Werner Joseph Pichler

Summary

Affiliation: University Hospital
Country: Switzerland

Publications

  1. ncbi request reprint T cells in drug allergy
    Werner J Pichler
    Division of Allergology, Clinic for Rheumatology and Clinical Immunology Allergology, Inselspital, University of Bern, CH 3010 Bern, Switzerland
    Curr Allergy Asthma Rep 2:9-15. 2002
  2. ncbi request reprint Immune mechanism of drug hypersensitivity
    Werner J Pichler
    Division of Allergology, Clinic for Rheumatology and Clinical Immunology Allergology, Inselspital, University of Bern, 3010 Bern, Switzerland
    Immunol Allergy Clin North Am 24:373-97, v-vi. 2004
  3. ncbi request reprint Predictive drug allergy testing: an alternative viewpoint
    W J Pichler
    Division of Allergology, Clinic for Rheumatology and Clinical Immunology Allergology Inselspital, University of Bern, CH 3010, Bern, Switzerland
    Toxicology 158:31-41. 2001
  4. ncbi request reprint Cellular and molecular pathophysiology of cutaneous drug reactions
    Werner J Pichler
    Division of Allergology, Clinic for Rheumatology and Clinical Immunology Allergology, Inselspital, University of Bern, Bern, Switzerland
    Am J Clin Dermatol 3:229-38. 2002
  5. pmc The p-i Concept: Pharmacological Interaction of Drugs With Immune Receptors
    Werner J Pichler
    From the Division of Allergology, Clinic for Rheumatology and Clinical Immunology Allergology, University of Berne, Berne, Switzerland
    World Allergy Organ J 1:96-102. 2008
  6. doi request reprint Immune pathomechanism of drug hypersensitivity reactions
    Werner J Pichler
    Division of Allergology, Clinic for Rheumatology and Clinical Immunology Allergology, Inselspital, University of Bern, Bern, Switzerland
    J Allergy Clin Immunol 127:S74-81. 2011
  7. ncbi request reprint Drug-induced autoimmunity
    Werner J Pichler
    Clinic for Rheumatology, University of Bern, Bern, Switzerland
    Curr Opin Allergy Clin Immunol 3:249-53. 2003
  8. ncbi request reprint Lessons from drug allergy: against dogmata
    Werner J Pichler
    Division of Allergology, Clinic of Rheumatology and Clinical Immunology Allergology, Inselspital, University of Bern, 3010 Bern, Switzerland
    Curr Allergy Asthma Rep 3:1-3. 2003
  9. ncbi request reprint Modes of presentation of chemical neoantigens to the immune system
    Werner J Pichler
    Division of Allergology, Clinic for Rheumatology and Clinical Immunology Allergology, Inselspital, CH 3010 Bern, Switzerland
    Toxicology 181:49-54. 2002
  10. ncbi request reprint Pharmacological interaction of drugs with antigen-specific immune receptors: the p-i concept
    Werner J Pichler
    Division of Allergology, Clinic for Rheumatology and Clinical Immunology Allergology, Inselspital, University of Bern, CH 3010 Bern, Switzerland
    Curr Opin Allergy Clin Immunol 2:301-5. 2002

Collaborators

Detail Information

Publications47

  1. ncbi request reprint T cells in drug allergy
    Werner J Pichler
    Division of Allergology, Clinic for Rheumatology and Clinical Immunology Allergology, Inselspital, University of Bern, CH 3010 Bern, Switzerland
    Curr Allergy Asthma Rep 2:9-15. 2002
    ..Moreover, in MPE CD4+, perforin+ T cells were found in vitro and in immunohistology that had cytotoxic potential and killed keratinocytes in vitro and in vivo...
  2. ncbi request reprint Immune mechanism of drug hypersensitivity
    Werner J Pichler
    Division of Allergology, Clinic for Rheumatology and Clinical Immunology Allergology, Inselspital, University of Bern, 3010 Bern, Switzerland
    Immunol Allergy Clin North Am 24:373-97, v-vi. 2004
    ..Based on recent investigation on different exanthemas, an extended classification of the Gell and Coombs type IV reaction is proposed...
