V Piguet

Summary

Affiliation: University of Geneva
Country: Switzerland

Publications

  1. pmc Dendritic cell-specific intercellular adhesion molecule 3-grabbing nonintegrin/CD209 is abundant on macrophages in the normal human lymph node and is not required for dendritic cell stimulation of the mixed leukocyte reaction
    Angela Granelli-Piperno
    Laboratory of Cellular Physiology and Immunology and Chris Browne Center for Immunology and Immune Diseases, Rockefeller University, New York, NY 10021, USA
    J Immunol 175:4265-73. 2005
  2. ncbi request reprint Analysis of HIV-1-X4 fusion with immature dendritic cells identifies a specific restriction that is independent of CXCR4 levels
    Marjorie Pion
    Department of Dermatology and Venereology, University Hospital and Medical School of Geneva, Geneva, Switzerland
    J Invest Dermatol 127:319-23. 2007
  3. ncbi request reprint Langerin is a natural barrier to HIV-1 transmission by Langerhans cells
    Lot de Witte
    Department of Molecular Cell Biology and Immunology, VU University Medical Center, van de Boechorstraat 7, 1081BT Amsterdam, The Netherlands
    Nat Med 13:367-71. 2007
  4. ncbi request reprint Essential roles for dendritic cells in the pathogenesis and potential treatment of HIV disease
    Vincent Piguet
    Department of Dermatology, University Hospital of Geneva, Switzerland Dermatology Branch, National Cancer Institute, Bethesda, Maryland, USA
    J Invest Dermatol 119:365-9. 2002
  5. ncbi request reprint Receptor modulation in viral replication: HIV, HSV, HHV-8 and HPV: same goal, different techniques to interfere with MHC-I antigen presentation
    V Piguet
    Department of Dermatology and Venerology, HUG, 1211 Geneva, Switzerland
    Curr Top Microbiol Immunol 285:199-217. 2005
  6. pmc Dangerous liaisons at the virological synapse
    Vincent Piguet
    Department of Dermatology and Venereology, University Hospital of Geneva, Geneva, Switzerland
    J Clin Invest 114:605-10. 2004
  7. ncbi request reprint The interaction of HIV with dendritic cells: outcomes and pathways
    Vincent Piguet
    Department of Dermatology and Venereology, University Hospital and Medical School of Geneva, 24 Rue Micheli du Crest, 1211 Geneva, Switzerland
    Trends Immunol 28:503-10. 2007
  8. doi request reprint Management of resistant mucocutaneous herpes simplex infections in AIDS patients: a clinical and virological challenge
    C Barde
    Department of Dermatology, Geneva University Hospital, Geneva, Switzerland
    HIV Med 12:367-73. 2011
  9. doi request reprint Cutaneous lumbosacral Herpes simplex virus among patients hospitalized for an advanced disease
    L Toutous-Trellu
    Division of Dermatology, University Hospital Geneva, Geneva, Switzerland
    J Eur Acad Dermatol Venereol 26:417-22. 2012
  10. ncbi request reprint Linear Darier disease with herpes zoster superinfection treated successfully by brivudine
    S Abraham
    Department of Dermatology and Venereology, University Hospital Geneva, 24 Rue Micheli du Crest, CH 1211 Geneva 14, Switzerland
    Br J Dermatol 154:365-7. 2006

Collaborators

Detail Information

Publications41

  1. pmc Dendritic cell-specific intercellular adhesion molecule 3-grabbing nonintegrin/CD209 is abundant on macrophages in the normal human lymph node and is not required for dendritic cell stimulation of the mixed leukocyte reaction
    Angela Granelli-Piperno
    Laboratory of Cellular Physiology and Immunology and Chris Browne Center for Immunology and Immune Diseases, Rockefeller University, New York, NY 10021, USA
    J Immunol 175:4265-73. 2005
    ..These results indicate that DC-SIGN has the potential to contribute to macrophage function in normal human lymph node, and that DCs do not require DC-SIGN to transmit HIV or to initiate T cell responses...
