D Pittet

Summary

Affiliation: University Hospital
Country: Switzerland

Publications

  1. ncbi request reprint Hand hygiene: improved standards and practice for hospital care
    Didier Pittet
    Infection Control Program, University of Geneva Hospitals, Switzerland
    Curr Opin Infect Dis 16:327-35. 2003
  2. ncbi request reprint Evidence-based model for hand transmission during patient care and the role of improved practices
    Didier Pittet
    Infection Control Programme, University of Geneva Hospitals, Geneva, Switzerland
    Lancet Infect Dis 6:641-52. 2006
  3. ncbi request reprint The effect of workload on infection risk in critically ill patients
    Stephane Hugonnet
    Infection Control Program, Department of Internal Medicine, University of Geneva Hospitals, Geneva, Switzerland
    Crit Care Med 35:76-81. 2007
  4. pmc Liquid versus gel handrub formulation: a prospective intervention study
    Ousmane Traore
    Infection Control Programme, University of Geneva Hospitals, 24 Rue Micheli du Crest, 1211 Geneva 14, Switzerland
    Crit Care 11:R52. 2007
  5. doi request reprint A predictive model for identifying surgical patients at risk of methicillin-resistant Staphylococcus aureus carriage on admission
    Stephan Harbarth
    Infection Control Program, University of Geneva Hospitals and Medical Schools, Geneva, Switzerland
    J Am Coll Surg 207:683-9. 2008
  6. pmc Nosocomial bloodstream infection and clinical sepsis
    Stephane Hugonnet
    Infection Control Program, University of Geneva Hospitals, Geneva, Switzerland
    Emerg Infect Dis 10:76-81. 2004
  7. pmc Bacterial diversity in oral samples of children in niger with acute noma, acute necrotizing gingivitis, and healthy controls
    Ignacio Bolivar
    Institut für Angewandte Immunologie, Zuchwil, Switzerland
    PLoS Negl Trop Dis 6:e1556. 2012
  8. pmc Implementation of infection control best practice in intensive care units throughout Europe: a mixed-method evaluation study
    Hugo Sax
    Infection Control Programme, University of Geneva Hospitals and Medical Faculty, World Health Organization Collaborating Centre on Patient Safety, Geneva, Switzerland
    Implement Sci 8:24. 2013
  9. pmc Methicillin-resistant Staphylococcus aureus risk profiling: who are we missing?
    Janet Pasricha
    Infection Control Program, University of Geneva Hospitals and Faculty of Medicine, 4 rue Gabrielle Perret Gentil, Geneva 1211, Switzerland
    Antimicrob Resist Infect Control 2:17. 2013
  10. pmc Access to antibiotics: a safety and equity challenge for the next decade
    Jean Carlet
    World Alliance Against Antibiotic Resistance WAAR, 9 rue de la Terrasse, 94000 Creteil, France
    Antimicrob Resist Infect Control 2:1. 2013

Detail Information

Publications132 found, 100 shown here

  1. ncbi request reprint Hand hygiene: improved standards and practice for hospital care
    Didier Pittet
    Infection Control Program, University of Geneva Hospitals, Switzerland
    Curr Opin Infect Dis 16:327-35. 2003
    ..To review the most recently published literature on hand hygiene practices in healthcare settings...
  2. ncbi request reprint Evidence-based model for hand transmission during patient care and the role of improved practices
    Didier Pittet
    Infection Control Programme, University of Geneva Hospitals, Geneva, Switzerland
    Lancet Infect Dis 6:641-52. 2006
    ..We review the evidence supporting each of these steps and propose a dynamic model for hand hygiene research and education strategies, together with corresponding indications for hand hygiene during patient care...
  3. ncbi request reprint The effect of workload on infection risk in critically ill patients
    Stephane Hugonnet
    Infection Control Program, Department of Internal Medicine, University of Geneva Hospitals, Geneva, Switzerland
    Crit Care Med 35:76-81. 2007
    ..There is growing evidence that low nurse staffing jeopardizes quality of patient care. The objective of the study was to determine whether low staffing level increases the infection risk in critical care...
  4. pmc Liquid versus gel handrub formulation: a prospective intervention study
    Ousmane Traore
    Infection Control Programme, University of Geneva Hospitals, 24 Rue Micheli du Crest, 1211 Geneva 14, Switzerland
    Crit Care 11:R52. 2007
    ..Alcohol-based handrub is the new standard for hand hygiene action worldwide and usually requires a system change for its successful introduction in routine care. Product acceptability by HCWs is a crucial step in this process...
  5. doi request reprint A predictive model for identifying surgical patients at risk of methicillin-resistant Staphylococcus aureus carriage on admission
    Stephan Harbarth
    Infection Control Program, University of Geneva Hospitals and Medical Schools, Geneva, Switzerland
    J Am Coll Surg 207:683-9. 2008
    ..Indiscriminate application of these guidelines can result in a large number of unnecessary screening tests...
  6. pmc Nosocomial bloodstream infection and clinical sepsis
    Stephane Hugonnet
    Infection Control Program, University of Geneva Hospitals, Geneva, Switzerland
    Emerg Infect Dis 10:76-81. 2004
    ..We conclude that laboratory-based surveillance alone will underestimate the incidence of primary BSI and thus jeopardize benchmarking...
  7. pmc Bacterial diversity in oral samples of children in niger with acute noma, acute necrotizing gingivitis, and healthy controls
    Ignacio Bolivar
    Institut für Angewandte Immunologie, Zuchwil, Switzerland
    PLoS Negl Trop Dis 6:e1556. 2012
    ....
