L Pellerin

Summary

Affiliation: University of Lausanne
Country: Switzerland

Publications

  1. ncbi Activity-dependent regulation of energy metabolism by astrocytes: an update
    Luc Pellerin
    Departement de Physiologie, Universite de Lausanne, Switzerland
    Glia 55:1251-62. 2007
  2. ncbi Role of neuron-glia interaction in the regulation of brain glucose utilization
    L Pellerin
    Institut de Physiologie, , Lausanne, Switzerland
    Diabetes Nutr Metab 15:268-73; discussion 273. 2002
  3. ncbi Neuroenergetics: calling upon astrocytes to satisfy hungry neurons
    Luc Pellerin
    Institut de Physiologie, Universite de Lausanne, Switzerland
    Neuroscientist 10:53-62. 2004
  4. ncbi How to balance the brain energy budget while spending glucose differently
    Luc Pellerin
    Institut de Physiologie, Universite de Lausanne, 1005 Lausanne, Switzerland
    J Physiol 546:325. 2003
  5. ncbi Food for thought: challenging the dogmas
    Luc Pellerin
    Institut de Physiologie, , Switzerland
    J Cereb Blood Flow Metab 23:1282-6. 2003
  6. ncbi Neuroscience. Let there be (NADH) light
    Luc Pellerin
    Institut de Physiologie, 1005 Lausanne, Switzerland
    Science 305:50-2. 2004
  7. ncbi Lactate as a pivotal element in neuron-glia metabolic cooperation
    Luc Pellerin
    Institut de Physiologie, 7 rue du Bugnon, 1005 Lausanne, Switzerland
    Neurochem Int 43:331-8. 2003
  8. ncbi Expression of monocarboxylate transporter mRNAs in mouse brain: support for a distinct role of lactate as an energy substrate for the neonatal vs. adult brain
    L Pellerin
    Institut de Physiologie et Laboratoire de Recherche du Service de Neurologie du Centre Hospitalier Universitaire Vaudois, Faculte de Medecine, Universite de Lausanne, 7 rue du Bugnon, 1005 Lausanne, Switzerland
    Proc Natl Acad Sci U S A 95:3990-5. 1998
  9. ncbi Evidence supporting the existence of an activity-dependent astrocyte-neuron lactate shuttle
    L Pellerin
    Institut de Physiologie, Universite de Lausanne, Switzerland
    Dev Neurosci 20:291-9. 1998
  10. ncbi How astrocytes feed hungry neurons
    Luc Pellerin
    Departement de Physiologie, Universite de Lausanne, Switzerland
    Mol Neurobiol 32:59-72. 2005

Collaborators

Detail Information

Publications64

  1. ncbi Activity-dependent regulation of energy metabolism by astrocytes: an update
    Luc Pellerin
    Departement de Physiologie, Universite de Lausanne, Switzerland
    Glia 55:1251-62. 2007
    ....
  2. ncbi Role of neuron-glia interaction in the regulation of brain glucose utilization
    L Pellerin
    Institut de Physiologie, , Lausanne, Switzerland
    Diabetes Nutr Metab 15:268-73; discussion 273. 2002
  3. ncbi Neuroenergetics: calling upon astrocytes to satisfy hungry neurons
    Luc Pellerin
    Institut de Physiologie, Universite de Lausanne, Switzerland
    Neuroscientist 10:53-62. 2004
    ..Recent data have revealed a more intricate picture in which astrocytes play a key role in supplying lactate as an additional energy substrate in register with glutamatergic activity...