  2. ncbi request reprint Analysis of HIV-1-X4 fusion with immature dendritic cells identifies a specific restriction that is independent of CXCR4 levels
    Marjorie Pion
    Department of Dermatology and Venereology, University Hospital and Medical School of Geneva, Geneva, Switzerland
    J Invest Dermatol 127:319-23. 2007
    ..We conclude that an env-specific block early in the viral cycle operates in iDCs. This restriction may play a role in the exclusion of X4-tropic strains during HIV-1 transmission...
  3. ncbi request reprint Langerin is a natural barrier to HIV-1 transmission by Langerhans cells
    Lot de Witte
    Department of Molecular Cell Biology and Immunology, VU University Medical Center, van de Boechorstraat 7, 1081BT Amsterdam, The Netherlands
    Nat Med 13:367-71. 2007
    ..Thus Langerin is a natural barrier to HIV-1 infection, and strategies to combat infection must enhance, preserve or, at the very least, not interfere with Langerin expression and function...
  4. ncbi request reprint Essential roles for dendritic cells in the pathogenesis and potential treatment of HIV disease
    Vincent Piguet
    Department of Dermatology, University Hospital of Geneva, Switzerland Dermatology Branch, National Cancer Institute, Bethesda, Maryland, USA
    J Invest Dermatol 119:365-9. 2002
    ..Although these approaches are promising for both therapeutic and prophylactic vaccines, much additional work is needed in order to optimize dendritic-cell-based immunization strategies...
  5. ncbi request reprint Receptor modulation in viral replication: HIV, HSV, HHV-8 and HPV: same goal, different techniques to interfere with MHC-I antigen presentation
    V Piguet
    Department of Dermatology and Venerology, HUG, 1211 Geneva, Switzerland
    Curr Top Microbiol Immunol 285:199-217. 2005
    ..In return, the precise dissection of these processes may offer new weapons against the ruses viruses employ to propagate and establish chronic infections...
  6. pmc Dangerous liaisons at the virological synapse
    Vincent Piguet
    Department of Dermatology and Venereology, University Hospital of Geneva, Geneva, Switzerland
    J Clin Invest 114:605-10. 2004
    ..Deciphering the molecular mechanisms of VS formation provides a fascinating insight into how pathogens subvert immune cell communication programs and achieve viral spread...
  7. ncbi request reprint The interaction of HIV with dendritic cells: outcomes and pathways
    Vincent Piguet
    Department of Dermatology and Venereology, University Hospital and Medical School of Geneva, 24 Rue Micheli du Crest, 1211 Geneva, Switzerland
    Trends Immunol 28:503-10. 2007
    ..Here we review the literature covering these areas, including current knowledge of underlying mechanisms or pathways...
  8. doi request reprint Management of resistant mucocutaneous herpes simplex infections in AIDS patients: a clinical and virological challenge
    C Barde
    Department of Dermatology, Geneva University Hospital, Geneva, Switzerland
    HIV Med 12:367-73. 2011
    ..However, chronic mucocutaneous herpes simplex virus (HSV) infection remains a difficult clinical challenge...
  9. doi request reprint Cutaneous lumbosacral Herpes simplex virus among patients hospitalized for an advanced disease
    L Toutous-Trellu
    Division of Dermatology, University Hospital Geneva, Geneva, Switzerland
    J Eur Acad Dermatol Venereol 26:417-22. 2012
    ..Cutaneous Herpes simplex virus (HSV) infections are regularly observed in lumbosacral areas, and many are refractory to appropriate initial diagnosis and management...
  10. ncbi request reprint Linear Darier disease with herpes zoster superinfection treated successfully by brivudine
    S Abraham
    Department of Dermatology and Venereology, University Hospital Geneva, 24 Rue Micheli du Crest, CH 1211 Geneva 14, Switzerland
    Br J Dermatol 154:365-7. 2006
    ..We report the case of a human immunodeficiency virus-positive patient presenting linear Darier disease with varicella-zoster virus superinfection following the lines of Blaschko. The lesions healed after treatment with brivudine...
  11. ncbi request reprint Living in oblivion: HIV immune evasion
    V Piguet
    Department of Dermatology, DHURDV, University of Geneva, Geneva, Switzerland
    Semin Immunol 13:51-7. 2001
    ..Examining the mechanisms of these phenomena not only helps to understand how HIV wins its war against the immune system, but it also suggests as yet unexploited avenues to combat the virus through therapies and to develop a vaccine...