  8. pmc Implementation of infection control best practice in intensive care units throughout Europe: a mixed-method evaluation study
    Hugo Sax
    Infection Control Programme, University of Geneva Hospitals and Medical Faculty, World Health Organization Collaborating Centre on Patient Safety, Geneva, Switzerland
    Implement Sci 8:24. 2013
    ....
  9. pmc Methicillin-resistant Staphylococcus aureus risk profiling: who are we missing?
    Janet Pasricha
    Infection Control Program, University of Geneva Hospitals and Faculty of Medicine, 4 rue Gabrielle Perret Gentil, Geneva 1211, Switzerland
    Antimicrob Resist Infect Control 2:17. 2013
    ..We aimed to determine the rate and characteristics of patients who were missed by a MRSA screening programme at our institution to see how the failure to include these patients might impact the accuracy of clinical prediction tools...
  10. pmc Access to antibiotics: a safety and equity challenge for the next decade
    Jean Carlet
    World Alliance Against Antibiotic Resistance WAAR, 9 rue de la Terrasse, 94000 Creteil, France
    Antimicrob Resist Infect Control 2:1. 2013
    ..There is an urgent need for an international, integrated, multi-level action to preserve antibiotics in the armamentarium of the 21st century and address the global issue of antimicrobial resistance...
  11. pmc High proportion of healthcare-associated urinary tract infection in the absence of prior exposure to urinary catheter: a cross-sectional study
    Ilker Uckay
    Infection Control Programme and WHO Collaborating Centre on Patient Safety, University of Geneva Hospitals and Faculty of Medicine, 4 rue Gabrielle Perret Gentil, 1211, Geneva 14, Switzerland
    Antimicrob Resist Infect Control 2:5. 2013
    ..In this study, we assessed the impact of urinary catheterisation (UC) on symptomatic healthcare-associated UTI among hospitalized patients...
  12. pmc Developed-developing country partnerships: benefits to developed countries?
    Shamsuzzoha B Syed
    African Partnerships for Patient Safety, WHO Patient Safety, WHO Headquarters, Avenue Appia, 1211 Geneva 27, Switzerland
    Global Health 8:17. 2012
    ....
  13. pmc Staffing level: a determinant of late-onset ventilator-associated pneumonia
    Stephane Hugonnet
    Infection Control Program, University of Geneva Hospitals, Rue Micheli du Crest, 1211 Geneva 14, Switzerland
    Crit Care 11:R80. 2007
    ..We conducted the present study to determine whether low nurse-to-patient ratio increases the risk for VAP and whether this effect is similar for early-onset and late-onset VAP...
  14. pmc Evaluation of rapid screening and pre-emptive contact isolation for detecting and controlling methicillin-resistant Staphylococcus aureus in critical care: an interventional cohort study
    Stephan Harbarth
    Infection Control Program, Geneva University Hospitals, Geneva, Switzerland
    Crit Care 10:R25. 2006
    ....
  15. ncbi request reprint Infection control and quality health care in the new millennium
    Didier Pittet
    Infection Control Program, University of Geneva Hospitals, 24 Rue Micheli du Crest, 1211 Geneva 4, Switzerland
    Am J Infect Control 33:258-67. 2005
    ....
  16. doi request reprint Involving the patient to ask about hospital hand hygiene: a National Patient Safety Agency feasibility study
    D Pittet
    Infection Control Programme and WHO Collaborating Centre on Patient Safety, University of Geneva Hospitals and Faculty of Medicine, Geneva, Switzerland
    J Hosp Infect 77:299-303. 2011
    ..However, further work is required to refute the myth among HCWs that patient involvement undermines the doctor- or HCW-patient relationship...
  17. ncbi request reprint Revolutionising hand hygiene in health-care settings: guidelines revisited
    Didier Pittet
    Infection Control Programme, University of Geneva Hospitals, Switzerland
    Lancet Infect Dis 3:269-70. 2003
  18. ncbi request reprint [The role of hospital hygiene in the reduction of antibiotic resistance]
    Didier Pittet
    Service de Prévention et Contrôle de l Infection, Direction médicale, Hopitaux Universitaires de Geneve, Suisse
    Bull Acad Natl Med 188:1269-80; discussion 1280-1. 2004
    ..The strategies proposed in this review target both the appropriate use of antimicrobials in order to decrease resistance acquisition, and improvements in health care practices to reduce cross-transmission...
  19. ncbi request reprint Considerations for a WHO European strategy on health-care-associated infection, surveillance, and control
    Didier Pittet
    Infection Control Programme, University of Geneva Hospitals, Geneva, Switzerland
    Lancet Infect Dis 5:242-50. 2005
    ..An update on HAI activities and related networks throughout Europe, together with the outcome of the meeting, are presented, with special emphasis on future considerations for a European WHO strategy on HAI prevention...
  20. ncbi request reprint Challenging the world: patient safety and health care-associated infection
    Didier Pittet
    Global Patient Safety Challenge, Geneva, Switzerland
    Int J Qual Health Care 18:4-8. 2006
    ..The Challenge addresses health care-associated infection, a major, patient safety problem affecting hundreds of millions of people worldwide...