  4. ncbi How to balance the brain energy budget while spending glucose differently
    Luc Pellerin
    Institut de Physiologie, Universite de Lausanne, 1005 Lausanne, Switzerland
    J Physiol 546:325. 2003
  5. ncbi Food for thought: challenging the dogmas
    Luc Pellerin
    Institut de Physiologie, , Switzerland
    J Cereb Blood Flow Metab 23:1282-6. 2003
  6. ncbi Neuroscience. Let there be (NADH) light
    Luc Pellerin
    Institut de Physiologie, 1005 Lausanne, Switzerland
    Science 305:50-2. 2004
  7. ncbi Lactate as a pivotal element in neuron-glia metabolic cooperation
    Luc Pellerin
    Institut de Physiologie, 7 rue du Bugnon, 1005 Lausanne, Switzerland
    Neurochem Int 43:331-8. 2003
    ..Thus, lactate is emerging as a valuable intercellular exchange molecule in different systems including the brain where it might be an essential element of neuron-glia metabolic interactions...
  8. ncbi Expression of monocarboxylate transporter mRNAs in mouse brain: support for a distinct role of lactate as an energy substrate for the neonatal vs. adult brain
    L Pellerin
    Institut de Physiologie et Laboratoire de Recherche du Service de Neurologie du Centre Hospitalier Universitaire Vaudois, Faculte de Medecine, Universite de Lausanne, 7 rue du Bugnon, 1005 Lausanne, Switzerland
    Proc Natl Acad Sci U S A 95:3990-5. 1998
    ....
  9. ncbi Evidence supporting the existence of an activity-dependent astrocyte-neuron lactate shuttle
    L Pellerin
    Institut de Physiologie, Universite de Lausanne, Switzerland
    Dev Neurosci 20:291-9. 1998
    ..This set of data is consistent with the existence of an activity-dependent astrocyte-neuron lactate shuttle for the supply of energy substrates to neurons...
  10. ncbi How astrocytes feed hungry neurons
    Luc Pellerin
    Departement de Physiologie, Universite de Lausanne, Switzerland
    Mol Neurobiol 32:59-72. 2005
    ....
  11. ncbi Cellular mechanisms of brain energy metabolism and their relevance to functional brain imaging
    P J Magistretti
    Institut de Physiologie, Faculte de Medecine, Lausanne, Switzerland
    Philos Trans R Soc Lond B Biol Sci 354:1155-63. 1999
    ..This conclusion does not question the validity of the 2-DG-based techniques, rather it provides a cellular and molecular basis for these functional brain imaging techniques...
  12. ncbi Cell-specific localization of monocarboxylate transporters, MCT1 and MCT2, in the adult mouse brain revealed by double immunohistochemical labeling and confocal microscopy
    K Pierre
    Institut de Physiologie, Rue du Bugnon 7, 1005, Lausanne, Switzerland
    Neuroscience 100:617-27. 2000
    ..In conclusion, these observations are consistent with the possibility that lactate, produced and released by astrocytes (via MCT1), could be taken up (via MCT2) and used by neurons as an energy substrate...
  13. ncbi Glycogen metabolism as a marker of astrocyte differentiation
    J F Brunet
    Neurosurgery Research Group, CHUV FBM UNIL, Lausanne, Switzerland
    J Cereb Blood Flow Metab 30:51-5. 2010
    ..These results show that glycogen metabolism constitutes a useful marker of astrocyte differentiation...
  14. ncbi [Functional brain imaging: role metabolic coupling between astrocytes and neurons]
    P J Magistretti
    Institut de Physiologie, Faculte de Medecine, Universite de Lausanne
    Rev Med Suisse Romande 120:739-42. 2000
    ..These data support the notion that astrocytes markedly contribute to the FDG-PET signal...
  15. ncbi Enhanced expression of three monocarboxylate transporter isoforms in the brain of obese mice
    Karin Pierre
    Departement de Physiologie, Universite de Lausanne, Lausanne, Switzerland
    J Physiol 583:469-86. 2007
    ..This observation could be relevant in the context of obesity development and its consequences for brain function...
  16. ncbi A2B receptor activation promotes glycogen synthesis in astrocytes through modulation of gene expression
    Igor Allaman
    Institut de Physiologie, , , Switzerland
    Am J Physiol Cell Physiol 284:C696-704. 2003
    ....
  17. ncbi MCT2 is a major neuronal monocarboxylate transporter in the adult mouse brain
    Karin Pierre
    Institut de Physiologie, 7 rue du Bugnon, 1005 Lausanne, Switzerland
    J Cereb Blood Flow Metab 22:586-95. 2002
    ....
