Genomes and Genes
Affiliation: University of Zurich
- Lost in the jungle: new hurdles for optic nerve axon regenerationVincent Pernet
Brain Research Institute, University of Zurich, and Department of Health Sciences and Technology, ETH Zurich, Winterthurerstrasse 190, CH 8057 Zurich, Switzerland Electronic address
Trends Neurosci 37:381-7. 2014..We propose that a balanced growth stimulatory treatment will have to be combined with guidance factors and suppression of local growth inhibitory factors to obtain the full regeneration of long CNS axonal tracts. ..
- Misguidance and modulation of axonal regeneration by Stat3 and Rho/ROCK signaling in the transparent optic nerveV Pernet
Brain Research Institute, University of Zürich and Department of Health Sciences and Technology, ETH Zurich, Zurich, Switzerland
Cell Death Dis 4:e734. 2013..The correction of axonal misguidance was associated with improved long-distance axon regeneration in the injured adult CNS. ..
- Long-distance axonal regeneration induced by CNTF gene transfer is impaired by axonal misguidance in the injured adult optic nerveVincent Pernet
Brain Research Institute, University of Zurich, and Dept of Health Sciences and Technology, ETH Zurich, Winterthurerstrasse 190, CH 8057 Zurich, Switzerland
Neurobiol Dis 51:202-13. 2013....
- The role of Nogo-A in axonal plasticity, regrowth and repairVincent Pernet
Brain Research Institute, University of Zürich ETH, Department of Health Sciences and Technology ETH Zürich, Winterthurerstrasse 190, Room 55J34a, 8057 Zurich, Switzerland
Cell Tissue Res 349:97-104. 2012..Function-blocking anti-Nogo-A antibodies are currently being tested in a clinical trial for improved outcome after spinal cord injury...
- Nogo-A and myelin-associated glycoprotein differently regulate oligodendrocyte maturation and myelin formationVincent Pernet
Department of Biology, Brain Research Institute, University of Zurich, Swiss Federal Institute of Technology, CH 8057 Zurich, Switzerland
J Neurosci 28:7435-44. 2008..Together, our results demonstrate that Nogo-A and MAG are differently involved in oligodendrocyte maturation in vivo, and suggest that Nogo-A may influence also remyelination in pathological conditions such as multiple sclerosis...
- The Ephrin receptor EphA4 restricts axonal sprouting and enhances branching in the injured mouse optic nerveSandrine Joly
Brain Research Institute, University of Zurich, Winterthurerstrasse 190, Zurich, CH 8057, Switzerland Department of Health Sciences and Technology, ETH Zurich, Zurich, Switzerland
Eur J Neurosci 40:3021-31. 2014..In summary, our three-dimensional analysis of injured mouse optic nerves reveals beneficial effects of EphA4 ablation on the intensity and the pattern of optic nerve axon regeneration. ..
- New mouse retinal stroke model reveals direction-selective circuit damage linked to permanent optokinetic response lossSandrine Joly
Brain Research Institute, University of Zurich, and Department of Health Sciences and Technology, ETH Zurich, Zurich, Switzerland
Invest Ophthalmol Vis Sci 55:4476-89. 2014..Ischemic insults give rise to severe visual deficits after blood vessel occlusion. In this study we investigated the effects of retinal stroke on the direction-selective circuit of the inner retina in a new adult mouse model...
- Nogo-A is a negative regulator of CNS angiogenesisThomas Wälchli
Brain Research Institute, University of Zurich, CH 8057 Zurich, Switzerland
Proc Natl Acad Sci U S A 110:E1943-52. 2013..These findings identify Nogo-A as an important negative regulator of developmental angiogenesis in the CNS. They may have important implications in CNS pathologies involving angiogenesis such as stroke, brain tumors, and retinopathies...
- Pax6-positive Müller glia cells express cell cycle markers but do not proliferate after photoreceptor injury in the mouse retinaSandrine Joly
Laboratory for Retinal Cell Biology, Department of Ophthalmology, University of Zurich, Switzerland
Glia 59:1033-46. 2011..Our results suggest that a release of the S-phase blockade may be crucial for Müller cells to successfully transdifferentiate and replace injured photoreceptors in mammals...
- The sphingolipid receptor S1PR2 is a receptor for Nogo-a repressing synaptic plasticityAnissa Kempf
Brain Research Institute, University of Zurich, and Dept of Health Sciences and Technology, Swiss Federal Institute of Technology, Zurich, Switzerland
PLoS Biol 12:e1001763. 2014..Elucidating Nogo-A/S1PR2 signaling platforms will provide new insights into regulation of synaptic plasticity. ..
- Neuroprotection in the juvenile rat model of light-induced retinopathy: evidence suggesting a role for FGF-2 and CNTFSandrine Joly
Departments of Biological Sciences, University of Montreal, Quebec, Canada
Invest Ophthalmol Vis Sci 48:2311-20. 2007..The purpose of the present study was to investigate the cellular and molecular mechanisms underlying this endogenous resistance to light-induced damage...
- Light-induced retinopathy: comparing adult and juvenile ratsSandrine Joly
Department of Biological Sciences, University of Montreal, and Department of Ophthalmology, McGill University Montreal Children s Hospital Research Institute, Quebec, Canada
Invest Ophthalmol Vis Sci 47:3202-12. 2006..To investigate the effect of chronic exposure to a bright, luminous environment, starting at the opening of the eyes, on the retinal structure and function of the suckling rat...
- Synergistic action of brain-derived neurotrophic factor and lens injury promotes retinal ganglion cell survival, but leads to optic nerve dystrophy in vivoVincent Pernet
Department of Pathology and Cell Biology, Universite de Montreal, Montreal, Quebec, Canada
Brain 129:1014-26. 2006..We propose that loss of axonal integrity may limit neuronal recovery in the injured, adult CNS...