Research Topics
Species | E A NiggSummaryAffiliation: University of Geneva Country: Switzerland Publications
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Detail Information
Publications
Polo-like kinases: positive regulators of cell division from start to finishE A Nigg
Department of Molecular Biology University of Geneva Sciences II, 30, quai Ernest Ansermet CH 1211 Geneva 4 Switzerland
Curr Opin Cell Biol 10:776-83. 1998..Finally, recent evidence implicates Plks in the temporal and spatial coordination of cytokinesis...- Dynamic changes in nuclear architecture during mitosis: on the role of protein phosphorylation in spindle assembly and chromosome segregationE A Nigg
Department of Molecular Biology, Sciences II, University of Geneva, 30, Quai Ernest Ansermet, Geneva 4, CH 1211, Switzerland
Exp Cell Res 229:174-80. 1996..This observation hints at the existence of a checkpoint linking Cdc2 activation to the presence of functional centrosomes... - Nucleocytoplasmic transport: signals, mechanisms and regulationE A Nigg
Department of Molecular Biology, Sciences II, University of Geneva, Switzerland
Nature 386:779-87. 1997..Here I summarize current understanding of nucleocytoplasmic transport and illustrate the importance of regulated transport for signal transduction... 
Drosophila Cdk8, a kinase partner of cyclin C that interacts with the large subunit of RNA polymerase IIV Leclerc
URA 671 Centre National de la Recherche Scientifique, Villefranche sur Mer, France
Mol Biol Cell 7:505-13. 1996..Based on these observations and sequence similarity to the kinase/cyclin pair Srb10/Srb11 in S. cerevisiae, we suggest that cyclin C and Cdk8 control RNA polymerase II function...- MAT1, cdk7 and cyclin H form a kinase complex which is UV light-sensitive upon association with TFIIHJ P Adamczewski
Institut de Genetique et de Biologie Moleculaire et Cellulaire, UPR 6520 CNRS, Unité 184 INSERM, CU de Strasbourg, France
EMBO J 15:1877-84. 1996..Although not strictly required for the formation and activity of the complex, it stimulates its kinase activity. The kinase activity of TFIIH, which is constant during the cell cycle, is reduced after UV light irradiation... - In vitro assembly of a functional human CDK7-cyclin H complex requires MAT1, a novel 36 kDa RING finger proteinJ P Tassan
Swiss Institute for Experimental Cancer Research ISREC, Epalinges, Switzerland
EMBO J 14:5608-17. 1995..MAT1 constitutes the first example of an assembly factor that appears to be essential for the formation of an active CDK-cyclin complex... - C-Nap1, a novel centrosomal coiled-coil protein and candidate substrate of the cell cycle-regulated protein kinase Nek2A M Fry
Department of Molecular Biology, Sciences II, University of Geneva, CH 1211 Geneva 4, Switzerland
J Cell Biol 141:1563-74. 1998..Based on these findings, we propose a model implicating both Nek2 and C-Nap1 in the regulation of centriole-centriole cohesion during the cell cycle... - Cell cycle analysis and chromosomal localization of human Plk1, a putative homologue of the mitotic kinases Drosophila polo and Saccharomyces cerevisiae Cdc5R M Golsteyn
Swiss Institute for Experimental Cancer Research ISREC, Epalinges
J Cell Sci 107:1509-17. 1994..Thus, like Drosophila polo and S. cerevisiae Cdc5, human Plk1 is likely to function in cell cycle progression... - Cell cycle analysis of the activity, subcellular localization, and subunit composition of human CAK (CDK-activating kinase)J P Tassan
Swiss Institute for Experimental Cancer Research ISREC, Epalinges
J Cell Biol 127:467-78. 1994..It suggests that the phosphorylation state of threonine 161 in p34cdc2 (and the corresponding residue in other cdks) may be regulated primarily by the availability of the cdk/cyclin substrates, and by phosphatase(s)... - Cell cycle regulation of the activity and subcellular localization of Plk1, a human protein kinase implicated in mitotic spindle functionR M Golsteyn
Swiss Institute for Experimental Cancer Research (ISREC, Epalinges