  18. ncbi Food for thought: the importance of glucose and other energy substrates for sustaining brain function under varying levels of activity
    L Pellerin
    Department of Physiology, University of Lausanne, Lausanne, Switzerland
    Diabetes Metab 36:S59-63. 2010
    ....
  19. ncbi Brain-derived neurotrophic factor enhances the expression of the monocarboxylate transporter 2 through translational activation in mouse cultured cortical neurons
    Camille Robinet
    Department of Physiology, University of Lausanne, Lausanne, Switzerland
    J Cereb Blood Flow Metab 30:286-98. 2010
    ..Moreover, our observations suggest that changes in MCT2 expression could participate in the process of synaptic plasticity induced by BDNF...
  20. ncbi Noradrenaline enhances monocarboxylate transporter 2 expression in cultured mouse cortical neurons via a translational regulation
    Karin Pierre
    Institut de Physiologie, Lausanne, Switzerland
    J Neurochem 86:1468-76. 2003
    ..These results suggest that regulation of MCT2 expression in neurons by NA occurs at the translational level despite the requirement for an as yet unknown transcriptional step...
  21. ncbi The contribution of astrocytes to the 18F-2-deoxyglucose signal in PET activation studies
    P J Magistretti
    Laboratoire de Recherche Neurologique, Institut de Physiologie et Service de Neurologie du CHUV, Faculte de Medecine, Universite de Lausanne, Switzerland
    Mol Psychiatry 1:445-52. 1996
    ..These data support the notion that astrocytes markedly contribute to the FDG-PET signal. This perspective may also provide renewed insights for the interpretation of FDG-PET studies in psychiatric disorders...
  22. ncbi Early acquisition of typical metabolic features upon differentiation of mouse neural stem cells into astrocytes
    J F Brunet
    Service of Neurosurgery, CHUV, Lausanne, Switzerland
    Glia 46:8-17. 2004
    ..Altogether, our results show that acquisition of some specific metabolic features by astrocytes occurs early in their differentiation process and that LIF represents a candidate signal to induce their expression...
  23. ncbi Focal cerebral ischaemia induces a decrease in activity and a shift in ouabain affinity of Na+, K+-ATPase isoforms without modifications in mRNA and protein expression
    I Jamme
    University of Caen, UMR 6551 CNRS, Laboratory of Neurosciences, Bd H Becquerel, BP 5229, 14074, Caen Cedex, France
    Brain Res 819:132-42. 1999
    ..Surprisingly, no modifications in protein and mRNA expression of any alpha or beta isoforms of the enzyme were observed, thus suggesting that ischaemia could induce intrinsic modifications of the Na+, K+-ATPase...
  24. ncbi Unusual astrocyte reactivity caused by the food mycotoxin ochratoxin A in aggregating rat brain cell cultures
    M G Zurich
    Department of Physiology, University of Lausanne, Rue du Bugnon 7, CH 1005 Lausanne, Switzerland
    Neuroscience 134:771-82. 2005
    ..Furthermore, these results suggest that, by inducing an atypical glial reactivity, OTA may severely affect the neuroprotective capacity of glial cells...
  25. ncbi Cell-specific expression pattern of monocarboxylate transporters in astrocytes and neurons observed in different mouse brain cortical cell cultures
    Ruth Debernardi
    Institut de Physiologie, Lausanne, Switzerland
    J Neurosci Res 73:141-55. 2003
    ..In addition to providing an extensive description of MCT distribution in cultured cells, our data underscore the potential of such preparations for future studies on the regulation of MCT expression...
  26. ncbi Ampakine CX546 bolsters energetic response of astrocytes: a novel target for cognitive-enhancing drugs acting as alpha-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid (AMPA) receptor modulators
    Luc Pellerin
    Department of Physiology, University of Lausanne, 7 rue du Bugnon, 1005 Lausanne, Switzerland
    J Neurochem 92:668-77. 2005
    ..Our data suggest that astrocyte energetics represents a novel target for cognitive-enhancing drugs acting as AMPA receptor modulators...
