CHRISTIAN MUNZ

Summary

Affiliation: University Hospital
Country: Switzerland

Publications

  1. pmc Immune escape by Epstein-Barr virus associated malignancies
    CHRISTIAN MUNZ
    Viral Immunobiology, Institute of Experimental Immunology, University Hospital of Zurich, Zurich, Switzerland
    Semin Cancer Biol 18:381-7. 2008
  2. pmc Antiviral immune responses: triggers of or triggered by autoimmunity?
    CHRISTIAN MUNZ
    Viral Immunobiology, Institute of Experimental Immunology, University Hospital Zurich, Winterthurerstrasse 190, CH 8057 Zurich, Switzerland
    Nat Rev Immunol 9:246-58. 2009
  3. pmc Priming of protective T cell responses against virus-induced tumors in mice with human immune system components
    Till Strowig
    Laboratory of Viral Immunobiology, Christopher H Browne Center for Immunology and Immune Diseases, The Rockefeller University, New York, NY 10065, USA
    J Exp Med 206:1423-34. 2009
  4. pmc Macroautophagy during Innate Immune Activation
    CHRISTIAN MUNZ
    Viral Immunobiology, Institute of Experimental Immunology, University of Zurich Zurich, Switzerland
    Front Microbiol 2:72. 2011
  5. pmc Antigen processing for MHC presentation by autophagy
    CHRISTIAN MUNZ
    Viral Immunobiology, Institute of Experimental Immunology, University Hospital Zürich Winterthurerstrasse 190, CH 8057 Zürich Switzerland
    F1000 Biol Rep 2:61. 2010
  6. pmc Autophagy in herpesvirus immune control and immune escape
    Graham S Taylor
    School of Cancer Sciences and Medical Research Council Centre for Immune Regulation, University of Birmingham, Birmingham, UK
    Herpesviridae 2:2. 2011
  7. doi Enhancing immunity through autophagy
    CHRISTIAN MUNZ
    Viral Immunobiology, Institute of Experimental Immunology, University Hospital of Zurich, CH 8057 Zurich, Switzerland
    Annu Rev Immunol 27:423-49. 2009
  8. pmc Antigen processing via autophagy--not only for MHC class II presentation anymore?
    CHRISTIAN MUNZ
    Viral Immunobiology, Institute of Experimental Immunology, University Hospital of Zurich, Switzerland
    Curr Opin Immunol 22:89-93. 2010
  9. ncbi Selective macroautophagy for immunity
    CHRISTIAN MUNZ
    Viral Immunobiology, Institute of Experimental Immunology, University Hospital of Zurich, Zurich, Switzerland
    Immunity 32:298-9. 2010
  10. pmc Targeting the nuclear antigen 1 of Epstein-Barr virus to the human endocytic receptor DEC-205 stimulates protective T-cell responses
    Cagan Gurer
    Laboratory of Viral Immunobiology, Christopher H Browne Center for Immunology and Immune Diseases, The Rockefeller University, New York, NY 10065, USA
    Blood 112:1231-9. 2008

Research Grants

  1. Endogenous MHC class II antigen processing via autophagy
    CHRISTIAN MUNZ; Fiscal Year: 2006
  2. DC/NK interactions in human secondary lymphoid organs
    CHRISTIAN MUNZ; Fiscal Year: 2004
  3. DC/NK interactions in human secondary lymphoid organs
    CHRISTIAN MUNZ; Fiscal Year: 2005
  4. DC/NK interactions in human secondary lymphoid organs
    CHRISTIAN MUNZ; Fiscal Year: 2006
  5. Anti-viral DC/NK interactions
    CHRISTIAN MUNZ; Fiscal Year: 2009
  6. Anti-viral DC/NK interactions
    CHRISTIAN MUNZ; Fiscal Year: 2010

Collaborators

Detail Information

Publications72

  1. pmc Immune escape by Epstein-Barr virus associated malignancies
    CHRISTIAN MUNZ
    Viral Immunobiology, Institute of Experimental Immunology, University Hospital of Zurich, Zurich, Switzerland
    Semin Cancer Biol 18:381-7. 2008
    ..Furthermore, we discuss how current vaccine approaches against EBV might be able to target these selective deficiencies...
  2. pmc Antiviral immune responses: triggers of or triggered by autoimmunity?
