Research Topics
| M PihlgrenSummaryAffiliation: University of Geneva Country: Switzerland Publications
| Collaborators
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Detail Information
Publications
Delayed and deficient establishment of the long-term bone marrow plasma cell pool during early lifeM Pihlgren
World Health Organization Collaborating Center for Vaccinology and Neonatal Immunology, University of Geneva, Geneva, Switzerland
Eur J Immunol 31:939-46. 2001....- Unresponsiveness to lymphoid-mediated signals at the neonatal follicular dendritic cell precursor level contributes to delayed germinal center induction and limitations of neonatal antibody responses to T-dependent antigensMaria Pihlgren
Department of Pathology, World Health Organization Collaborating Center for Vaccinology and Neonatal Immunology, University of Geneva, Geneva, Switzerland
J Immunol 170:2824-32. 2003..Thus, unresponsiveness to lymphoid-mediated signals at the level of neonatal FDC precursors delays FDC maturation and GC induction, thus limiting primary Ab-secreting cell responses to T-dependent Ags in early postnatal life... - Influence of complement C3 amount on IgG responses in early life: immunization with C3b-conjugated antigen increases murine neonatal antibody responsesMaria Pihlgren
World Health Organization Collaborating Center for Vaccinology and Neonatal Immunology, University of Geneva, CMU, Rue Michel Servet 1, 1211 Geneva 4, Switzerland
Vaccine 23:329-35. 2004..Altogether, this identifies C3 as one of the factors limiting early life antibody response and emphasizes the potential interest of immunization strategies overcoming this limitation... - Generation of adult-like antibody avidity profiles after early-life immunization with protein vaccinesNadine Schallert
World Health Organization Collaborating Center for Vaccinology and Neonatal Immunology, Department of Pathology, University of Geneva Medical School, Geneva, Switzerland
Eur J Immunol 32:752-60. 2002.... - Limitations of in vivo IL-12 supplementation strategies to induce Th1 early life responses to model viral and bacterial vaccine antigensJ Kovarik
World Health Organization Collaborating Centre for Neonatal Vaccinology, University of Geneva Medical School, Geneva, Switzerland
Virology 268:122-31. 2000..However, these immunomodulatory effects appear limited to certain antigen-presentation approaches and may not be broadly applicable to vaccines... - CpG-motifs enhance initial and sustained primary tetanus-specific antibody secreting cell responses in spleen and bone marrow, but are more effective in adult than in neonatal miceMaria Pihlgren
Department of Pathology and Pediatrics, World Health Organization Collaborating Center for Vaccinology and Neonatal Immunology, CMU, Rue Michel Servet 1, 1211 Geneva 4, Switzerland
Vaccine 21:2492-9. 2003..In 1-week-old mice, CpG-ODN also enhanced TT-specific splenic ASC responses, but failed to correct limitations of the GC reaction and of the development of the BM ASC pool... - CpG oligodeoxynucleotides can circumvent the Th2 polarization of neonatal responses to vaccines but may fail to fully redirect Th2 responses established by neonatal primingJ Kovarik
World Health Organization Collaborating Centre for Neonatal Vaccinology, University of Geneva, Geneva, Switzerland
J Immunol 162:1611-7. 1999..These observations could be important for the development of novel vaccines that will have to be effective early in life... - Co-administration of CpG oligonucleotides enhances the late affinity maturation process of human anti-hepatitis B vaccine responseClaire Anne Siegrist
Department of Pediatrics, Center for Vaccinology and Neonatal Immunology, University of Geneva, C M U, 1 rue Michel Servet, 1211 Geneva 4, Switzerland
Vaccine 23:615-22. 2004..This is the first demonstration that a novel human adjuvant may induce antibodies with higher antigen-binding affinity... - Reduced ability of neonatal and early-life bone marrow stromal cells to support plasmablast survivalMaria Pihlgren
World Health Organization Collaborating Center for Vaccinology and Neonatal Immunology, Department of Pathology-Immunology, University of Geneva, Geneva, Switzerland
J Immunol 176:165-72. 2006..Thus, early-life BM stromal cells fail to provide the molecular signals that support plasmablast survival and differentiation into surviving plasma cells... - Predominant influence of environmental determinants on the persistence and avidity maturation of antibody responses to vaccines in infantsArnaud Marchant
Institute for Medical Immunology, Universite Libre de Bruxelles, Gosselies, Belgium
J Infect Dis 193:1598-605. 2006..CONCLUSIONS: Genetic determinants control the early phase of the vaccine antibody response in Gambian infants, whereas environmental determinants predominantly influence antibody persistence and avidity maturation... - Inhibition of B cell death causes the development of an IgA nephropathy in (New Zealand white x C57BL/6)F(1)-bcl-2 transgenic miceRegina Marquina
Laboratory of Immunology, Department of Molecular Biology, Unit Associated with Centro de Investigaciones Biologicas/Consejo Superior de Investigaciones Cientificas, University of Cantabria, Santander, Spain
J Immunol 172:7177-85. 2004....