D Picard

Summary

Affiliation: University of Geneva
Country: Switzerland

Publications

  1. ncbi request reprint The glucocorticoid responses are shaped by molecular chaperones
    Iwona Grad
    Departement de Biologie Cellulaire, Universite de Geneve, Sciences III, 30 Quai Ernest Ansermet, 1211 Geneve 4, Switzerland
    Mol Cell Endocrinol 275:2-12. 2007
  2. ncbi request reprint Intracellular dynamics of the Hsp90 co-chaperone p23 is dictated by Hsp90
    Didier Picard
    European Molecular Biology Laboratory, D 69117 Heidelberg, Germany
    Exp Cell Res 312:198-204. 2006
  3. pmc The Hsp90 cochaperone p23 is essential for perinatal survival
    Iwona Grad
    Departement de Biologie Cellulaire, Universite de Geneve, Sciences III, 1211 Geneve 4, Switzerland
    Mol Cell Biol 26:8976-83. 2006
  4. ncbi request reprint A web application to manage a database for liquid nitrogen tanks
    Cyril Picard
    VisibilityWeb, 61, Chemin des Voirets, CH 1228 Plan les Ouates, Switzerland
    Immunol Cell Biol 82:257-9. 2004
  5. ncbi request reprint Heat-shock protein 90, a chaperone for folding and regulation
    D Picard
    Cell Mol Life Sci 59:1640-8. 2002
  6. ncbi request reprint Chaperoning steroid hormone action
    Didier Picard
    Departement de Biologie Cellulaire, Universite de Geneve, Sciences III, 30 Quai Ernest Ansermet, CH 1211 Geneve 4, Switzerland
    Trends Endocrinol Metab 17:229-35. 2006
  7. ncbi request reprint The molecular chaperone Cdc37 is required for Ste11 function and pheromone-induced cell cycle arrest
    T Abbas-Terki
    Departement de Biologie Cellulaire, Universite de Geneve, Sciences III, 30 Quai Ernest Ansermet, CH 1211, Geneve, Switzerland
    FEBS Lett 467:111-6. 2000
  8. pmc Hsp104 interacts with Hsp90 cochaperones in respiring yeast
    T Abbas-Terki
    Departement de Biologie Cellulaire, Universite de Geneve, Sciences III, Geneva, Switzerland
    Mol Cell Biol 21:7569-75. 2001
  9. pmc Hsp90 binds and regulates Gcn2, the ligand-inducible kinase of the alpha subunit of eukaryotic translation initiation factor 2 [corrected]
    O Donze
    Departement de Biologie Cellulaire, Universite de Geneve, Sciences III, CH 1211 Geneva 4, Switzerland
    Mol Cell Biol 19:8422-32. 1999
  10. pmc The Hsp90 chaperone complex is both a facilitator and a repressor of the dsRNA-dependent kinase PKR
    O Donze
    Departement de Biologie Cellulaire, Universite de Geneve, Sciences III, 30 Quai Ernest Ansermet, CH 1211 Geneve 4, Switzerland
    EMBO J 20:3771-80. 2001

Collaborators

  • Gary W Hoyle
  • J W Liu
  • Charles A Miller
  • Penny A Jeggo
  • Hamid Mehenni
  • S E Antonarakis
  • David F Smith
  • O Donze
  • Nicolas Foray
  • Iwona Grad
  • T Abbas-Terki
  • Marcello Maggiolini
  • Lidia Albanito
  • Fedor Forafonov
  • Sebastiano Ando
  • Adele Vivacqua
  • Morag J Maclean
  • Cyril Picard
  • Peter Dudek
  • Morag MacLean
  • Daniel L Riggs
  • Toufik Abbas-Terki
  • Saveria Aquila
  • Rosamaria Lappano
  • Loredana Mauro
  • Oyetunji A Toogun
  • Elena Suslova
  • Deo Prakash Pandey
  • Diego Sisci
  • Antonio Madeo
  • P A Briand
  • Elvira Brunelli
  • Brian C Freeman
  • Sara M Ludwig
  • Wolfgang Wurst
  • J F Louvion
  • Thomas Floss
  • Thomas A McKee
  • Patricia Ruiz
  • Marc Martínez Llordella
  • Nathalie Bot
  • R Warth
  • Thomas Ratajczak
  • Joyce Cheung-Flynn
  • Richard Gaber
  • Patricia J Roberts
  • Samantha C Chirillo
  • Viravan Prapapanich
  • Amalia Carpino
  • Daniela Bonofiglio
  • Giovanna Fasanella
  • Pierre André Briand
  • Michele Salerno

