Research Topics
| C J PournarasSummaryAffiliation: University Hospital Country: Switzerland Publications
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Publications
Regulation of optic nerve head blood flow in normal tension glaucoma patientsC J Pournaras
Department of Ophthalmology, University of Geneva, Geneva, Switzerland
Eur J Ophthalmol 14:226-35. 2004..To investigate the regulation of the optic nerve blood flow (Fonh) in response to an increase of the perfusion pressure (PPm) in normal tension glaucoma (NTG) patients and in age-matched normal volunteers...
The rationale of retinal endovascular fibrinolysis in the treatment of retinal vein occlusion: from experimental data to clinical applicationConstantin J Pournaras
Laboratory of Neurobiology and Physiology of Retinal Circulation, Department of Ophthalmology, University of Geneva, Geneva, Switzerland
Retina 32:1566-73. 2012..We describe a retinal endovascular fibrinolysis technique to directly reperfuse experimentally occluded retinal veins using a simple micropipette...
[Dynamic phototherapy: treatment and retreatment criteria]C J Pournaras
Hopitaux Universitaires de Geneve, Clinique d ophtalmologie, Rue Alcide Jentzer 22, 1211 Geneve 14, Suisse
J Fr Ophtalmol 26:864-71. 2003..The extension and persistence of leakage from the CNV remains an indication for retreatment. Ongoing studies are evaluating a number of features in order to define the responder group and possibly simplify the retreatment indications...
Regulation of subfoveal choroidal blood flow in age-related macular degenerationConstantin J Pournaras
Department of Ophthalmology, University of Geneva, Geneva, Switzerland
Invest Ophthalmol Vis Sci 47:1581-6. 2006....
Regulation of retinal blood flow in health and diseaseConstantin J Pournaras
Department of Ophthalmology, Vitreo Retina Unit, University Hospitals of Geneva, 22 rue Alcide Jentzer, CH 1211 Geneva 14, Switzerland
Prog Retin Eye Res 27:284-330. 2008....
[Pseudophakic retinal detachment: treatment by vitrectomy and scleral buckling. Pilot study]C J Pournaras
Hopitaux Universitaires de Geneve
J Fr Ophtalmol 23:1006-11. 2000..Our pilot survey report anatomic and functional results of a surgical treatment of pseudophakic RD, associating vitrectomy and scleral buckling...
Primary vitrectomy for pseudophakic retinal detachment: a prospective non-randomized studyC J Pournaras
Ophthalmology Clinic, Geneva University Hospital, Geneva, Switzerland
Eur J Ophthalmol 13:298-306. 2003..Vitrectomy permits a detailed view of the peripheral retina, so otherwise undetectable holes or additional small lesions can be found which, left untreated, may cause a residual RD...
Pars plana vitrectomy in the treatment of severe complicated toxoplasmic retinochoroiditisDomniki N Papadopoulou
Department of Ophthalmology, Faculty of Medicine, University of Geneva, Geneva, Switzerland
Eur J Ophthalmol 21:83-8. 2011..To present the anatomic and functional results of pars plana vitrectomy performed in severe complicated toxoplasmic retinochoroiditis...
Idiopathic macular epiretinal membrane surgery and ILM peeling: anatomical and functional outcomesConstantin J Pournaras
Semin Ophthalmol 26:42-6. 2011..Evaluation of the visual and anatomical outcomes following idiopathic macular epiretinal membrane (ERM) removal, with or without internal limiting membrane (ILM) peeling, and review of the literature...
[Studies of the hemodynamics of the optic head nerve using laser Doppler flowmetry]C J Pournaras
Hopitaux Universitaires, Département Clinique d Ophtalmologie, Geneve
J Fr Ophtalmol 24:199-205. 2001....
[Photodynamic therapy. Foreword ]C J Pournaras
, Clinique d'Ophtalmologie, , Suisse
J Fr Ophtalmol 27:72-4. 2004
Intravitreal l-Arginine injection reverses the retinal arteriolar vasoconstriction that occurs after experimental acute branch retinal vein occlusionE Mendrinos
Laboratory of Neurobiology and Physiology of the Retinal Circulation, Department of Ophthalmology, University of Geneva, Geneva, Switzerland
Exp Eye Res 91:205-10. 2010..l-Arginine micro-injection can reverse the arteriolar vasoconstriction that occurs in acute experimental BRVO by stimulating nitric oxide production...
Effect of acetazolamide on the optic disc oxygenation in miniature pigsI K Petropoulos
Department of Ophthalmology, University Hospitals of Geneva, Geneva, Switzerland
Klin Monatsbl Augenheilkd 221:367-70. 2004..The association of acetazolamide injection with systemic hyperoxia can further improve the oxygenation of the optic disc...