  21. ncbi request reprint Double-blind, randomized, crossover trial of 3 hand rub formulations: fast-track evaluation of tolerability and acceptability
    Didier Pittet
    Infection Control Program, University of Geneva Hospitals, Geneva, Switzerland
    Infect Control Hosp Epidemiol 28:1344-51. 2007
    ..To compare healthcare workers' skin tolerance for and acceptance of 3 alcohol-based hand rub formulations...
  22. ncbi request reprint Hand-cleansing during postanesthesia care
    Didier Pittet
    Infection Control Program, Department of Internal Medicine, University of Geneva Hospitals, Switzerland
    Anesthesiology 99:530-5. 2003
    ..The authors assessed the compliance rate with hand-cleansing practices in the postanesthesia care unit and investigated factors associated with noncompliance...
  23. ncbi request reprint [Hand hygiene: revolution and globalization]
    Didier Pittet
    Service prévention et contrôle de l Infection et Centre de collaboration de l Organisation mondiale de la santé pour la sécurité des patients, HUG, 1211 Geneve 14
    Rev Med Suisse 5:716-8, 720-1. 2009
    ..Patient participation in hand hygiene promotion is under testing. Early results of the strategy tested in a large number of healthcare settings in both limited- and high-resource countries are extremely encouraging...
  24. doi request reprint The World Health Organization Guidelines on Hand Hygiene in Health Care and their consensus recommendations
    Didier Pittet
    Infection Control Program, University of Geneva Hospitals and Faculty of Medicine, Geneva, Switzerland
    Infect Control Hosp Epidemiol 30:611-22. 2009
    ....
  25. doi request reprint Commentary: hand hygiene: it's all about when and how
    Didier Pittet
    Infection Control Program, University of Geneva Hospitals and Faculty of Medicine, Geneva, Switzerland
    Infect Control Hosp Epidemiol 29:957-9. 2008
  26. ncbi request reprint The Lowbury lecture: behaviour in infection control
    D Pittet
    Infection Control Programme, University of Geneva Hospitals, Geneva, Switzerland
    J Hosp Infect 58:1-13. 2004
    ....
  27. doi request reprint Infection control as a major World Health Organization priority for developing countries
    D Pittet
    Infection Control Programme, University of Geneva Hospitals, Geneva, Switzerland
    J Hosp Infect 68:285-92. 2008
    ....
  28. ncbi request reprint 'Clean Care is Safer Care': the Global Patient Safety Challenge 2005-2006
    Didier Pittet
    Infection Control Programme, University of Geneva Hospitals, 24 Rue Micheli du Crest, 1211 Geneva 14, Switzerland
    Int J Infect Dis 10:419-24. 2006
    ..The impact of healthcare-associated infection may imply prolonged stays in hospital, long-term disability, massive additional financial burden, and deaths...
  29. pmc Improving adherence to hand hygiene practice: a multidisciplinary approach
    D Pittet
    University of Geneva Hospitals, Geneva, Switzerland
    Emerg Infect Dis 7:234-40. 2001
    ..This article reviews barriers to appropriate hand hygiene and risk factors for noncompliance and proposes strategies for promoting hand hygiene...
  30. ncbi request reprint Effectiveness of a hospital-wide programme to improve compliance with hand hygiene. Infection Control Programme
    D Pittet
    Department of Internal Medicine, University of Geneva Hospitals, and Institute of Social and Preventive Medicine, University of Geneva, Switzerland
    Lancet 356:1307-12. 2000
    ..We attempted to promote hand hygiene by implementing a hospital-wide programme, with special emphasis on bedside, alcohol-based hand disinfection. We measured nosocomial infections in parallel...
  31. ncbi request reprint Impact of immunomodulating therapy on morbidity in patients with severe sepsis
    D Pittet
    Infection Control Program and Division of Surgical Intensive Care, Geneva University Hospitals, Geneva, Switzerland
    Am J Respir Crit Care Med 160:852-7. 1999
    ....
  32. ncbi request reprint Clean care is safer care: the first global challenge of the WHO World Alliance for Patient Safety
    Didier Pittet
    Global Patient Safety Challenge, WHO World Alliance for Patient Safety, WHO Headquarters, Geneva, Switzerland
    Am J Infect Control 33:476-9. 2005
  33. ncbi request reprint Clean Care is Safer Care: the first global challenge of the WHO World Alliance for Patient Safety
    Didier Pittet
    Global Patient Safety Challenge, WHO World Alliance for Patient Safety, Geneva, Switzerland
    Infect Control Hosp Epidemiol 26:891-4. 2005
  34. ncbi request reprint Compliance with hand disinfection and its impact on hospital-acquired infections
    D Pittet
    Infection Control Programme, University of Geneva Hospitals, Switzerland
    J Hosp Infect 48:S40-6. 2001
    ..This paper reviews barriers to appropriate hand hygiene and describes the results of the first successful experience of sustained hand hygiene promotion and its effectiveness on hospital-acquired infection...
  35. ncbi request reprint Outcome of diabetic foot infections treated conservatively: a retrospective cohort study with long-term follow-up
    D Pittet
    Division of Infectious Diseases and Clinic of Orthopedic Surgery, University Hospital of Geneva, Switzerland
    Arch Intern Med 159:851-6. 1999
    ..Diabetic foot lesion is associated with increased morbidity and high resource use. Although early amputation has been advocated in case of osteomyelitis, conservative treatment is a more attractive alternative...
  36. ncbi request reprint Clean Care is Safer Care: a worldwide priority
    Didier Pittet
    WHO World Alliance for Patient Safety, WHO, Geneva, Switzerland
    Lancet 366:1246-7. 2005
  37. pmc Infective endocarditis: too ill to be operated?