    CHRISTIAN MUNZ
    Viral Immunobiology, Institute of Experimental Immunology, University Hospital Zurich, Winterthurerstrasse 190, CH 8057 Zurich, Switzerland
    Nat Rev Immunol 9:246-58. 2009
    ..In this Review, we outline the mechanisms by which viral infection can trigger autoimmune disease and describe the pathways by which infection and immune control of infectious disease might be dysregulated during autoimmunity...
  3. pmc Priming of protective T cell responses against virus-induced tumors in mice with human immune system components
    Till Strowig
    Laboratory of Viral Immunobiology, Christopher H Browne Center for Immunology and Immune Diseases, The Rockefeller University, New York, NY 10065, USA
    J Exp Med 206:1423-34. 2009
    ..Both loss of CD4(+) and CD8(+) T cells abolished immune control. Therefore, this mouse model recapitulates features of symptomatic primary EBV infection and generates T cell-mediated immune control that resists oncogenic transformation...
  4. pmc Macroautophagy during Innate Immune Activation
    CHRISTIAN MUNZ
    Viral Immunobiology, Institute of Experimental Immunology, University of Zurich Zurich, Switzerland
    Front Microbiol 2:72. 2011
    ..The improved understanding of the capabilities of macroautophagy for immunity suggests that this pathway should be harnessed in immunotherapies against infectious diseases...
  5. pmc Antigen processing for MHC presentation by autophagy
    CHRISTIAN MUNZ
    Viral Immunobiology, Institute of Experimental Immunology, University Hospital Zürich Winterthurerstrasse 190, CH 8057 Zürich Switzerland
    F1000 Biol Rep 2:61. 2010
    ..In addition, recent evidence suggests that it also facilitates the processing of extracellular antigens for both MHC class I and II presentation...
  6. pmc Autophagy in herpesvirus immune control and immune escape
    Graham S Taylor
    School of Cancer Sciences and Medical Research Council Centre for Immune Regulation, University of Birmingham, Birmingham, UK
    Herpesviridae 2:2. 2011
    ..These studies suggest that herpesviruses significantly modulate autophagy to escape from its functions in innate and adaptive immunity...
  7. doi Enhancing immunity through autophagy
    CHRISTIAN MUNZ
    Viral Immunobiology, Institute of Experimental Immunology, University Hospital of Zurich, CH 8057 Zurich, Switzerland
    Annu Rev Immunol 27:423-49. 2009
    ..These immune-enhancing functions make autophagy an attractive target for therapeutic manipulation in human disease...
  8. pmc Antigen processing via autophagy--not only for MHC class II presentation anymore?
    CHRISTIAN MUNZ
    Viral Immunobiology, Institute of Experimental Immunology, University Hospital of Zurich, Switzerland
    Curr Opin Immunol 22:89-93. 2010
    ..Here, I will review the contribution of autophagy for MHC class I and class II antigen processing and presentation to T cells...
  9. ncbi Selective macroautophagy for immunity
    CHRISTIAN MUNZ
    Viral Immunobiology, Institute of Experimental Immunology, University Hospital of Zurich, Zurich, Switzerland
    Immunity 32:298-9. 2010
    ..However, Ponpuak et al. (2010) show in this issue of Immunity that cytosolic proteins are selectively recruited to autophagosomes to become metabolized to bactericidal peptides...
  10. pmc Targeting the nuclear antigen 1 of Epstein-Barr virus to the human endocytic receptor DEC-205 stimulates protective T-cell responses
    Cagan Gurer
    Laboratory of Viral Immunobiology, Christopher H Browne Center for Immunology and Immune Diseases, The Rockefeller University, New York, NY 10065, USA
    Blood 112:1231-9. 2008
    ....
  11. ncbi Mature human Langerhans cells derived from CD34+ hematopoietic progenitors stimulate greater cytolytic T lymphocyte activity in the absence of bioactive IL-12p70, by either single peptide presentation or cross-priming, than do dermal-interstitial or monoc
    Gudrun Ratzinger
    Laboratory of Cellular Immunobiology, Division of Hematologic Oncology, Department of Medicine, Memorial Sloan Kettering Cancer Center, New York, NY 10021, USA
    J Immunol 173:2780-91. 2004
    ..These findings merit further comparisons in clinical trials designed to determine the physiologic relevance of these distinctions in activity between LCs and other DCs...
  12. pmc Human NK cells of mice with reconstituted human immune system components require preactivation to acquire functional competence
    Till Strowig
    Laboratory of Viral Immunobiology, and Christopher H Browne Center for Immunology and Immune Diseases, The Rockefeller University, New York, NY, USA
    Blood 116:4158-67. 2010
    ..These data suggest that a functional, but resting, NK-cell compartment can be established in immune-compromised mice after human hematopoietic progenitor cell transfer...