  3. ncbi request reprint Predictive drug allergy testing: an alternative viewpoint
    W J Pichler
    Division of Allergology, Clinic for Rheumatology and Clinical Immunology Allergology Inselspital, University of Bern, CH 3010, Bern, Switzerland
    Toxicology 158:31-41. 2001
    ..A change and expansion of currently performed test procedures is required to predict the allergenic potential of drugs...
  4. ncbi request reprint Cellular and molecular pathophysiology of cutaneous drug reactions
    Werner J Pichler
    Division of Allergology, Clinic for Rheumatology and Clinical Immunology Allergology, Inselspital, University of Bern, Bern, Switzerland
    Am J Clin Dermatol 3:229-38. 2002
    ....
  5. pmc The p-i Concept: Pharmacological Interaction of Drugs With Immune Receptors
    Werner J Pichler
    From the Division of Allergology, Clinic for Rheumatology and Clinical Immunology Allergology, University of Berne, Berne, Switzerland
    World Allergy Organ J 1:96-102. 2008
    ..Nevertheless, because the reactions lead to expansion of drug-reactive cells, many features such as skin test reactivity and stronger reactivity upon reexposure are identical to real immune reactions...
  6. doi request reprint Immune pathomechanism of drug hypersensitivity reactions
    Werner J Pichler
    Division of Allergology, Clinic for Rheumatology and Clinical Immunology Allergology, Inselspital, University of Bern, Bern, Switzerland
    J Allergy Clin Immunol 127:S74-81. 2011
    ..Among many other presentations, the important role of regulatory T cells in drug hypersensitivity was addressed...
  7. ncbi request reprint Drug-induced autoimmunity
    Werner J Pichler
    Clinic for Rheumatology, University of Bern, Bern, Switzerland
    Curr Opin Allergy Clin Immunol 3:249-53. 2003
    ..Presentation of different mechanism of drug-induced autoimmunity and highlighting of new developments...
  8. ncbi request reprint Lessons from drug allergy: against dogmata
    Werner J Pichler
    Division of Allergology, Clinic of Rheumatology and Clinical Immunology Allergology, Inselspital, University of Bern, 3010 Bern, Switzerland
    Curr Allergy Asthma Rep 3:1-3. 2003
  9. ncbi request reprint Modes of presentation of chemical neoantigens to the immune system
    Werner J Pichler
    Division of Allergology, Clinic for Rheumatology and Clinical Immunology Allergology, Inselspital, CH 3010 Bern, Switzerland
    Toxicology 181:49-54. 2002
    ..This seems to be sufficient to stimulate T-cells. Such structural features of a drug have to be considered in the evaluation of drug hypersensitivity reactions and should be taken into account in predictive drug allergy testing...
  10. ncbi request reprint Pharmacological interaction of drugs with antigen-specific immune receptors: the p-i concept
    Werner J Pichler
    Division of Allergology, Clinic for Rheumatology and Clinical Immunology Allergology, Inselspital, University of Bern, CH 3010 Bern, Switzerland
    Curr Opin Allergy Clin Immunol 2:301-5. 2002
    ..In this review a new concept of drug presentation to T-cells is presented...
  11. ncbi request reprint Direct T-cell stimulations by drugs--bypassing the innate immune system
    Werner J Pichler
    Division of Allergology, Clinic for Rheumatology and Clinical Immunology Allergology, Inselspital, University of Berne, CH 3010 Berne, Switzerland
    Toxicology 209:95-100. 2005
    ..This concept has major implications for preclinical testing of the allergenic potential of a drug, which normally is measured by the ability of the drug to cause a new immune response...
