M Pihlgren

Summary

Affiliation: University of Geneva
Country: Switzerland

Publications

  1. ncbi request reprint Delayed and deficient establishment of the long-term bone marrow plasma cell pool during early life
    M Pihlgren
    World Health Organization Collaborating Center for Vaccinology and Neonatal Immunology, University of Geneva, Geneva, Switzerland
    Eur J Immunol 31:939-46. 2001
  2. ncbi request reprint Unresponsiveness to lymphoid-mediated signals at the neonatal follicular dendritic cell precursor level contributes to delayed germinal center induction and limitations of neonatal antibody responses to T-dependent antigens
    Maria Pihlgren
    Department of Pathology, World Health Organization Collaborating Center for Vaccinology and Neonatal Immunology, University of Geneva, Geneva, Switzerland
    J Immunol 170:2824-32. 2003
  3. ncbi request reprint Influence of complement C3 amount on IgG responses in early life: immunization with C3b-conjugated antigen increases murine neonatal antibody responses
    Maria Pihlgren
    World Health Organization Collaborating Center for Vaccinology and Neonatal Immunology, University of Geneva, CMU, Rue Michel Servet 1, 1211 Geneva 4, Switzerland
    Vaccine 23:329-35. 2004
  4. ncbi request reprint Generation of adult-like antibody avidity profiles after early-life immunization with protein vaccines
    Nadine Schallert
    World Health Organization Collaborating Center for Vaccinology and Neonatal Immunology, Department of Pathology, University of Geneva Medical School, Geneva, Switzerland
    Eur J Immunol 32:752-60. 2002
  5. ncbi request reprint Limitations of in vivo IL-12 supplementation strategies to induce Th1 early life responses to model viral and bacterial vaccine antigens
    J Kovarik
    World Health Organization Collaborating Centre for Neonatal Vaccinology, University of Geneva Medical School, Geneva, Switzerland
    Virology 268:122-31. 2000
  6. ncbi request reprint CpG-motifs enhance initial and sustained primary tetanus-specific antibody secreting cell responses in spleen and bone marrow, but are more effective in adult than in neonatal mice
    Maria Pihlgren
    Department of Pathology and Pediatrics, World Health Organization Collaborating Center for Vaccinology and Neonatal Immunology, CMU, Rue Michel Servet 1, 1211 Geneva 4, Switzerland
    Vaccine 21:2492-9. 2003
  7. ncbi request reprint CpG oligodeoxynucleotides can circumvent the Th2 polarization of neonatal responses to vaccines but may fail to fully redirect Th2 responses established by neonatal priming
    J Kovarik
    World Health Organization Collaborating Centre for Neonatal Vaccinology, University of Geneva, Geneva, Switzerland
    J Immunol 162:1611-7. 1999
  8. ncbi request reprint Co-administration of CpG oligonucleotides enhances the late affinity maturation process of human anti-hepatitis B vaccine response
    Claire Anne Siegrist
    Department of Pediatrics, Center for Vaccinology and Neonatal Immunology, University of Geneva, C M U, 1 rue Michel Servet, 1211 Geneva 4, Switzerland
    Vaccine 23:615-22. 2004
  9. ncbi request reprint Reduced ability of neonatal and early-life bone marrow stromal cells to support plasmablast survival
    Maria Pihlgren
    World Health Organization Collaborating Center for Vaccinology and Neonatal Immunology, Department of Pathology Immunology, University of Geneva, Geneva, Switzerland
    J Immunol 176:165-72. 2006
  10. ncbi request reprint Predominant influence of environmental determinants on the persistence and avidity maturation of antibody responses to vaccines in infants
    Arnaud Marchant
    Institute for Medical Immunology, Universite Libre de Bruxelles, Gosselies, Belgium
    J Infect Dis 193:1598-605. 2006