  13. pmc Epstein-barr virus: environmental trigger of multiple sclerosis?
    Jan D Lunemann
    Laboratory of Viral Immunobiology, Christopher H Browne Center for Immunology and Immune Diseases, The Rockefeller University, Box 390, 1230 York Avenue, New York, NY 10021 6399, USA
    J Virol 81:6777-84. 2007
  14. pmc Tonsilar NK cells restrict B cell transformation by the Epstein-Barr virus via IFN-gamma
    Till Strowig
    Laboratory of Viral Immunobiology, The Rockefeller University, New York, New York, United States of America
    PLoS Pathog 4:e27. 2008
    ..These results suggest that NK cell activation by DCs can limit primary EBV infection in tonsils until adaptive immunity establishes immune control of this persistent and oncogenic human pathogen...
  15. pmc EBNA1-specific T cells from patients with multiple sclerosis cross react with myelin antigens and co-produce IFN-gamma and IL-2
    Jan D Lunemann
    Laboratory of Viral Immunobiology, Christopher H Browne Center for Immunology and Immune Diseases, The Rockefeller University, New York, NY 10065, USA
    J Exp Med 205:1763-73. 2008
    ..Our data support the concept that clonally expanded EBNA1-specific CD4(+) T cells potentially contribute to the development of MS by cross-recognition of myelin antigens...
  16. ncbi Epstein-Barr nuclear antigen 1-specific CD4(+) Th1 cells kill Burkitt's lymphoma cells
    Casper Paludan
    Laboratory of Cellular Physiology and Immunology, The Rockefeller University, New York, NY 10021, USA
    J Immunol 169:1593-603. 2002
    ..Therefore, adaptive immunity can be directed against Burkitt's lymphoma, and perhaps this role for CD4(+) Th1 cells extends to other tumors that escape MHC class I presentation...
  17. ncbi Endogenous MHC class II processing of a viral nuclear antigen after autophagy
    Casper Paludan
    Laboratory of Viral Immunobiology, Rockefeller University, New York, NY 10021, USA
    Science 307:593-6. 2005
    ..Thus, lysosomal processing after autophagy may contribute to MHC class II-restricted surveillance of long-lived endogenous antigens including nuclear proteins relevant to disease...
  18. ncbi NK cells of human secondary lymphoid tissues enhance T cell polarization via IFN-gamma secretion
    Barbara Morandi
    Laboratory of Viral Immunobiology and Christopher H Browne Center for Immunology and Immune Diseases, The Rockefeller University, New York, NY 10021, USA
    Eur J Immunol 36:2394-400. 2006
    ..Our data suggest that NK cells in secondary lymphoid organs assist priming of Th1 cells via cytokine secretion and this effect should be harnessed during vaccination against viruses and tumors...
  19. pmc Dendritic cells initiate immune control of epstein-barr virus transformation of B lymphocytes in vitro
    Kara Bickham
    Laboratory of Cellular Physiology and Immunology, The Rockefeller University, New York, NY 10021, USA
    J Exp Med 198:1653-63. 2003
    ..We suggest that the cross-presentation of EBV-latent antigens from infected B cells by DCs is required for the initiation of EBV-specific immune control in vivo and that future EBV vaccine strategies should target viral antigens to DCs...
  20. ncbi Activation of influenza virus-specific CD4+ and CD8+ T cells: a new role for plasmacytoid dendritic cells in adaptive immunity
    Jean Francois Fonteneau
    Laboratory of Molecular Neuro Oncology, Rockefeller University, New York, NY, USA
    Blood 101:3520-6. 2003
    ..Our results pinpoint a new role of pDCs in the induction of antiviral T-cell responses and suggest that these DCs play a prominent role in the adaptive immune response against viruses...
  21. ncbi NK cells interactions with dendritic cells shape innate and adaptive immunity
    Fabienne Brilot
    Laboratory of Viral Immunobiology and Christopher H Browne Center for Immunology and Immune Diseases, The Rockefeller University, New York, New York 10065, USA
    Front Biosci 13:6443-54. 2008
    ..Based on this better understanding, we propose that NK cells should be targeted for their protective functions and as an adjuvant during immunotherapy development...