    Bina Rubinovitch
    Director of Infection Control Program, Department of Internal Medicine, University of Geneva Hospitals, Switzerland
    Crit Care 6:106-7. 2002
    ..Until such data are obtained, clinical judgement is still the best tool in decision-making regarding the individual patient...
  38. ncbi request reprint Compliance with handwashing in a teaching hospital. Infection Control Program
    D Pittet
    University of Geneva Medical School and University of Geneva Hospitals, Switzerland
    Ann Intern Med 130:126-30. 1999
    ..Transmission of microorganisms from the hands of health care workers is the main source of cross-infection in hospitals and can be prevented by handwashing...
  39. ncbi request reprint Clean hands reduce the burden of disease
    Didier Pittet
    Infection Control Programme, Hôpitaux Universitaires de Genève et Faculté de Médecine, 1211 Geneva 14, Switzerland
    Lancet 366:185-7. 2005
  40. doi request reprint The WHO Clean Care is Safer Care programme: field-testing to enhance sustainability and spread of hand hygiene improvements
    Didier Pittet
    Infection Control Programme, University of Geneva Hospitals and Faculty of Medicine, Geneva, Switzerland
    J Infect Public Health 1:4-10. 2008
    ..It is important to note that the First Global Patient Safety Challenge has mobilized an unprecedented number of countries over a short timeframe to commit to take action on HAI...
  41. ncbi request reprint Variation in nosocomial infection prevalence according to patient care setting:a hospital-wide survey
    H Sax
    Infection Control Program, University of Geneva Hospitals, Geneva, Switzerland
    J Hosp Infect 48:27-32. 2001
    ..Prevalence studies are an easy surveillance tool that can be exploited further by analysing data according to hospital care settings to identify high-risk areas...
  42. ncbi request reprint Bacterial contamination of the hands of hospital staff during routine patient care
    D Pittet
    Department of Internal Medicine, University of Geneva Hospitals
    Arch Intern Med 159:821-6. 1999
    ..Cross-transmission of microorganisms by the hands of health care workers is considered the main route of spread of nosocomial infections...
  43. doi request reprint Community-associated methicillin-resistant Staphylococcus aureus: risk factors for infection, and long-term follow-up
    Y Longtin
    University of Geneva Hospitals and Faculty of Medicine, Geneva, Switzerland
    Clin Microbiol Infect 15:552-9. 2009
    ..Further studies are needed to elucidate the role of migration as a factor contributing to the emergence of CA-MRSA in Europe...
  44. doi request reprint Burden of meticillin-resistant Staphylococcus aureus infections at a Swiss University hospital: excess length of stay and costs
    M Macedo-Vinas
    Infectious Diseases Service, University of Geneva Hospitals and Faculty of Medicine, Geneva, Switzerland
    J Hosp Infect 84:132-7. 2013
    ..Meticillin-resistant Staphylococcus aureus (MRSA) infections increase hospital costs primarily by prolonging patient length of stay (LOS)...
  45. doi request reprint Promoting hand hygiene in healthcare through national/subnational campaigns
    E Mathai
    WHO Patient Safety, World Health Organization, Geneva, Switzerland
    J Hosp Infect 77:294-8. 2011
    ..While this is important for sustainability, further action is required to initiate coordinated activities across the world, including countries with limited resources...
  46. doi request reprint Role of hand hygiene in healthcare-associated infection prevention
    B Allegranzi
    First Global Patient Safety Challenge, World Alliance for Patient Safety, IER PSP, Room L319, L Building, World Health Organization, 20 Avenue Appia, 1211 Geneva 27, Switzerland
    J Hosp Infect 73:305-15. 2009
    ..We also report considerations and solutions resulting from the implementation of the multimodal strategy proposed in the WHO Guidelines on Hand Hygiene in Health Care...
  47. ncbi request reprint Control of a cluster of community-associated, methicillin-resistant Staphylococcus aureus in neonatology
    H Sax
    Infection Control Programme, University of Geneva Hospitals, Switzerland
    J Hosp Infect 63:93-100. 2006
    ..This spread among neonates and was subsequently transmitted to another mother and a sibling. This is the first report of a successfully controlled neonatology outbreak of genetically distinct PVL-producing CA-MRSA in Europe...
  48. doi request reprint Surveillance of extended-spectrum-beta-lactamase-producing Enterobacteriaceae in a Swiss Tertiary Care Hospital
    C Fankhauser
    Infection Control Programme, University of Geneva Hospitals, Geneva, Switzerland
    Swiss Med Wkly 139:747-51. 2009
    ....
  49. doi request reprint Multistate modelling to estimate the excess length of stay associated with meticillin-resistant Staphylococcus aureus colonisation and infection in surgical patients
    G De Angelis
    Infection Control Program, University of Geneva Hospitals and Faculty of Medicine, Geneva, Switzerland
    J Hosp Infect 78:86-91. 2011
    ..00; 95% CI: 0.93, 1.07). Multistate modelling is a promising statistical method to evaluate the health-economic impact of nosocomial antibiotic-resistant infections...
  50. ncbi request reprint Dynamics of bacterial hand contamination during routine neonatal care
    Carmem Lucia Pessoa-Silva
    Infection Control Program, Department of Internal, University of Geneva Hospitals, Geneva, Switzerland
    Infect Control Hosp Epidemiol 25:192-7. 2004
    ..To evaluate the dynamics of bacterial contamination of healthcare workers' (HCWs) hands during neonatal care...