  12. ncbi request reprint Transfection of drug-specific T-cell receptors into hybridoma cells: tools to monitor drug interaction with T-cell receptors and evaluate cross-reactivity to related compounds
    Daphné Anne Schmid
    MD Division of Allergology, Inselspital, University of Bern, 3010 Bern, Switzerland
    Mol Pharmacol 70:356-65. 2006
    ....
  13. doi request reprint Drug hypersensitivity reactions: pathomechanism and clinical symptoms
    Werner J Pichler
    Division of Allergology, Clinic for Rheumatology and Clinical Immunology Allergology, Inselspital, University of Bern, CH 3010 Bern, Switzerland
    Med Clin North Am 94:645-64, xv. 2010
    ..Based on progress in T cell immunology, this heterogeneity of T cell reaction is now also reflected in a subclassification of type IVa to IVd reactions...
  14. doi request reprint [Intolerance as consequence of hyperreactivity]
    W J Pichler
    Universitätsklinik für Rheumatologie and klinische Immunologie Allergologie, Universitatsspital, Inselspital, Bern
    Praxis (Bern 1994) 98:389-94. 2009
    ..Four examples are presented where this cause--trigger model of hyperreactivity is illustrated (exercise induced asthma, pollen associated food allergy, flare-up reactions in drug allergy and hyperreactivity in chronic urticaria)...
  15. ncbi request reprint Predicting drug hypersensitivity by in vitro tests
    Werner J Pichler
    Department for Rheumatology and Clinical Immunology Allergology, Inselspital, University of Bern, Bern, Switzerland
    ALTEX 24:49-52. 2007
    ..It is frequent in systemic drug hypersensitivity reactions and has major implications for predicting them. First experiments to identify such drugs able to interact with T cells are presented...
  16. ncbi request reprint Pharmacological interaction of drugs with immune receptors: the p-i concept
    Werner J Pichler
    Division of Allergology, Clinic for Rheumatology and Clinical Immunology Allergology, Inselspitel, Berne, Switzerland
    Allergol Int 55:17-25. 2006
    ....
  17. ncbi request reprint Delayed drug hypersensitivity reactions
    Werner J Pichler
    Division of Allergology, Clinic for Rheumatology and Clinical Immunology Allergology, Inselspital, University of Bern, Bern, Switzerland
    Ann Intern Med 139:683-93. 2003
    ..Moreover, cytotoxic functions by either CD4+ or CD8+ T cells (type IVc) seem to participate in all type IV reactions...
  18. ncbi request reprint Drug interaction with T-cell receptors: T-cell receptor density determines degree of cross-reactivity
    Jan Paul Heribert Depta
    Division of Allergology, Clinic of Rheumatology and Clinical Immunology Allergology, Inselspital, University of Bern, Bern, Switzerland
    J Allergy Clin Immunol 113:519-27. 2004
    ..Immune-mediated adverse reactions to drugs are often due to T-cell reactivity, and cross-reactivity is an important problem in pharmacotherapy...
  19. doi request reprint Robust expression of CCR3 as a single basophil selection marker in flow cytometry
    O V Hausmann
    Department of Rheumatology, Clinical Immunology and Allergology, Inselspital, University Bern, Bern, Switzerland
    Allergy 66:85-91. 2011
    ..Whereas activation markers, especially CD63, are widely validated, the most suitable and robust marker for basophil selection is still a matter of debate...
  20. ncbi request reprint Boletus edulis: a digestion-resistant allergen may be relevant for food allergy
    A Helbling
    Division of Allergology, Department of Rheumathology and Clinical Immunology Allergology, University Hospital, 3010 Bern, Switzerland
    Clin Exp Allergy 32:771-5. 2002
    ..Reports of food-related allergic reactions due to the edible mushroom Boletus edulis have occasionally been reported...
  21. ncbi request reprint Incidence of anaphylaxis with circulatory symptoms: a study over a 3-year period comprising 940,000 inhabitants of the Swiss Canton Bern
    A Helbling
    Division of Allergology, Department of Rheumatology, Immunology and Allergology, University Hospital Bern, Switzerland
    Clin Exp Allergy 34:285-90. 2004
    ..However, data on the epidemiology of anaphylaxis, particularly the most profound and life-threatening form such as anaphylactic shock are limited and thought to be under-reported...