  22. ncbi Autophagy in innate and adaptive immunity against intracellular pathogens
    Dorothee Schmid
    Laboratory of Viral Immunobiology, and Christopher H Browne Center for Immunology and Immune Diseases, The Rockefeller University, New York, NY 10021, USA
    J Mol Med (Berl) 84:194-202. 2006
    ..Therefore, autophagy might contribute to immune surveillance of intracellular pathogens via MHC class II presentation of intracellular pathogen-derived peptides...
  23. pmc Patients with Epstein Barr virus-positive lymphomas have decreased CD4(+) T-cell responses to the viral nuclear antigen 1
    Kevin N Heller
    Laboratory of Viral Immunobiology, Christopher H Browne Center for Immunology and Immune Diseases, The Rockefeller University, New York, NY, USA
    Int J Cancer 123:2824-31. 2008
    ..These data suggest a selective loss of EBNA1-specific immune control in EBV-associated lymphoma patients, which should be targeted for immunotherapy of these malignancies...
  24. ncbi NK cell compartments and their activation by dendritic cells
    Guido Ferlazzo
    Laboratory of Cellular Physiology and Immunology, The Rockefeller University, New York, NY 10021, USA
    J Immunol 172:1333-9. 2004
  25. ncbi CD4+ T cell responses in the immune control against latent infection by Epstein-Barr virus
    Casper Paludan
    Laboratory of Cellular Physiology and Immunology, The Rockefeller University, New York, NY 10021, USA
    Curr Mol Med 3:341-7. 2003
    ....
  26. pmc NK cell survival mediated through the regulatory synapse with human DCs requires IL-15Ralpha
    Fabienne Brilot
    Laboratory of Viral Immunobiology and Christopher H Browne Center for Immunology and Immune Diseases, Rockefeller University, New York, New York 10065, USA
    J Clin Invest 117:3316-29. 2007
    ..We suggest that this synapse formation enables optimal NK cell activation by DCs during innate immune responses...
  27. pmc Elevated Epstein-Barr virus-encoded nuclear antigen-1 immune responses predict conversion to multiple sclerosis
    Jan D Lunemann
    Viral Immunobiology, Institute of Experimental Immunology, University Hospital of Zurich, Zurich, Switzerland
    Ann Neurol 67:159-69. 2010
    ..The aims of the study were to determine the immune responses to candidate viral triggers of multiple sclerosis (MS) in patients with clinically isolated syndromes (CISs), and to evaluate their potential value in predicting conversion to MS...
  28. doi EBV in MS: guilty by association?
    Jan D Lunemann
    Institute of Experimental Immunology, University Hospital Zurich, Switzerland
    Trends Immunol 30:243-8. 2009
    ....
  29. pmc DEC-205/CD205+ dendritic cells are abundant in the white pulp of the human spleen, including the border region between the red and white pulp
    Maggi Pack
    The Rockefeller University, New York, NY 10021, USA
    Immunology 123:438-46. 2008
    ..Therefore, anti-DEC-205/CD205 antibodies are useful for identifying DCs in human splenic white pulp and its border region with the red pulp...
  30. pmc Human NK cells kill resting but not activated microglia via NKG2D- and NKp46-mediated recognition
    Anna Lünemann
    Laboratory of Viral Immunobiology, Christopher H Browne Center for Immunology and Immune Diseases, The Rockefeller University, New York, NY 10065, USA
    J Immunol 181:6170-7. 2008
    ..These data suggest that brain-infiltrating NK cells might restrict innate and adaptive immune responses within the human CNS via elimination of resting microglia...
  31. pmc Distinct roles of IL-12 and IL-15 in human natural killer cell activation by dendritic cells from secondary lymphoid organs
    Guido Ferlazzo
    Laboratory of Viral Immunobiology, The Rockefeller University, New York, NY 10021, USA
    Proc Natl Acad Sci U S A 101:16606-11. 2004
    ..These results identify secondary lymphoid organs as a potential DC/NK cell interaction site and identify the distinct roles for DC-derived IL-12 and IL-15 in NK cell activation...
  32. pmc Matrix protein 2 of influenza A virus blocks autophagosome fusion with lysosomes
    Monique Gannage
    Viral Immunobiology, Institute of Experimental Immunology, University Hospital of Zurich, 8057 Zurich, Switzerland
    Cell Host Microbe 6:367-80. 2009
    ..We propose that influenza A virus, which also encodes proapoptotic proteins, is able to determine the death of its host cell by inducing apoptosis and also by blocking macroautophagy...
