Stephan C F Neuhauss

Summary

Affiliation: University of Zurich
Country: Switzerland

Publications

  1. ncbi Oculomotor instabilities in zebrafish mutant belladonna: a behavioral model for congenital nystagmus caused by axonal misrouting
    Ying Yu Huang
    Institute of Zoology, University of Zurich, CH 8057 Zurich, Switzerland
    J Neurosci 26:9873-80. 2006
  2. ncbi Behavioral genetic approaches to visual system development and function in zebrafish
    Stephan C F Neuhauss
    Brain Research Institute, University of Zurich and Swiss Federal Institute of Technology ETH Zurich, Winterthurerstrasse 190, CH 8057 Zurich, Switzerland
    J Neurobiol 54:148-60. 2003
  3. pmc Large-scale mapping of mutations affecting zebrafish development
    Robert Geisler
    Department 3 Genetics, Max Planck Institut fur Entwicklungsbiologie, Spemannstr, 35 III, 72076 Tubingen, Germany
    BMC Genomics 8:11. 2007
  4. ncbi Retinal defects in the zebrafish bleached mutant
    Stephan C F Neuhauss
    Brain Research Institute, University of Zurich and Department of Biology, Swiss Federal Institute of Technology Zurich, Winterthurerstr 190, CH 8057 Zurich, Switzerland
    Doc Ophthalmol 107:71-8. 2003
  5. ncbi The zebrafish mutant lbk/vam6 resembles human multisystemic disorders caused by aberrant trafficking of endosomal vesicles
    Helia B Schonthaler
    Swiss Federal Institute of Technology, Department of Biology, and Brain Research Institute of the University of Zurich, Winterthurerstrasse 190, CH 8057 Zurich, Switzerland
    Development 135:387-99. 2008
  6. pmc Evidence for RPE65-independent vision in the cone-dominated zebrafish retina
    Helia B Schonthaler
    University of Zurich, Institute of Zoology, Winterthurerstrasse 190, CH 8057 Zurich, Switzerland
    Eur J Neurosci 26:1940-9. 2007
  7. ncbi Knockdown of cone-specific kinase GRK7 in larval zebrafish leads to impaired cone response recovery and delayed dark adaptation
    Oliver Rinner
    Brain Research Institute, University of Zurich, Winterthurerstrasse 190, CH 8057 Zurich, Switzerland Institute for Molecular Systems Biology, Swiss Federal Institute of Technology ETH, CH 8093 Zurich, Switzerland
    Neuron 47:231-42. 2005
  8. doi Cone arrestin confers cone vision of high temporal resolution in zebrafish larvae
    Sabine L Renninger
    Institute of Molecular Life Sciences, Neuroscience Center Zurich and Center for Integrative Human Physiology, University of Zurich, Winterthurerstrasse 190, CH 8057 Zurich, Switzerland
    Eur J Neurosci 33:658-67. 2011
  9. ncbi Retinal function and morphology in two zebrafish models of oculo-renal syndromes
    Ronja Bahadori
    Swiss Federal Institute of Technology ETH Zurich, Department of Biology, and the Brain Research Institute, University of Zurich, Winterthurerstrasse 190, CH 8057 Zurich, Switzerland
    Eur J Neurosci 18:1377-86. 2003
  10. doi Severity of infantile nystagmus syndrome-like ocular motor phenotype is linked to the extent of the underlying optic nerve projection defect in zebrafish belladonna mutant
    Sabina P Huber-Reggi
    Institute of Molecular Life Sciences, University of Zurich, CH 8057 Zurich, Switzerland
    J Neurosci 32:18079-86. 2012

Collaborators

Detail Information

Publications35

  1. ncbi Oculomotor instabilities in zebrafish mutant belladonna: a behavioral model for congenital nystagmus caused by axonal misrouting
    Ying Yu Huang
    Institute of Zoology, University of Zurich, CH 8057 Zurich, Switzerland
    J Neurosci 26:9873-80. 2006
    ..The strong resemblance between the SO and congenital nystagmus (CN) seen in humans with defective retinotectal projections implies that CN, of so far unknown etiology, may be directly caused by a projection defect...
