Olivier Potterat

Summary

Affiliation: University of Basel
Country: Switzerland

Publications

  1. ncbi request reprint Chlorocyclinones A-D, chlorinated angucyclinones from Streptomyces sp. strongly antagonizing rosiglitazone-induced PPAR-gamma activation
    Olivier Potterat
    Boehringer Ingelheim Pharma GmbH and Co KG, Birkendorfer Strasse 65, D 88397, Biberach an der Riss, Germany
    J Nat Prod 70:1934-8. 2007
  2. ncbi request reprint Identification of TLC markers and quantification by HPLC-MS of various constituents in noni fruit powder and commercial noni-derived products
    Olivier Potterat
    Institute of Pharmaceutical Biology, University of Basel, Klingelbergstrasse 50, CH 4056 Basel, Switzerland
    J Agric Food Chem 55:7489-94. 2007
  3. doi request reprint Goji (Lycium barbarum and L. chinense): Phytochemistry, pharmacology and safety in the perspective of traditional uses and recent popularity
    Olivier Potterat
    Department of Pharmaceutical Sciences, Division of Pharmaceutical Biology, University of Basel, Basel, Switzerland
    Planta Med 76:7-19. 2010
  4. ncbi request reprint Clausine Z, a new carbazole alkaloid from Clausena excavata with inhibitory activity on CDK5
    O Potterat
    Boehringer Ingelheim Pharma GmbH and Co KG, Biberach an der Riss, Germany
    Pharmazie 60:637-9. 2005
  5. doi request reprint Library-based discovery of DYRK1A/CLK1 inhibitors from natural product extracts
    Patrick Grabher
    Division of Pharmaceutical Biology, University of Basel, Basel, Switzerland
    Planta Med 78:951-6. 2012
  6. ncbi request reprint Noniosides E - H, new trisaccharide fatty acid esters from the fruit of Morinda citrifolia (Noni)
    Petur W Dalsgaard
    Institute of Pharmaceutical Biology, University of Basel, Basel, Switzerland
    Planta Med 72:1322-7. 2006
  7. doi request reprint Comprehensive analysis of Phyteuma orbiculare L., a wild Alpine food plant
    Christian Abbet
    Division of Pharmaceutical Biology, Department of Pharmaceutical Sciences, University of Basel, Klingelbergstrasse 50, CH 4056 Basel, Switzerland
    Food Chem 136:595-603. 2013
  8. ncbi request reprint Terphenylquinone inhibitors of the src protein tyrosine kinase from Stilbella sp
    Carsten Puder
    Boehringer Ingelheim Pharma GmbH and Co KG, Birkendorfer Strasse 65, D 88397 Biberach Riss, Germany
    J Nat Prod 68:323-6. 2005
  9. ncbi request reprint Quantification of active principles and pigments in leaf extracts of Isatis tinctoria by HPLC/UV/MS
    Tobias Mohn
    Institute of Pharmaceutical Biology, University of Basel, Basel, Switzerland
    Planta Med 73:151-6. 2007
  10. ncbi request reprint Morinda citrifolia (Noni) fruit--phytochemistry, pharmacology, safety
    Olivier Potterat
    Institute of Pharmaceutical Biology, Department of Pharmaceutical Sciences, University of Basel, Basel, Switzerland
    Planta Med 73:191-9. 2007

Collaborators

  • Carsten Puder
  • Matthias Hamburger
  • Ana Paula Simoes-Wüst
  • Yang Ye
  • F Gillardon
  • Michael Adams
  • Leandros A Skaltsounis
  • Hans Peter Fiedler
  • Christian Abbet
  • Karin Fürer
  • Melanie Raith
  • Vincent Vidal
  • Patrick Grabher
  • Adriana Passos Oliveira
  • Melanie Quitschau
  • Petra Weber
  • Cornelia Schütz
  • Xinzhou Yang
  • V Iseli
  • Tobias Mohn
  • María Carmen Recio
  • Janine Zaugg
  • Petur W Dalsgaard
  • Christina Bruntner
  • Romain Mayor
  • Rodolphe Spichiger
  • Didier Roguet
  • Ivan Slacanin
  • Mónica Mennet
  • Rudolf Brenneisen
  • Ursula von Mandach
  • Severine Louvel
  • François Hamy
  • Maria Halabalaki
  • Mahdi Mojarrab
  • Laurent Meijer
  • Jean Jacques Sanglier
  • Thomas Klimkait
  • Ricardo Machado Kuster
  • Leandro Machado Rocha
  • Eirini Kouloura
  • Emilie Durieu
  • Nina Schafroth
  • Markus Neuburger
  • Trixie Wagner
  • Inken Plitzko
  • Peter Küenzi
  • J Egli
  • L Hagmann
  • Till Kühn
  • Bernd Honermeier
  • Jose Luis Rios
  • Fiona Dieterle
  • Miguel Cerda-Nicolas
  • Thomas Paululat
  • Andreas Plescher
  • Klaus Wagner
  • Stefan Hörer
  • Walter Bolek
  • Tatiana Binder
  • Michael Goodfellow
  • Angela Schmid
  • Gerhard Mihm
  • Wasu Pathom-aree
  • Alan T Bull

