Joachim Muller

Summary

Affiliation: University of Bern
Country: Switzerland

Publications

  1. ncbi request reprint Neospora caninum: functional inhibition of protein disulfide isomerase by the broad-spectrum anti-parasitic drug nitazoxanide and other thiazolides
    Joachim Muller
    Institute of Parasitology, University of Berne, Langgass strasse 122, CH 3012 Berne, Switzerland
    Exp Parasitol 118:80-8. 2008
  2. doi request reprint Stable expression of Escherichia coli beta-glucuronidase A (GusA) in Giardia lamblia: application to high-throughput drug susceptibility testing
    Joachim Muller
    Institute of Parasitology, University of Berne, Berne, Switzerland
    J Antimicrob Chemother 64:1187-91. 2009
  3. pmc A novel Giardia lamblia nitroreductase, GlNR1, interacts with nitazoxanide and other thiazolides
    Joachim Muller
    Institute of Parasitology, University of Berne, Langgass strasse 122, CH 3012 Berne, Switzerland
    Antimicrob Agents Chemother 51:1979-86. 2007
  4. doi request reprint Identification of a host cell target for the thiazolide class of broad-spectrum anti-parasitic drugs
    Joachim Muller
    Institute of Parasitology, University of Berne, Langgass strasse 122, CH 3012 Berne, Switzerland
    Exp Parasitol 128:145-50. 2011
  5. ncbi request reprint Characterization of Giardia lamblia WB C6 clones resistant to nitazoxanide and to metronidazole
    Joachim Muller
    Institute of Parasitology, University of Berne, Langgass strasse 122, CH 3012 Berne, Switzerland
    J Antimicrob Chemother 60:280-7. 2007
  6. doi request reprint Identification of differentially expressed genes in a Giardia lamblia WB C6 clone resistant to nitazoxanide and metronidazole
    Joachim Muller
    Institute of Parasitology, University of Berne, Langgass strasse 122, CH 3012 Berne, Switzerland
    J Antimicrob Chemother 62:72-82. 2008
  7. doi request reprint Thioureides of 2-(phenoxymethyl)benzoic acid 4-R substituted: a novel class of anti-parasitic compounds
    Joachim Muller
    Institute of Parasitology, University of Berne, Langgass strasse 122, CH 3012 Berne, Switzerland
    Parasitol Int 58:128-35. 2009
  8. doi request reprint Metabolism of nitro drugs metronidazole and nitazoxanide in Giardia lamblia: characterization of a novel nitroreductase (GlNR2)
    Joachim Muller
    Institute of Parasitology, Vetsuisse Faculty, University of Berne, Langgass strasse 122, CH 3012 Berne, Switzerland
    J Antimicrob Chemother 68:1781-9. 2013
  9. doi request reprint Nitroreductase (GlNR1) increases susceptibility of Giardia lamblia and Escherichia coli to nitro drugs
    Dorothea Nillius
    Institute of Parasitology, University of Berne, Berne, Switzerland
    J Antimicrob Chemother 66:1029-35. 2011
  10. ncbi request reprint Characterization of a Giardia lamblia WB C6 clone resistant to the isoflavone formononetin
    Maaike Sterk
    Institute of Parasitology, University of Berne, Langgass strasse 122, CH 3012 Berne, Switzerland
    Microbiology 153:4150-8. 2007

