Andreas Papassotiropoulos

Summary

Affiliation: University of Zurich
Country: Switzerland

Publications

  1. ncbi Genetic polymorphism of cathepsin D is strongly associated with the risk for developing sporadic Alzheimer's disease
    A Papassotiropoulos
    Department of Psychiatry, University of Bonn, Germany
    Neurosci Lett 262:171-4. 1999
  2. ncbi Allelic association between the D10S1423 marker and Alzheimer's disease in a German population
    M Majores
    Department of Psychiatry, University of Bonn, Germany
    Neurosci Lett 289:224-6. 2000
  3. ncbi No association between an intronic biallelic polymorphism of the FE65 gene and Alzheimer's disease
    A Papassotiropoulos
    Department of Psychiatry Research, University of Zurich, CH 8029 Zurich, Switzerland
    Int J Mol Med 6:587-9. 2000
  4. ncbi A family study of Alzheimer disease and early- and late-onset depression in elderly patients
    R Heun
    Department of Psychiatry, University of Bonn, Venusberg, D 53105 Bonn, Germany
    Arch Gen Psychiatry 58:190-6. 2001
  5. ncbi Cerebrospinal fluid levels of beta-amyloid(42) in patients with Alzheimer's disease are related to the exon 2 polymorphism of the cathepsin D gene
    Andreas Papassotiropoulos
    Department of Psychiatry, University of Bonn, Sigmund Freud Str 25, 53105 Bonn, Germany
    Neuroreport 13:1291-4. 2002
  6. ncbi A cluster of cholesterol-related genes confers susceptibility for Alzheimer's disease
    Andreas Papassotiropoulos
    Division of Psychiatry Research, University of Zurich, Zurich, Switzerland
    J Clin Psychiatry 66:940-7. 2005
  7. pmc Genetics, transcriptomics, and proteomics of Alzheimer's disease
    Andreas Papassotiropoulos
    Division of Psychiatry Research, University of Zurich, Zurich, Switzerland
    J Clin Psychiatry 67:652-70. 2006
  8. ncbi Genetics of interleukin 6: implications for Alzheimer's disease
    A Papassotiropoulos
    Division of Psychiatry Research, University of Zurich, Switzerland
    Neurobiol Aging 22:863-71. 2001
  9. ncbi 24S-hydroxycholesterol in cerebrospinal fluid is elevated in early stages of dementia
    A Papassotiropoulos
    Department of Psychiatry, University of Bonn, Sigmund Freud Strasse 25, 53105, Bonn, Germany
    J Psychiatr Res 36:27-32. 2002
  10. ncbi The prion gene is associated with human long-term memory
    Andreas Papassotiropoulos
    Division of Psychiatry Research, University of Zurich, 8032 Zurich, Switzerland
    Hum Mol Genet 14:2241-6. 2005

Collaborators

Detail Information

Publications69

  1. ncbi Genetic polymorphism of cathepsin D is strongly associated with the risk for developing sporadic Alzheimer's disease
    A Papassotiropoulos
    Department of Psychiatry, University of Bonn, Germany
    Neurosci Lett 262:171-4. 1999
    ..The odds ratio for subjects with the apolipoprotein E epsilon 4 and the cathepsin D*T allele was 5.9. Our data suggest that the cathepsin D genotype is strongly associated with the risk for Alzheimer's disease...
  2. ncbi Allelic association between the D10S1423 marker and Alzheimer's disease in a German population
    M Majores
    Department of Psychiatry, University of Bonn, Germany
    Neurosci Lett 289:224-6. 2000
    ..033). In conclusion, our results support that the D10S1423 marker is associated with an increased AD risk and provides further evidence for an AD susceptibility locus on chromosome 10...
  3. ncbi No association between an intronic biallelic polymorphism of the FE65 gene and Alzheimer's disease
    A Papassotiropoulos
    Department of Psychiatry Research, University of Zurich, CH 8029 Zurich, Switzerland
    Int J Mol Med 6:587-9. 2000
    ..We conclude that, whereas FE65 is implicated in AD pathology, the gene encoding FE65 does not appear to confer a substantial risk for AD...
