Research Topics
Genomes and Genes | N PerroudSummaryAffiliation: University Hospital Country: Switzerland Publications
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Publications
Response to psychotherapy in borderline personality disorder and methylation status of the BDNF geneN Perroud
Department of Psychiatry, University of Geneva, Chene Bourg, Switzerland
Transl Psychiatry 3:e207. 2013..These results moreover support the idea that these epigenetic marks may be changed through psychotherapeutic approaches and that these changes underline changes in cognitive functions...
Temperament personality profiles in suicidal behaviour: an investigation of associated demographic, clinical and genetic factorsNader Perroud
Department of Psychiatry, School of Medicine, University of Geneva, Geneva, Switzerland
J Affect Disord 146:246-53. 2013..Cloninger's model of personality (TCI), given its neurobiological background, might provide an ideal tool for the identification of dimensions associated with suicide attempt...
Mindfulness skills in borderline personality disorder patients during dialectical behavior therapy: preliminary resultsNader Perroud
Department of Psychiatry and Mental Health, University Hospitals of Geneva, Geneva, Switzerland
Int J Psychiatry Clin Pract 16:189-96. 2012..In this study, we investigated changes in and correlates of mindfulness skills over a 1-year follow-up including a 4-week session of intensive DBT followed by 10 months of standard DBT...
Increased methylation of glucocorticoid receptor gene (NR3C1) in adults with a history of childhood maltreatment: a link with the severity and type of traumaN Perroud
Department of Psychiatry, University of Geneva, Chene Bourg, Switzerland
Transl Psychiatry 1:e59. 2011..These findings suggest that early life events may permanently impact on the HPA axis though epigenetic modifications of the NR3C1. This is a mechanism by which childhood maltreatment may lead to adulthood psychopathology...
Functions and timescale of self-cutting in participants suffering from borderline personality disorderNader Perroud
Department of Psychiatry, Division of Adult Psychiatry, Rue du 31 Décembre 8, Geneva, Switzerland
J Pers Disord 26:267-79. 2012..In conclusion, self-cuttings can be reasonably addressed by self-report. Attention to specific issues such as intent to die and the time of the self-cuttings may improve the outcome of these particularly high-risk subjects...
Genome-wide association study of increasing suicidal ideation during antidepressant treatment in the GENDEP projectN Perroud
MRC Social, Genetic and Developmental Psychiatry Centre, Institute of Psychiatry, King s College London, London, UK
Pharmacogenomics J 12:68-77. 2012..Limited power precludes definitive conclusions and replication in larger sample is warranted...
Suicidal ideation during antidepressant treatment: do genetic predictors exist?Nader Perroud
Department of Psychiatry, University Hospitals of Geneva, Geneva, Switzerland
CNS Drugs 25:459-71. 2011..This should therefore encourage them to prescribe antidepressant medication even in patients with suicidal ideation...
Clinical and genetic correlates of suicidal ideation during antidepressant treatment in a depressed outpatient sampleNader Perroud
Department of Psychiatry, University Hospitals of Geneva, Geneva, Switzerland
Pharmacogenomics 12:365-77. 2011..This study investigated clinical and genetic predictors of increasing suicidal ideation during antidepressant treatment...
Predictors of response and drop-out during intensive dialectical behavior therapyNader Perroud
Department of Psychiatry, University of Geneva, Geneva, Switzerland
J Pers Disord 24:634-50. 2010..A discussion on the usefulness of a second course of treatment should be held with patients and staff as it was not effective in reducing depression and hopelessness...
COMT but not serotonin-related genes modulates the influence of childhood abuse on anger traitsN Perroud
Department of Psychiatry, University of Geneva, Hôpital Belle Idée, Geneva, Switzerland
Genes Brain Behav 9:193-202. 2010..This study was carried out in a population with a high frequency of childhood abuse and a high disposition toward anger, and replication in healthy subjects is needed...
Suicidal ideation during treatment of depression with escitalopram and nortriptyline in genome-based therapeutic drugs for depression (GENDEP): a clinical trialNader Perroud
MRC SGDP Centre, Institute of Psychiatry at King s College London, UK
BMC Med 7:60. 2009..The aim of the present study is to investigate the course and predictors of emergence and worsening of suicidal ideation during tricyclic antidepressant and serotonin reuptake inhibitor treatment...
History of suicide attempts among patients with depression in the GENDEP projectNader Perroud
MRC SGDP Centre, Institute of Psychiatry at King s College London, SE5 8AF, London, United Kingdom
J Affect Disord 123:131-7. 2010..We investigated clinical and demographic characteristics associated with SA and tested the hypothesis that a history of suicide attempts predicts poor response to antidepressants...
Interaction between BDNF Val66Met and childhood trauma on adult's violent suicide attemptN Perroud
Department of Psychiatry, University Hospital of Geneva, Switzerland
Genes Brain Behav 7:314-22. 2008..It is proposed that childhood sexual abuse elicits brain structural modifications through BDNF dysfunction and enhances the risk of violent SB in adulthood...
Modulation of anger control in suicide attempters by TPH-1P Baud
Department of Psychiatry, University Hospital of Geneva, Geneva, Switzerland
Genes Brain Behav 8:97-100. 2009....
Association of AKT1 gene variants and protein expression in both schizophrenia and bipolar disorderF Karege
Department of Medical Genetics and Laboratory, Geneva University Hospitals and Geneva University, Chene Bourg, Switzerland
Genes Brain Behav 9:503-11. 2010....
CREB1 modulates the influence of childhood sexual abuse on adult's anger traitsR Hasler
Department of Psychiatry, University of Geneva, Geneva, Switzerland
Genes Brain Behav 11:720-6. 2012..This is, to our knowledge, the first study to show such an interaction and to highlight the main effect of this gene on modulating the effect of child abuse on psychopathologies and warrant further investigation on this topic...
Increasing self-esteem: efficacy of a group intervention for individuals with severe mental disordersL Borras
University Hospitals of Geneva, Department of Psychiatry, Division of Adult Psychiatry, Secteur 1 Eaux Vives, Rue du XXXI Décembre 36, 1207 Geneva, Switzerland
Eur Psychiatry 24:307-16. 2009..This study aimed at assessing the efficacy of a self-esteem enhancement program for individuals with severe mental illness and at analyzing the results in their European context...
The genetics of affective disorder and suicideP McGuffin
MRC Social Genetic and Developmental Psychiatry Centre, Institute of Psychiatry, King s College London, DeCrespigny Park, London SE5 8AF, United Kingdom
Eur Psychiatry 25:275-7. 2010..The GWAS approach is also beginning to be applied in the search for genes that underlie suicidal ideation and behaviour...