Detail Information

Publications27

  1. ncbi request reprint Chlorocyclinones A-D, chlorinated angucyclinones from Streptomyces sp. strongly antagonizing rosiglitazone-induced PPAR-gamma activation
    Olivier Potterat
    Boehringer Ingelheim Pharma GmbH and Co KG, Birkendorfer Strasse 65, D 88397, Biberach an der Riss, Germany
    J Nat Prod 70:1934-8. 2007
    ..60 and 7.0 microM. Chlorocyclinone C ( 3) exhibited the most potent activity in all assays...
  2. ncbi request reprint Identification of TLC markers and quantification by HPLC-MS of various constituents in noni fruit powder and commercial noni-derived products
    Olivier Potterat
    Institute of Pharmaceutical Biology, University of Basel, Klingelbergstrasse 50, CH 4056 Basel, Switzerland
    J Agric Food Chem 55:7489-94. 2007
    ..Scopoletin was mainly found in juices. The anthraquinone alizarin, which has been reported from roots and leaves, was not detected in the samples investigated...
  3. doi request reprint Goji (Lycium barbarum and L. chinense): Phytochemistry, pharmacology and safety in the perspective of traditional uses and recent popularity
    Olivier Potterat
    Department of Pharmaceutical Sciences, Division of Pharmaceutical Biology, University of Basel, Basel, Switzerland
    Planta Med 76:7-19. 2010
    ..barbarum and L. chinense certainly deserve further investigation. However, clinical evidences and rigorous procedures for quality control are indispensable before any recommendation of use can be made for Goji products...
  4. ncbi request reprint Clausine Z, a new carbazole alkaloid from Clausena excavata with inhibitory activity on CDK5
    O Potterat
    Boehringer Ingelheim Pharma GmbH and Co KG, Biberach an der Riss, Germany
    Pharmazie 60:637-9. 2005
    ..Rutaceae). Its structure was established by spectroscopic methods. The compound exhibits inhibitory activity against cyclin-dependent kinase 5 (CDK5) and shows protective effects on cerebellar granule neurons in vitro...
  5. doi request reprint Library-based discovery of DYRK1A/CLK1 inhibitors from natural product extracts
    Patrick Grabher
    Division of Pharmaceutical Biology, University of Basel, Basel, Switzerland
    Planta Med 78:951-6. 2012
    ....
  6. ncbi request reprint Noniosides E - H, new trisaccharide fatty acid esters from the fruit of Morinda citrifolia (Noni)
    Petur W Dalsgaard
    Institute of Pharmaceutical Biology, University of Basel, Basel, Switzerland
    Planta Med 72:1322-7. 2006
    ..In addition, an HPLC-MS analysis of a methanolic extract of the fruit powder revealed the presence of further derivatives including new disaccharide and trisaccharide esters with fatty acid residues of various lengths...
  7. doi request reprint Comprehensive analysis of Phyteuma orbiculare L., a wild Alpine food plant
    Christian Abbet
    Division of Pharmaceutical Biology, Department of Pharmaceutical Sciences, University of Basel, Klingelbergstrasse 50, CH 4056 Basel, Switzerland
    Food Chem 136:595-603. 2013
    ..The antioxidant capacity was determined with an ORAC assay, and total phenolic compounds were quantified. Finally, the phytochemical profile was compared to that of the related species P. spicatum, P. hemisphaericum and P. ovatum...
  8. ncbi request reprint Terphenylquinone inhibitors of the src protein tyrosine kinase from Stilbella sp
    Carsten Puder
    Boehringer Ingelheim Pharma GmbH and Co KG, Birkendorfer Strasse 65, D 88397 Biberach Riss, Germany
    J Nat Prod 68:323-6. 2005
    ..strain 1586. The structures of these compounds were established by spectroscopic and chemical methods. The terphenylquinones 3-5 exhibited significant activity against human src protein tyrosine kinase...
  9. ncbi request reprint Quantification of active principles and pigments in leaf extracts of Isatis tinctoria by HPLC/UV/MS
    Tobias Mohn
    Institute of Pharmaceutical Biology, University of Basel, Basel, Switzerland
    Planta Med 73:151-6. 2007
    ..30, 0.035, 2.48 and 0.84%, respectively). Compound 3 was not detected in the methanolic extract and only traces of compounds 1, 4 and 5 and low amount of alpha-linolenic acid (0.39%) were present in this extract...
  10. ncbi request reprint Morinda citrifolia (Noni) fruit--phytochemistry, pharmacology, safety
    Olivier Potterat
