Peter Philippsen

Summary

Affiliation: University of Basel
Country: Switzerland

Publications

  1. pmc Limited functional redundancy and oscillation of cyclins in multinucleated Ashbya gossypii fungal cells
    A Katrin Hungerbuehler
    Department of Molecular Microbiology, Biozentrum University of Basel, Klingelbergstrasse 50 70, 4056 Basel, Switzerland
    Eukaryot Cell 6:473-86. 2007
  2. pmc The SH3/PH domain protein AgBoi1/2 collaborates with the Rho-type GTPase AgRho3 to prevent nonpolar growth at hyphal tips of Ashbya gossypii
    Philipp Knechtle
    Molecular Microbiology, Biozentrum der Universitat Basel, Klingelbergstrasse 50, 4056 Basel, Switzerland
    Eukaryot Cell 5:1635-47. 2006
  3. ncbi request reprint Homologues of yeast polarity genes control the development of multinucleated hyphae in Ashbya gossypii
    Peter Philippsen
    Applied Microbiology, Biozentrum, University of Basel, Klingelbergstr 50 70, CH 4056 Basel, Switzerland
    Curr Opin Microbiol 8:370-7. 2005
  4. pmc The anaphase-promoting complex/cyclosome is required for anaphase progression in multinucleated Ashbya gossypii cells
    Amy S Gladfelter
    University of Basel Biozentrum, Molecular Microbiology, Klingelbergstrasse 0 70, 4056 Basel, Switzerland
    Eukaryot Cell 6:182-97. 2007
  5. pmc Of bars and rings: Hof1-dependent cytokinesis in multiseptated hyphae of Ashbya gossypii
    Andreas Kaufmann
    Biozentrum, Basel, Switzerland
    Mol Cell Biol 29:771-83. 2009
  6. pmc From function to shape: a novel role of a formin in morphogenesis of the fungus Ashbya gossypii
    Hans Peter Schmitz
    Biozentrum der Universitat Basel, 4056 Basel, Switzerland
    Mol Biol Cell 17:130-45. 2006
  7. ncbi request reprint The Ashbya gossypii genome as a tool for mapping the ancient Saccharomyces cerevisiae genome
    Fred S Dietrich
    Biozentrum der Universitat Basel, Klingelbergstrasse 50, CH 4056 Basel, Switzerland
    Science 304:304-7. 2004
  8. pmc Clustering of nuclei in multinucleated hyphae is prevented by dynein-driven bidirectional nuclear movements and microtubule growth control in Ashbya gossypii
    Sandrine Grava
    Department of Molecular Microbiology, Biozentrum, University of Basel, Klingelbergstrasse 50 70, Basel, Switzerland
    Eukaryot Cell 10:902-15. 2011
  9. pmc A Ras-like GTPase is involved in hyphal growth guidance in the filamentous fungus Ashbya gossypii
    Yasmina Bauer
    Department of Molecular Microbiology, Biozentrum, University of Basel, CH 4056 Basel, Switzerland
    Mol Biol Cell 15:4622-32. 2004
  10. pmc Maximal polar growth potential depends on the polarisome component AgSpa2 in the filamentous fungus Ashbya gossypii
    Philipp Knechtle
    Applied Microbiology, Biozentrum, Universitaet Basel, 4056 Basel, Switzerland
    Mol Biol Cell 14:4140-54. 2003