  4. ncbi A family study of Alzheimer disease and early- and late-onset depression in elderly patients
    R Heun
    Department of Psychiatry, University of Bonn, Venusberg, D 53105 Bonn, Germany
    Arch Gen Psychiatry 58:190-6. 2001
    ..The substantial symptomatic overlap between depression and dementia in old age may be explained by common genetic vulnerability factors...
  5. ncbi Cerebrospinal fluid levels of beta-amyloid(42) in patients with Alzheimer's disease are related to the exon 2 polymorphism of the cathepsin D gene
    Andreas Papassotiropoulos
    Department of Psychiatry, University of Bonn, Sigmund Freud Str 25, 53105 Bonn, Germany
    Neuroreport 13:1291-4. 2002
    ....
  6. ncbi A cluster of cholesterol-related genes confers susceptibility for Alzheimer's disease
    Andreas Papassotiropoulos
    Division of Psychiatry Research, University of Zurich, Zurich, Switzerland
    J Clin Psychiatry 66:940-7. 2005
    ..Polygenic diseases are related to the complex interplay of genetic variations. We evaluated whether clusters of cholesterol- and lipid-related genetic variations are associated with Alzheimer's disease...
  7. pmc Genetics, transcriptomics, and proteomics of Alzheimer's disease
    Andreas Papassotiropoulos
    Division of Psychiatry Research, University of Zurich, Zurich, Switzerland
    J Clin Psychiatry 67:652-70. 2006
    ....
  8. ncbi Genetics of interleukin 6: implications for Alzheimer's disease
    A Papassotiropoulos
    Division of Psychiatry Research, University of Zurich, Switzerland
    Neurobiol Aging 22:863-71. 2001
    ....
  9. ncbi 24S-hydroxycholesterol in cerebrospinal fluid is elevated in early stages of dementia
    A Papassotiropoulos
    Department of Psychiatry, University of Bonn, Sigmund Freud Strasse 25, 53105, Bonn, Germany
    J Psychiatr Res 36:27-32. 2002
    ..We believe that the CSF concentration of 24S-hydroxycholesterol is altered in AD-related neurodegeneration and thus, CSF 24S-hydroxycholesterol may be a marker for monitoring the onset and progression of the disease...
  10. ncbi The prion gene is associated with human long-term memory
    Andreas Papassotiropoulos
    Division of Psychiatry Research, University of Zurich, 8032 Zurich, Switzerland
    Hum Mol Genet 14:2241-6. 2005
    ..These results suggest a role for the prion protein in the formation of long-term memory in humans...
  11. ncbi Biochemical markers of Alzheimer's disease: wish and reality
    Andreas Papassotiropoulos
    Division of Psychiatry Research, University of Zurich, Switzerland
    Neurobiol Aging 23:513-4. 2002
  12. ncbi Age-dependent effects of the 5-hydroxytryptamine-2a-receptor polymorphism (His452Tyr) on human memory
    Andreas Papassotiropoulos
    Division of Psychiatry Research, University of Zurich, Lenggstr 31, 8029 Zurich, Switzerland
    Neuroreport 16:839-42. 2005
    ..In the group of elderly cognitively healthy participants, the His452Tyr genotype did not affect memory performance. We conclude that age strongly modulates the effect of the 5-HT2a receptor polymorphism at residue 452 on episodic memory...
  13. ncbi No association of a non-synonymous PLAU polymorphism with Alzheimer's disease and disease-related traits
    Andreas Papassotiropoulos
    Division of Psychiatry Research, University of Zurich, Lengstrasse 31, 8029 Zurich, Switzerland
    Am J Med Genet B Neuropsychiatr Genet 132:21-3. 2005
    ..Although PLAU may be pathophysiologially related to AD, the contribution of common genetic variants of this gene to the risk for developing AD is likely to be low...