  33. pmc CD141+ dendritic cells produce prominent amounts of IFN-α after dsRNA recognition and can be targeted via DEC-205 in humanized mice
    Sonja Meixlsperger
    Viral Immunobiology, Institute of Experimental Immunology, University of Zurich, Zurich, Switzerland
    Blood 121:5034-44. 2013
    ..Thus, the human CD141+ DC subset is a prominent source of IFN-α and interleukin-12 production and should be further evaluated for vaccine development...
  34. pmc Increased frequency of EBV-specific effector memory CD8+ T cells correlates with higher viral load in rheumatoid arthritis
    Jan D Lunemann
    Laboratory of Viral Immunobiology, Christopher H Browne Center for Immunology and Immune Diseases, Rockefeller University, New York, NY 10021, USA
    J Immunol 181:991-1000. 2008
    ..Our data show that the regulation of EBV infection is perturbed in RA and suggest that increased EBV-specific effector T cell and Ab responses are driven by an elevated EBV load in RA...
  35. doi Antigen processing for MHC presentation via macroautophagy
    Monique Gannage
    Viral Immunobiology, Institute of Experimental Immunology, University of Zurich, Zurich, Switzerland
    Methods Mol Biol 960:473-88. 2013
    ..And finally, we will describe how macroautophagy can be silenced in antigen presenting cells, like human monocyte-derived dendritic cells (DCs)...
  36. doi MHC presentation via autophagy and how viruses escape from it
    Monique Gannage
    Viral Immunobiology, Institute of Experimental Immunology, University of Zurich, Winterthurerstrasse 190, CH 8057, Zurich, Switzerland
    Semin Immunopathol 32:373-81. 2010
    ..Moreover, they are targeted by viruses for immune escape and could maybe be harnessed for immunotherapy...
  37. pmc Antigen-loading compartments for major histocompatibility complex class II molecules continuously receive input from autophagosomes
    Dorothee Schmid
    Laboratory of Viral Immunobiology and Christopher H Browne Center for Immunology and Immune Diseases, The Rockefeller University, New York, NY 10021, USA
    Immunity 26:79-92. 2007
    ..We suggest that macroautophagy constitutively and efficiently delivers cytosolic proteins for MHC class II presentation and can be harnessed for improved helper T cell stimulation...
  38. pmc Dendritic cell maturation by innate lymphocytes: coordinated stimulation of innate and adaptive immunity
    CHRISTIAN MUNZ
    Laboratory of Viral Immunobiology, Christopher H Browne Center for Immunology and Immune Diseases, The Rockefeller University, New York, NY 10021, USA
    J Exp Med 202:203-7. 2005
    ..Here, we comment on the evidence that these pathways are TLR independent and have the potential to respond to infection, malignancy, and immunotherapy...
  39. ncbi Epstein-Barr virus and multiple sclerosis
    Jan D Lunemann
    Laboratory of Viral Immunobiology, Christopher H Browne Center for Immunology and Immune Diseases, The Rockefeller University, Box 390, 1230 York Avenue, New York, NY 10021 6399, USA
    Curr Neurol Neurosci Rep 7:253-8. 2007
    ....
  40. doi Localization and MHC class II presentation of antigens targeted for macroautophagy
    Dorothee Schmid
    Laboratory of Viral Immunobiology and Christopher H Browne Center for Immunology and Immune Diseases, The Rockefeller University, New York, NY, USA
    Methods Mol Biol 445:213-25. 2008
    ....
  41. pmc TNF-alpha induces macroautophagy and regulates MHC class II expression in human skeletal muscle cells
    Christian W Keller
    Laboratory of Viral Immunobiology, Christopher H Browne Center for Immunology and Immune Diseases, The Rockefeller University, New York, New York 10065, USA
    J Biol Chem 286:3970-80. 2011
    ....
  42. ncbi Beta-amyloid is a substrate of autophagy in sporadic inclusion body myositis
    Jan D Lunemann
    Laboratory of Viral Immunobiology, Christopher H Browne Center for Immunology and Immune Diseases, The Rockefeller University, New York, NY 10021, USA
    Ann Neurol 61:476-83. 2007
    ..Therefore, we analyzed macroautophagy of APP in human muscle cell lines and sIBM muscle biopsies...