  12. ncbi request reprint The Nef protein of primate lentiviruses
    V Piguet
    Department of Genetics and Microbiology, Centre Medical Universitaire, Geneva, Switzerland
    Rev Med Virol 9:111-20. 1999
    ..Moreover, the possibility of developing vaccines using attenuated viruses with deletions in nef and other crucial genes raises the possibility that the AIDS epidemic might one day be restrained...
  13. doi request reprint Assessment of a real-time PCR test to diagnose syphilis from diverse biological samples
    A Gayet-Ageron
    HIV Care Unit, Division of Infectious Diseases, Geneva s University Hospitals and School of Medicine, Geneva, Switzerland
    Sex Transm Infect 85:264-9. 2009
    ..To investigate the contribution of a real-time PCR assay for the detection of Treponema pallidum in various biological specimens with the secondary objective of comparing its value according to HIV status...
  14. doi request reprint Kaposi's sarcoma after repeated surgical procedures in an immunocompetent patient: the lymphatic hypothesis
    M Kostaki
    Department of Dermatology, Geneva University Hospital, Geneva, Switzerland
    Dermatology 221:313-6. 2010
    ....
  15. ncbi request reprint [Treatment of cutaneous human papilloma virus, poxvirus and herpes simplex virus infections with topical cidofovir in HIV positive patients]
    L Toutous-Trellu
    Division des maladies infectieuses, Hopital Cantonal Universitaire de Geneve, 24 Rue Micheli du Crest, 1211 Geneve 14, Switzerland
    Ann Dermatol Venereol 131:445-9. 2004
    ..In immunodepressed patients, these infectious dermatoses are often recurrent and resistant. In an open study, we assessed the efficacy and clinical tolerance of cidofovir gel at 1 p. 100...
  16. doi request reprint Bortezomib-induced skin eruption
    S Sanchez-Politta
    Department of Dermatology and Venereology, University Hospital and Medical School of Geneva, Geneva, Switzerland
    Dermatology 216:156-8. 2008
    ..This case illustrates one of the potential reactions associated with bortezomib administration and underlines the need to recognize and report cutaneous side effects of this new drug...
  17. pmc Nef-induced CD4 and major histocompatibility complex class I (MHC-I) down-regulation are governed by distinct determinants: N-terminal alpha helix and proline repeat of Nef selectively regulate MHC-I trafficking
    A Mangasarian
    Department of Genetics and Microbiology, University of Geneva, Geneva, Switzerland
    J Virol 73:1964-73. 1999
    ....
  18. ncbi request reprint Extensive annular verrucous late secondary syphilis
    C C Pournaras
    Department of Dermatology, Geneva University Medical School, 24 Rue Micheli du Crest, 1211 Geneva 14, Switzerland
    Br J Dermatol 152:1343-5. 2005
    ..We present this case to illustrate a rare and potentially misleading clinical feature of late secondary syphilis, a disease considered to be of the past but still present in today's practice...
  19. pmc APOBEC3G/3F mediates intrinsic resistance of monocyte-derived dendritic cells to HIV-1 infection
    Marjorie Pion
    Department of Dermatology and Venereology, University Hospital and Medical School of Geneva, 1211 Geneva, Switzerland
    J Exp Med 203:2887-93. 2006
    ..An increase in the A3G/3F-mediated intrinsic resistance of iDCs could result in a block of HIV infection at its mucosal point of entry...
  20. ncbi request reprint Microbicides and other topical agents in the prevention of HIV and sexually transmitted infections
    Damjan S Nikolic
    Department of Dermatology and Venereology, University Hospital and Medical School of Geneva, Geneva, Switzerland
    Expert Rev Anti Infect Ther 5:77-88. 2007
    ..With concerted efforts directed towards developing efficient microbicides, topical anti-infective compounds may well become a new weapon against sexually transmitted infections, including HIV, in everyday clinical practice...
  21. ncbi request reprint HIV-1 replication in dendritic cells occurs through a tetraspanin-containing compartment enriched in AP-3
    Eduardo Garcia
    Department of Dermatology and Venereology, University Hospital and Medical School of Geneva, 1211 Geneva, Switzerland
    Traffic 9:200-14. 2008
    ....