  14. ncbi Increased brain beta-amyloid load, phosphorylated tau, and risk of Alzheimer disease associated with an intronic CYP46 polymorphism
    Andreas Papassotiropoulos
    Division of Pychiatry Research, University of Zurich, Switzerland
    Arch Neurol 60:29-35. 2003
    ..CYP46, the gene encoding cholesterol 24-hydroxylase, plays a key role in the hydroxylation of cholesterol and thereby mediates its removal from brain...
  15. ncbi Common Kibra alleles are associated with human memory performance
    Andreas Papassotiropoulos
    Division of Psychiatry Research, University of Zurich, Zurich 8057, Switzerland
    Science 314:475-8. 2006
    ..Functional magnetic resonance imaging detected KIBRA allele-dependent differences in hippocampal activations during memory retrieval. Evidence from these experiments suggests a role for KIBRA in human memory...
  16. ncbi Prion protein M129V polymorphism affects retrieval-related brain activity
    Andreas Buchmann
    Division of Psychiatry Research and Hospital for Psychogeriatric Medicine, University of Zurich, Minervastrasse 145, 8032 Zurich, Switzerland
    Neuropsychologia 46:2389-402. 2008
    ..Findings suggest that the prion protein Met129Val polymorphism affects neural plasticity following learning at a time-scale of minutes to hours...
  17. ncbi Cholesterol 25-hydroxylase on chromosome 10q is a susceptibility gene for sporadic Alzheimer's disease
    Andreas Papassotiropoulos
    Division of Psychiatry Research, University of Zurich, Zurich, Switzerland
    Neurodegener Dis 2:233-41. 2005
    ....
  18. ncbi A functional genetic variation of the 5-HT2a receptor affects human memory
    Dominique J F de Quervain
    Division of Psychiatry Research, University of Zurich, Lenggstr 31, 8029 Zurich, Switzerland
    Nat Neurosci 6:1141-2. 2003
    ..Therefore, we investigated a functional variation of a memory-related serotonin receptor in 349 healthy young volunteers, and found 21% poorer memory performance in subjects with the rare variant...
  19. ncbi Ethnicity-dependent genetic association of ABCA2 with sporadic Alzheimer's disease
    M Axel Wollmer
    Division of Psychiatry Research, University of Zurich, Switzerland
    Am J Med Genet B Neuropsychiatr Genet 141:534-6. 2006
    ..These data suggest that ABCA2 may exert population-dependent effects on the genetic risk for sporadic AD and support a role of ABC lipid transporters in the pathogenesis of this disease...
  20. ncbi ABCA1 modulates CSF cholesterol levels and influences the age at onset of Alzheimer's disease
    M Axel Wollmer
    Division of Psychiatry Research, University of Zurich, August Forel Street 1, 8008, Zurich, Switzerland
    Neurobiol Aging 24:421-6. 2003
    ..We conclude that genetic variability of ABCA1 influences the development of AD, possibly by interfering with CNS cholesterol homeostasis...
  21. ncbi Antibodies against beta-amyloid slow cognitive decline in Alzheimer's disease
    Christoph Hock
    Division of Psychiatry Research, University of Zurich, August Forel Strasse 1, 8008 Zurich, Switzerland
    Neuron 38:547-54. 2003
    ..Our results establish that antibodies against beta-amyloid plaques can slow cognitive decline in patients with Alzheimer's disease...
  22. ncbi Glucocorticoid-related genetic susceptibility for Alzheimer's disease
    Dominique J F de Quervain
    Division of Psychiatry Research, University of Zurich, Zurich, Switzerland
    Hum Mol Genet 13:47-52. 2004
    ..Our results indicate that a functional variation in the glucocorticoid system increases the risk for AD, which may have important implications for the diagnosis and treatment of this disease...