  2. ncbi Behavioral genetic approaches to visual system development and function in zebrafish
    Stephan C F Neuhauss
    Brain Research Institute, University of Zurich and Swiss Federal Institute of Technology ETH Zurich, Winterthurerstrasse 190, CH 8057 Zurich, Switzerland
    J Neurobiol 54:148-60. 2003
    ..Here, I summarize visually mediated behaviors of both larval and adult zebrafish and their applicability for genetic screens, and present, the approaches and results of visual behavior carried out to date...
  3. pmc Large-scale mapping of mutations affecting zebrafish development
    Robert Geisler
    Department 3 Genetics, Max Planck Institut fur Entwicklungsbiologie, Spemannstr, 35 III, 72076 Tubingen, Germany
    BMC Genomics 8:11. 2007
    ..Here we report on a large-scale effort to map the mutations generated in mutagenesis screening at the Max Planck Institute for Developmental Biology by genome scanning with microsatellite markers...
  4. ncbi Retinal defects in the zebrafish bleached mutant
    Stephan C F Neuhauss
    Brain Research Institute, University of Zurich and Department of Biology, Swiss Federal Institute of Technology Zurich, Winterthurerstr 190, CH 8057 Zurich, Switzerland
    Doc Ophthalmol 107:71-8. 2003
    ..Hence, the lack of visual responses in homozygous bleached larvae can be attributed to a severe defect of the outer retina, preceded by increased levels of apoptotic cell death in all retinal cell layers...
  5. ncbi The zebrafish mutant lbk/vam6 resembles human multisystemic disorders caused by aberrant trafficking of endosomal vesicles
    Helia B Schonthaler
    Swiss Federal Institute of Technology, Department of Biology, and Brain Research Institute of the University of Zurich, Winterthurerstrasse 190, CH 8057 Zurich, Switzerland
    Development 135:387-99. 2008
    ....
  6. pmc Evidence for RPE65-independent vision in the cone-dominated zebrafish retina
    Helia B Schonthaler
    University of Zurich, Institute of Zoology, Winterthurerstrasse 190, CH 8057 Zurich, Switzerland
    Eur J Neurosci 26:1940-9. 2007
    ..Thus, our study of zebrafish provides in vivo evidence for the existence of an RPE65-independent pathway for the regeneration of 11-cis-retinal for cone vision...
  7. ncbi Knockdown of cone-specific kinase GRK7 in larval zebrafish leads to impaired cone response recovery and delayed dark adaptation
    Oliver Rinner
    Brain Research Institute, University of Zurich, Winterthurerstrasse 190, CH 8057 Zurich, Switzerland Institute for Molecular Systems Biology, Swiss Federal Institute of Technology ETH, CH 8093 Zurich, Switzerland
    Neuron 47:231-42. 2005
    ....
  8. doi Cone arrestin confers cone vision of high temporal resolution in zebrafish larvae
    Sabine L Renninger
    Institute of Molecular Life Sciences, Neuroscience Center Zurich and Center for Integrative Human Physiology, University of Zurich, Winterthurerstrasse 190, CH 8057 Zurich, Switzerland
    Eur J Neurosci 33:658-67. 2011
    ..Behavioral measurements further revealed Arr3a deficiency to be sufficient to reduce temporal contrast sensitivity, providing evidence for the importance of arrestin in cone vision of high temporal resolution...
  9. ncbi Retinal function and morphology in two zebrafish models of oculo-renal syndromes
    Ronja Bahadori
    Swiss Federal Institute of Technology ETH Zurich, Department of Biology, and the Brain Research Institute, University of Zurich, Winterthurerstrasse 190, CH 8057 Zurich, Switzerland
    Eur J Neurosci 18:1377-86. 2003
    ....