  27. ncbi Cellular and subcellular distribution of monocarboxylate transporters in cultured brain cells and in the adult brain
    Luc Pellerin
    Department of Physiology, University of Lausanne, 7 rue du Bugnon, 1005 Lausanne, Switzerland
    J Neurosci Res 79:55-64. 2005
    ....
  28. ncbi Brain lactate kinetics: Modeling evidence for neuronal lactate uptake upon activation
    Agnès Aubert
    Departement de Physiologie, Universite de Lausanne, 1005 Lausanne, Switzerland
    Proc Natl Acad Sci U S A 102:16448-53. 2005
    ....
  29. ncbi Expression of the monocarboxylate transporter MCT1 in the adult human brain cortex
    Oriana Chiry
    Departement de Physiologie, Universite de Lausanne, Rue du Bugnon 7, 1005 Lausanne, Switzerland
    Brain Res 1070:65-70. 2006
    ..Moreover, the distinct laminar pattern of MCT1 expression between primary and non-primary cortical areas may reflect different types of neuronal activity requiring adequate supply of specific energy substrates...
  30. ncbi Regulation of the intracellular distribution, cell surface expression, and protein levels of AMPA receptor GluR2 subunits by the monocarboxylate transporter MCT2 in neuronal cells
    Fumihiko Maekawa
    Department of Physiology, University of Lausanne, Lausanne, Switzerland
    J Neurochem 109:1767-78. 2009
    ..These results suggest that MCT2 could influence AMPA receptor trafficking within neurons by modulating GluR2 sorting between different subcellular compartments...
  31. ncbi Linking supply to demand: the neuronal monocarboxylate transporter MCT2 and the alpha-amino-3-hydroxyl-5-methyl-4-isoxazole-propionic acid receptor GluR2/3 subunit are associated in a common trafficking process
    Karin Pierre
    Departement de Physiologie, Universite de Lausanne, 7 rue du Bugnon, CH 1005 Lausanne, Switzerland
    Eur J Neurosci 29:1951-63. 2009
    ..MCT2 emerges as a novel component of the synaptic machinery putatively linking neuroenergetics to synaptic transmission...
  32. ncbi Brain energetics (thought needs food)
    Luc Pellerin
    Departement de Physiologie, Universite de Lausanne, Lausanne, Switzerland
    Curr Opin Clin Nutr Metab Care 11:701-5. 2008
    ..Recent developments have provided further evidence for its validity and have extended its application to different areas of neuroscience...
  33. ncbi A coherent neurobiological framework for functional neuroimaging provided by a model integrating compartmentalized energy metabolism
    Agnès Aubert
    Departement de Physiologie, Universite de Lausanne, 1005 Lausanne, Switzerland
    Proc Natl Acad Sci U S A 104:4188-93. 2007
    ..In summary, our results, obtained with such a modeling approach, support the concept that both neuronal and glial metabolic responses form essential components of neuroimaging signals...
  34. ncbi Glucocorticoids modulate neurotransmitter-induced glycogen metabolism in cultured cortical astrocytes
    Igor Allaman
    Institut de Physiologie, Faculte de Medecine, Universite de Lausanne, 1005 Lausanne, Switzerland
    J Neurochem 88:900-8. 2004
    ..These results suggest that GC could have a significant influence on neuroenergetics as they could modulate activity-related changes in brain glycogen metabolism...
  35. ncbi Noradrenaline enhances the expression of the neuronal monocarboxylate transporter MCT2 by translational activation via stimulation of PI3K/Akt and the mTOR/S6K pathway
    Julie Chenal
    Departement de Physiologie, Universite de Lausanne, Lausanne, Switzerland
    J Neurochem 102:389-97. 2007
    ..Moreover, considering the role of NA in synaptic plasticity, alterations in MCT2 expression as described in this study might represent an adaptation to face energy demands associated with enhanced synaptic transmission...