Detail Information

Publications26

  1. ncbi request reprint The glucocorticoid responses are shaped by molecular chaperones
    Iwona Grad
    Departement de Biologie Cellulaire, Universite de Geneve, Sciences III, 30 Quai Ernest Ansermet, 1211 Geneve 4, Switzerland
    Mol Cell Endocrinol 275:2-12. 2007
    ..We discuss the contributions of these molecular chaperones to folding, activation, intracellular transport, transcriptional regulation, and decay of the glucocorticoid receptor...
  2. ncbi request reprint Intracellular dynamics of the Hsp90 co-chaperone p23 is dictated by Hsp90
    Didier Picard
    European Molecular Biology Laboratory, D 69117 Heidelberg, Germany
    Exp Cell Res 312:198-204. 2006
    ..In contrast, when wild-type p23 is able to bind Hsp90, a more complex FRAP behavior is observed, suggesting that it is quantitatively bound in Hsp90 complexes undergoing a multitude of other interactions...
  3. pmc The Hsp90 cochaperone p23 is essential for perinatal survival
    Iwona Grad
    Departement de Biologie Cellulaire, Universite de Geneve, Sciences III, 1211 Geneve 4, Switzerland
    Mol Cell Biol 26:8976-83. 2006
    ..Thus, p23 contributes a nonredundant, temporally restricted, and tissue-specific function during mouse development...
  4. ncbi request reprint A web application to manage a database for liquid nitrogen tanks
    Cyril Picard
    VisibilityWeb, 61, Chemin des Voirets, CH 1228 Plan les Ouates, Switzerland
    Immunol Cell Biol 82:257-9. 2004
    ..Our web application allows import of data from other database programs and adaptation to different tank formats, types of samples, and archiving needs...
  5. ncbi request reprint Heat-shock protein 90, a chaperone for folding and regulation
    D Picard
    Cell Mol Life Sci 59:1640-8. 2002
    ..The large conformational flexibility of Hsp90 and a multitude of dynamic co-chaperone complexes contribute to generating functional diversity, and allow Hsp90 to assist a wide range of substrates...
  6. ncbi request reprint Chaperoning steroid hormone action
    Didier Picard
    Departement de Biologie Cellulaire, Universite de Geneve, Sciences III, 30 Quai Ernest Ansermet, CH 1211 Geneve 4, Switzerland
    Trends Endocrinol Metab 17:229-35. 2006
    ..This review discusses the complexities of the chaperone machinery and the diversity of regulatory options afforded by this assistance for hormone action...
  7. ncbi request reprint The molecular chaperone Cdc37 is required for Ste11 function and pheromone-induced cell cycle arrest
    T Abbas-Terki
    Departement de Biologie Cellulaire, Universite de Geneve, Sciences III, 30 Quai Ernest Ansermet, CH 1211, Geneve, Switzerland
    FEBS Lett 467:111-6. 2000
    ..Thus, Hsp90 and Cdc37 may transiently associate with Ste11 to promote proper folding and/or association with additional regulatory factors. Our results establish Ste11 as the first endogenous Cdc37 client protein in yeast...
  8. pmc Hsp104 interacts with Hsp90 cochaperones in respiring yeast
    T Abbas-Terki
    Departement de Biologie Cellulaire, Universite de Geneve, Sciences III, Geneva, Switzerland
    Mol Cell Biol 21:7569-75. 2001
    ..This suggests that cochaperone sharing may favor adaptation to altered metabolic conditions...
  9. pmc Hsp90 binds and regulates Gcn2, the ligand-inducible kinase of the alpha subunit of eukaryotic translation initiation factor 2 [corrected]
    O Donze
    Departement de Biologie Cellulaire, Universite de Geneve, Sciences III, CH 1211 Geneva 4, Switzerland
    Mol Cell Biol 19:8422-32. 1999
    ..Taken together, these data identify Gcn2 as a novel target for Hsp90, which plays a crucial role for the maturation and regulation of Gcn2...