  23. ncbi Biochemical diagnosis of Alzheimer disease by measuring the cerebrospinal fluid ratio of phosphorylated tau protein to beta-amyloid peptide42
    Alessia Maddalena
    Division of Psychiatry Research, University of Zurich, Switzerland
    Arch Neurol 60:1202-6. 2003
    ....
  24. ncbi Polymorphisms of the gene encoding the inflammatory cytokine interleukin-6 determine the magnitude of the increase in soluble interleukin-6 receptor levels in Alzheimer's disease. Results of a pilot study
    Metin Bagli
    Department of Psychiatry, University of Bonn, Venusberg, 53105 Bonn, Germany
    Eur Arch Psychiatry Clin Neurosci 253:44-8. 2003
    ..We conclude that plasma and CSF levels of sIL-6R are significantly increased in AD patients and that the magnitude of increase is determined by the IL-6 genotype...
  25. ncbi Investigation of a genetic variation of a variable number tandem repeat polymorphism of interleukin-6 gene in patients with multiple sclerosis
    Stephan Schmidt
    Dept of Neurology, University of Bonn, Sigmund Freud Str 25, 53105 Bonn, Germany
    J Neurol 250:607-11. 2003
    ..Taken together, a disease-modifying effect of IL-6 C allele could not be demonstrated in MS patients of German Caucasian descent...
  26. ncbi Genetic association study on colony-stimulating factor 1 in Alzheimer's disease
    M Axel Wollmer
    Division of Psychiatry Research, University of Zurich, Zurich, Switzerland
    Neurodegener Dis 3:334-7. 2006
    ..The human CSF1 gene maps to chromosome 1p21-p13, a region previously linked to Alzheimer's disease (AD). Thus, CSF1 is a functional and positional candidate gene for AD...
  27. ncbi Better memory and neural efficiency in young apolipoprotein E epsilon4 carriers
    Christian R A Mondadori
    Division of Psychiatry Research, University of Zurich, 8032 Zurich, Switzerland
    Cereb Cortex 17:1934-47. 2007
    ..We suggest that APOE epsilon4 is associated with good episodic memory and an economic use of memory-related neural resources in young, healthy humans...
  28. ncbi Cerebrospinal fluid profile of amyloid beta peptides in patients with Alzheimer's disease determined by protein biochip technology
    Alessia S Maddalena
    Division of Psychiatry Research, University of Zurich, Zurich, Switzerland
    Neurodegener Dis 1:231-5. 2004
    ..Quantitation revealed that CSF levels of Abeta1-38 were significantly decreased in AD as compared to CTR subjects. The CSF profile of Abeta peptides may be used for diagnostic and therapeutic purposes in clinical studies...
  29. ncbi Association study of cholesterol-related genes in Alzheimer's disease
    M Axel Wollmer
    Division of Psychiatry Research, University of Zurich, August Forel Str 1, 8008 Zurich, Switzerland
    Neurogenetics 8:179-88. 2007
    ..004). We conclude that genetic variants investigated in this study may be associated with a moderate modification of the risk for AD in some samples...
  30. pmc Role for glyoxalase I in Alzheimer's disease
    Feng Chen
    Division of Psychiatry Research, University of Zurich, August Forel Strasse 1, 8008 Zurich, Switzerland
    Proc Natl Acad Sci U S A 101:7687-92. 2004
    ..Together, our data demonstrate the potential of transcriptomics applied to animal models of human diseases. They suggest a previously unidentified role for glyoxalase I in neurodegenerative disease...
  31. ncbi Genetic polymorphisms and cerebrospinal fluid levels of tissue inhibitor of metalloproteinases 1 in sporadic Alzheimer's disease
    M Axel Wollmer
    Division of Psychiatry Research, University of Zurich, Switzerland
    Psychiatr Genet 12:155-60. 2002
    ..In addition, no significant differences were observed after stratification for TIMP 1 genotypes. Our data show that neither genetic variability nor protein levels of TIMP-1 are associated with AD...
