Alexander A Navarini

Summary

Affiliation: University Hospital
Country: Switzerland

Publications

  1. pmc Disfiguring annular sarcoidosis improved by adalimumab
    C A Kaiser
    Department of Dermatology, University Hospital of Zurich, Zurich, Switzerland
    Case Rep Dermatol 3:103-6. 2011
  2. doi request reprint Antihistamines are superior to topical steroids in managing human immunodeficiency virus (HIV)-associated papular pruritic eruption
    Alexander A Navarini
    Ifakara Health Institute, Ifakara, Kilombero, Tanzania
    Int J Dermatol 49:83-6. 2010
  3. doi request reprint Trauma as triggering factor for development of melanocytic nevi
    Alexander A Navarini
    Department of Dermatology, University Hospital of Zurich, Gloriastrasse 31, Zurich, Switzerland
    Dermatology 220:291-6. 2010
  4. doi request reprint Estimation of cost-of-illness in patients with psoriasis in Switzerland
    Alexander A Navarini
    Department of Dermatology, University of Zurich, Zurich, Switzerland
    Swiss Med Wkly 140:85-91. 2010
  5. doi request reprint Long-lasting immunity by early infection of maternal-antibody-protected infants
    Alexander A Navarini
    Institute for Experimental Immunology, University Hospital Zurich, Zurich, Switzerland
    Eur J Immunol 40:113-6. 2010
  6. pmc Innate immune-induced depletion of bone marrow neutrophils aggravates systemic bacterial infections
    Alexander A Navarini
    Institute for Experimental Immunology and Department of Pathology, University Hospital Zurich, Schmelzbergstrasse 12, CH 8091 Zurich, Switzerland
    Proc Natl Acad Sci U S A 106:7107-12. 2009
  7. doi request reprint Melanoma and innate immunity--aActive inflammation or just erroneous attraction? Melanoma as the source of leukocyte-attracting chemokines
    Alexander A Navarini-Meury
    Department of Dermatology, University Hospital of Zurich, Gloriastrasse 31, 8091 Zurich, Switzerland
    Semin Cancer Biol 19:84-91. 2009
  8. pmc Increased susceptibility to bacterial superinfection as a consequence of innate antiviral responses
    Alexander A Navarini
    Institute for Experimental Immunology, University Hospital Zurich, Schmelzbergstrasse 12, CH 8091 Zurich, Switzerland
    Proc Natl Acad Sci U S A 103:15535-9. 2006
  9. doi request reprint Hematopoietic cell-derived interferon controls viral replication and virus-induced disease
    Philipp A Lang
    Institute of Experimental Immunology, University Hospital of Zurich, Zurich, Switzerland
    Blood 113:1045-52. 2009
  10. ncbi request reprint MyD88 protects from lethal encephalitis during infection with vesicular stomatitis virus
    Karl S Lang
    Institutes of Experimental Immunology, Neuropathology and Surgical Pathology, University Hospital of Zurich, Zurich, Switzerland
    Eur J Immunol 37:2434-40. 2007