Collaborators

Detail Information

Publications27

  1. pmc Limited functional redundancy and oscillation of cyclins in multinucleated Ashbya gossypii fungal cells
    A Katrin Hungerbuehler
    Department of Molecular Microbiology, Biozentrum University of Basel, Klingelbergstrasse 50 70, 4056 Basel, Switzerland
    Eukaryot Cell 6:473-86. 2007
    ..We propose that the cohabitation of different cyclins in nuclei has led to enhanced substrate specificity and limited functional redundancy within classes of cyclins in multinucleated cells...
  2. pmc The SH3/PH domain protein AgBoi1/2 collaborates with the Rho-type GTPase AgRho3 to prevent nonpolar growth at hyphal tips of Ashbya gossypii
    Philipp Knechtle
    Molecular Microbiology, Biozentrum der Universitat Basel, Klingelbergstrasse 50, 4056 Basel, Switzerland
    Eukaryot Cell 5:1635-47. 2006
    ..We conclude that AgBoi1/2p and AgRho3p support polarisome-mediated actin cable formation at hyphal tips, thereby ensuring permanent polar tip growth...
  3. ncbi request reprint Homologues of yeast polarity genes control the development of multinucleated hyphae in Ashbya gossypii
    Peter Philippsen
    Applied Microbiology, Biozentrum, University of Basel, Klingelbergstr 50 70, CH 4056 Basel, Switzerland
    Curr Opin Microbiol 8:370-7. 2005
    ..Comparative genomics of both organisms also reveals rare examples of differences in the gene sets for some cellular processes, which as shown for phosphate homeostasis can be associated with differences in control levels...
  4. pmc The anaphase-promoting complex/cyclosome is required for anaphase progression in multinucleated Ashbya gossypii cells
    Amy S Gladfelter
    University of Basel Biozentrum, Molecular Microbiology, Klingelbergstrasse 0 70, 4056 Basel, Switzerland
    Eukaryot Cell 6:182-97. 2007
    ..These data suggest that the AgAPC/C may be constitutively active across the cell cycle and that proteolysis in these multinucleated cells may be regulated at the level of substrates rather than by the APC/C itself...
  5. pmc Of bars and rings: Hof1-dependent cytokinesis in multiseptated hyphae of Ashbya gossypii
    Andreas Kaufmann
    Biozentrum, Basel, Switzerland
    Mol Cell Biol 29:771-83. 2009
    ..Simultaneously, a septum forms between the adjacent hyphal compartments, which do not separate. During evolution, A. gossypii lost the homologs of two enzymes essential for cell separation in Saccharomyces cerevisiae...
  6. pmc From function to shape: a novel role of a formin in morphogenesis of the fungus Ashbya gossypii
    Hans Peter Schmitz
    Biozentrum der Universitat Basel, 4056 Basel, Switzerland
    Mol Biol Cell 17:130-45. 2006
    ....
  7. ncbi request reprint The Ashbya gossypii genome as a tool for mapping the ancient Saccharomyces cerevisiae genome
    Fred S Dietrich
    Biozentrum der Universitat Basel, Klingelbergstrasse 50, CH 4056 Basel, Switzerland
    Science 304:304-7. 2004
    ..cerevisiae included a whole genome duplication or fusion of two related species and showed, through inferred ancient gene orders, which of the duplicated genes lost one copy and which retained both copies...
  8. pmc Clustering of nuclei in multinucleated hyphae is prevented by dynein-driven bidirectional nuclear movements and microtubule growth control in Ashbya gossypii
    Sandrine Grava
    Department of Molecular Microbiology, Biozentrum, University of Basel, Klingelbergstrasse 50 70, Basel, Switzerland
    Eukaryot Cell 10:902-15. 2011
    ..Those combined dynein actions prevent nuclear clustering in A. gossypii and thus reveal a novel cellular role for dynein...
  9. pmc A Ras-like GTPase is involved in hyphal growth guidance in the filamentous fungus Ashbya gossypii
    Yasmina Bauer
    Department of Molecular Microbiology, Biozentrum, University of Basel, CH 4056 Basel, Switzerland
    Mol Biol Cell 15:4622-32. 2004