  43. pmc Human Langerhans cells use an IL-15R-α/IL-15/pSTAT5-dependent mechanism to break T-cell tolerance against the self-differentiation tumor antigen WT1
    Emanuela Romano
    Laboratory of Cellular Immunobiology, Immunology Program, Sloan Kettering Institute for Cancer Research, New York, NY 10065, USA
    Blood 119:5182-90. 2012
    ..These data support the use of mRNA-electroporated LCs, or moDCs supplemented with exogenous rhuIL-15, as vaccines for cancer immunotherapy to break tolerance against self-differentiation antigens shared by tumors...
  44. ncbi Macroautophagy as a pathomechanism in sporadic inclusion body myositis
    Jan D Lunemann
    Laboratory of Viral Immunobiology, Christopher H Browne Center for Immunology and Immune Diseases, The Rockefeller University, New York, New York 10021, USA
    Autophagy 3:384-6. 2007
    ..A better understanding of this pathway in skeletal muscle and in the inflammatory environment of sIBM might provide a rationale for novel therapeutic strategies targeting pathogenic protein aggregation...
  45. pmc Robust T-cell stimulation by Epstein-Barr virus-transformed B cells after antigen targeting to DEC-205
    Carol S Leung
    Departments of Viral Immunobiology and Neuroinflammation, Institute of Experimental Immunology, University of Zurich, Zurich, Switzerland
    Blood 121:1584-94. 2013
    ..These studies suggest that B cells, activated by virus transformation or other means, can contribute to T-cell stimulation after DEC-205 targeting of antigens during vaccination...
  46. ncbi Immune surveillance via self digestion
    Dorothee Schmid
    Laboratory of Viral Immunobiology and Christopher H Browne Center for Immunology and Immune Diseases, The Rockefeller University, New York, New York 10021, USA
    Autophagy 3:133-5. 2007
    ..We suggest that this pathway samples intracellular proteins for immune surveillance and induction of tolerance in CD4+ T cells, and could be targeted for improved MHC class II presentation of vaccine antigens...
  47. doi Do natural killer cells accelerate or prevent autoimmunity in multiple sclerosis?
    Jan D Lunemann
    Laboratory of Viral Immunobiology, Christopher H Browne Center for Immunology and Immune Diseases, The Rockefeller University, New York, NY 10021 6399, USA
    Brain 131:1681-3. 2008
  48. pmc Interactions of human myeloid cells with natural killer cell subsets in vitro and in vivo
    Obinna Chijioke
    Department of Viral Immunobiology, Institute of Experimental Immunology, University of Zurich, Zurich, Switzerland
    J Biomed Biotechnol 2011:251679. 2011
    ..These investigations will allow harnessing NK cells during vaccination for improved innate and adaptive immunity...
  49. pmc Regulatory NK-cell functions in inflammation and autoimmunity
    Anna Lünemann
    Viral Immunobiology, Institute of Experimental Immunology, University Hospital of Zurich, Switzerland
    Mol Med 15:352-8. 2009
    ....
  50. pmc Morbus Crohn--a disease of failing macroautophagy in the immune system?
    Sonja Meixlsperger
    Viral Immunobiology, Institute of Experimental Immunology, University Hospital of Zurich, Zurich, Switzerland
    Int Immunol 21:1205-11. 2009
    ..A better understanding of these mechanisms should allow us not only to develop therapeutical strategies for CD but also to utilize macroautophagy for enhanced immunity against pathogens and tumors...
  51. pmc Cytoskeletal stabilization of inhibitory interactions in immunologic synapses of mature human dendritic cells with natural killer cells
    Rosa Barreira da Silva
    Viral Immunobiology, Institute of Experimental Immunology, University of Zurich, Winterthurerstrasse 100, Zurich, Switzerland
    Blood 118:6487-98. 2011
    ..Thus, inhibitory signaling is stabilized by f-actin at the synapse between mature DCs and resting NK cells...
  52. doi Intrathymic Epstein-Barr virus infection is not a prominent feature of myasthenia gravis
    Kristina Kakalacheva
    Department of Neuroinflammation, Institute of Experimental Immunology, University of Zurich, Zurich, Switzerland
    Ann Neurol 70:508-14. 2011
    ..Furthermore, EBV-specific T- and B-cell responses were unchanged in patients with EOMG. These findings do not support an etiologic role for EBV in the initiation of EOMG...
  53. pmc Rituximab induces sustained reduction of pathogenic B cells in patients with peripheral nervous system autoimmunity
    Michael A Maurer
    Institute of Experimental Immunology, Department of Neuroinflammation, University of Zurich, Zurich, Switzerland
    J Clin Invest 122:1393-402. 2012
    ..These findings support the continued development of B cell-depleting therapies for autoimmune diseases...