  32. ncbi Abeta treatment and P301L tau expression in an Alzheimer's disease tissue culture model act synergistically to promote aberrant cell cycle re-entry
    Frederic J Hoerndli
    Division of Psychiatry Research, University of Zurich, August Forel Str 1, 8008 Zurich, Switzerland
    Eur J Neurosci 26:60-72. 2007
    ..Thus, our study shows that Abeta treatment and human tau overexpression in an AD cell culture model act synergistically to promote aberrant cell cycle re-entry, supporting the mitosis failure hypothesis in AD...
  33. ncbi Genetic association of a cystatin C gene polymorphism with late-onset Alzheimer disease
    U Finckh
    Division of Psychiatry Research, University of Zurich, August Forel Str 1, 8008 Zurich, Switzerland
    Arch Neurol 57:1579-83. 2000
    ..To determine whether the cystatin C gene (CST3) is genetically associated with late-onset Alzheimer disease (AD)...
  34. pmc Identification of a genetic cluster influencing memory performance and hippocampal activity in humans
    Dominique J F de Quervain
    Division of Psychiatry Research and Center for Integrative Human Physiology, University of Zurich, CH 8057 Zurich, Switzerland
    Proc Natl Acad Sci U S A 103:4270-4. 2006
    ..The present study indicates that genetic variability in the human homologues of memory-related signaling molecules contributes to interindividual differences in human memory performance and memory-related brain activations...
  35. ncbi A deletion variant of the alpha2b-adrenoceptor is related to emotional memory in Europeans and Africans
    Dominique J F de Quervain
    Division of Psychiatry Research, University of Zurich, Lenggstr 31, 8032 Zurich, Switzerland
    Nat Neurosci 10:1137-9. 2007
    ....
  36. ncbi Low-dose cortisol for symptoms of posttraumatic stress disorder
    Amanda Aerni
    Division of Psychiatry Research, University of Zurich, Lenggstr 31, 8029 Zurich, Switzerland
    Am J Psychiatry 161:1488-90. 2004
    ....
  37. ncbi Genetic variations and humoral immune responses to myelin oligodendroglia glycoprotein in adult phenotypes of X-linked adrenoleukodystrophy
    Stephan Schmidt
    Department of Neurology, University of Bonn, Sigmund Freud Str 20, 53105, Bonn, Germany
    J Neuroimmunol 135:148-53. 2003
    ..Anti-MOG antibodies were detectable in 17/54 X-ALD patients (31.5%). Anti-MOG antibodies were associated with the 226 bp (TAAA)(n) MOG gene polymorphism but not with distinct clinical phenotypes...
  38. ncbi Association between an interleukin-6 promoter and 3' flanking region haplotype and reduced Alzheimer's disease risk in a German population
    M Bagli
    Department of Psychiatry and Psychotherapy, Rheinische Friedrich Wilhelms Universitat, Sigmund Freud Strasse 25, 53105, Bonn, Germany
    Neurosci Lett 283:109-12. 2000
    ..However, haplotype analysis showed a strong linkage disequilibrium between IL-6vntr and IL-6prom and demonstrated an interaction between IL-6vntr and IL-6prom which modifies AD risk...
  39. ncbi Identical distribution of the alpha 2-macroglobulin pentanucleotide deletion in subjects with Alzheimer disease and controls in a German population
    M Bagli
    Department of Psychiatry, University of Bonn, Bonn, Germany
    Am J Med Genet 96:775-7. 2000
    ..Am. J. Med. Genet. (Neuropsychiatr. Genet.) 96:775-777, 2000...
  40. pmc Saitohin gene is not associated with Alzheimer's disease
    J R Streffer
    Division of Psychiatry Research, University of Zurich, Switzerland
    J Neurol Neurosurg Psychiatry 74:362-3. 2003
    ....