    ..Additionally, hyphal filaments in the mutant developed aberrant branching sites by mislocalizing AgSpa2p thus distorting hyphal morphology. These results define AgRsr1p/Bud1p as a key regulator of hyphal growth guidance...
  10. pmc Maximal polar growth potential depends on the polarisome component AgSpa2 in the filamentous fungus Ashbya gossypii
    Philipp Knechtle
    Applied Microbiology, Biozentrum, Universitaet Basel, 4056 Basel, Switzerland
    Mol Biol Cell 14:4140-54. 2003
    ..We suggest that AgSpa2p is required for the determination of the area of growth at the hyphal tip and that the extended internal domain plays an important role in this process...
  11. pmc Ashbya Genome Database 3.0: a cross-species genome and transcriptome browser for yeast biologists
    Alexandre Gattiker
    Biozentrum and Swiss Institute of Bioinformatics, Klingelbergstrasse 50 70, CH 4056 Basel, Switzerland
    BMC Genomics 8:9. 2007
    ..The Ashbya Genome Database (AGD) 3.0 is an innovative cross-species genome and transcriptome browser based on release 40 of the Ensembl developer environment...
  12. pmc Asynchronous nuclear division cycles in multinucleated cells
    Amy S Gladfelter
    Department of Molecular Microbiology, Biozentrum University of Basel, 4056 Basel, Switzerland
    J Cell Biol 172:347-62. 2006
    ..We hypothesize that the continuous cytoplasm in these cells promoted the evolution of a nuclear division cycle in which CDK inhibitors primarily control CDK activity rather than oscillating mitotic cyclin proteins...
  13. doi request reprint The Paxillin-like protein AgPxl1 is required for apical branching and maximal hyphal growth in A.gossypii
    Philipp Knechtle
    Molecular Microbiology, Biozentrum der Universitat Basel, Klingelbergstrasse 50, 4056 Basel, Switzerland
    Fungal Genet Biol 45:829-38. 2008
    ..AgCLA4, a PAK-like kinase, is epistatic to AgPXL1 and robust localisation of AgPxl1 depends on AgCla4. This suggests that AgCla4 acts upstream of AgPxl1...
  14. pmc Regulation of exit from mitosis in multinucleate Ashbya gossypii cells relies on a minimal network of genes
    Mark R Finlayson
    Department of Molecular Microbiology, Biozentrum, University of Basel, 4056 Basel, Switzerland
    Mol Biol Cell 22:3081-93. 2011
    ..We propose a reduced model of the networks described in yeast, with a low degree of functional redundancy, convenient for further investigations into these networks...
  15. pmc Dynamics of multiple nuclei in Ashbya gossypii hyphae depend on the control of cytoplasmic microtubules length by Bik1, Kip2, Kip3, and not on a capture/shrinkage mechanism
    Sandrine Grava
    Department of Molecular Microbiology, Biozentrum, University of Basel, CH 4056 Basel, Switzerland
    Mol Biol Cell 21:3680-92. 2010
    ..Thus, differences in cMT dynamics and length control between budding yeast and A. gossypii are key elements in the adaptation of the cMT cytoskeleton to much longer cells and much higher degrees of nuclear mobilities...
  16. pmc The Ashbya Genome Database (AGD)--a tool for the yeast community and genome biologists
    Leandro Hermida
    Department of Applied Microbiology, Biozentrum, Klingelbergstrasse 50 70, CH 4056 Basel, Switzerland
    Nucleic Acids Res 33:D348-52. 2005
    ..AGD is accessible at http://agd.unibas.ch/...
  17. doi request reprint Formation and stability of eisosomes in the filamentous fungus Ashbya gossypii
    Shanon Seger
    Biozentrum, University of Basel, Klingelbergstraße 50 70, CH 4056 Basel, Switzerland
    J Cell Sci 124:1629-34. 2011
    ..gossypii homologue of Ymr086w, another component of the eisosome, we identified a novel protein domain essential for eisosome stability. We also compare our results with recent findings about eisosomes in A. nidulans...
  18. doi request reprint Growth-speed-correlated localization of exocyst and polarisome components in growth zones of Ashbya gossypii hyphal tips
    Michael Köhli
    Biozentrum, University of Basel, Klingelbergstrasse 50 70, 4056 Basel, Switzerland
    J Cell Sci 121:3878-89. 2008
    ....
