Research Topics
Genomes and GenesSpecies | Stephan C F NeuhaussSummaryAffiliation: University of Zurich Country: Switzerland Publications
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Detail Information
Publications
Oculomotor instabilities in zebrafish mutant belladonna: a behavioral model for congenital nystagmus caused by axonal misroutingYing Yu Huang
Institute of Zoology, University of Zurich, CH 8057 Zurich, Switzerland
J Neurosci 26:9873-80. 2006..The strong resemblance between the SO and congenital nystagmus (CN) seen in humans with defective retinotectal projections implies that CN, of so far unknown etiology, may be directly caused by a projection defect...
Large-scale mapping of mutations affecting zebrafish developmentRobert Geisler
Department 3 Genetics, Max Planck Institut fur Entwicklungsbiologie, Spemannstr, 35 III, 72076 Tubingen, Germany
BMC Genomics 8:11. 2007..Here we report on a large-scale effort to map the mutations generated in mutagenesis screening at the Max Planck Institute for Developmental Biology by genome scanning with microsatellite markers...- Behavioral genetic approaches to visual system development and function in zebrafishStephan C F Neuhauss
Brain Research Institute, University of Zurich and Swiss Federal Institute of Technology ETH Zurich, Winterthurerstrasse 190, CH 8057 Zurich, Switzerland
J Neurobiol 54:148-60. 2003..Here, I summarize visually mediated behaviors of both larval and adult zebrafish and their applicability for genetic screens, and present, the approaches and results of visual behavior carried out to date... - Retinal defects in the zebrafish bleached mutantStephan C F Neuhauss
Brain Research Institute, University of Zurich and Department of Biology, Swiss Federal Institute of Technology Zurich, Winterthurerstr 190, CH 8057 Zurich, Switzerland
Doc Ophthalmol 107:71-8. 2003..Hence, the lack of visual responses in homozygous bleached larvae can be attributed to a severe defect of the outer retina, preceded by increased levels of apoptotic cell death in all retinal cell layers... - The zebrafish mutant lbk/vam6 resembles human multisystemic disorders caused by aberrant trafficking of endosomal vesiclesHelia B Schonthaler
Swiss Federal Institute of Technology, Department of Biology, and Brain Research Institute of the University of Zurich, Winterthurerstrasse 190, CH 8057 Zurich, Switzerland
Development 135:387-99. 2008.... - Evidence for RPE65-independent vision in the cone-dominated zebrafish retinaHelia B Schonthaler
University of Zurich, Institute of Zoology, Winterthurerstrasse 190, CH 8057 Zurich, Switzerland
Eur J Neurosci 26:1940-9. 2007..Thus, our study of zebrafish provides in vivo evidence for the existence of an RPE65-independent pathway for the regeneration of 11-cis-retinal for cone vision... - Retinal function and morphology in two zebrafish models of oculo-renal syndromesRonja Bahadori
Swiss Federal Institute of Technology ETH Zurich, Department of Biology, and the Brain Research Institute, University of Zurich, Winterthurerstrasse 190, CH 8057 Zurich, Switzerland
Eur J Neurosci 18:1377-86. 2003.... 
Cone arrestin confers cone vision of high temporal resolution in zebrafish larvaeSabine L Renninger
Institute of Molecular Life Sciences, Neuroscience Center Zurich and Center for Integrative Human Physiology, University of Zurich, Winterthurerstrasse 190, CH 8057 Zurich, Switzerland
Eur J Neurosci 33:658-67. 2011..Behavioral measurements further revealed Arr3a deficiency to be sufficient to reduce temporal contrast sensitivity, providing evidence for the importance of arrestin in cone vision of high temporal resolution...- Knockdown of cone-specific kinase GRK7 in larval zebrafish leads to impaired cone response recovery and delayed dark adaptationOliver Rinner
Brain Research Institute, University of Zurich, Winterthurerstrasse 190, CH 8057 Zurich, Switzerland Institute for Molecular Systems Biology, Swiss Federal Institute of Technology ETH, CH 8093 Zurich, Switzerland
Neuron 47:231-42. 2005.... - Severity of infantile nystagmus syndrome-like ocular motor phenotype is linked to the extent of the underlying optic nerve projection defect in zebrafish belladonna mutantSabina P Huber-Reggi
Institute of Molecular Life Sciences, University of Zurich, CH 8057 Zurich, Switzerland
J Neurosci 32:18079-86. 2012..Our data not only give new insights into the etiology of INS but may also be of interest for studies on how the brain deals with and adapts to conflicting inputs... - Subfunctionalization of a retinoid-binding protein provides evidence for two parallel visual cycles in the cone-dominant zebrafish retinaValerie C Fleisch