[Experimental branch vein occlusion: the effect of carbogen breathing on preretinal PO2]J-A C Pournaras
, Clinique d'Ophtalmologie, 22, Rue Alcide-Jentzer 22, , Suisse
J Fr Ophtalmol 26:813-8. 2003..Carbogen breathing significantly increases preretinal PO2 in normal and in ischemic post-BRVO retinal areas. This effect is probably due to the vasodilatation of the retinal arterioles induced by the intravascular PaCO2 increase...
[Recurrence after primary vitrectomy for pseudophakic retinal detachment]N P L Dang Burgener
Clinique d'Ophtalmologie, , , Suisse
J Fr Ophtalmol 29:1149-55. 2006....
[Pseudophakic inferior retinal detachment or detachment with inferior breaks: clinical outcome and recurrences after primary vitrectomy-gas]N P Dang Burgener
Clinique d'Ophtalmologie, , Suisse
Klin Monatsbl Augenheilkd 223:436-9. 2006..Recurrences after vitrectomy are most often related to the presence of PVR...
[Isovolumic hemodilution in the management of the acute phase of central retinal vein occlusion: a pilot study]G Donati
Clinique d ophtalmologie, Hôpitaux universitaires genevois, Geneva, Switzerland
J Fr Ophtalmol 32:750-6. 2009..We present here a pilot case-series study aiming to demonstrate the effect of isovolumic hemodilution at the acute phase of the disease, before any other treatment was applied...
Bilateral multifocal retinal pigment epithelium detachments associated with systemic corticosteroidsE Mendrinos
Department of Ophthalmology, Geneva University Hospitals, Geneva, Switzerland
Eur J Ophthalmol 18:649-51. 2008..To report an unusual case of central serous chorioretinopathy (CSC), presenting as bilateral and multifocal isolated serous retinal pigment epithelium detachments (RPEDs) following corticosteroid treatment...
[Value of indocyanine green angiography in detection of central serous chorioretinopathy]J Katsimpris
Clinique d'Ophtalmologie, , , Suisse
Klin Monatsbl Augenheilkd 218:335-7. 2001..The persistence of abnormal ICG findings in all the cases of inactive disease suggest that CSC could be not a recurrent but a chronic disease...
Congenital retinal macrovessels: description of three cases and review of the literatureI K Petropoulos
Department of Ophthalmology, University Hospital of Geneva, Geneva, Switzerland
Klin Monbl Augenheilkd 225:469-72. 2008..Congenital retinal macrovessels are large aberrant branches of retinal arteries or veins that cross the macula. We present three patients with a unilateral congenital retinal macrovessel and we conduct a review of the literature...
Retinal angiomatous proliferations: when should we suspect them and how should we detect them?E Mendrinos
Department of Ophthalmology, Geneva University Hospitals, Geneva, Switzerland
Klin Monbl Augenheilkd 226:284-8. 2009..The aim of this study was to identify the clinical and angiographic features of retinal angiomatous proliferations (RAPs) in patients with age-related macular degeneration...
Topographic variation of the choroidal watershed zone and its relationship to neovascularization in patients with age-related macular degenerationEfstratios Mendrinos
Department of Ophthalmology, Vitreo Retinal Unit, Geneva University Hospitals, Geneva, Switzerland
Acta Ophthalmol 87:290-6. 2009..To evaluate the patterns of choroidal watershed zones (WZs) in exudative age-related macular degeneration (AMD) and to describe their relationship with choroidal neovascularization (CNV)...
[Endogenous fungal endophthalmitis: results of antifungal treatment with and without vitrectomy]M Bagnoud
Clinique d'Ophtalmologie, , Rue Alcide Jentzer 22,
Klin Monatsbl Augenheilkd 218:398-400. 2001..CONCLUSION: The evolution of these four cases suggests that a rapid anti-fungal therapy associated with or without a vitrectomy represent a favourable therapeutic option when a fungal infection is suspected...
[Proliferative diabetic retinopathy: vitreo-retinal complications are often related to insufficient retinal photocoagulation]M Zaninetti
, Clinique d'Ophtalmologie, 22 rue Alcide-Jentzer, , Switzerland
J Fr Ophtalmol 28:381-4. 2005..To be effective, photocoagulation has to destroy more than 35% and up to 50% of photoreceptors. An intraoperative laser extension can reduce the risk of regrowth of fibrovascular membranes...
Retinal vessel analyzer measurements of the effect of panretinal photocoagulation on the retinal arteriolar diameter in diabetic retinopathyEfstratios Mendrinos
Department of Ophthalmology, Vitreo Retinal Unit, Geneva University Hospitals, Geneva, Switzerland
Retina 30:555-61. 2010..The purpose of this study was to investigate the effect of panretinal photocoagulation (PRP) on the retinal arteriolar diameter in patients with diabetic retinopathy using a retinal vessel analyzer...