  51. doi request reprint Educating healthcare workers to optimal hand hygiene practices: addressing the need
    E Mathai
    First Global Patient Safety Challenge, World Health Organization Patient Safety, Geneva, Switzerland
    Infection 38:349-56. 2010
    ..Several key elements for a successful educational programme are also identified. A particular emphasis is placed on concepts included in the tools developed by WHO for education, monitoring and performance feedback...
  52. doi request reprint Short duration of antibiotic prophylaxis in open fractures does not enhance risk of subsequent infection
    N Dunkel
    Geneva University Hospitals, 4 rue Gabrielle Perret Gentil, 1211 Geneva, Switzerland
    Bone Joint J 95:831-7. 2013
    ..Even for grade III fractures, a one-day course of prophylactic antibiotics might be as effective as prolonged prophylaxis...
  53. ncbi request reprint Screening for methicillin-resistant Staphylococcus aureus in the endemic hospital: what have we learned?
    B Rubinovitch
    Infection Control Programme, University of Geneva Hospitals, Geneva, Switzerland
    J Hosp Infect 47:9-18. 2001
    ..The most efficacious strategy to detect occult MRSA carriage is via the screening of high-risk patients on admission to the hospital which has proven to be cost-effective in varied acute-care endemic settings...
  54. doi request reprint Cost-effectiveness of universal MRSA screening on admission to surgery
    A Murthy
    Infection Control Program, University of Geneva Hospitals and Faculty of Medicine, 4 rue Gabrielle Perret Gentil, Geneva 14, Switzerland
    Clin Microbiol Infect 16:1747-53. 2010
    ..However, local epidemiology plays a critical role. Settings with a higher prevalence of MRSA colonization may find universal screening cost-effective and, in some cases, cost-saving...
  55. ncbi request reprint Cost implications of successful hand hygiene promotion
    Didier Pittet
    Infection Control Program, University of Geneva Hospitals, Switzerland
    Infect Control Hosp Epidemiol 25:264-6. 2004
    ..The total cost of the hand hygiene promotion corresponded to less than 1% of the costs associated with nosocomial infections. Successful hand hygiene promotion is probably cost-saving...
  56. doi request reprint Hand hygiene and healthcare system change within multi-modal promotion: a narrative review
    B Allegranzi
    Clean Care is Safer Care, Patient Safety Programme, World Health Organization, Geneva, Switzerland
    J Hosp Infect 83:S3-10. 2013
    ..This topic is also discussed in a global perspective and highlights some controversial issues...
  57. doi request reprint Testing the WHO Hand Hygiene Self-Assessment Framework for usability and reliability
    A J Stewardson
    Infection Control Programme, University of Geneva Hospitals and Faculty of Medicine, Geneva, Switzerland
    J Hosp Infect 83:30-5. 2013
    ....
  58. doi request reprint Hospital-wide survey of the use of central venous catheters
    W Zingg
    Infection Control Programme, University of Geneva Hospitals and Faculty of Medicine, Geneva, Switzerland
    J Hosp Infect 77:304-8. 2011
    ..ICU catheters have a short dwell time but are utilised more often, whereas catheters in non-ICU settings show a reverse characteristic. Prevention measures targeting catheter care are more likely to be successful in non-ICU settings...
  59. ncbi request reprint Ventilator-associated pneumonia: caveats for benchmarking
    Philippe Eggimann
    Infection Control Program, Department of Internal Medicine, University Hospitals of Geneva, 1211, Geneva 14, Switzerland
    Intensive Care Med 29:2086-9. 2003
    ..To determine the influence of using different denominators on risk estimates of ventilator-associated pneumonia (VAP)...
  60. ncbi request reprint Temporal effects of antibiotic use and hand rub consumption on the incidence of MRSA and Clostridium difficile
    Nathalie Vernaz
    Pharmacy Department, University of Geneva Hospitals and Medical School, Geneva, Switzerland
    J Antimicrob Chemother 62:601-7. 2008
    ..The aim of this study was to determine the temporal relation between the use of antibiotics and alcohol-based hand rubs (ABHRs) and the incidence of methicillin-resistant Staphylococcus aureus (MRSA) and Clostridium difficile...
  61. doi request reprint Prevention of surgical site infections in orthopaedic surgery and bone trauma: state-of-the-art update
    I Uckay
    Infection Control Programme and WHO Collaborating Centre on Patient Safety, University of Geneva Hospitals and Faculty of Medicine, University of Geneva, 4 rue Gabrielle Perret Gentil, Geneva, Switzerland
    J Hosp Infect 84:5-12. 2013
    ..Although theoretically reducible to zero, the maximum realistic extent to decrease surgical site infection in elective orthopaedic surgery remains unknown...
  62. doi request reprint Prevention and control of health care-associated infections through improved hand hygiene
    E Mathai
    World Health Organization Patient Safety, World Health Organization, Avenue Appia, 1211 Geneva 27, Switzerland
    Indian J Med Microbiol 28:100-6. 2010
    ..We also stress the need for action to increase the pace with which these recommendations are implemented in facilities across India...
  63. doi request reprint Meticillin resistance in orthopaedic coagulase-negative staphylococcal infections
    I Uckay
    Orthopaedic Surgery Service, University of Geneva Hospitals and Faculty of Medicine, Geneva, Switzerland
    J Hosp Infect 79:248-53. 2011
    ..The proportion of meticillin resistance among CoNS has remained stable over the last decade with a favourable clinical outcome...