Department of Biology, Brain Research Institute, Institute of Zoology, Swiss Federal Institute of Technology ETH Zurich, University of Zurich, CH 8057 Zurich, Switzerland
J Neurosci 28:8208-16. 2008.... - Quantitative measurements of the optokinetic response in adult fishKaspar P Mueller
University of Zurich, Institute of Zoology, Neuroscience Center Zurich and Center for Integrative Human Physiology, Winterthurerstrasse 190, CH 8057 Zurich, Switzerland
J Neurosci Methods 186:29-34. 2010..This method can be applied to any fish species of similar size... - Behavioral neurobiology: how larval fish orient towards the lightKaspar P Mueller
University of Zurich, Institute of Molecular Life Sciences, Neuroscience Center Zurich and Center for Integrative Human Physiology, Winterthurerstrasse 190, CH 8057 Zurich, Switzerland
Curr Biol 20:R159-61. 2010..A recent study using zebrafish larvae has revealed the underlying neural logic of this primal choice behavior, by differential use of the retinal ON- and OFF-pathways... - An inexpensive device for non-invasive electroretinography in small aquatic vertebratesYuri V Makhankov
Swiss Federal Institute of Technology, Department of Biology and Brain Research Institute of the University Zurich, Winterthurerstrasse 190, CH-8057 Zurich, Switzerland
J Neurosci Methods 135:205-10. 2004..This setup is easily built and will be particularly useful for laboratories setting up ERG measurements as a complement to their genetic studies... - A mutation in the silver gene leads to defects in melanosome biogenesis and alterations in the visual system in the zebrafish mutant fading visionHelia B Schonthaler
Swiss Federal Institute of Technology, Department of Biology, and Brain Research Institute of the University of Zurich, Winterthurerstrasse 190, CH 8057 Zurich, Switzerland
Dev Biol 284:421-36. 2005..The Silver protein is required for intralumenal fibril formation in melanosomes by amylogenic cleavage. Our data reveal an unexpected link between melanosome biogenesis and the visual system, undetectable in cell culture... - Application of zebrafish oculomotor behavior to model human disordersColette M Maurer
University of Zurich, Institute of Molecular Life Sciences, Neuroscience Center Zurich and Center for Integrative Human Physiology, Winterthurerstrasse 190, CH 8057 Zurich, Switzerland
Rev Neurosci 22:5-16. 2011..This mutant displays a reverse optokinetic response, spontaneous oscillations that closely mimic human congenital nystagmus and abnormal motor behavior linked to circular vection... - Impaired retinal differentiation and maintenance in zebrafish laminin mutantsOliver Biehlmaier
Department of Biology, Swiss Federal Institute of Technology ETH Zurich, Switzerland
Invest Ophthalmol Vis Sci 48:2887-94. 2007.... - Automated visual choice discrimination learning in zebrafish (Danio rerio)Kaspar P Mueller
Institute of Molecular Life Sciences, University of Zurich, Winterthurerstrasse 190, Zurich, CH 8057, Switzerland
J Integr Neurosci 11:73-85. 2012.... - Phylogenetic analysis of the vertebrate excitatory/neutral amino acid transporter (SLC1/EAAT) family reveals lineage specific subfamiliesMatthias Gesemann
University of Zurich, Institute of Molecular Life Sciences, Winterthurerstrasse 190, CH 8057 Zurich, Switzerland
BMC Evol Biol 10:117. 2010..These genes are supposed to be under strong selective pressure (purifying selection) due to their important role in the timely removal of glutamate at the synapse... - Phylogeny and expression divergence of metabotropic glutamate receptor genes in the brain of zebrafish (Danio rerio)Marion F Haug
Institute of Molecular Life Sciences, University of Zurich, CH 8057 Zurich, Switzerland
J Comp Neurol 521:1533-60. 2013..Group I mglurs are similarly expressed in brain areas of both larval and adult zebrafish, suggesting that their functions are comparable during these stages... - Light perception: more than meets the eyesKaspar P Mueller
University of Zurich, Institute of Molecular Life Sciences Neuroscience Center Zurich and Center for Integrative Human Physiology, Winterthurerstrasse 190, CH 8057 Zurich, Switzerland Electronic address
Curr Biol 22:R912-4. 2012..This behaviour, termed dark photokinesis, is mediated by hypothalamic deep brain photoreceptors expressing melanopsin... - Double cone dystrophy and RPE degeneration in the retina of the zebrafish gnn mutantOliver Biehlmaier
Department for Experimental Ophthalmology, University Eye Hospital, , Germany
Invest Ophthalmol Vis Sci 44:1287-98. 2003..The gnn zebrafish mutant may therefore be a useful model for examining the possible interplay and connection between cone dystrophy and RPE degeneration... - The optokinetic response in zebrafish and its applicationsYing Yu Huang