  10. pmc The Hsp90 chaperone complex is both a facilitator and a repressor of the dsRNA-dependent kinase PKR
    O Donze
    Departement de Biologie Cellulaire, Universite de Geneve, Sciences III, 30 Quai Ernest Ansermet, CH 1211 Geneve 4, Switzerland
    EMBO J 20:3771-80. 2001
    ..This suggests that the Hsp90 complex may more generally assist the regulatory domains of kinases and other Hsp90 substrates...
  11. pmc Hsp90 is required for pheromone signaling in yeast
    J F Louvion
    Departement de Biologie Cellulaire, Université de Genève Sciences III, CH 1211 Geneve 4, Switzerland
    Mol Biol Cell 9:3071-83. 1998
    ..These findings further corroborate the view that molecular chaperones must also be considered as transient or stable components of signal transduction pathways...
  12. ncbi request reprint Functional analysis of the yeast 40 kDa cyclophilin Cyp40 and its role for viability and steroid receptor regulation
    R Warth
    Departement de Biologie Cellulaire, Universite de Geneve, Switzerland
    Biol Chem 378:381-91. 1997
    ..While other immunophilins could conceivably compensate a Cyp40 defect, our results are compatible with the notion that immunophilins may be fortuitous partners in the biochemically established steroid receptor-Hsp90 complex...
  13. ncbi request reprint The anti-estrogen hydroxytamoxifen is a potent antagonist in a novel yeast system
    J W Liu
    Departement de Biologie Cellulaire, Universite de Geneve, Sciences III, Switzerland
    Biol Chem 380:1341-5. 1999
    ..While they all act as agonists for wild-type ERalpha, we have established a novel yeast assay system for anti-estrogens, in which at least the commonly used anti-estrogen hydroxytamoxifen is a potent antagonist...
  14. ncbi request reprint Molecular and clinical characteristics in 46 families affected with Peutz-Jeghers syndrome
    Hamid Mehenni
    Centre Médico Chirurgical Rond Point Plainpalais et Département de biologie cellulaire, Unité de recherche des maladies prédisposant aux cancers gastro intestinaux, Universite de Geneve, Geneve, Switzerland
    Dig Dis Sci 52:1924-33. 2007
    ....
  15. ncbi request reprint 2-color photobleaching experiments reveal distinct intracellular dynamics of two components of the Hsp90 complex
    Didier Picard
    Departement de Biologie Cellulaire, Universite de Geneve, Sciences III, 30 Quai Ernest Ansermet, CH 1211 Geneve 4, Switzerland
    Exp Cell Res 312:3949-58. 2006
    ..However, when Hsp90-p23 complexes are disrupted by the Hsp90 inhibitor geldanamycin, p23 moves by free diffusion while Hsp90 maintains its low mobility because it remains bound in remodeled multicomponent complexes...
  16. pmc p23/Sba1p protects against Hsp90 inhibitors independently of its intrinsic chaperone activity
    Fedor Forafonov
    Departement de Biologie Cellulaire, Universite de Geneve, Sciences III, CH 1211 Geneve 4, Switzerland
    Mol Cell Biol 28:3446-56. 2008
    ..The large interface may also contribute to preserving a protective function in an environment in which Hsp90 inhibitory compounds can be produced by various microorganisms...
  17. pmc RNA interference in mammalian cells using siRNAs synthesized with T7 RNA polymerase
    Olivier Donze
    Departement de Biologie Cellulaire, Universite de Geneve, Sciences III, 30 Quai Ernest Ansermet, CH 1211 Geneve 4, Switzerland
    Nucleic Acids Res 30:e46. 2002
    ..With multiple transfection procedures, including calcium phosphate co-precipitation, we demonstrate silencing of both exogenous and endogenous genes...
  18. ncbi request reprint LKB1 interacts with and phosphorylates PTEN: a functional link between two proteins involved in cancer predisposing syndromes