  41. ncbi Alpha-1-antichymotrypsin gene polymorphism and risk for sporadic Alzheimer's disease in a German population
    S G Schwab
    Department of Psychiatry, University of Bonn, Germany
    Dement Geriatr Cogn Disord 10:469-72. 1999
    ..When we analyzed the polymorphism in APOE epsilon4 carriers, no overrepresentation in our AD group could be shown for the ACT*AA genotype carriers. Copyrightz1999S.KargerAG,Basel..
  42. pmc A conserved function of C. elegans CASY-1 calsyntenin in associative learning
    Frederic J Hoerndli
    Institute of Zoology, University of Zurich, Zurich, Switzerland
    PLoS ONE 4:e4880. 2009
    ..Since polymorphisms in Calsyntenin 2 (CLSTN2) showed a significant association with episodic memory performance in humans, we tested the C. elegans CLSTN2 ortholog CASY-1 for possible functions in the associative behavior of C. elegans...
  43. ncbi Generation of antibodies specific for beta-amyloid by vaccination of patients with Alzheimer disease
    Christoph Hock
    Division of Psychiatry Research, University of Zurich, Zurich, Switzerland
    Nat Med 8:1270-5. 2002
    ..Whether vaccination to produce antibodies against beta-amyloid will halt the cognitive decline in AD will depend upon clinical assessments over time...
  44. ncbi Cathepsin D: screening for new polymorphisms using single-strand conformation polymorphism analysis
    Micael Majores
    Department of Psychiatry, University of Bonn, D 53105 Bonn, Germany
    Int J Mol Med 9:185-7. 2002
    ..Thus, if sequence variations within the CTSD gene influence the risk for various diseases, the pathogenic mechanism is likely to be linked to the amino acid substitution in the profragment of CTSD...
  45. ncbi Genetic association of acyl-coenzyme A: cholesterol acyltransferase with cerebrospinal fluid cholesterol levels, brain amyloid load, and risk for Alzheimer's disease
    M A Wollmer
    Division of Psychiatry Research, University of Zurich, Switzerland
    Mol Psychiatry 8:635-8. 2003
    ..005). This polymorphism of SOAT1 is also associated with reduced risk for Alzheimer's disease in ethnically distinct populations (P=0.0001, odds ratio: 0.6, 95% confidence interval 0.4-0.8)...
  46. ncbi No association of serum levels of interleukin-6 and its soluble receptor components with a genetic variation in the 3'flanking region of the interleukin-6 gene in patients with multiple sclerosis
    S Schmidt
    Department of Neurology, University of Bonn, Sigmund Freud Strasse 25, D 53105, Bonn, Germany
    Neurosci Lett 294:139-42. 2000
    ....
  47. ncbi A genetic variation of cathepsin D is a major risk factor for Alzheimer's disease
    A Papassotiropoulos
    Department of Psychiatry, University of Bonn, Germany
    Ann Neurol 47:399-403. 2000
    ..0 compared with subjects with neither of these two alleles. Our data confirm the results of a recently performed pilot study in an independent sample and suggest that the catD genotype is strongly associated with the risk for AD...
  48. ncbi Seasonal distribution of births in patients with Alzheimer's disease and elderly depressive patients
    U Ptok
    Department of Psychiatry, University of Bonn, Sigmund Freud St 25 53105, Bonn, Germany
    Eur Psychiatry 16:157-61. 2001
    ..We concluded that in our sample a seasonal distribution of births was not found to increase the risk for AD or geriatric depression...
  49. ncbi No association between an intronic polymorphism in the presenilin-1 gene and Alzheimer disease in a German population
    M Bagli
    Department of Psychiatry, University of Bonn, Sigmund Freud Strasse 25, 53105, Bonn, Germany
    J Neurol Sci 167:34-6. 1999
    ..Our data do not support an association between the intronic polymorphism of the PS-1 gene and AD and there was no interaction between the PS-1 genotype and apolipoprotein E epsilon4 allele...