  54. pmc Noncytotoxic functions of NK cells: direct pathogen restriction and assistance to adaptive immunity
    Till Strowig
    Laboratory of Viral Immunobiology and Christopher H Browne Center for Immunology and Immune Diseases, The Rockefeller University, New York, NY 10065, USA
    J Immunol 180:7785-91. 2008
    ..In humans, a dedicated NK cell subset primarily fulfills these later functions. In this review we discuss the noncytotoxic effector functions of NK cells and how they could be harnessed for immunotherapy and vaccine development...
  55. pmc Virus-specific CD4+ T cells: ready for direct attack
    Kevin N Heller
    Laboratory of Viral Immunobiology and Christopher H Browne Center for Immunology and Immune Diseases, The Rockefeller University, New York, NY 10021, USA
    J Exp Med 203:805-8. 2006
    ..Thus, antiviral vaccines should aim to stimulate both helper and cytolytic CD4+ T cells...
  56. pmc Autophagy proteins stabilize pathogen-containing phagosomes for prolonged MHC II antigen processing
    Susana Romao
    Viral Immunobiology, Institute of Experimental Immunology, and 2 Center for Microscopy and Image Analysis, University of Zurich, 8006 Zurich, Switzerland
    J Cell Biol 203:757-66. 2013
    ..A deficiency in the NOX2-dependent formation of these antigen storage phagosomes could contribute to compromise antifungal immune control in chronic granulomatous disease patients. ..
  57. pmc Mice with human immune system components as in vivo models for infections with human pathogens
    Patrick C Rämer
    Viral Immunobiology, Institute of Experimental Immunology, University of Zurich, Zurich, Switzerland
    Immunol Cell Biol 89:408-16. 2011
    ..Moreover, these new animal models of human infectious disease should replicate the reactivity of the human immune system to vaccine candidates and, especially, the adjuvants contained in them, more faithfully...
  58. pmc Impaired IFN-γ production and proliferation of NK cells in multiple sclerosis
    Anna Lünemann
    Christopher H Browne Center for Immunology and Immune Diseases, The Rockefeller University, New York, NY 10065, USA
    Int Immunol 23:139-48. 2011
    ..Thus, characteristic functions of CD56(bright)CD16(-) NK cells, namely cytokine-induced NK cell expansion and IFN-γ production, are compromised in the NK cell compartment of MS patients...
  59. ncbi Checking the garbage bin for problems in the house, or how autophagy assists in antigen presentation to the immune system
    Susana Romao
    Viral Immunobiology, Institute of Experimental Immunology, University of Zurich, Switzerland
    Semin Cancer Biol 23:391-6. 2013
    ....
  60. doi Natural killer cell activation by dendritic cells: balancing inhibitory and activating signals
    Rosa Barreira da Silva
    Department of Viral Immunobiology, Institute of Experimental Immunology, University of Zurich, Winterthurerstrasse 190, 8057 Zurich, Switzerland
    Cell Mol Life Sci 68:3505-18. 2011
    ..This feature of DCs, to activate different waves of immune responses, could be harnessed for immunotherapies, including vaccinations...
  61. doi Monitoring macroautophagy by major histocompatibility complex class II presentation of targeted antigens
    Monique Gannage
    Viral Immunobiology, Institute of Experimental Immunology, University Hospital of Zurich, Zurich, Switzerland
    Methods Enzymol 452:403-21. 2009
    ..Together these immunological assays are well suited to investigate autophagic flux and analyze experimental conditions and physiological perturbations for their influence on macroautophagy...
  62. pmc Innate immune responses against Epstein Barr virus infection
    Obinna Chijioke
    1 University of Zurich, Winterthurerstrasse 190, CH 8057, Zurich, Switzerland
    J Leukoc Biol 94:1185-90. 2013
    ....
  63. pmc Human natural killer cells prevent infectious mononucleosis features by targeting lytic Epstein-Barr virus infection
    Obinna Chijioke
    Department of Viral Immunobiology, Institute of Experimental Immunology, University of Zurich, 8057 Zurich, Switzerland
    Cell Rep 5:1489-98. 2013
    ..These data suggest that failure of innate immune control by human NK cells augments symptomatic lytic EBV infection, which drives lymphocyte expansion and predisposes for EBV-associated malignancies. ..
  64. doi Viral triggers of multiple sclerosis
    Kristina Kakalacheva
    Institute of Experimental Immunology, University of Zurich, Switzerland
    Biochim Biophys Acta 1812:132-40. 2011
    ....