Swiss Federal Institute of Technology ETH Zurich, Department of Biology, Zurich, Switzerland
Front Biosci 13:1899-916. 2008..A case in point is the belladonna mutation, where an axonal misrouting effect at the optic chiasm leads to a reversed OKR with a number of interesting properties... - Ganzfeld ERG in zebrafish larvaeMathias W Seeliger
Retinal Electrodiagnostics Research Group, University Eye Hospital, Dept II, Tubingen, Germany
Doc Ophthalmol 104:57-68. 2002..The above techniques allowed to reliably obtain Ganzfeld ERGs in larvae aged 5 dpf. This underlines the important role of the zebrafish as a model for the functional analysis of mutations disrupting the visual system... - belladonna/(Ihx2) is required for neural patterning and midline axon guidance in the zebrafish forebrainAnandita Seth
Biology Department, University of Massachusetts, Amherst, MA 01003 9297, USA
Development 133:725-35. 2006..Our analysis reveals new roles for Ihx2 in midline axon guidance, forebrain patterning and eye morphogenesis... - The Zebrafish fade out mutant: a novel genetic model for Hermansky-Pudlak syndromeRonja Bahadori
Swiss Federal Institute of Technology (ETH, Department of Biology, and Brain Research Institute, University of Zurich, Zurich, Switzerland
Invest Ophthalmol Vis Sci 47:4523-31. 2006..This syndrome is characteristic of Hermansky-Pudlak syndrome (HPS), making fad a novel genetic model of HPS. The gene does not cosegregate with the known human HPS genes, suggesting a novel molecular cause of HPS... - Nyctalopin is essential for synaptic transmission in the cone dominated zebrafish retinaRonja Bahadori
Swiss Federal Institute of Technology ETH Zurich, Department of Biology, at the University Zurich, Zurich, Switzerland
Eur J Neurosci 24:1664-74. 2006..We therefore demonstrated that nyctalopin plays a similar role in retinal synapse function in the cone pathway as in the rod pathway, thereby creating a genetic model for CSNB1 and its effects on cone vision... - Duplicated genes with split functions: independent roles of protocadherin15 orthologues in zebrafish hearing and visionChristoph Seiler
Max Planck Institut fur Entwicklungsbiologie, Spemannstrasse 35, 72076 Tubingen, Germany
Development 132:615-23. 2005..We conclude that after a duplication of pcdh15, one gene retained an essential function in the ear and the other in the eye... - Contrast sensitivity, spatial and temporal tuning of the larval zebrafish optokinetic responseOliver Rinner
Swiss Federal Institute of Technology, Department of Biology, and Brain Research Institute of the University Zurich, Zurich, Switzerland
Invest Ophthalmol Vis Sci 46:137-42. 2005..This behavioral paradigm will be useful for analyzing visual performance in mutant and gene-knockdown larval zebrafish... - Time course and development of light adaptation processes in the outer zebrafish retinaCorinne Hodel
Department of Biology, Swiss Federal Institute of Technology (ETH, Zurich, Switzerland
Anat Rec A Discov Mol Cell Evol Biol 288:653-62. 2006.... - Genetic identification of AChE as a positive modulator of addiction to the psychostimulant D-amphetamine in zebrafishJovica Ninkovic
Zebrafish Neurogenetics Junior Research Group, Institute of Virology, Technical University Munich, Trogerstrasse 4b, D 81675, Munich, Germany
J Neurobiol 66:463-75. 2006..More generally, they validate the zebrafish model to study the effect of developmental mutations on the molecular neurobiology of addiction in vertebrates... - The zebrafish, brain-specific, aromatase cyp19a2 is neither expressed nor distributed in a sexually dimorphic manner during sexual differentiationEvangelia Kallivretaki
Centre for Fish and Wildlife Health, University of Bern, Bern, Switzerland
Dev Dyn 236:3155-66. 2007.... - Fish possess multiple copies of fgfrl1, the gene for a novel FGF receptorBeat Trueb
ITI Research Institute, University of Bern, Murtenstrasse 35, CH 3010 Bern, Switzerland
Biochim Biophys Acta 1727:65-74. 2005..These genes are also found adjacent to the fgfrl1a gene of Fugu, suggesting that FGFRL1, SPON2, CTBP1 and MEAEA were preserved as a coherent block during the evolution of Fugu and man... - Synaptic plasticity and functionality at the cone terminal of the developing zebrafish retinaOliver Biehlmaier
Department for Experimental Ophthalmology, University Eye Hospital, Roentgenweg 11, 72076 Tuebingen, Germany
J Neurobiol 56:222-36. 2003..However, the mere number of spinules and ribbons at 7dpf still remains below the adult values, indicating that synaptic functionality of the zebrafish retina is not entirely completed at this stage of development...