  22. pmc Identification of an arsenic-sensitive block to primate lentiviral infection of human dendritic cells
    Marjorie Pion
    Department of Dermatology and Venereology, Department of Microbiology and Molecular Medicine, University Hospital and Medical School of Geneva, 4 712, 24 Rue Micheli du Crest, 1211 Geneva, Switzerland
    J Virol 81:12086-90. 2007
    ..Our data suggest the presence of powerful, arsenic-sensitive antiviral activities in primary human immune cells of the dendritic cell lineage...
  23. ncbi request reprint IgG opsonization of HIV impedes provirus formation in and infection of dendritic cells and subsequent long-term transfer to T cells
    Doris Wilflingseder
    Department of Hygiene, Microbiology and Social Medicine, Innsbruck Medical University, Innsbruck, Austria
    J Immunol 178:7840-8. 2007
    ..Therefore, the intracellular fate and transmission of immune-complexed HIV seems to differ depending on time and opsonization pattern...
  24. ncbi request reprint Impaired CD40L signaling is a cause of defective IL-12 and TNF-alpha production in S├ęzary syndrome: circumvention by hexameric soluble CD40L
    Lars E French
    Louis Jeantet Skin Cancer Center, Department of Dermatology, Geneva University Medical School, Switzerland
    Blood 105:219-25. 2005
    ..Taken together, our results demonstrate that impaired IL-12 and TNF-alpha production in SzS is associated with defective CD4+ T lymphocyte CD40L induction and indicate that CD40L may have therapeutic potential in SzS...
  25. pmc Lentivirus-mediated RNA interference of DC-SIGN expression inhibits human immunodeficiency virus transmission from dendritic cells to T cells
    Jean Francois Arrighi
    Department of Dermatology and Venereology, University Hospital of Geneva, 4 752, 24 Rue Micheli du Crest, 1211 Geneva, Switzerland
    J Virol 78:10848-55. 2004
    ..The present system should have broad applications for studying the function of DC-SIGN in the pathogenesis of HIV as well as other pathogens also recognized by this receptor...
  26. pmc DC-SIGN-mediated infectious synapse formation enhances X4 HIV-1 transmission from dendritic cells to T cells
    Jean Francois Arrighi
    Dept of Dermatology and Venereology, University Hospital of Geneva, 4 752, 24 Rue Micheli du Crest, 1211 Geneva, Switzerland
    J Exp Med 200:1279-88. 2004
    ..These findings provide a novel explanation for the role of DC-SIGN in the transfer and enhancement of HIV infection from DCs to T cells, a crucial step for HIV transmission and pathogenesis...
  27. ncbi request reprint HIV-1 trafficking to the dendritic cell-T-cell infectious synapse uses a pathway of tetraspanin sorting to the immunological synapse
    Eduardo Garcia
    Department of Dermatology and Venereology, University Hospital of Geneva, Geneva, Switzerland
    Traffic 6:488-501. 2005
    ....
  28. ncbi request reprint HIV interaction with endosomes in macrophages and dendritic cells
    Beatrice Kramer
    Cell Biology Unit, MRC Laboratory for Molecular Cell Biology, and Department of Biochemistry and Molecular Biology, University College London, Gower Street, London WC1E 6BT, UK
    Blood Cells Mol Dis 35:136-42. 2005
    ....
  29. ncbi request reprint Transduction of dendritic cells by antigen-encoding lentiviral vectors permits antigen processing and MHC class I-dependent presentation
    Shohreh Zarei
    Division of Allergy and Immunology and the Division of Hematology, Department of Dermatology, University Hospital of Geneva, Switzerland
    J Allergy Clin Immunol 109:988-94. 2002
    ..Because antigen-presenting dendritic cells (DCs) play a major role in the polarization of T cells, including T(H)2 cells involved in allergy, strategies to modify DCs genetically are required...
  30. ncbi request reprint The dendritic cell-specific adhesion receptor DC-SIGN internalizes antigen for presentation to T cells
    Anneke Engering
    Department of Molecular Cell Biology, Vrye Universiteit Medical Center, Van der Boechorststraat 7, 1081 BT Amsterdam, The Netherlands
    J Immunol 168:2118-26. 2002
    ..These data point to a novel function of the adhesion receptor DC-SIGN as an efficient DC-specific Ag receptor that can be used as a target to induce viral and antitumor immunity...