Intravitreal ranibizumab may induce retinal arteriolar vasoconstriction in patients with neovascular age-related macular degenerationDomniki N Papadopoulou
Vitreo Retinal Unit, Department of Ophthalmology, 22 rue Alcide Jentzer, Geneva, Switzerland
Ophthalmology 116:1755-61. 2009..To study the effect of intravitreal (IVT) ranibizumab (Lucentis; Genentech, Inc, San Francisco, CA) on the retinal arteriolar diameter in patients with neovascular age-related macular degeneration (AMD)...
Effect of systemic nitric oxide synthase inhibition on optic disc oxygen partial pressure in normoxia and in hypercapniaIoannis K Petropoulos
Laboratory of Ocular Vascular Diseases, Faculty of Medicine, University of Geneva, Geneva, Switzerland
Invest Ophthalmol Vis Sci 50:378-84. 2009..To investigate the effect of systemic nitric oxide synthase (NOS) inhibition on optic disc oxygen partial pressure (PO(2)) in normoxia and hypercapnia...
Experimental retinal vein occlusion: effect of acetazolamide and carbogen (95% O2/5% CO2) on preretinal PO2Jean-Antoine C Pournaras
Department of Ophthalmology, University Hospital of Geneva, Geneva, Switzerland
Invest Ophthalmol Vis Sci 45:3669-77. 2004..The concomitant use of acetazolamide injection and carbogen breathing or hyperoxia could restore an appropriate oxygenation of BRVO areas...
Optical coherence tomography and multifocal electroretinogram findings in chronic solar retinopathyAlexandros N Stangos
Division of Ophthalmology, Department of Clinical Neurosciences, University Hospitals of Geneva, Geneva, Switzerland
Am J Ophthalmol 144:131-4. 2007..To correlate the structural and functional retinal defects, which are induced photochemically in chronic solar retinopathy...
Lactate-induced retinal arteriolar vasodilation implicates neuronal nitric oxide synthesis in minipigsEfstratios Mendrinos
Department of Ophthalmology, Laboratory of Ocular Vascular Diseases, Vitreo Retinal Unit, Geneva University Hospitals, Geneva, Switzerland
Invest Ophthalmol Vis Sci 49:5060-6. 2008..To investigate the role of neuronal nitric oxide (NO) synthesis in the retinal vasodilatory response to lactate in minipigs...
Effect of indomethacin on the hypercapnia-associated vasodilation of the optic nerve head vessels: an experimental study in miniature pigsIoannis K Petropoulos
Department of Ophthalmology, Geneva University Hospitals, 22 rue Alcide-Jentzer, CH-1211 Geneva, Switzerland
Ophthalmic Res 37:59-66. 2005..Indomethacin also inhibits the increase in the optic disc PO(2) seen during hypercapnia. Those results indicate that prostaglandins are mediators of the hypercapnia-associated vasodilation of the optic nerve head vessels...
Effect of carbogen breathing and acetazolamide on optic disc PO2Ioannis K Petropoulos
Department of Ophthalmology, University Hospitals of Geneva, Switzerland
Invest Ophthalmol Vis Sci 46:4139-46. 2005..The association of acetazolamide injection with carbogen breathing could induce an additional increase in optic disc PO(2) through the effect of higher systemic PaCO(2)...
Ocular pulse amplitude measurement after retinal detachment surgeryJohn M Katsimpris
Department of Ophthalmology, General Hospital of Patras Agios Andreas, Patras, Greece
Klin Monbl Augenheilkd 220:127-30. 2003..The purpose of our study was to evaluate the influence of scleral buckling on the ocular pulse amplitude (OPA) following retinal detachment (RD) surgery...
Light-induced retinal vascular damage by Pd-porphyrin luminescent oxygen probesThomas K Stepinac
Swiss Federal Institute of Technology (EPFL, The Institute of Environmental Engineering, CH-1015 Lausanne, Switzerland
Invest Ophthalmol Vis Sci 46:956-66. 2005..The severity of tissue damage correlates with the phosphorescence measurements...
Effect of isovolumic hemodilution on oxygen delivery to the optic nerve headStephane R Chamot
Laboratoire d Optique et de Biophysique, Institut de Recherche en Ophtalmologie, Sion, Switzerland
Klin Monbl Augenheilkd 219:292-5. 2002..To investigate the effect of isovolumic hemodilution on the tissue oxygenation of the optic nerve head (ONH)...
