohammad Pashmforoush
    UCSD Institute of Molecular Medicine, University of California San Diego School of Medicine, La Jolla, CA 92093, USA
    Cell 117:373-86. 2004
    ..Accordingly, loss of ventricular muscle cell lineage specification into trabecular and conduction system myocytes is a new mechanistic pathway for progressive cardiomyopathy and conduction defects in congenital heart disease...
  32. ncbi request reprint Identification of corticosteroid-regulated genes in cardiomyocytes by serial analysis of gene expression
    Olivier Muller
    Cardiology Service, University Hospital, CHUV, CH 1011 Lausanne, Switzerland
    Genomics 89:370-7. 2007
    ..Our study identifies a new set of corticosteroid-regulated genes in cardiomyocytes and demonstrates a new approach to studying the selectivity of MR- vs GR-dependent effects...
  33. pmc Identification of signaling components required for the prediction of cytokine release in RAW 264.7 macrophages
    Sylvain Pradervand
    Bioinformatics and Data Coordination Laboratory, Alliance for Cellular Signaling, San Diego Supercomputer Center, University of California at San Diego, Gilman Drive, La Jolla, CA 92093, USA
    Genome Biol 7:R11. 2006
    ....
  34. ncbi request reprint Low expression of the beta-ENaC subunit impairs lung fluid clearance in the mouse
    Nadia Randrianarison
    INSERM U773, CRB3, Universite Denis Diderot Paris 7, 16 rue Henri Huchard, 75018 Paris, France
    Am J Physiol Lung Cell Mol Physiol 294:L409-16. 2008
    ..Finally, adequate beta-ENaC expression appears to be required for AFC stimulation by beta2-agonists...