    Hamid Mehenni
    Departement de Biologie Cellulaire, Universite de Geneve, 1211 Geneve 4, Switzerland
    Hum Mol Genet 14:2209-19. 2005
    ....
  19. ncbi request reprint A yeast-based assay reveals a functional defect of the Q488H polymorphism in human Hsp90alpha
    Morag J Maclean
    Departement de Biologie Cellulaire, Universite de Geneve, Sciences III, 30 Quai Ernest Ansermet, CH 1211 Geneve 4, Switzerland
    Biochem Biophys Res Commun 337:133-7. 2005
    ..Hence, the characteristics of this yeast-based system-simplicity, rapidity, low cost-make it ideal for phenotype screening of polymorphisms in HSP90 and possibly many other human genes...
  20. pmc TROD: T7 RNAi Oligo Designer
    Peter Dudek
    Departement de Biologie Cellulaire, Universite de Geneve, Sciences III, Quai Ernest Ansermet 30, CH 1211 Geneve 4, Switzerland
    Nucleic Acids Res 32:W121-3. 2004
    ..The TROD web service is available at http://www.cellbio.unige.ch/RNAi.html...
  21. pmc Cdc37 goes beyond Hsp90 and kinases
    Morag MacLean
    Departement de Biologie Cellulaire, Universite de Geneve, Sciences III, 30, Quai Ernest Ansermet, CH 1211 Geneve 4, Switzerland
    Cell Stress Chaperones 8:114-9. 2003
    ..Thus, for many substrates, there may be many alternative chaperone pathways involving Cdc37, Hsp90, or both...
  22. pmc The Hsp90-binding peptidylprolyl isomerase FKBP52 potentiates glucocorticoid signaling in vivo
    Daniel L Riggs
    Department of Biochemistry and Molecular Biology, Mayo Clinic Scottsdale, Scottsdale, AZ 85259, USA
    EMBO J 22:1158-67. 2003
    ..The mechanism for potentiation is an increase in GR hormone-binding affinity that requires both the Hsp90-binding ability and the prolyl isomerase activity of FKBP52...
  23. ncbi request reprint The Hsp90 co-chaperones Cdc37 and Sti1 interact physically and genetically
    Toufik Abbas-Terki
    Departement de Biologie Cellulaire, Universite de Geneve, Switzerland
    Biol Chem 383:1335-42. 2002
    ..Here we show that the combination of cdc37 and sti1 mutations is synthetically lethal, suggesting that direct contacts between Cdc37 and Sti1 may at least contribute to vital functions in yeast...
  24. ncbi request reprint The mutant androgen receptor T877A mediates the proliferative but not the cytotoxic dose-dependent effects of genistein and quercetin on human LNCaP prostate cancer cells
    Marcello Maggiolini
    Department of Pharmaco Biology, University of Calabria, Rende, Italy
    Mol Pharmacol 62:1027-35. 2002
    ..The results of our study provide evidence that phytoestrogens may regulate several signaling processes in LNCaP cells; however, further studies are needed to assess their potential capability to restrain prostate tumor progression...
  25. pmc Constitutive association of BRCA1 and c-Abl and its ATM-dependent disruption after irradiation
    Nicolas Foray
    Radiobiologie Cellulaire et Moléculaire, U350 INSERM, Institut Curie, 91405 Orsay, France
    Mol Cell Biol 22:4020-32. 2002
    ..BRCA1-mutated cells exhibit constitutively high c-Abl kinase activity that is not further increased on exposure to IR. We suggest a model in which BRCA1 acts in concert with ATM to regulate c-Abl tyrosine kinase activity...
  26. pmc Epidermal growth factor induces G protein-coupled receptor 30 expression in estrogen receptor-negative breast cancer cells
    Lidia Albanito
    Department Pharmaco Biology, University of Calabria, 87030 Rende Cosenze, Italy
    Endocrinology 149:3799-808. 2008
    ..On the basis of our results, the action of EGF may include the up-regulation of GPR30 in facilitating a stimulatory role of estrogen, even in ER-negative breast tumor cells...