  64. ncbi request reprint 'My five moments for hand hygiene': a user-centred design approach to understand, train, monitor and report hand hygiene
    H Sax
    Infection Control Programme, University of Geneva Hospitals, Geneva, Switzerland Global Patient Safety Challenge, World Alliance for Patient Safety, World Health Organization, Geneva, Switzerland
    J Hosp Infect 67:9-21. 2007
    ..My five moments for hand hygiene' bridges the gap between scientific evidence and daily health practice and provides a solid basis to understand, teach, monitor and report hand hygiene practices...
  65. ncbi request reprint Diagnostic value of procalcitonin, interleukin-6, and interleukin-8 in critically ill patients admitted with suspected sepsis
    S Harbarth
    Infection Control Program, Division of Infectious Diseases, Department of Pathology, The University of Geneva Hospital, Geneva, Switzerland
    Am J Respir Crit Care Med 164:396-402. 2001
    ..14). Elevated PCT concentrations appear to be a promising indicator of sepsis in newly admitted, critically ill patients capable of complementing clinical signs and routine laboratory parameters suggestive of severe infection...
  66. ncbi request reprint Nonantibibiotic measures for the prevention of Gram-positive infections
    P Eggimann
    Medical Intensive Care Unit, Department of Internal Medicine, University of Geneva Hospitals, Switzerland
    Clin Microbiol Infect 7:91-9. 2001
    ..New evidence of the effectiveness of basic infection control measures that have been regarded of little importance during the last two decades by the exponential progress of technologically sophisticated medicine, is discussed...
  67. pmc Methicillin-resistant Staphylococcus aureus, Geneva, Switzerland, 1993-2005
    Patrice Francois
    University of Geneva Hospitals, Geneva, Switzerland
    Emerg Infect Dis 14:304-7. 2008
    ..We demonstrated strain diversity, including clones rarely found in Europe. Local epidemiology of community-associated MRSA is diverse and is evolving by importation and transmission of new strains...
  68. doi request reprint Successful implementation of the World Health Organization hand hygiene improvement strategy in a referral hospital in Mali, Africa
    Benedetta Allegranzi
    World Health Organization Patient Safety, Geneva, Switzerland
    Infect Control Hosp Epidemiol 31:133-41. 2010
    ..To assess the feasibility and effectiveness of the World Health Organization hand hygiene improvement strategy in a low-income African country...
  69. ncbi request reprint Prevalence and prediction of previously unknown MRSA carriage on admission to a geriatric hospital
    Hugo Sax
    Infection Control Program, Geneva University Hospitals, Geneva, Switzerland
    Age Ageing 34:456-62. 2005
    ..to determine the prevalence and characteristics of previously unknown methicillin-resistant Staphylococcus aureus (MRSA) carriers at admission...
  70. doi request reprint Hospital-wide surveillance of catheter-related bloodstream infection: from the expected to the unexpected
    W Zingg
    Infection Control Programme, University of Geneva Hospitals and Faculty of Medicine, Geneva, Switzerland
    J Hosp Infect 73:41-6. 2009
    ..Our surveillance revealed similar CRBSI rates in both ICU and non-ICU departments, and when frequent ward transfers occurred. Hospital-wide CRBSI surveillance is advisable when a large proportion of CVC-days occur outside the ICU...
  71. ncbi request reprint African partnerships for patient safety: a vehicle for enhancing patient safety across two continents. [corrected]
    S B Syed
    African Partnerships for Patient Safety, WHO Patient Safety, Geneva, Switzerland corrected
    World Hosp Health Serv 45:24-7. 2009
    ..APPS is working with six first wave hospital partnerships and will capture and report learning from implementation. A range of APPS resources will shortly be available to hospitals working on patient safety systems...
  72. ncbi request reprint Infection control in the ICU
    P Eggimann
    Medical Intensive Care Unit, Department of Internal Medicine, University of Geneva Hospitals, Geneva, Switzerland
    Chest 120:2059-93. 2001
    ..Accordingly, infection control measures are to be viewed as a priority and have to be integrated fully into the continuous process of improvement of the quality of care...
  73. ncbi request reprint Multi-resistant infections in repatriated patients after natural disasters: lessons learned from the 2004 tsunami for hospital infection control
    I Uckay
    Infection Control Programme, University of Geneva Hospitals, Switzerland
    J Hosp Infect 68:1-8. 2008
    ..Infections may also become manifest after several weeks of hospitalisation. In case of life-threatening infection, antibiotic therapy should cover non-fermenting pathogens...
  74. ncbi request reprint The First Global Patient Safety Challenge "Clean Care is Safer Care": from launch to current progress and achievements
    Benedetta Allegranzi
    First Global Patient Safety Challenge, WHO World Alliance for Patient Safety, World Health Organization, Geneva, Switzerland
    J Hosp Infect 65:115-23. 2007
    ..The latter are currently undergoing testing in several pilot sites to evaluate feasibility, acceptability and sustainability...