Detail Information

Publications22

  1. ncbi request reprint Neospora caninum: functional inhibition of protein disulfide isomerase by the broad-spectrum anti-parasitic drug nitazoxanide and other thiazolides
    Joachim Muller
    Institute of Parasitology, University of Berne, Langgass strasse 122, CH 3012 Berne, Switzerland
    Exp Parasitol 118:80-8. 2008
    ..Thus, thiazolides readily interfere with NcPDI, and possibly also with PDIs from other microorganisms susceptible to thiazolides...
  2. doi request reprint Stable expression of Escherichia coli beta-glucuronidase A (GusA) in Giardia lamblia: application to high-throughput drug susceptibility testing
    Joachim Muller
    Institute of Parasitology, University of Berne, Berne, Switzerland
    J Antimicrob Chemother 64:1187-91. 2009
    ....
  3. pmc A novel Giardia lamblia nitroreductase, GlNR1, interacts with nitazoxanide and other thiazolides
    Joachim Muller
    Institute of Parasitology, University of Berne, Langgass strasse 122, CH 3012 Berne, Switzerland
    Antimicrob Agents Chemother 51:1979-86. 2007
    ..In this assay system, NR activity was severely inhibited by NTZ and other thiazolides, demonstrating that the antigiardial activity of these drugs could be, at least partially, mediated through inhibition of GlNR1...
  4. doi request reprint Identification of a host cell target for the thiazolide class of broad-spectrum anti-parasitic drugs
    Joachim Muller
    Institute of Parasitology, University of Berne, Langgass strasse 122, CH 3012 Berne, Switzerland
    Exp Parasitol 128:145-50. 2011
    ..The thiazolides NTZ, tizoxanide and RM4847 inhibited recQR activity on menadione in a concentration-dependent manner. Moreover, a small residual reducing activity was observed when these thiazolides were offered as substrates...
  5. ncbi request reprint Characterization of Giardia lamblia WB C6 clones resistant to nitazoxanide and to metronidazole
    Joachim Muller
    Institute of Parasitology, University of Berne, Langgass strasse 122, CH 3012 Berne, Switzerland
    J Antimicrob Chemother 60:280-7. 2007
    ....
  6. doi request reprint Identification of differentially expressed genes in a Giardia lamblia WB C6 clone resistant to nitazoxanide and metronidazole
    Joachim Muller
    Institute of Parasitology, University of Berne, Langgass strasse 122, CH 3012 Berne, Switzerland
    J Antimicrob Chemother 62:72-82. 2008
    ..The characterization of differential gene expression in Giardia lamblia WB C6 strain C4 resistant to metronidazole and nitazoxanide using microarray technology and quantitative real-time PCR...
  7. doi request reprint Thioureides of 2-(phenoxymethyl)benzoic acid 4-R substituted: a novel class of anti-parasitic compounds
    Joachim Muller
    Institute of Parasitology, University of Berne, Langgass strasse 122, CH 3012 Berne, Switzerland
    Parasitol Int 58:128-35. 2009
    ..Thioureides may thus present a promising class of anti-infective agents...
  8. doi request reprint Metabolism of nitro drugs metronidazole and nitazoxanide in Giardia lamblia: characterization of a novel nitroreductase (GlNR2)
    Joachim Muller
    Institute of Parasitology, Vetsuisse Faculty, University of Berne, Langgass strasse 122, CH 3012 Berne, Switzerland
    J Antimicrob Chemother 68:1781-9. 2013
    ..Nitroreductases may play a role in activating these drugs. G. lamblia contains two nitroreductases, GlNR1 and GlNR2. The aim of this work was to elucidate the role of GlNR2...
  9. doi request reprint Nitroreductase (GlNR1) increases susceptibility of Giardia lamblia and Escherichia coli to nitro drugs
    Dorothea Nillius
    Institute of Parasitology, University of Berne, Berne, Switzerland
    J Antimicrob Chemother 66:1029-35. 2011
    ..lamblia nitroreductase 1 (GlNR1) was identified as a nitazoxanide-binding protein. The aim of the present project was to elucidate the role of this enzyme in the mode of action of the nitro drugs nitazoxanide and metronidazole...
  10. ncbi request reprint Characterization of a Giardia lamblia WB C6 clone resistant to the isoflavone formononetin
    Maaike Sterk
    Institute of Parasitology, University of Berne, Langgass strasse 122, CH 3012 Berne, Switzerland
    Microbiology 153:4150-8. 2007
    ..However, the capacity of Giardia to develop resistance to isoflavones can potentially interfere with this alternative treatment of the disease...
  11. pmc In vitro effects of thiazolides on Giardia lamblia WB clone C6 cultured axenically and in coculture with Caco2 cells
    Joachim Muller
    Institute of Parasitology, University of Bern, Langgass strasse 122, CH 3012 Bern, Switzerland