  10. doi Severity of infantile nystagmus syndrome-like ocular motor phenotype is linked to the extent of the underlying optic nerve projection defect in zebrafish belladonna mutant
    Sabina P Huber-Reggi
    Institute of Molecular Life Sciences, University of Zurich, CH 8057 Zurich, Switzerland
    J Neurosci 32:18079-86. 2012
    ..Our data not only give new insights into the etiology of INS but may also be of interest for studies on how the brain deals with and adapts to conflicting inputs...
  11. doi Subfunctionalization of a retinoid-binding protein provides evidence for two parallel visual cycles in the cone-dominant zebrafish retina
    Valerie C Fleisch
    Department of Biology, Brain Research Institute, Institute of Zoology, Swiss Federal Institute of Technology ETH Zurich, University of Zurich, CH 8057 Zurich, Switzerland
    J Neurosci 28:8208-16. 2008
    ....
  12. doi Quantitative measurements of the optokinetic response in adult fish
    Kaspar P Mueller
    University of Zurich, Institute of Zoology, Neuroscience Center Zurich and Center for Integrative Human Physiology, Winterthurerstrasse 190, CH 8057 Zurich, Switzerland
    J Neurosci Methods 186:29-34. 2010
    ..This method can be applied to any fish species of similar size...
  13. doi Behavioral neurobiology: how larval fish orient towards the light
    Kaspar P Mueller
    University of Zurich, Institute of Molecular Life Sciences, Neuroscience Center Zurich and Center for Integrative Human Physiology, Winterthurerstrasse 190, CH 8057 Zurich, Switzerland
    Curr Biol 20:R159-61. 2010
    ..A recent study using zebrafish larvae has revealed the underlying neural logic of this primal choice behavior, by differential use of the retinal ON- and OFF-pathways...
  14. doi Light perception: more than meets the eyes
    Kaspar P Mueller
    University of Zurich, Institute of Molecular Life Sciences, Neuroscience Center Zurich and Center for Integrative Human Physiology, Winterthurerstrasse 190, CH 8057 Zurich, Switzerland
    Curr Biol 22:R912-4. 2012
    ..This behaviour, termed dark photokinesis, is mediated by hypothalamic deep brain photoreceptors expressing melanopsin...
  15. doi Phylogeny and expression divergence of metabotropic glutamate receptor genes in the brain of zebrafish (Danio rerio)
    Marion F Haug
    Institute of Molecular Life Sciences, University of Zurich, CH 8057 Zurich, Switzerland
    J Comp Neurol 521:1533-60. 2013
    ..Group I mglurs are similarly expressed in brain areas of both larval and adult zebrafish, suggesting that their functions are comparable during these stages...
  16. ncbi An inexpensive device for non-invasive electroretinography in small aquatic vertebrates
    Yuri V Makhankov
    Swiss Federal Institute of Technology, Department of Biology and Brain Research Institute of the University Zurich, Winterthurerstrasse 190, CH 8057 Zurich, Switzerland
    J Neurosci Methods 135:205-10. 2004
    ..This setup is easily built and will be particularly useful for laboratories setting up ERG measurements as a complement to their genetic studies...
  17. ncbi A mutation in the silver gene leads to defects in melanosome biogenesis and alterations in the visual system in the zebrafish mutant fading vision
    Helia B Schonthaler
    Swiss Federal Institute of Technology, Department of Biology, and Brain Research Institute of the University of Zurich, Winterthurerstrasse 190, CH 8057 Zurich, Switzerland
    Dev Biol 284:421-36. 2005
    ..The Silver protein is required for intralumenal fibril formation in melanosomes by amylogenic cleavage. Our data reveal an unexpected link between melanosome biogenesis and the visual system, undetectable in cell culture...