Occult anterior-chamber metallic fragment post-phacoemulsification masquerading as chronic recalcitrant postoperative inflammationAlexandros N Stangos
Division of Ophthalmology, Department of Clinical Neurosciences, University Hospitals of Geneva, Geneva, Switzerland
Am J Ophthalmol 139:541-2. 2005..To report a case of an occult, metallic, anterior-chamber intraocular foreign body after uneventful phacoemulsification that was masquerading as chronic recalcitrant postoperative inflammation...
Management of branch retinal vein occlusion with vitrectomy and arteriovenous adventitial sheathotomy, the possible role of surgical posterior vitreous detachmentJérôme Charbonnel
Clinique Ophtalmologique Universitaire de Creteil, Hôpital Intercommunal et Hôpital Henri Mondor Assistance Publique des Hôpitaux de Paris, Universite Paris XII, 40 avenue de Verdun, 94 000 Creteil, France
Graefes Arch Clin Exp Ophthalmol 242:223-8. 2004..To analyze the results of vitrectomy and adventitial sheathotomy in the management of branch retinal vein occlusion (BRVO). This is a nonrandomized interventional case series...
Verteporfin therapy for subfoveal choroidal neovascularization in age-related macular degeneration: four-year results of an open-label extension of 2 randomized clinical trials: TAP Report No. 7Neil M Bressler
Arch Ophthalmol 123:1283-5. 2005
Blood pO2 and blood flow at the optic discStephane R Chamot
Institut de Recherche en Ophtalmologie, Grand Champsec 64, CP 4168, 1950 Sion 4, Switzerland
J Biomed Opt 8:63-9. 2003..This instrument appears to be a useful tool for the investigation of the oxygenation of the optic nerve...
Effect of isometric exercise on choroidal blood flow in type I diabetic patientsArmand Movaffaghy
Laboratoire de d'Optique et de Biophysique, Institut de Recherche en Ophtalmologie, Grand Champsec 64, CP 4168, 1950 Sion 4, Switzerland
Klin Monatsbl Augenheilkd 219:299-301. 2002..In DR patients, the absence of this control could be due to a failure of the autonomic nervous system, as suggested by pupillometry results...
Severe bilateral central serous chorioretinopathy in a black patient: 16 years follow-upJohn M Katsimpris
Department of Ophthalmology, General Hospital of Patras Agios Andreas, 26110, Patras, Greece
Graefes Arch Clin Exp Ophthalmol 245:460-3. 2007..To describe the exceptionally severe, bilateral, sight-compromising course of central serous chorioretinopathy (CSC) in a black patient...
Pars-plana vitrectomy alone vs vitrectomy with scleral buckling for primary rhegmatogenous pseudophakic retinal detachmentAlexandros N Stangos
Division of Ophthalmology, Department of Clinical Neurosciences, University Hospitals of Geneva, Geneva, Switzerland
Am J Ophthalmol 138:952-8. 2004..We detected additional breaks intraoperatively in 54.9% of cases (both groups). CONCLUSIONS: Vitrectomy is an effective initial treatment for PsRD, whereas the benefit of an additional encircling buckling procedure is questionable...
Primary vitrectomy without scleral buckling for pseudophakic rhegmatogenous retinal detachmentEfstratios Mendrinos
Department of Ophthalmology, Vitreo Retinal Unit, Geneva University Hospitals, 22 rue Alcide Jentzer, Geneva 14, Switzerland
Am J Ophthalmol 145:1063-1070. 2008..To report the anatomic and functional results of primary vitrectomy without scleral buckling for the treatment of pseudophakic rhegmatogenous retinal detachment (PsRD)...
[Vitrectomy for vitreo-macular traction syndrome]Ioannis K Petropoulos
Clinique d'Ophtalmologie, , , Suisse
Klin Monatsbl Augenheilkd 220:122-6. 2003..CONCLUSIONS: Vitrectomy is effective in releasing vitreomacular traction, restoring macular anatomy and inducing a regression of CME. Visual acuity improves significantly in most cases...
Central serous chorioretinopathy and glucocorticoidsEvrydiki A Bouzas
Department of Ophthalmology, Henry Dunant Hospital, Athens, Greece
Surv Ophthalmol 47:431-48. 2002..Glucocorticoids should not be used in the treatment of central serous chorioretinopathy and central serous chorioretinopathy should be added to the list of ocular complications of glucocorticoids...
Cavernous sinus thrombosis elicited by a central retinal vein venous stasis retinopathyMarc Zaninetti
, 1004 Lausanne, Switzerland
Graefes Arch Clin Exp Ophthalmol 243:834-6. 2005..However, careful clinical examination and extensive laboratory work-up is needed to exclude central retinal vein occlusion not associated with common vascular pathologies of the elderly...