  36. ncbi Metabolic compartmentalization in the human cortex and hippocampus: evidence for a cell- and region-specific localization of lactate dehydrogenase 5 and pyruvate dehydrogenase
    Jocelyn D Laughton
    Department of Psychiatry, Service of Neuropsychiatry, University Hospitals of Geneva, Belle Idee, Switzerland
    BMC Neurosci 8:35. 2007
    ..1.1.27) that catalyses the interconversion of lactate and pyruvate and the pyruvate dehydrogenase complex that irreversibly funnels pyruvate towards the mitochondrial TCA and oxydative phosphorylation...
  37. ncbi GABA uptake into astrocytes is not associated with significant metabolic cost: implications for brain imaging of inhibitory transmission
    Jean Yves Chatton
    Institute of Physiology, Centre Hospitalier Universitaire Vaudois, University of Lausanne Medical School, 1005 Lausanne, Switzerland
    Proc Natl Acad Sci U S A 100:12456-61. 2003
    ....
  38. ncbi Brain-derived neurotrophic factor enhances the hippocampal expression of key postsynaptic proteins in vivo including the monocarboxylate transporter MCT2
    C Robinet
    Department of Physiology, University of Lausanne, 7 rue du Bugnon, CH 1005 Lausanne, Switzerland
    Neuroscience 192:155-63. 2011
    ....
  39. ncbi Astrocytes as a predominant cellular site of (99m)Tc-HMPAO retention
    S Zerarka
    Institute of Physiology, University of Lausanne, Lausanne, Switzerland
    J Cereb Blood Flow Metab 21:456-68. 2001
    ..In addition, the data also suggest that specific alterations in glial cell metabolism could explain flow-independent changes in (99m)Tc-HMPAO retention in the brain as observed by SPECT in some pathologies...
  40. ncbi Basal and stimulated lactate fluxes in primary cultures of astrocytes are differentially controlled by distinct proteins
    Fumihiko Maekawa
    Department of Physiology, University of Lausanne, Lausanne, Switzerland
    J Neurochem 107:789-98. 2008
    ..In contrast, basigin appears to critically regulate the enhancement of lactate release caused by glutamate (or sodium azide) but via an effect on another unidentified transporter at least present in astrocytes in vitro...
  41. ncbi Insulin and IGF-1 enhance the expression of the neuronal monocarboxylate transporter MCT2 by translational activation via stimulation of the phosphoinositide 3-kinase-Akt-mammalian target of rapamycin pathway
    Julie Chenal
    Department of Physiology, Universite de Lausanne, 7 rue du Bugnon, 1005 Lausanne, Switzerland
    Eur J Neurosci 27:53-65. 2008
    ....
  42. ncbi Enhanced cerebral expression of MCT1 and MCT2 in a rat ischemia model occurs in activated microglial cells
    Tiago J T P Moreira
    Department of Physiology, University of Lausanne, Lausanne, Switzerland
    J Cereb Blood Flow Metab 29:1273-83. 2009
    ..Overall, our study indicates that changes in MCT expression around and also away from the ischemic area, both at the mRNA and protein levels, are a part of the metabolic adaptations taking place in the brain after ischemia...
  43. ncbi Feeding active neurons: (re)emergence of a nursing role for astrocytes
    Anne Karine Bouzier-Sore
    Institut de Physiologie, 7 rue du Bugnon, 1005 Lausanne, Switzerland
    J Physiol Paris 96:273-82. 2002
    ..The importance of this metabolic cooperation within the central nervous system, although not unique if compared to other organs, still remains to be explored...
  44. ncbi Long-term modulation of glucose utilization by IL-1 alpha and TNF-alpha in astrocytes: Na+ pump activity as a potential target via distinct signaling mechanisms
    Céline Véga
    Institut de Physiologie, Lausanne, Switzerland
    Glia 39:10-8. 2002
    ..These data suggest that Na(+) pump activity is a common target for both the long-term metabolic action of cytokines promoted by the activation of distinct signaling pathways and the enhanced metabolic response to glutamate...