  18. doi Application of zebrafish oculomotor behavior to model human disorders
    Colette M Maurer
    University of Zurich, Institute of Molecular Life Sciences, Neuroscience Center Zurich and Center for Integrative Human Physiology, Winterthurerstrasse 190, CH 8057 Zurich, Switzerland
    Rev Neurosci 22:5-16. 2011
    ..This mutant displays a reverse optokinetic response, spontaneous oscillations that closely mimic human congenital nystagmus and abnormal motor behavior linked to circular vection...
  19. ncbi Impaired retinal differentiation and maintenance in zebrafish laminin mutants
    Oliver Biehlmaier
    Department of Biology, Swiss Federal Institute of Technology ETH Zurich, Switzerland
    Invest Ophthalmol Vis Sci 48:2887-94. 2007
    ....
  20. ncbi Automated visual choice discrimination learning in zebrafish (Danio rerio)
    Kaspar P Mueller
    Institute of Molecular Life Sciences, University of Zurich, Winterthurerstrasse 190, Zurich, CH 8057, Switzerland
    J Integr Neurosci 11:73-85. 2012
    ....
  21. pmc Phylogenetic analysis of the vertebrate excitatory/neutral amino acid transporter (SLC1/EAAT) family reveals lineage specific subfamilies
    Matthias Gesemann
    University of Zurich, Institute of Molecular Life Sciences, Winterthurerstrasse 190, CH 8057 Zurich, Switzerland
    BMC Evol Biol 10:117. 2010
    ..These genes are supposed to be under strong selective pressure (purifying selection) due to their important role in the timely removal of glutamate at the synapse...
  22. doi Reverse genetics tools in zebrafish: a forward dive into endocrinology
    Yuya Sugano
    Institute of Molecular Life Sciences, University of Zurich, Winterthurerstrasse 190, CH 8057 Zurich, Switzerland
    Gen Comp Endocrinol 188:303-8. 2013
    ..Here, we focus on both commonly used and recently established reverse genetic and transgenic tools available in zebrafish. These new developments make the zebrafish an even more attractive animal model in comparative endocrinology...
  23. ncbi Ganzfeld ERG in zebrafish larvae
    Mathias W Seeliger
    Retinal Electrodiagnostics Research Group, University Eye Hospital, Dept II, Tubingen, Germany
    Doc Ophthalmol 104:57-68. 2002
    ..The above techniques allowed to reliably obtain Ganzfeld ERGs in larvae aged 5 dpf. This underlines the important role of the zebrafish as a model for the functional analysis of mutations disrupting the visual system...
  24. ncbi Double cone dystrophy and RPE degeneration in the retina of the zebrafish gnn mutant
    Oliver Biehlmaier
    Department for Experimental Ophthalmology, University Eye Hospital, Tubingen, Germany
    Invest Ophthalmol Vis Sci 44:1287-98. 2003
    ..To characterize morphologic alterations in the retina of the visual mutant zebrafish gantenbein (gnn) and to examine whether these alterations correlate with those present in human hereditary eye diseases...
  25. ncbi Contrast sensitivity, spatial and temporal tuning of the larval zebrafish optokinetic response
    Oliver Rinner
    Swiss Federal Institute of Technology, Department of Biology, and Brain Research Institute of the University Zurich, Zurich, Switzerland
    Invest Ophthalmol Vis Sci 46:137-42. 2005
    ..To characterize the quantitative properties of the optokinetic response (OKR) in zebrafish larvae as a tool to test visual performance in genetically modified larvae...
  26. ncbi Duplicated genes with split functions: independent roles of protocadherin15 orthologues in zebrafish hearing and vision
    Christoph Seiler
    Max Planck Institut fur Entwicklungsbiologie, Spemannstrasse 35, 72076 Tubingen, Germany
    Development 132:615-23. 2005
    ..We conclude that after a duplication of pcdh15, one gene retained an essential function in the ear and the other in the eye...