Collaborators

Detail Information

Publications26

  1. pmc Disfiguring annular sarcoidosis improved by adalimumab
    C A Kaiser
    Department of Dermatology, University Hospital of Zurich, Zurich, Switzerland
    Case Rep Dermatol 3:103-6. 2011
    ..5/10, and the Dermatology Life Quality Index from 16/30 to 3/30 points. In conclusion, TNF-α inhibition can control inflammation and disfigurement by cutaneous sarcoidosis and restore quality of life...
  2. doi request reprint Antihistamines are superior to topical steroids in managing human immunodeficiency virus (HIV)-associated papular pruritic eruption
    Alexander A Navarini
    Ifakara Health Institute, Ifakara, Kilombero, Tanzania
    Int J Dermatol 49:83-6. 2010
    ..Disease activity did not correlate with CD4+ and CD8+ T cell counts and was independent of anti-retroviral medication. Therefore, oral antihistamines are an effective first-line treatment for PPE...
  3. doi request reprint Trauma as triggering factor for development of melanocytic nevi
    Alexander A Navarini
    Department of Dermatology, University Hospital of Zurich, Gloriastrasse 31, Zurich, Switzerland
    Dermatology 220:291-6. 2010
    ..We conclude that in predisposed patients, the trigger for eruptive nevi can be reduced to a simple localized minor trauma...
  4. doi request reprint Estimation of cost-of-illness in patients with psoriasis in Switzerland
    Alexander A Navarini
    Department of Dermatology, University of Zurich, Zurich, Switzerland
    Swiss Med Wkly 140:85-91. 2010
    ..Evaluation of the current clinical treatment of psoriasis in Switzerland remains to be measured with the parameters cost-of-illness and quality of life...
  5. doi request reprint Long-lasting immunity by early infection of maternal-antibody-protected infants
    Alexander A Navarini
    Institute for Experimental Immunology, University Hospital Zurich, Zurich, Switzerland
    Eur J Immunol 40:113-6. 2010
    ..This implies that both the absence of exposure to infection during early infancy or of effective vaccination renders the population highly susceptible to new or old re-emerging pathogens...
  6. pmc Innate immune-induced depletion of bone marrow neutrophils aggravates systemic bacterial infections
    Alexander A Navarini
    Institute for Experimental Immunology and Department of Pathology, University Hospital Zurich, Schmelzbergstrasse 12, CH 8091 Zurich, Switzerland
    Proc Natl Acad Sci U S A 106:7107-12. 2009
    ..These data implicate systemic innate immune stimulation as a mechanism of bone marrow neutrophil exhaustion which negatively influences the outcome of bacterial infections...
  7. doi request reprint Melanoma and innate immunity--aActive inflammation or just erroneous attraction? Melanoma as the source of leukocyte-attracting chemokines
    Alexander A Navarini-Meury
    Department of Dermatology, University Hospital of Zurich, Gloriastrasse 31, 8091 Zurich, Switzerland
    Semin Cancer Biol 19:84-91. 2009
    ..Therefore, the observed leukocyte infiltration in melanoma might be at least in part an epiphenomenon of neoplastic self-stimulation rather than a full-fledged innate anti-tumor immune response...
  8. pmc Increased susceptibility to bacterial superinfection as a consequence of innate antiviral responses
    Alexander A Navarini
    Institute for Experimental Immunology, University Hospital Zurich, Schmelzbergstrasse 12, CH 8091 Zurich, Switzerland
    Proc Natl Acad Sci U S A 103:15535-9. 2006
    ..The finding that the innate antiviral immune response reduces the antibacterial granulocyte defense offers an explanation for enhanced susceptibility to bacterial superinfection during viral disease...
  9. doi request reprint Hematopoietic cell-derived interferon controls viral replication and virus-induced disease
    Philipp A Lang
    Institute of Experimental Immunology, University Hospital of Zurich, Zurich, Switzerland
    Blood 113:1045-52. 2009
    ..These data suggest that during systemic viral infection primarily hematopoietic cell-derived IFN-I controls viral replication and viral-induced disease...
  10. ncbi request reprint MyD88 protects from lethal encephalitis during infection with vesicular stomatitis virus
    Karl S Lang
    Institutes of Experimental Immunology, Neuropathology and Surgical Pathology, University Hospital of Zurich, Zurich, Switzerland
    Eur J Immunol 37:2434-40. 2007
    ..Susceptibility of myd88(-/-) mice correlated with impaired recruitment of immune cells to the site of infection. In the absence of MyD88 signalling, VSV rapidly spread to the spinal cord and brain causing lethal encephalitis...
  11. pmc Immunoprivileged status of the liver is controlled by Toll-like receptor 3 signaling
    Karl S Lang
    Institute of Experimental Immunology, University Hospital of Zurich, Zurich, Switzerland
    J Clin Invest 116:2456-63. 2006
    ..Thus, nonspecific activation of innate immunity can drastically enhance susceptibility to immune destruction of a solid organ...
  12. ncbi request reprint Requirement for neutralizing antibodies to control bone marrow transplantation-associated persistent viral infection and to reduce immunopathology
    Karl S Lang
    Institute of Experimental Immunology, University Hospital, Zurich, Switzerland
    J Immunol 175:5524-31. 2005
    ..These data underscore the in vivo efficacy and immunopathological "safety" of neutralizing antibodies...
  13. ncbi request reprint Inverse correlation between IL-7 receptor expression and CD8 T cell exhaustion during persistent antigen stimulation
    Karl S Lang
    Institute of Experimental Immunology, Zurich, Switzerland