  45. ncbi A novel method for in vitro production of human glial-like cells from neurosurgical resection tissue
    Jean Francois Brunet
    Department of Neurosurgery, Lausanne and Geneva University Medical School, Lausanne, Switzerland
    Lab Invest 82:809-12. 2002
  46. ncbi Quantitative rt-PCR analysis of uncoupling protein isoforms in mouse brain cortex: methodological optimization and comparison of expression with brown adipose tissue and skeletal muscle
    Sylvain Lengacher
    Institut de Physiologie, , Switzerland
    J Cereb Blood Flow Metab 24:780-8. 2004
    ..These data provide a first quantitative assessment of UCP mRNA expression in mouse brain, showing the presence of all five isoforms with distinct proportions, thus suggesting specific roles in the central nervous system...
  47. ncbi Monocarboxylate transporters in the central nervous system: distribution, regulation and function
    Karin Pierre
    , , Switzerland
    J Neurochem 94:1-14. 2005
    ....
  48. ncbi Metabolic activation pattern of distinct hippocampal subregions during spatial learning and memory retrieval
    Jacqueline Ros
    Department of Physiology, University of Lausanne, Lausanne, Switzerland
    J Cereb Blood Flow Metab 26:468-77. 2006
    ....
  49. ncbi Cryopreservation of human brain tissue allowing timely production of viable adult human brain cells for autologous transplantation
    Jean Francois Brunet
    Department of Neurosurgery of Lausanne and Geneva University Medical School, Bugnon 46, 1011, Lausanne, Switzerland
    Cryobiology 47:179-83. 2003
    ..A major obstacle is the capacity to produce cells for transplantation at the appropriate time. We describe a cryopreservation procedure for adult human brain tissue allowing the generation of cells in vitro...
  50. ncbi Transfer of glycogen-derived lactate from astrocytes to axons via specific monocarboxylate transporters supports mouse optic nerve activity
    Selva Baltan Tekkök
    Department of Neurology, University of Washington School of Medicine, Seattle, Washington, USA
    J Neurosci Res 81:644-52. 2005
    ....
  51. ncbi Selective postsynaptic co-localization of MCT2 with AMPA receptor GluR2/3 subunits at excitatory synapses exhibiting AMPA receptor trafficking
    Linda Hildegard Bergersen
    Anatomical Institute, Centre for Molecular Biology and Neuroscience, University of Oslo, Blindern, Oslo, Norway
    Cereb Cortex 15:361-70. 2005
    ..Altogether, the data presented provide evidence for MCT2 expression in the postsynaptic density area at specific subsets of glutamatergic synapses, and also suggest that MCT2, like AMPA receptors, could undergo membrane trafficking...
  52. ncbi Does glutamate image your thoughts?
    Gilles Bonvento
    CEA CNRS URA 2210, Service Hospitalier Frédéric Joliot 4, place du General Leclerc, 91401 Orsay Cedex, France
    Trends Neurosci 25:359-64. 2002
    ..In this article we review the hypothesis that glutamate represents a common trigger for both neurometabolic and neurovascular coupling...
  53. ncbi Dual-gene, dual-cell type therapy against an excitotoxic insult by bolstering neuroenergetics
    Tonya M Bliss
    Department of Biological Sciences, Stanford University, Stanford, California 94305-5020, USA
    J Neurosci 24:6202-8. 2004
    ....
  54. ncbi [Is lactate a major energy substrate for neurons?]
    Robert Costalat
    Med Sci (Paris) 22:356-7. 2006
  55. ncbi Glial glutamate transporters mediate a functional metabolic crosstalk between neurons and astrocytes in the mouse developing cortex
    Brigitte Voutsinos-Porche
    CNRS FRE 2363, Paris, France
    Neuron 37:275-86. 2003
    ..These data suggest that a metabolic crosstalk takes place between neurons and astrocytes in the developing cortex, which would be regulated by synaptic activity and mediated by glial glutamate transporters...