  27. ncbi belladonna/(Ihx2) is required for neural patterning and midline axon guidance in the zebrafish forebrain
    Anandita Seth
    Biology Department, University of Massachusetts, Amherst, MA 01003 9297, USA
    Development 133:725-35. 2006
    ..Our analysis reveals new roles for Ihx2 in midline axon guidance, forebrain patterning and eye morphogenesis...
  28. ncbi The Zebrafish fade out mutant: a novel genetic model for Hermansky-Pudlak syndrome
    Ronja Bahadori
    Swiss Federal Institute of Technology ETH, Department of Biology, and Brain Research Institute, University of Zurich, Zurich, Switzerland
    Invest Ophthalmol Vis Sci 47:4523-31. 2006
    ..To characterize retinal morphology and visual system function in the zebrafish mutant fade out (fad) and to establish the mutant as a lower vertebrate model for Hermansky-Pudlak syndrome (HPS)...
  29. ncbi Nyctalopin is essential for synaptic transmission in the cone dominated zebrafish retina
    Ronja Bahadori
    Swiss Federal Institute of Technology ETH Zurich, Department of Biology, at the University Zurich, Zurich, Switzerland
    Eur J Neurosci 24:1664-74. 2006
    ..We therefore demonstrated that nyctalopin plays a similar role in retinal synapse function in the cone pathway as in the rod pathway, thereby creating a genetic model for CSNB1 and its effects on cone vision...
  30. ncbi The optokinetic response in zebrafish and its applications
    Ying Yu Huang
    Swiss Federal Institute of Technology ETH Zurich, Department of Biology, Zurich, Switzerland
    Front Biosci 13:1899-916. 2008
    ..A case in point is the belladonna mutation, where an axonal misrouting effect at the optic chiasm leads to a reversed OKR with a number of interesting properties...
  31. ncbi Genetic identification of AChE as a positive modulator of addiction to the psychostimulant D-amphetamine in zebrafish
    Jovica Ninkovic
    Zebrafish Neurogenetics Junior Research Group, Institute of Virology, Technical University Munich, Trogerstrasse 4b, D 81675, Munich, Germany
    J Neurobiol 66:463-75. 2006
    ..More generally, they validate the zebrafish model to study the effect of developmental mutations on the molecular neurobiology of addiction in vertebrates...
  32. ncbi Time course and development of light adaptation processes in the outer zebrafish retina
    Corinne Hodel
    Department of Biology, Swiss Federal Institute of Technology ETH, Zurich, Switzerland
    Anat Rec A Discov Mol Cell Evol Biol 288:653-62. 2006
    ....
  33. ncbi Fish possess multiple copies of fgfrl1, the gene for a novel FGF receptor
    Beat Trueb
    ITI Research Institute, University of Bern, Murtenstrasse 35, CH 3010 Bern, Switzerland
    Biochim Biophys Acta 1727:65-74. 2005
    ..These genes are also found adjacent to the fgfrl1a gene of Fugu, suggesting that FGFRL1, SPON2, CTBP1 and MEAEA were preserved as a coherent block during the evolution of Fugu and man...
  34. ncbi Synaptic plasticity and functionality at the cone terminal of the developing zebrafish retina
    Oliver Biehlmaier
    Department for Experimental Ophthalmology, University Eye Hospital, Roentgenweg 11, 72076 Tuebingen, Germany
    J Neurobiol 56:222-36. 2003
    ..However, the mere number of spinules and ribbons at 7dpf still remains below the adult values, indicating that synaptic functionality of the zebrafish retina is not entirely completed at this stage of development...
  35. ncbi The zebrafish, brain-specific, aromatase cyp19a2 is neither expressed nor distributed in a sexually dimorphic manner during sexual differentiation
    Evangelia Kallivretaki
    Centre for Fish and Wildlife Health, University of Bern, Bern, Switzerland
    Dev Dyn 236:3155-66. 2007
    ....