  50. ncbi Early-onset and late-onset depression are independent of the genetic polymorphism of apolipoprotein E
    A Papassotiropoulos
    Department of Psychiatry, University of Bonn, Germany
    Dement Geriatr Cogn Disord 10:258-61. 1999
    ..Our data do not disconfirm the hypothesis of depression sharing some common pathophysiologic features with AD, however, it seems very unlikely that the APOE genotype will elucidate the assumed common mechanisms...
  51. ncbi Association between a functional polymorphism in the monoamine oxidase A gene promoter and major depressive disorder
    T G Schulze
    Department of Psychiatry, University of Bonn, Bonn, Germany
    Am J Med Genet 96:801-3. 2000
    ..Am. J. Med. Genet. (Neuropsychiatr. Genet.) 96:801-803, 2000...
  52. ncbi Evidence of a genetic basis of Morgagni-Stewart-Morel syndrome. A case report of identical twins
    Michael F Koller
    Division of Psychiatry Research, University of Zurich, Zurich, Switzerland
    Neurodegener Dis 2:56-60. 2005
    ..The symptoms common to both twins appear to correspond to the Morgagni-Stewart-Morel syndrome and indicate a genetic basis of this disorder as these features occur in genetically identical patients...
  53. ncbi Advanced parental age: a risk factor for Alzheimer's disease or depression in the elderly?
    U Ptok
    Department of Psychiatry, University of Bonn, Germany
    Int Psychogeriatr 12:445-51. 2000
    ..In the present investigation, a sample of gerontopsychiatric patients was examined for a possible parental age effect...
  54. ncbi Physical disorders and causes of death in relatives of Alzheimer's disease patients
    M Kockler
    Department of Psychiatry, University of Bonn, Bonn, Germany
    Int J Geriatr Psychiatry 17:335-42. 2002
    ..g. Down's syndrome or Parkinson's disease. In the present study the risk of physical disorders in relatives of AD patients, of depressed patients and of control subjects were compared...
  55. ncbi Differential validity of informant-based diagnoses of dementia and depression in index subjects and in their first-degree relatives
    R Heun
    Department of Psychiatry, University of Bonn, Germany
    Soc Psychiatry Psychiatr Epidemiol 33:510-3. 1998
    ..Observations in selected samples, i.e. subjects treated, hospitalised and/or autopsied, cannot be generalised to first-degree relatives in family studies...
  56. ncbi Sensory gating deficit expressed by a disturbed suppression of the P50 event-related potential in patients with Alzheimer's disease
    F Jessen
    Department of Psychiatry, University of Bonn, Sigmind Freud Str 25, 53105 Bonn, Germany
    Am J Psychiatry 158:1319-21. 2001
    ..In this study, the authors tested whether sensory gating is disturbed in patients with Alzheimer's disease...
  57. ncbi Proton MR spectroscopy detects a relative decrease of N-acetylaspartate in the medial temporal lobe of patients with AD
    F Jessen
    Department of Psychiatry and Psychotherapy, University of Bonn, Germany
    Neurology 55:684-8. 2000
    ..The reduction of N-acetylaspartate (NAA) detected by proton MR spectroscopy (1H-MRS) represents a robust but unspecific marker for neuronal loss or dysfunction...
  58. ncbi Distinction of early- and late-onset depression in the elderly by their lifetime symptomatology
    R Heun
    Department of Psychiatry, University of Bonn, Sigmund Freud Str 25, 53127 Bonn, Germany
    Int J Geriatr Psychiatry 15:1138-42. 2000
    ..To validate the phenomenological distinction, the affective symptoms of elderly subjects with EOD and LOD were compared...
  59. ncbi Detection of subthreshold depression and subthreshold anxiety in the elderly
    A Papassotiropoulos
    Department of Psychiatry, University of Bonn, Germany
    Int J Geriatr Psychiatry 14:643-50. 1999
    ..To assess the ability of screening instruments to detect subthreshold depression or subthreshold anxiety and to make suggestions for the improvement of instrument performance...