  65. doi Autophagy in MHC class II presentation of endogenous antigens
    Monique Gannage
    Viral Immunobiology, Institute of Experimental Immunology, University Hospital of Zurich, Winterthurerstrasse 190, CH 8057 Zurich, Switzerland
    Curr Top Microbiol Immunol 335:123-40. 2009
    ..Based on this discussion, it is apparent that the regulation of macroautophagy may be beneficial in various disease settings in order to enhance adaptive immune responses or to reduce autoimmunity...
  66. pmc A distinct subpopulation of human NK cells restricts B cell transformation by EBV
    Anna Lünemann
    Viral Immunobiology, Institute of Experimental Immunology, University of Zurich, CH 8057 Zurich, Switzerland
    J Immunol 191:4989-95. 2013
    ..This subset should be exploited for future development of cell-based therapeutic approaches in EBV-associated malignancies. ..
  67. doi Infectious diseases in humanized mice
    Carol Leung
    Department of Viral Immunobiology, Institute of Experimental Immunology, University of Zurich, Zurich, Switzerland
    Eur J Immunol 43:2246-54. 2013
    ....
  68. pmc Beclin-1 targeting for viral immune escape
    CHRISTIAN MUNZ
    Viral Immunobiology, Institute of Experimental Immunology, University of Zurich, Winterthurerstrasse 190, CH 8057 Zurich, Switzerland
    Viruses 3:1166-78. 2011
    ..Inhibition either before or after autophagosome formation seems to benefit their viral replication by different mechanisms, which are discussed here...
  69. ncbi Targeting Beclin 1 for viral subversion of macroautophagy
    Monique Gannage
    Viral Immunobiology, Institute of Experimental Immunology, University Hospital of Zurich, Zurich, Switzerland
    Autophagy 6:166-7. 2010
    ....
  70. pmc Cytokine complex-expanded natural killer cells improve allogeneic lung transplant function via depletion of donor dendritic cells
    Wolfgang Jungraithmayr
    Viral Immunobiology, Institute of Experimental Immunology, University of Zurich, Zurich, Switzerland
    Am J Respir Crit Care Med 187:1349-59. 2013
    ..Natural killer (NK) cells are innate lymphocytes that target virus-infected and tumor cells. Much less is known about their ability to limit adaptive immune responses...
  71. doi TNF-α upregulates macroautophagic processing of APP/β-amyloid in a human rhabdomyosarcoma cell line
    Christian W Keller
    Department of Neurology, University Medical Center Gottingen, Gottingen, Germany
    J Neurol Sci 325:103-7. 2013
    ..Thus, macroautophagy may be a crucial mediator between inflammation and β-amyloid-associated degeneration in skeletal muscle...
  72. doi Non-cytotoxic protection by human NK cells in mucosal secondary lymphoid tissues
    CHRISTIAN MUNZ
    Viral Immunobiology, Institute of Experimental Immunology, University Hospital of Zurich, Zurich, Switzerland
    Eur J Immunol 38:2946-8. 2008
    ..This exciting new aspect of NK-cell biology is discussed in this viewpoint...

Research Grants9

  1. Endogenous MHC class II antigen processing via autophagy
    CHRISTIAN MUNZ; Fiscal Year: 2006
    ..These studies will allow us to understand better how tumors can be detected by the immune system and how we can enhance immune responses to cancer. ..
  2. DC/NK interactions in human secondary lymphoid organs
    CHRISTIAN MUNZ; Fiscal Year: 2004
    ..We will investigate the effect of NK activation in secondary lymphoid organs on DC maturation and alloreactive as well as EBV specific T cell polarization. ..
  3. DC/NK interactions in human secondary lymphoid organs
    CHRISTIAN MUNZ; Fiscal Year: 2005
    ..We will investigate the effect of NK activation in secondary lymphoid organs on DC maturation and alloreactive as well as EBV specific T cell polarization. ..
  4. DC/NK interactions in human secondary lymphoid organs
    CHRISTIAN MUNZ; Fiscal Year: 2006
    ..We will investigate the effect of NK activation in secondary lymphoid organs on DC maturation and alloreactive as well as EBV specific T cell polarization. ..
  5. Anti-viral DC/NK interactions
    CHRISTIAN MUNZ; Fiscal Year: 2009
    ....
  6. Anti-viral DC/NK interactions
    CHRISTIAN MUNZ; Fiscal Year: 2010
    ....