  22. pmc Influence of reduced glutathione on the proliferative response of sulfamethoxazole-specific and sulfamethoxazole-metabolite-specific human CD4+ T-cells
    C Burkhart
    Clinic of Rheumatology and Clinical Immunology Allergology, Inselspital, 3010 Bern, Switzerland
    Br J Pharmacol 132:623-30. 2001
    ..4. Our data support the concept that in allergic individuals T-cells recognize the non-covalently bound parent drug rather than APC covalently modified by SMX-NO...
  23. ncbi request reprint Non-covalent presentation of sulfamethoxazole to human CD4+ T cells is independent of distinct human leucocyte antigen-bound peptides
    C Burkhart
    Clinic of Rheumatology and Clinical Immunology Allergology, Inselspital, Bern, Switzerland
    Clin Exp Allergy 32:1635-43. 2002
    ..However, there is little information so far on the precise molecular mechanisms of this non-covalent drug presentation...
  24. ncbi request reprint Hypersensitivity reactions to quinolones
    Daphné Anne Schmid
    Division of Allergology, Clinic of Rheumatology and Clinical Immunology Allergology, Inselspital, University of Bern, Bern, Switzerland
    Curr Pharm Des 12:3313-26. 2006
    ..This review gives an insight into the different immunological mechanisms leading to the diverse symptoms of quinolone-induced hypersensitivity reactions, with special emphasis on the role of T cells in such reactions...
  25. ncbi request reprint T-cell reactions to drugs in distinct clinical manifestations of drug allergy
    C B Neukomm
    Division of Allergology, Clinic of Rheumatology and Clinical Immunology/Allergology, Inselspital, Bern, Switzerland
    J Investig Allergol Clin Immunol 11:275-84. 2001
    ..A combined approach using a detailed case history, lymphocyte transformation tests, skin tests (immediate and delayed type) appears to be helpful to identifying the incriminated drug...
  26. ncbi request reprint T cell involvement in cutaneous drug eruptions
    Y Hari
    Allergy Division of the Clinic for Rheumatology and Clinical Immunology/Allergology, Inselspital, Bern, Switzerland
    Clin Exp Allergy 31:1398-408. 2001
    ..A predominant CD8(+) T cell activation leads to more severe (bullous) skin symptoms or liver involvement, while predominant activation of CD4(+) cells elicits mainly maculo-papular reactions...
  27. ncbi request reprint Effect of tree pollen specific, subcutaneous immunotherapy on the oral allergy syndrome to apple and hazelnut
    X Bucher
    Division of Allergology, Department of Rheumatology and Clinical Immunology Allergology, Bern, Switzerland
    Allergy 59:1272-6. 2004
    ..The efficacy of specific immunotherapy (SIT) in pollen allergy is well established. However, its effect on pollen associated food allergy particularly the oral allergy syndrome (OAS) is not definitely ascertained...
  28. ncbi request reprint Degeneracy and additional alloreactivity of drug-specific human alpha beta(+) T cell clones
    S von Greyerz
    Allergology, Clinic for Rheumatology and Clinical Immunology/Allergology, Inselspital, 3010 Bern, Switzerland
    Int Immunol 13:877-85. 2001
    ..Finally, the biological functions of bispecific TCC were not influenced by the nature of the stimulating ligand. Both drug as well as allogeneic stimulation led to similar reaction patterns in the analyzed TCC...
  29. ncbi request reprint Delayed drug hypersensitivity reactions - new concepts
    S J Posadas
    Division Allergology, Clinic for Rheumatology and Clinical Immunology Allergology, Bern, Switzerland
    Clin Exp Allergy 37:989-99. 2007
    ..This new concept has major implications for understanding clinical and immunological features of drug hypersensitivity and a model to explain the frequent skin symptoms in drug hypersensitivity is proposed...