    Institute of Pharmaceutical Biology, Department of Pharmaceutical Sciences, University of Basel, Basel, Switzerland
    Planta Med 73:191-9. 2007
    ..While the European Food Safety Authority sees no link between adverse effects on liver and consumption of Noni juice, a continuing monitoring of the situation is desirable and some vigilance advised...
  11. doi request reprint Bicyclononane aldehydes and antiproliferative constituents from Amomum tsao-ko
    Xinzhou Yang
    Institute of Pharmaceutical Biology, University of Basel, Basel, Switzerland
    Planta Med 75:543-6. 2009
    ..The structure of 1 was determined on the basis of extensive spectroscopic analysis, including 1D and 2D NMR data. The antiproliferative activity of compounds 1-13 was assessed in the murine neuroblastoma cell line N2a...
  12. doi request reprint Profiling of isoflavonoids in Iris germanica rhizome extracts by microprobe NMR and HPLC-PDA-MS analysis
    Cornelia Schütz
    Division of Pharmaceutical Biology, University of Basel, Switzerland
    Fitoterapia 82:1021-6. 2011
    ..This study demonstrates the applicability of the HPLC/off-line microprobe NMR approach as a robust means for rapid phytochemical profiling of plant extracts...
  13. ncbi request reprint BI-32169, a bicyclic 19-peptide with strong glucagon receptor antagonist activity from Streptomyces sp
    Olivier Potterat
    Boehringer Ingelheim Pharma GmbH and Co KG, Birkendorfer Strasse 65, D 88397 Biberach an der Riss, Germany
    J Nat Prod 67:1528-31. 2004
    ..BI-32169 and its methyl ester derivative showed potent inhibitory activity against the human glucagon receptor (IC(50) 440 and 320 nM, respectively) in a functional cell-based assay...
  14. ncbi request reprint Drug discovery and development with plant-derived compounds
    Olivier Potterat
    University of Basel, Institute of Pharmaceutical Biology, Klingelbergstrasse 50, 4056 Basel, Switzerland
    Prog Drug Res 65:45, 47-118. 2008
    ..Aspects which are specific to plant-based drug discovery and development are also addressed, such as supply issues in the commercial development, and the Convention on Biological Diversity...
  15. doi request reprint Metabolite profiling of the leaves of the Brazilian folk medicine Sideroxylon obtusifolium
    Adriana Passos Oliveira
    Division of Pharmaceutical Biology, University of Basel, Klingelbergstrasse 50, Basel, Switzerland
    Planta Med 78:703-10. 2012
    ..In addition, catechin and a glycerogalactolipid, gingerglycolipid A, were obtained from the ethyl acetate-soluble fraction. The isolated compounds could be used in the future as chemical markers for quality control of this herbal drug...
  16. doi request reprint Phyteumosides A and B: new saponins with unique triterpenoid aglycons from Phyteuma orbiculare L
    Christian Abbet
    Division of Pharmaceutical Biology, Department of Pharmaceutical Sciences, University of Basel, Klingelbergstrasse 50, CH 4056 Basel, Switzerland
    Org Lett 13:1354-7. 2011
    ..The aglycon of 1 can be considered as an incompletely cyclized onoceroid or gammaceroid triterpene with two additional tetrahydropyran rings arising from oxygen bridges. Compound 2 possesses a new 17-polypodene aglycon...
  17. doi request reprint Ethnobotanical survey on wild alpine food plants in Lower and Central Valais (Switzerland)
    Christian Abbet
    Division of Pharmaceutical Biology, Department of Pharmaceutical Sciences, University of Basel, Klingelbergstrasse 50, CH 4056 Basel, Switzerland
    J Ethnopharmacol 151:624-34. 2014
    ..Aim of the study was to identify wild edible plants used today and during the last two centuries by the alpine population of Valais (Switzerland)...
  18. doi request reprint Two new flavonol glycosides and a metabolite profile of Bryophyllum pinnatum, a phytotherapeutic used in obstetrics and gynaecology
    Karin Fürer
    Division of Pharmaceutical Biology, Department of Pharmaceutical Sciences, University of Basel, Basel, Switzerland
    Planta Med 79:1565-71. 2013
    ..daigremontianum, the presence of four bufadienolides, bersaldegenin-1-acetate (12), bryophyllin A (13), bersaldegenin-3-acetate (14), and bersaldegenin-1,3,5-orthoacetate (15) was detected in B. pinnatum. ..
  19. doi request reprint Case study of the Swiss flora for prior phytochemical and biological investigations