  56. ncbi Competition between glucose and lactate as oxidative energy substrates in both neurons and astrocytes: a comparative NMR study
    Anne Karine Bouzier-Sore
    Centre de Résonance Magnétique des Systèmes Biologiques, UMR5536 CNRS University, 146 rue Leo Saignat, 33076 Bordeaux Cedex, France
    Eur J Neurosci 24:1687-94. 2006
    ....
  57. ncbi Immunocytochemical expression of monocarboxylate transporters in the human visual cortex at midgestation
    Laurence Fayol
    INSERM E9935, Hopital Robert Debre, 48, Bd Sérurier 75019, Paris, France
    Brain Res Dev Brain Res 148:69-76. 2004
    ..w.). These data suggest that lactate or other monocarboxylates could represent a significant energy source for the human visual cortex at this early stage...
  58. ncbi Differential energetic response of brain vs. skeletal muscle upon glycemic variations in healthy humans
    Kerstin M Oltmanns
    Department of Psychiatry and Psychotherapy, University of Luebeck, Ratzeburger Allee 160, 23538, Luebeck, Germany
    Am J Physiol Regul Integr Comp Physiol 294:R12-6. 2008
    ..A disturbance of these mechanisms may have far-reaching implications for metabolic dysregulation associated with obesity or diabetes mellitus...
  59. ncbi Lactate is a preferential oxidative energy substrate over glucose for neurons in culture
    Anne Karine Bouzier-Sore
    Centre de Résonance Magnétique des Systèmes Biologiques, UMR 5536 CNRS Université, Bordeaux, France
    J Cereb Blood Flow Metab 23:1298-306. 2003
    ..Results clearly indicate that when neurons are in the presence of both glucose and lactate, they preferentially use lactate as their main oxidative substrate...
  60. ncbi Making sense of AMPA receptor trafficking by modeling molecular mechanisms of synaptic plasticity
    Dirk Langemann
    Institute of Mathematics, University of Lubeck, Wallstr 40, D 23560 Lübeck, Germany
    Brain Res 1207:60-72. 2008
    ..Furthermore, we could show that the heteromeric combination of short- and long-tail AMPA receptor subunits fulfills the function of a memory tag...
  61. ncbi Increased expression of monocarboxylate transporters 1, 2, and 4 in colorectal carcinomas
    Celine Pinheiro
    Life and Health Sciences Research Institute, University of Minho, Campus de Gualtar, 4710 057, Braga, Portugal
    Virchows Arch 452:139-46. 2008
    ..The increased expression of these transporters suggests an important role in CRC, which might justify their use, especially MCT1 and MCT4, as targets in CRC drug therapy...
  62. ncbi Activation of astrocytes by CNTF induces metabolic plasticity and increases resistance to metabolic insults
    Carole Escartin
    Commissariat à l Energie Atomique Direction des Sciences du Vivant, Institut d Imagerie Biomédicale, Service Hospitalier Frederic Joliot, Centre National de la Recherche Scientifique, Unité de Recherche Associée 2210, 91401 Orsay, France
    J Neurosci 27:7094-104. 2007
    ..We conclude that CNTF-activated astrocytes may have a strong protective potential to face severe metabolic insults...
  63. ncbi Perinatal and early postnatal changes in the expression of monocarboxylate transporters MCT1 and MCT2 in the rat forebrain
    Olivier Baud
    Institut National de la Santé et de la Recherche Médicale E9935, Laboratoire de Neurologie du Développement, Hopital Robert Debre, 48 Boulevard Serurier, 75019 Paris, France
    J Comp Neurol 465:445-54. 2003
    ..The transient pattern of expression of MCTs throughout the perinatal period suggests a potential relationship with the maturation of the blood-brain barrier...
  64. ncbi Developmental and hormonal regulation of the monocarboxylate transporter 2 (MCT2) expression in the mouse germ cells
    Fayçal Boussouar
    Institut National pour la Santé et la Recherche Médicale INSERM U 407, Faculté de médecine Lyon Sud, Oullins Cedex, France
    Biol Reprod 69:1069-78. 2003
    ....