J Cell Biol 129:1617-28. 1995.... - Centrosome cohesion is regulated by a balance of kinase and phosphatase activitiesP Meraldi
Department of Cell Biology, Max-Planck-Institute for Biochemistry, D-82152 Martinsried, Germany
J Cell Sci 114:3749-57. 2001..These studies highlight the importance of protein phosphorylation in the control of centrosome cohesion, and they point to Nek2 and PP1 alpha as critical regulators of centrosome structure... - The centrosome cycleP Meraldi
Department of Cell Biology, Max-Planck-Institute for Biochemistry, D-82152 Martinsried, Germany
FEBS Lett 521:9-13. 2002..Here we summarize recent information on the regulation of the centrosome cycle and its coordination with the chromosomal cell cycle... - Identification of human Asf1 chromatin assembly factors as substrates of Tousled-like kinasesH H Silljé
Max Planck Institute for Biochemistry, Department of Cell Biology, Am Klopferspitz 18a, D 82152, Martinsried, Germany
Curr Biol 11:1068-73. 2001..These data indicate that Tlk family members regulate chromatin assembly during DNA replication, and they suggest a plausible explanation for the pleiotropic developmental defects of plant tousled mutants... - Mitotic kinases as regulators of cell division and its checkpointsE A Nigg
Max Planck Institute for Biochemistry, Department of Cell Biology, Am Klopferspitz 18a, D 82152 Martinsried, Germany
Nat Rev Mol Cell Biol 2:21-32. 2001..Here, I give an overview of the many mitotic kinases that regulate cell division and the fidelity of chromosome transmission... - Cloning and characterization of the murine Nek3 protein kinase, a novel member of the NIMA family of putative cell cycle regulatorsK Tanaka
Department of Molecular Biology, Sciences II, University of Geneva 30, Quai Ernest Ansermet, 1211 Geneve 4, Switzerland
J Biol Chem 274:13491-7. 1999.... - The centrosomal protein C-Nap1 is required for cell cycle-regulated centrosome cohesionT Mayor
Department of Molecular Biology, Sciences II, University of Geneva, CH-1211 Geneva, Switzerland
J Cell Biol 151:837-46. 2000..We conclude that C-Nap1 is a key component of a dynamic, cell cycle-regulated structure that mediates centriole-centriole cohesion... - Activity of the human centrosomal kinase, Nek2, depends on an unusual leucine zipper dimerization motifA M Fry
Department of Molecular Biology, Sciences II, University of Geneva, 30, Quai Ernest Ansermet, CH 1211 Geneva 4, Switzerland
J Biol Chem 274:16304-10. 1999..Thus, this study reveals not only an important mechanism for the regulation of the Nek2 kinase but, furthermore, highlights an unusual organization of a leucine zipper dimerization motif... - Protein kinases in control of the centrosome cycleT Mayor
Department of Molecular Biology, University of Geneva, Switzerland
FEBS Lett 452:92-5. 1999..Here, we focus on two protein kinases, the polo-like kinase 1 and the NIMA-related kinase 2, for which recent data indicate key roles during the centrosome cycle... - Mammalian homologues of the plant Tousled gene code for cell-cycle-regulated kinases with maximal activities linked to ongoing DNA replicationH H Silljé
Department of Molecular Biology, Sciences II, 30 Quai Ernest Ansermet, University of Geneva, CH 1211 Geneva 4, Switzerland
EMBO J 18:5691-702. 1999..These findings provide the first biochemical clues as to the possible molecular functions of Tlks, a highly conserved family of kinases implicated in the development of multicellular organisms... - The in vivo expression pattern of mouse Nek2, a NIMA-related kinase, indicates a role in both mitosis and meiosisK Tanaka
Department of Molecular Biology, Sciences II, University of Geneva, Switzerland
Exp Cell Res 237:264-74. 1997..Taken together, these results indicate that Nek2 may play an important role not only during mitosis but also during meiosis... - A centrosomal function for the human Nek2 protein kinase, a member of the NIMA family of cell cycle regulatorsA M Fry
Department of Molecular Biology, Sciences II, University of Geneva, Switzerland