  30. ncbi request reprint The lymphocyte transformation test in the diagnosis of drug hypersensitivity
    W J Pichler
    Division of Allergology, Clinic of Rheumatology and Clinical Immunology Allergology, Inselspital, University of Bern, 3010 Bern, Switzerland
    Allergy 59:809-20. 2004
    ..Further work on the simplification of this test and systematic evaluation of its sensitivity and specificity in some main groups of drugs are necessary to make this test more widely available...
  31. ncbi request reprint CD69 upregulation on T cells as an in vitro marker for delayed-type drug hypersensitivity
    A Beeler
    Division of Allergology, Clinic of Rheumatology and Clinical Immunology Allergology, Inselspital, Bern, Switzerland
    Allergy 63:181-8. 2008
    ..However, the LTT imposes limitations in terms of practicability, and an alternative method that is easier to implement than the LTT would be desirable...
  32. pmc T-cell involvement in drug-induced acute generalized exanthematous pustulosis
    M Britschgi
    Clinic of Rheumatology and Clinical Immunology/Allergology, Inselspital, Bern, Switzerland
    J Clin Invest 107:1433-41. 2001
    ..In addition, they indicate that even in some neutrophil-rich inflammatory responses specific T cells are engaged and might orchestrate the immune reaction...
  33. ncbi request reprint Multiple drug hypersensitivity--proof of multiple drug hypersensitivity by patch and lymphocyte transformation tests
    C Gex-Collet
    Division of Allergology, Department of Rheumatology and Clinical Immunology Allergology, Inselspital Bern, Switzerland
    J Investig Allergol Clin Immunol 15:293-6. 2005
    ..as drug allergies to two or more chemically different drugs. So far, the diagnosis of MDH was associated almost exclusively with antibiotics and was defined based on history alone...
  34. ncbi request reprint T cell-mediated hypersensitivity to quinolones: mechanisms and cross-reactivity
    D A Schmid
    Division of Allergology, Clinic of Rheumatology and Clinical Immunology Allergology, University of Bern, Bern, Switzerland
    Clin Exp Allergy 36:59-69. 2006
    ..Quinolones are widely used, broad spectrum antibiotics that can induce immediate- and delayed-type hypersensitivity reactions, presumably either IgE or T cell mediated, in about 2-3% of treated patients...
  35. doi request reprint Effect of natural seasonal pollen exposure and repeated nasal allergen provocations on elevation of exhaled nitric oxide
    K Bergmann-Hug
    Department of Rheumatology and Clinical Immunology Allergology, Division of Allergology, Inselspital, University of Bern, Bern, Switzerland
    Allergy 64:1629-34. 2009
    ..We wondered whether in patients with intermittent allergic rhinitis only (i) natural pollen exposure and (ii) artificial pollen exposure by repeated nasal allergen provocations may lead to an elevation of FENO...
  36. ncbi request reprint Three years of specific immunotherapy with house-dust-mite extracts in patients with rhinitis and asthma: significant improvement of allergen-specific parameters and of nonspecific bronchial hyperreactivity
    C E Pichler
    Division of Allergology, Clinic for Rheumatology and Clinical Immunology/Allergology, University Hospital, Bern, Switzerland
    Allergy 56:301-6. 2001
    ..This beneficial effect of SIT on allergen-specific immune parameters seems to induce also a diminution of nonspecific bronchial hyperreactivity and enables reduction of symptomatic treatment...
  37. ncbi request reprint [Specific and nonspecific (anti-IgE) immunotherapy of allergic diseases]
    W J Pichler
    Abteilung Allergologie, , Inselspital, Bern
    Ther Umsch 58:329-36. 2001
    ..e. patients suffering from mite, fungal and pollen allergy) or is effective in patients which have manifestations of their allergy in different organs...