  31. ncbi request reprint Efficient transduction of primary human B lymphocytes and nondividing myeloma B cells with HIV-1-derived lentiviral vectors
    Fabrice Bovia
    Division of Hematology, Department of Medicine, University Hospital, Geneva, Switzerland
    Blood 101:1727-33. 2003
    ..In conclusion, HIV vectors are promising tools for studies of gene functions in primary human B cells and myeloma cells for the purposes of research and the development of gene therapies...
  32. ncbi request reprint Erosive pustular dermatosis of the scalp: treatment with topical tacrolimus
    Emmanuel Laffitte
    Department of Dermatology, University Hospital, Geneva, Switzerland
    Arch Dermatol 139:712-4. 2003
  33. ncbi request reprint Efficient induction of CD8 T-associated immune protection by vaccination with mRNA transfected dendritic cells
    Shohreh Zarei
    Allergy Unit, Division of Immunology and Allergy, University Hospital, Geneva Switzerland
    J Invest Dermatol 121:745-50. 2003
    ..Targeting dendritic cells with antigen-encoding mRNA may find wider application for immune intervention in disorders such as autoimmunity and cancer...
  34. ncbi request reprint ARF1 regulates Nef-induced CD4 degradation
    Julien Faure
    Department of Biochemistry, University of Geneva, 1211 Geneva, Switzerland
    Curr Biol 14:1056-64. 2004
    ..The HIV Nef protein downregulates CD4 through sequential connection with clathrin-coated pits and the COP1 coatomer, resulting in accelerated endocytosis and lysosomal targeting...
  35. ncbi request reprint Metabolism and biological activities of topical 4-oxoretinoids in mouse skin
    Olivier Sorg
    Department of Dermatology, University Hospital, Geneva, Switzerland
    J Invest Dermatol 128:999-1008. 2008
    ....
  36. pmc Lentiviral transduction of dendritic cells confers protective antiviral immunity in vivo
    Shohreh Zarei
    Department of Immunology and Allergy, University Hospital of Geneva, Geneva, Switzerland
    J Virol 78:7843-5. 2004
    ..Therefore, lentiviral vectors may be excellent vaccine candidates for viral infections...
  37. ncbi request reprint Increased incidence of sexually transmitted infections in Geneva, Switzerland
    Shahnaz Abraham
    Department of Dermatology and Venereology, University Hospital of Geneva, Geneva, Switzerland
    Dermatology 212:41-6. 2006
    ..The aim of our study was to determine whether a similar trend is observed in Geneva and the situation with regard to HIV infection...
  38. pmc Melanomas require HEDGEHOG-GLI signaling regulated by interactions between GLI1 and the RAS-MEK/AKT pathways
    Barbara Stecca
    Department of Genetic Medicine and Development, University of Geneva School of Medicine, 1 rue Michel Servet, 1211 Geneva, Switzerland
    Proc Natl Acad Sci U S A 104:5895-900. 2007
    ....
  39. ncbi request reprint [Cell proliferation of HIV: new action strategy]
    Vincent Piguet
    Rev Med Suisse 2:1548. 2006
  40. ncbi request reprint Topical tacrolimus for effective treatment of eosinophilic folliculitis associated with human immunodeficiency virus infection
    Laurence Toutous-Trellu
    Department of Dermatology and Venereology, Division of Infectious Disease, University Hospital Geneva, Geneva, Switzerland
    Arch Dermatol 141:1203-8. 2005
  41. ncbi request reprint Extralymphatic tumors prepare draining lymph nodes to invasion via a T-cell cross-tolerance process
    Olivier Preynat-Seauve
    Louis Jeantet Skin Cancer Laboratory, Department of Dermatology, University Medical Center, Geneva, Switzerland
    Cancer Res 67:5009-16. 2007
    ..Such distant cross-tolerization of tumor-specific CD8(+) T cells may be a determinant permissive event leading to invasion of DLN. In this situation, metastatic tumor cells do not need to down-regulate their immunogenicity to spread...