  75. ncbi request reprint Healthcare-associated infection in developing countries: simple solutions to meet complex challenges
    Benedetta Allegranzi
    World Alliance for Patient Safety, World Health Organization Headquarters, Geneva, Switzerland
    Infect Control Hosp Epidemiol 28:1323-7. 2007
  76. ncbi request reprint Effect of vancomycin therapy for osteomyelitis on colonization by methicillin-resistant Staphylococcus aureus: lack of emergence of glycopeptide resistance
    Louis Bernard
    Orthopedic Clinic, Geneva University Hospital, Geneva, Switzerland
    Infect Control Hosp Epidemiol 24:650-4. 2003
    ..In treating orthopedic infections, the long-term impact of vancomycin therapy on colonization by methicillin-resistant Staphylococcus aureus (MRSA) and the emergence of vancomycin-intermediate S. aureus is unknown...
  77. ncbi request reprint Epidemiology of Candida species infections in critically ill non-immunosuppressed patients
    Philippe Eggimann
    Medical Clinic II, the Medical Intensive Care Unit and the Infection Control Programme, Department of Internal Medicine, University of Geneva Hospitals, Geneva, Switzerland
    Lancet Infect Dis 3:685-702. 2003
    ..Management of invasive candidiasis in these patients will be addressed in the December issue of The Lancet Infectious Diseases...
  78. doi request reprint Effect of screening for methicillin-resistant Staphylococcus aureus carriage by polymerase chain reaction on the duration of unnecessary preemptive contact isolation
    Ilker Uckay
    Infection Control Program, University of Geneva Hospitals and Faculty of Medicine, Geneva, Switzerland
    Infect Control Hosp Epidemiol 29:1077-9. 2008
    ..88 to 3.14 isolation-days) and related costs by 45% (from US dollars 113.2 to US dollars 62.1) for patients who test negative for MRSA...
  79. doi request reprint Foreign body infections due to Staphylococcus epidermidis
    Ilker Uckay
    University of Geneva Hospitals and Faculty of Medicine, Switzerland
    Ann Med 41:109-19. 2009
    ..Here, we review the pathogenesis, prevention, and treatment of implant infections due to S. epidermidis and highlight some new compounds with already promising in vitro results...
  80. pmc Evaluation of three molecular assays for rapid identification of methicillin-resistant Staphylococcus aureus
    Patrice Francois
    Department of Internal Medicine, Service of Infectious Diseases Genomic Research Laboratory, University of Geneva Hospitals, CH 1211 Geneva 14, Switzerland
    J Clin Microbiol 45:2011-3. 2007
    ..Our results suggest that users of orfX-staphylococcal cassette chromosome mec-based assays should repeatedly monitor the local epidemiology to minimize the risks of detection bias and the omission of emerging MRSA clones...
  81. pmc Use of oligoarrays for characterization of community-onset methicillin-resistant Staphylococcus aureus
    Thibaud Koessler
    Genomic Research Laboratory, Service of Infectious Diseases, University of Geneva Hospitals, CH 1211 Geneva 14, Switzerland
    J Clin Microbiol 44:1040-8. 2006
    ....
  82. ncbi request reprint Alcohol-based handrub improves compliance with hand hygiene in intensive care units
    Stephane Hugonnet
    Infection Control Program, Department of Internal Medicine, University of Geneva Hospitals, 24 Rue Micheli du Crest, 1211 Geneva 14, Switzerland
    Arch Intern Med 162:1037-43. 2002
    ..Nosocomial infection is a leading complication in intensive care units. Although hand hygiene is the single most efficient preventive measure, compliance with this simple action remains low...
  83. ncbi request reprint Attitudes and perceptions toward hand hygiene among healthcare workers caring for critically ill neonates
    Carmem Lucia Pessoa-Silva
    Infection Control Program, Department of Internal Medicine, University Hospitals of Geneva, Geneva, Switzerland
    Infect Control Hosp Epidemiol 26:305-11. 2005
    ..Hand hygiene promotion requires a complex approach that should consider personal factors affecting healthcare workers' attitudes...
  84. ncbi request reprint Secular trends of candidemia over 12 years in adult patients at a tertiary care hospital
    Jorge Garbino
    Department of Internal Medicine, University of Geneva Hospital, Switzerland
    Medicine (Baltimore) 81:425-33. 2002
    ..Factors independently associated with higher mortality were patient age greater than 65 years, intensive care unit admission, and underlying cancer...
  85. ncbi request reprint Lack of effect of combination antibiotic therapy on mortality in patients with pneumococcal sepsis
    S Harbarth
    Division of Infectious Diseases, University of Geneva Hospitals, Geneva, Switzerland
    Eur J Clin Microbiol Infect Dis 24:688-90. 2005
    ..Overall, in contrast to recently published reports, these results suggest that combination antibiotic therapy does not decrease mortality after severe pneumococcal sepsis...
  86. ncbi request reprint Overview of catheter-related infections with special emphasis on prevention based on educational programs
    P Eggimann
    Medical Intensive Care Unit, Department of Internal Medicine, University of Geneva Hospitals, Geneva, Switzerland
    Clin Microbiol Infect 8:295-309. 2002
    ..Practical aspects regarding educational approaches will help clinicians to adapt and incorporate educational programs into clinical practice...
  87. ncbi request reprint [Invasive candidiasis in critically ill patients]
    P Eggimann
    Clinique de médecine 2, Hopitaux Universitaires de Geneve
    Schweiz Med Wochenschr 130:1525-37. 2000
    ....
  88. doi request reprint Infection prevention research in Europe: recent advances and future priorities
    Stephan Harbarth
    Infection Control Program, University of Geneva Hospitals and Faculty of Medicine, 4 rue Gabrielle Perret Gentil, Geneva, Switzerland
    Infect Control Hosp Epidemiol 31:S11-3. 2010
    ..This short overview highlights recent advances and future priorities in infection prevention research, including methodological challenges to be addressed...