    Eur J Immunol 35:738-45. 2005
    ..Persistent antigen also suppressed IL-7Ralpha expression on primed T cells and this correlated with exhaustion of a previously stable primed T cell population. These findings suggest that antigen longevity regulates T cell fate...
  14. doi request reprint A platelet-mediated system for shuttling blood-borne bacteria to CD8α+ dendritic cells depends on glycoprotein GPIb and complement C3
    Admar Verschoor
    Institute for Medical Microbiology, Immunology and Hygiene, and Focus Group, Clinical Cell Processing and Purification, Technische Universitat Munchen, Munich, Germany
    Nat Immunol 12:1194-201. 2011
    ..Other gram-positive bacteria also were rapidly tagged by platelets, revealing a broadly active shuttling mechanism for systemic bacteria...
  15. pmc Epidermal IL-15Rα acts as an endogenous antagonist of psoriasiform inflammation in mouse and man
    Gregory Bouchaud
    Laboratory of Applied Immunobiology and 2 Department of Dermatology, University of Zurich, 8006 Zurich, Switzerland
    J Exp Med 210:2105-17. 2013
    ..Thus, stressed epidermal stromal cells use soluble IL-15Rα to dampen chronic inflammatory skin disease. ..
  16. ncbi request reprint Toll-like receptor engagement converts T-cell autoreactivity into overt autoimmune disease
    Karl S Lang
    Institute of Experimental Immunology, University Hospital of Zurich, Schmelzbergstrasse 12, Zurich, Switzerland
    Nat Med 11:138-45. 2005
    ..These data identify the 'inflammatory status' of the target organ as a separate and limiting factor determining the development of autoimmune disease...
  17. pmc Rorγt+ innate lymphocytes and γδ T cells initiate psoriasiform plaque formation in mice
    Stanislav Pantelyushin
    Institute of Experimental Immunology, University of Zurich, Zurich, Switzerland
    J Clin Invest 122:2252-6. 2012
    ..Furthermore, our findings establish that RORγt(+) innate lymphocytes and γδ T cells are necessary and sufficient for psoriatic plaque formation in an experimental disease model that closely resembles human psoriatic plaque formation...
  18. doi request reprint Spitzoid melanoma and micrometastases in two lymph node regions: a critical situation
    Alexander A Navarini
    Department of Dermatology, University Hospital Zurich, Gloriastrasse 31, 8091 Zurich, Switzerland
    Eur J Dermatol 21:229-33. 2011
    ..Treatment decisions for atypical Spitz tumors are a major medical and ethical challenge due to the limited available data...
  19. doi request reprint Control of widespread hypertrophic lupus erythematosus with T-cell-directed biologic efalizumab
    Alexander A Navarini
    Department of Dermatology, University Hospital of Zurich, Zurich, Switzerland
    Dermatology 220:249-53. 2010
    ..In a patient with a disease refractory to conventional therapy, we observed a predominantly CD4+ T cell infiltrate that we sought to target therapeutically...
  20. doi request reprint Acutely ill patients in internal medicine departments want treatment for undiagnosed, symptomatic skin conditions
    Yasemin Goeksu
    Department of Dermatology, Zurich University Hospital, Zurich, Switzerland
    Dermatology 225:115-20. 2012
    ..Concomitant skin conditions may be neglected in internal medicine patients due to lack of knowledge or resources. Thus, we investigated the prevalence of undiagnosed skin conditions in this population...
  21. doi request reprint 3 cases of dissecting cellulitis of the scalp treated with adalimumab: control of inflammation within residual structural disease
    Alexander A Navarini
    Department of Dermatology, University Hospital of Zurich, Gloriastrasse 31, CH 8091 Zurich, Switzerland
    Arch Dermatol 146:517-20. 2010
    ..04) was reduced rapidly by adalimumab. Histopathologic characteristics demonstrated marked improvement of inflammation, despite persistence of underlying structural disease. Relapse was observed following discontinuation of adalimumab...
  22. pmc Weight-Based Adaptation of TNF-Antagonist Induction versus Maintenance Dose
    Alexander A Navarini
    Department of Dermatology, University Hospital of Zurich, Zurich, Switzerland
    Case Rep Dermatol 3:124-9. 2011
    ..6) and DLQI (22/30 to 5/30) decreased. This strategy might be an effective and less costly alternative to doubling the maintenance doses, and could be further evaluated for psoriasis patients refractory to previous treatments...
  23. doi request reprint Oral, esophageal and cutaneous lichen ruber planus controlled with alitretinoin: case report and review of the literature
    Antonios G A Kolios
    Department of Dermatology, University Hospital of Zurich, Zurich, Switzerland
    Dermatology 226:302-10. 2013
    ..Therapy-resistant lichen planus (LP) can be a challenging condition for dermatologists. There are some case reports about successful treatments with alitretinoin of cutaneous and oral, but not of esophageal LP...
  24. pmc Why Henry III of Navarre's Hair Probably did not Turn White Overnight
    Alexander A Navarini
    Department of Dermatology, University Hospital of Zurich, Switzerland
    Int J Trichology 2:2-4. 2010
    ....
  25. ncbi request reprint The prion protein is neuroprotective against retinal degeneration in vivo
    Rico Frigg
    Lab for Retinal Cell Biology, Department of Ophthalmology, Center for Integrative Human Physiology CIHP and Neuroscience Center ZNZ, University of Zurich, Frauenklinikstrasse 24, Zurich, Switzerland
    Exp Eye Res 83:1350-8. 2006
    ..Our results reveal PrP as a neuroprotective/anti-apoptotic factor in vivo and suggest that PrPc may function as a guardian of neuronal integrity...