  38. doi request reprint Drug-specific in vitro release of IL-2, IL-5, IL-13 and IFN-gamma in patients with delayed-type drug hypersensitivity
    P Lochmatter
    Clinic of Rheumatology and Clinical Immunology Allergology, Inselspital, Bern University Hospital, University of Bern, Switzerland
    Allergy 64:1269-78. 2009
    ....
  39. ncbi request reprint Cytotoxic mechanisms in different forms of T-cell-mediated drug allergies
    P C Kuechler
    Clinic of Rheumatology and Clinical Immunology Allergology, PKT 2 D572, Inselspital University Hospital, CH 3010 Berne, Switzerland
    Allergy 59:613-22. 2004
    ..Cytotoxic mechanisms are involved in different forms of drug induced exanthems...
  40. ncbi request reprint The butterbur extract petasin has no effect on skin test reactivity induced by different stimuli: a randomized, double-blind crossover study using histamine, codeine, methacholine, and aeroallergen solutions
    C Gex-Collet
    Division of Allergology, Department of Rheumatology and Clinical Immunology Allergology, Inselspital, Bern, Switzerland
    J Investig Allergol Clin Immunol 16:156-61. 2006
    ..Few clinical studies have been performed so far addressing the clinical effectiveness of Ze 339...
  41. ncbi request reprint Zafirlukast has no beneficial effects in the treatment of chronic urticaria
    A Reimers
    Medial Division, Zieglerspital Bern, Bern, Switzerland
    Clin Exp Allergy 32:1763-8. 2002
    ..Indeed, various reports have indicated a beneficial effect for leukotriene receptor antagonists in patients with chronic urticaria...
  42. ncbi request reprint Pathogenesis of drug-induced exanthema
    N Yawalkar
    Clinic for Rheumatology and Clinical Immunology/Allergology, University of Bern, Switzerland
    Int Arch Allergy Immunol 124:336-8. 2001
    ....
  43. doi request reprint Processing-dependent and -independent pathways for recognition of iodinated contrast media by specific human T cells
    M Keller
    Adverse Drug Reactions Analysis and Consulting ADR AC GmbH, Bern, Switzerland
    Clin Exp Allergy 40:257-68. 2010
    ..We have previously demonstrated that CM-specific T cell clones (TCCs) show a broad range of cross-reactivity to different CM. However, the mechanism of specific CM recognition by T cell receptors (TCRs) has not been analysed so far...
  44. doi request reprint In vitro detection of cytotoxic T and NK cells in peripheral blood of patients with various drug-induced skin diseases
    A Zawodniak
    Division of Allergology, Clinic for Rheumatology and Clinical Immunology Allergology Inselspital, Bern University Hospital, University of Bern, Bern, Switzerland
    Allergy 65:376-84. 2010
    ....
  45. ncbi request reprint Adverse side-effects to biological agents
    W J Pichler
    Department for Rheumatology and Clinical Immunology Allergology, Inselspital, University of Bern, Bern, Switzerland
    Allergy 61:912-20. 2006
    ..This classification could help to better deal with the clinical features of these side-effects, to identify possible individual and general risk factors and to direct research in this novel area of medicine...
  46. ncbi request reprint Oral prednisolone induced acute generalized exanthematous pustulosis due to corticosteroids of group A confirmed by epicutaneous testing and lymphocyte transformation tests
    U Buettiker
    Department of Dermatology, Inselspital, University of Berne, Berne, Switzerland
    Dermatology 213:40-3. 2006
    ..Acute generalized exanthematous pustulosis (AGEP) is a rare cutaneous eruption which is often provoked by drugs...
  47. ncbi request reprint Scratch-patch and patch testing in drug allergy--an assessment of specificity
    K Hug
    Division of Allergology, Clinic for Rheumatology and Clinical Immunology Allergology, University of Bern, Inselspital, Bern, Switzerland
    J Investig Allergol Clin Immunol 13:12-9. 2003
    ..The aim of this study was to evaluate and compare scratch-patch and patch tests prospectively with frequently used drugs in persons exposed or not exposed to the drug in order to define a nonirritating concentration...