  89. doi request reprint Peripheral venous catheters: an under-evaluated problem
    Walter Zingg
    Infection Control Programme, University of Geneva Hospitals and Faculty of Medicine, 4 rue Gabrielle Perret Gentil, 1211 Geneva 14, Switzerland
    Int J Antimicrob Agents 34:S38-42. 2009
    ..It remains unclear whether PVC-BSI should be considered a serious healthcare problem or simply a very rare event. More research is needed both to capture the dimension of the problem and to provide efficient control measures...
  90. ncbi request reprint Epidemiology of candidemia in Swiss tertiary care hospitals: secular trends, 1991-2000
    Oscar Marchetti
    Infectious Diseases Service, Department of Internal Medicine, Centre Hospitalier Universitaire Vaudois, Lausanne, Switzerland
    Clin Infect Dis 38:311-20. 2004
    ..krusei remained rare (2%). Fluconazole consumption increased significantly (P<.001). Despite increasing high-risk activities, the incidence of candidemia remained unchanged, and no shift to resistant species occurred...
  91. doi request reprint The World Health Organization hand hygiene observation method
    Hugo Sax
    Infection Control Program, University of Geneva Hospitals and Faculty of Medicine, 1211 Geneva 14, Switzerland
    Am J Infect Control 37:827-34. 2009
    ..Sample size estimates, survey analysis and report, and major bias and confounding factors associated with observation are discussed...
  92. pmc Rapid detection of methicillin-resistant Staphylococcus aureus directly from sterile or nonsterile clinical samples by a new molecular assay
    Patrice Francois
    Genomic Research Laboratory, Division of Infectious Diseases, University Hospitals of Geneva, CH 1211 Geneva 14, Switzerland
    J Clin Microbiol 41:254-60. 2003
    ..The complete protocol may provide results in less than 6 h (while standard procedure needs 2 to 3 days), thus allowing prompt and cost-effective implementation of contact precautions...
  93. doi request reprint Risk factors for methicillin-resistant Staphylococcus aureus surgical site infection
    Stephan Harbarth
    Infection Control Program, University of Geneva Hospitals and Medical School, Geneva, Switzerland
    Infect Control Hosp Epidemiol 29:890-3. 2008
    ..MRSA carriage on admission did not predict MRSA SSI...
  94. pmc Use of an automated multiple-locus, variable-number tandem repeat-based method for rapid and high-throughput genotyping of Staphylococcus aureus isolates
    Patrice Francois
    Genomic Research Laboratory, University of Geneva Hospitals, CH 1211 Geneva 14, Switzerland
    J Clin Microbiol 43:3346-55. 2005
    ..All steps of this new procedure were developed to ensure a rapid turnaround time and moderate cost. The results obtained suggest that this rapid approach is a valuable tool for the genotyping of S. aureus isolates in real time...
  95. ncbi request reprint Evaluating the probability of previously unknown carriage of MRSA at hospital admission
    Stephan Harbarth
    Infection Control Program and Division of Infectious Diseases, University of Geneva Hospitals, Geneva, Switzerland
    Am J Med 119:275.e15-23. 2006
    ..We determined the prevalence and risk profile of patients with previously unknown carriage of methicillin-resistant Staphylococcus aureus (MRSA) at hospital admission...
  96. ncbi request reprint Semmelweis' legacy: insights from an international survey among 265,000 students in 32 countries
    Stephan Harbarth
    Infection Control Program, Geneva University Hospitals, Geneva, Switzerland
    Int J Hyg Environ Health 207:481-5. 2004
    ..The present report describes the questions and student performance for this infection control exercise set and evaluates performance variability between countries...
  97. ncbi request reprint Nosocomial bacteremia: clinical significance of a single blood culture positive for coagulase-negative staphylococci
    Benoît Favre
    Infection Control Program, University of Geneva Hospitals, Geneva, Switzerland
    Infect Control Hosp Epidemiol 26:697-702. 2005
    ..To describe the epidemiology of nosocomial coagulase-negative staphylococci (CoNS) bacteremia and to evaluate the clinical significance of a single blood culture positive for CoNS...
  98. doi request reprint Overall burden of healthcare-associated infections among surgical patients. Results of a national study
    Hugo Sax
    Infection Control Program, University of Geneva Hospitals and Faculty of Medicine, Rue Gabrielle Perret Gentil 4, Geneva 14, Switzerland
    Ann Surg 253:365-70. 2011
    ..To assess the overall burden of healthcare-associated infections (HAIs) in patients exposed and nonexposed to surgery...
  99. ncbi request reprint Does antibiotic selection impact patient outcome?
    Stephan Harbarth
    Infection Control Program and Division of Infectious Diseases, University of Geneva Hospitals, Geneva, CH 1211, Switzerland
    Clin Infect Dis 44:87-93. 2007
    ..Finally, better risk scores and laboratory tools are urgently needed to improve the adequacy of empirical antibiotic therapy and patient outcomes...
  100. ncbi request reprint Catheter-related infections
    Philippe Eggimann
    Medical Intensive Care Unit, Department of Internal Medicine, University of Geneva Hospitals, 24 Rue Micheli du Crest, 1211 Geneva 14, Switzerland
    Microbes Infect 6:1033-42. 2004
    ..This paper reviews the epidemiology and impact of infections associated with the use of intravenous catheters. Principles of therapy are reviewed, as well as major aspects of prevention...