EMBO J 17:470-81. 1998..Moreover, they indicate that one function of mammalian Nek2 relates to the centrosome cycle and thus provide a new perspective on the role of NIMA-related kinases... - Differential phosphorylation of vertebrate p34cdc2 kinase at the G1/S and G2/M transitions of the cell cycle: identification of major phosphorylation sitesW Krek
Swiss Institute for Experimental Cancer Research, ISREC, Epalinges
EMBO J 10:305-16. 1991.... - Structure and developmental expression of the chicken CDC2 kinaseW Krek
Swiss Institute for Experimental Cancer Research ISREC, Epalinges s Lausanne
EMBO J 8:3071-8. 1989..Interestingly, however, when examining individual embryonic tissues, no correlation was observed between levels of cdc2 mRNA and protein, suggesting that cdc2 expression in developing chicken may be regulated at multiple levels... - Cell cycle-dependent expression of Nek2, a novel human protein kinase related to the NIMA mitotic regulator of Aspergillus nidulansS J Schultz
Swiss Institute for Experimental Cancer Research, Epalinges
Cell Growth Differ 5:625-35. 1994..These observations demonstrate that Nek2 resembles Aspergillus NIMA, not only in its catalytic domain, but also in its cell cycle-dependent expression. Hence, the human Nek2 protein kinase may also function at the onset of mitosis... - Identification of human cyclin-dependent kinase 8, a putative protein kinase partner for cyclin CJ P Tassan
Swiss Institute for Experimental Cancer Research ISREC, Epalinges
Proc Natl Acad Sci U S A 92:8871-5. 1995..cerevisiae. Hence, we propose that human K35(CDK8)-cyclin C might be functionally associated with the mammalian transcription apparatus, perhaps involved in relaying growth-regulatory signals... - MAT1 ('menage à trois') a new RING finger protein subunit stabilizing cyclin H-cdk7 complexes in starfish and Xenopus CAKA Devault
Centre de Recherches de Biochimie Macromoleculaire, CNRS UPR 9008, Montpellier, France
EMBO J 14:5027-36. 1995.... - A cyclin associated with the CDK-activating kinase MO15T P Mäkelä
Whitehead Institute for Biomedical Research, Cambridge, Massachusetts 02142
Nature 371:254-7. 1994..These findings demonstrate that a cyclin/kinase complex can function as a regulator of other cyclin/kinase complexes, and suggest that cyclin/kinase cascades may exist... - Identification of 21 novel human protein kinases, including 3 members of a family related to the cell cycle regulator nimA of Aspergillus nidulansS J Schultz
Swiss Institute for Experimental Cancer Research, Epalinges
Cell Growth Differ 4:821-30. 1993.... - Identification of a novel vertebrate cyclin: cyclin B3 shares properties with both A- and B-type cyclinsP Gallant
Swiss Institute for Experimental Cancer Research ISREC, Epalinges
EMBO J 13:595-605. 1994..Based on these observations, we conclude that cyclin B3 may share functional properties with both A- and B-type cyclins... - Phosphorylation by p34cdc2 regulates spindle association of human Eg5, a kinesin-related motor essential for bipolar spindle formation in vivoA Blangy
Swiss Institute for Experimental Cancer Research, Epalinges, Switzerland
Cell 83:1159-69. 1995..These results indicate that HsEg5 is required for establishing a bipolar spindle and that p34cdc2 protein kinase directly regulates its localization... - Cyclin B2 undergoes cell cycle-dependent nuclear translocation and, when expressed as a non-destructible mutant, causes mitotic arrest in HeLa cellsP Gallant
Swiss Institute for Experimental Cancer Research ISREC, CH 1066 Epalinges
J Cell Biol 117:213-24. 1992..Many of the arrested cells displayed multiple mitotic spindles, suggesting that the centrosome cycle had continued in spite of the cell cycle arrest... - Centriole overduplication through the concurrent formation of multiple daughter centrioles at single maternal templatesA Duensing
Department of Pathology, University of Pittsburgh School of Medicine, Pittsburgh, PA 15213, USA
Oncogene 26:6280-8. 2007..These results help to explain how oncogenic stimuli can rapidly induce abnormal centriole numbers within a single cell-division cycle and provide insights into the regulation of centriole duplication...