Collaborators

Detail Information

Publications11

  1. ncbi request reprint Delayed and deficient establishment of the long-term bone marrow plasma cell pool during early life
    M Pihlgren
    World Health Organization Collaborating Center for Vaccinology and Neonatal Immunology, University of Geneva, Geneva, Switzerland
    Eur J Immunol 31:939-46. 2001
    ....
  2. ncbi request reprint Unresponsiveness to lymphoid-mediated signals at the neonatal follicular dendritic cell precursor level contributes to delayed germinal center induction and limitations of neonatal antibody responses to T-dependent antigens
    Maria Pihlgren
    Department of Pathology, World Health Organization Collaborating Center for Vaccinology and Neonatal Immunology, University of Geneva, Geneva, Switzerland
    J Immunol 170:2824-32. 2003
    ..Thus, unresponsiveness to lymphoid-mediated signals at the level of neonatal FDC precursors delays FDC maturation and GC induction, thus limiting primary Ab-secreting cell responses to T-dependent Ags in early postnatal life...
  3. ncbi request reprint Influence of complement C3 amount on IgG responses in early life: immunization with C3b-conjugated antigen increases murine neonatal antibody responses
    Maria Pihlgren
    World Health Organization Collaborating Center for Vaccinology and Neonatal Immunology, University of Geneva, CMU, Rue Michel Servet 1, 1211 Geneva 4, Switzerland
    Vaccine 23:329-35. 2004
    ..Altogether, this identifies C3 as one of the factors limiting early life antibody response and emphasizes the potential interest of immunization strategies overcoming this limitation...
  4. ncbi request reprint Generation of adult-like antibody avidity profiles after early-life immunization with protein vaccines
    Nadine Schallert
    World Health Organization Collaborating Center for Vaccinology and Neonatal Immunology, Department of Pathology, University of Geneva Medical School, Geneva, Switzerland
    Eur J Immunol 32:752-60. 2002
    ....
  5. ncbi request reprint Limitations of in vivo IL-12 supplementation strategies to induce Th1 early life responses to model viral and bacterial vaccine antigens
    J Kovarik
    World Health Organization Collaborating Centre for Neonatal Vaccinology, University of Geneva Medical School, Geneva, Switzerland
    Virology 268:122-31. 2000
    ..However, these immunomodulatory effects appear limited to certain antigen-presentation approaches and may not be broadly applicable to vaccines...
  6. ncbi request reprint CpG-motifs enhance initial and sustained primary tetanus-specific antibody secreting cell responses in spleen and bone marrow, but are more effective in adult than in neonatal mice
    Maria Pihlgren
    Department of Pathology and Pediatrics, World Health Organization Collaborating Center for Vaccinology and Neonatal Immunology, CMU, Rue Michel Servet 1, 1211 Geneva 4, Switzerland
    Vaccine 21:2492-9. 2003
    ..In 1-week-old mice, CpG-ODN also enhanced TT-specific splenic ASC responses, but failed to correct limitations of the GC reaction and of the development of the BM ASC pool...
  7. ncbi request reprint CpG oligodeoxynucleotides can circumvent the Th2 polarization of neonatal responses to vaccines but may fail to fully redirect Th2 responses established by neonatal priming
    J Kovarik
    World Health Organization Collaborating Centre for Neonatal Vaccinology, University of Geneva, Geneva, Switzerland
    J Immunol 162:1611-7. 1999
    ..These observations could be important for the development of novel vaccines that will have to be effective early in life...
  8. ncbi request reprint Co-administration of CpG oligonucleotides enhances the late affinity maturation process of human anti-hepatitis B vaccine response
    Claire Anne Siegrist
    Department of Pediatrics, Center for Vaccinology and Neonatal Immunology, University of Geneva, C M U, 1 rue Michel Servet, 1211 Geneva 4, Switzerland
    Vaccine 23:615-22. 2004
    ..This is the first demonstration that a novel human adjuvant may induce antibodies with higher antigen-binding affinity...
  9. ncbi request reprint Reduced ability of neonatal and early-life bone marrow stromal cells to support plasmablast survival
    Maria Pihlgren
    World Health Organization Collaborating Center for Vaccinology and Neonatal Immunology, Department of Pathology Immunology, University of Geneva, Geneva, Switzerland
    J Immunol 176:165-72. 2006
    ..Thus, early-life BM stromal cells fail to provide the molecular signals that support plasmablast survival and differentiation into surviving plasma cells...
  10. ncbi request reprint Predominant influence of environmental determinants on the persistence and avidity maturation of antibody responses to vaccines in infants
    Arnaud Marchant
    Institute for Medical Immunology, Universite Libre de Bruxelles, Gosselies, Belgium
    J Infect Dis 193:1598-605. 2006
    ..We previously reported that genetic factors control early antibody responses to vaccines in Gambian infants. For the present study, we evaluated the determinants of the memory phase of immunoglobulin G (IgG) responses...
  11. ncbi request reprint Inhibition of B cell death causes the development of an IgA nephropathy in (New Zealand white x C57BL/6)F(1)-bcl-2 transgenic mice
    Regina Marquina
    Laboratory of Immunology, Department of Molecular Biology, Unit Associated with Centro de Investigaciones Biologicas Consejo Superior de Investigaciones Cientificas, University of Cantabria, Santander, Spain
    J Immunol 172:7177-85. 2004
    ....