  60. pmc Cholesterol-related genetic risk scores are associated with hypometabolism in Alzheimer's-affected brain regions
    Eric M Reiman
    Banner Alzheimer s Institute and Banner Good Samaritan PET Center, Phoenix, AZ 85006, USA
    Neuroimage 40:1214-21. 2008
    ..The results support the role of cholesterol-related genes in the predisposition to AD and support the value of neuroimaging in the presymptomatic assessment of putative modifiers of AD risk...
  61. ncbi Sorl1 as an Alzheimer's disease predisposition gene?
    Jennifer A Webster
    Neurogenomics Division, Translational Genomics Research Institute, Phoenix, Ariz, USA
    Neurodegener Dis 5:60-4. 2008
    ..Here we present the results of our large case-control whole-genome scan at over 500,000 polymorphisms which presents weak evidence for association and potentially narrows the association interval...
  62. ncbi Are genetic components related to cognitive decline after coronary artery surgery? Genetics and brain function after bypass heart surgery
    Georgios I Tagarakis
    J Card Surg 23:280-1. 2008
  63. ncbi The role of apolipoprotein E in cognitive decline and delirium after bypass heart operations
    Georgios I Tagarakis
    Herz und Gefaess Klinik, Rhoen Klinikum, Bad Neustadt a d Saale, Germany gtagarakis hotmail com
    Am J Alzheimers Dis Other Demen 22:223-8. 2007
    ..This study confirms the high incidence of cognitive decline and delirium after coronary surgery, but it does not support the role of the APOE-epsilon 4 allele in the occurrence of these complications...
  64. pmc Common genetic variation within the low-density lipoprotein receptor-related protein 6 and late-onset Alzheimer's disease
    Giancarlo V De Ferrari
    Howard Hughes Medical Institute, University of Washington School of Medicine, Seattle, WA 98195, USA
    Proc Natl Acad Sci U S A 104:9434-9. 2007
    ..Our study unveils a genetic relationship between LRP6 and APOE and supports the hypothesis that altered Wnt/beta-catenin signaling may be involved in this neurodegenerative disease...
  65. ncbi A high-density whole-genome association study reveals that APOE is the major susceptibility gene for sporadic late-onset Alzheimer's disease
    Keith D Coon
    Neurogenomics Division, Translational Genomics Research Institute, Phoenix, Ariz 85004, USA
    J Clin Psychiatry 68:613-8. 2007
    ....
  66. ncbi Calmodulin-binding transcription activator 1 (CAMTA1) alleles predispose human episodic memory performance
    Matthew J Huentelman
    Neurogenomics Division, The Translational Genomics Research Institute, 445 N Fifth Street, Phoenix, AZ 85004, USA
    Hum Mol Genet 16:1469-77. 2007
    ..Our validated genomic and functional biological findings described herein suggest a role for CAMTA1 in human episodic memory...
  67. pmc Identification of the genetic basis for complex disorders by use of pooling-based genomewide single-nucleotide-polymorphism association studies
    John V Pearson
    Translational Genomics Research Institute, Phoenix, AZ, 85004, USA
    Am J Hum Genet 80:126-39. 2007
    ....
  68. pmc Preliminary demonstration of an allelic association of the IREB2 gene with Alzheimer's disease
    Keith D Coon
    Neurogenomics Division, Translational Genomics Research Institute, Phoenix, AZ 85004, USA
    J Alzheimers Dis 9:225-33. 2006
    ..Confirmation of this association in a larger cohort of cases and controls would further support the role of iron regulation in the pathogenesis of this catastrophic and increasingly common neurodegenerative disorder...
  69. pmc GAB2 alleles modify Alzheimer's risk in APOE epsilon4 carriers
    Eric M Reiman
    Neurogenomics Division, Translational Genomics Research Institute, Phoenix, AZ, 85004, USA
    Neuron 54:713-20. 2007
    ..Our findings suggest that GAB2 modifies LOAD risk in APOE epsilon4 carriers and influences Alzheimer's neuropathology...