    Michael Adams
    Department of Pharmaceutical Sciences, Division of Pharmaceutical Biology, University of Basel, Klingelbergstrasse 50, Basel, Switzerland
    J Nat Prod 76:209-15. 2013
    ..The predictive value of random sampling of subsets of plants is compared to the study of the entire Swiss flora, to show that a credible estimate of the extent of prior studies can be achieved with just 5% of these species...
  20. doi request reprint Library-based discovery and characterization of daphnane diterpenes as potent and selective HIV inhibitors in Daphne gnidium
    Vincent Vidal
    InPheno AG, Basel, Switzerland
    J Nat Prod 75:414-9. 2012
    ..Mode of action studies that narrowed the site of activity to viral entry events suggested a direct interference with the expression of the two main HIV co-receptors, CCR5 and CXCR4, at the cell surface by daphnetoxin (1)...
  21. doi request reprint Flash chromatography on cartridges for the separation of plant extracts: rules for the selection of chromatographic conditions and comparison with medium pressure liquid chromatography
    Petra Weber
    Division of Pharmaceutical Biology, University of Basel, Switzerland
    Fitoterapia 82:155-61. 2011
    ..The chromatographic resolution remained, however, lower than that achieved on classical columns packed with material of smaller particle size. For poorly soluble extracts, solid introduction gave better results than liquid injection...
  22. ncbi request reprint Quantitative analysis of anti-inflammatory and radical scavenging triterpenoid esters in evening primrose seeds
    Janine Zaugg
    Institute of Pharmaceutical Biology, University of Basel, Klingelbergstrasse 50, CH 4056 Basel, Switzerland
    J Agric Food Chem 54:6623-8. 2006
    ..Three types of qualitative patterns were observed for the triterpenoidal esters. The influence of different harvest times and plant treatments was studied with the cultivar Anothera. Variations between 1.5 and 2.3 mg/g were found...
  23. ncbi request reprint Characterization of the pungent principles and the essential oil of Zanthoxylum schinifolium pericarp
    V Iseli
    Institute of Pharmaceutical Biology, University of Basel, Switzerland
    Pharmazie 62:396-400. 2007
    ..GC-FID and GC-MS analyses of the essential oil showed that limonene was, like in Z. bungeanum, the main component (21%), followed by 4-terpineol, gamma-terpinene, alpha-terpineol acetate, beta-pinene, alpha-terpineol and beta-linalool...
  24. doi request reprint Concepts and technologies for tracking bioactive compounds in natural product extracts: generation of libraries, and hyphenation of analytical processes with bioassays
    Olivier Potterat
    Division of Pharmaceutical Biology, Department of Pharmaceutical Sciences, University of Basel, Basel, Switzerland
    Nat Prod Rep 30:546-64. 2013
    ..In addition, compatibility issues of natural product extracts and HTS are addressed, and selected protocols for the generation of high quality libraries are presented...
  25. ncbi request reprint Frigocyclinone, a novel angucyclinone antibiotic produced by a Streptomyces griseus strain from Antarctica
    Christina Bruntner
    Mikrobiologisches Institut, Universitat Tubingen, au der Morgenstelle 28, D 72076 Tubingen, Germany
    J Antibiot (Tokyo) 58:346-9. 2005
    ..Frigocyclinone showed antibacterial activities against Gram-positive bacteria...
  26. ncbi request reprint Anti-inflammatory and antiallergic activity in vivo of lipophilic Isatis tinctoria extracts and tryptanthrin
    María Carmen Recio
    Department of Pharmacology, Faculty of Pharmacy, University of Valencia, Valencia, Spain
    Planta Med 72:539-46. 2006
    ..The extract had no effect in this model when administered orally. The DCM extract (200 mg/kg P. O.) inhibited the acetic acid-induced writhing by 49%...
  27. ncbi request reprint Marine actinomycetes as a source of novel secondary metabolites
    Hans Peter Fiedler
    Mikrobiologisches Institut, Universitat Tubingen, Auf der Morgenstelle 28, D 72076 Tubingen, Germany
    Antonie Van Leeuwenhoek 87:37-42. 2005
    ..New marine members of the rare genus Verrucosispora seem to be a promising source for novel bioactive secondary metabolites as shown in the case of the abyssomicin producing strain AB-18-032...