  19. pmc Reorientation of mispositioned spindles in short astral microtubule mutant spc72Delta is dependent on spindle pole body outer plaque and Kar3 motor protein
    Dominic Hoepfner
    Lehrstuhl für Angewandte Mikrobiologie, Biozentrum, Universitat Basel, CH 4056 Basel, Switzerland
    Mol Biol Cell 13:1366-80. 2002
    ..In addition, our data exclude involvement of Spc72 in spindle formation and elongation functions...
  20. pmc Reinvestigation of the Saccharomyces cerevisiae genome annotation by comparison to the genome of a related fungus: Ashbya gossypii
    Sophie Brachat
    Institute of Applied Microbiology, Biozentrum der Universitat Basel, Klingelbergstrasse 70, CH 4056 Basel, Switzerland
    Genome Biol 4:R45. 2003
    ..Thus, it became possible to reinvestigate the S. cerevisiae genome in the syntenic regions leading to an improved annotation...
  21. pmc Mobility, microtubule nucleation and structure of microtubule-organizing centers in multinucleated hyphae of Ashbya gossypii
    Claudia Lang
    Department of Molecular Microbiology, Biozentrum University of Basel, 4056 Basel, Switzerland
    Mol Biol Cell 21:18-28. 2010
    ..Each SPB nucleates its own array of cMTs, and the lack of overlapping cMT arrays between neighboring nuclei explains the autonomous nuclear oscillations and bypassing observed in A. gossypii hyphae...
  22. pmc Structural mutants of the spindle pole body cause distinct alteration of cytoplasmic microtubules and nuclear dynamics in multinucleated hyphae
    Claudia Lang
    Department of Molecular Microbiology, Biozentrum University of Basel, Basel, Switzerland
    Mol Biol Cell 21:753-66. 2010
    ..Our electron microscopy ultrastructural analysis also indicated that assembly of the OP occurs in a stepwise manner, starting with AgCnm67, followed by AgNud1 and lastly AgSpc72...
  23. ncbi request reprint Functional profiling of the Saccharomyces cerevisiae genome
    Guri Giaever
    Stanford Genome Technology Center, Stanford University, Palo Alto, California 94304, USA
    Nature 418:387-91. 2002
    ..Our results validate the yeast gene-deletion collection as a valuable resource for functional genomics...
  24. ncbi request reprint An IQGAP-related protein, encoded by AgCYK1, is required for septation in the filamentous fungus Ashbya gossypii
    JURGEN WENDLAND
    Department of Microbiology, Friedrich Schiller University, Winzerlaer Str 10, Jena, Germany
    Fungal Genet Biol 37:81-8. 2002
    ..gossypii. AgCyk1p-GFP localizes to sites of future septation as a ring prior to chitin depositioning. Furthermore, decrease in Cyk1p-ring diameter was found to be a prerequisite for the accumulation of chitin and septum formation...
  25. ncbi request reprint Molecular basis for the functional interaction of dynein light chain with the nuclear-pore complex
    Philipp Stelter
    Biochemie Zentrum der Universität Heidelberg BZH, Im Neuenheimer Feld 328, D 69120 Heidelberg, Germany
    Nat Cell Biol 9:788-96. 2007
    ..Thus, it is possible that dynein light chain plays a role in organizing natively unfolded Phe-Gly repeats within the NPC scaffold to facilitate nucleocytoplasmic transport...
  26. ncbi request reprint Contribution of the endoplasmic reticulum to peroxisome formation
    Dominic Hoepfner
    Department of Cellular Protein Chemistry, University of Utrecht, Padualaan 8, NL 3548 CH Utrecht, The Netherlands
    Cell 122:85-95. 2005
    ..This trafficking route of Pex3-YFP is the same in wild-type cells. These results demonstrate that peroxisomes are generated from domains in the ER...
  27. ncbi request reprint Asymmetric recruitment of dynein to spindle poles and microtubules promotes proper spindle orientation in yeast
    Sandrine Grava
    Institute of Biochemistry, Biology Department, Swiss Federal Institute of Technology, ETH Zurich, 8093 Zurich, Switzerland
    Dev Cell 10:425-39. 2006
    ..Together, our data indicate that proper orientation of the spindle requires dynein to act on a single spindle pole...