    Antimicrob Agents Chemother 50:162-70. 2006
    ..Trophozoites treated with NTZ showed distinct lesions on the ventral disk as soon as 2 to 3 h after treatment, whereas treatment with metronidazole resulted in severe damage to the dorsal surface membrane at later time points...
  12. doi request reprint Echinococcus multilocularis phosphoglucose isomerase (EmPGI): a glycolytic enzyme involved in metacestode growth and parasite-host cell interactions
    Britta Stadelmann
    Institute of Parasitology, Vetsuisse Faculty, University of Berne, Berne, Switzerland
    Int J Parasitol 40:1563-74. 2010
    ..Thus, besides its role in glycolysis, EmPGI could also act as a factor that stimulates parasite growth and potentially induces the formation of novel blood vessels around the developing metacestode in vivo...
  13. ncbi request reprint Drug target identification in intracellular and extracellular protozoan parasites
    Joachim Muller
    Institute of Parasitology, University of Berne, Länggass Strasse, Switzerland
    Curr Top Med Chem 11:2029-38. 2011
    ..In this review, we provide an overview of strategies for target identification, and present examples of selected drug targets, ranging from proteins to nucleic acids to intermediary metabolism...
  14. doi request reprint Tritrichomonas foetus isolates from cats and cattle show minor genetic differences in unrelated loci ITS-2 and EF-1α
    Karin Reinmann
    Institute of Parasitology, Vetsuisse Faculty, University of Berne, Langgassstrasse 122, 3012 Berne, Switzerland
    Vet Parasitol 185:138-44. 2012
    ..foetus from feline isolates and also from other trichomonads. The implications these minor genetic differences may have on the biological properties of the distinct isolates remain to be investigated...
  15. doi request reprint Vaccination with recombinant NcROP2 combined with recombinant NcMIC1 and NcMIC3 reduces cerebral infection and vertical transmission in mice experimentally infected with Neospora caninum tachyzoites
    Karim Debache
    Institute of Parasitology, Vetsuisse Faculty, University of Berne, Langgass strasse 122, CH 3012 Berne, Switzerland
    Int J Parasitol 39:1373-84. 2009
    ..In conclusion, a mixture of recombinant antigens representing important secretory micronemal and rhoptry proteins leads to a significant protection against vertical transmission of N. caninum in mice...
  16. doi request reprint Application of an in vitro drug screening assay based on the release of phosphoglucose isomerase to determine the structure-activity relationship of thiazolides against Echinococcus multilocularis metacestodes
    Britta Stadelmann
    Institute of Parasitology, Vetsuisse Faculty, University of Berne, Langgass strasse 122, CH 3012 Berne, Switzerland
    J Antimicrob Chemother 65:512-9. 2010
    ..multilocularis metacestode cultivation, we aimed to develop a rapid and reliable drug screening test, which enables efficient screening of a large number of compounds in a relatively short time frame...
  17. pmc Hepatic gene expression profile in mice perorally infected with Echinococcus multilocularis eggs
    Bruno Gottstein
    Vetsuisse Faculty, Institute of Parasitology, University of Bern, Bern, Switzerland
    PLoS ONE 5:e9779. 2010
    ..Despite this severe course and outcome of disease, the genetic program that regulates the host response leading to organ damage as a consequence of hepatic alveolar echinococcosis is largely unknown...
  18. ncbi request reprint Induction of tachyzoite egress from cells infected with the protozoan Neospora caninum by nitro- and bromo-thiazolides, a class of broad-spectrum anti-parasitic drugs
    Marco Esposito
    Institute of Parasitology, Vetsuisse Faculty, University of Berne, Langgass strasse 122, CH 3012 Berne, Switzerland
    Int J Parasitol 37:1143-52. 2007
    ..This demonstrated that bromo- and nitro-thiazolides exhibit differential effects against the intracellular protozoan N. caninum and bromo-thiazolides could represent a valuable alternative to the nitro-thiazolyl-salicylamide drugs...
  19. doi request reprint In vitro and in vivo effects of 2-methoxyestradiol, either alone or combined with albendazole, against Echinococcus metacestodes
    Martin Spicher
    Institute of Parasitology, Vetsuisse Faculty, University of Berne, Langgass strasse 122, CH 3012 Berne, Switzerland
    Exp Parasitol 119:475-82. 2008
    ....
  20. doi request reprint Thiazolides inhibit growth and induce glutathione-S-transferase Pi (GSTP1)-dependent cell death in human colon cancer cells
    Joachim Muller
    Institute of Parasitology, University of Berne, Langgass strasse 122, CH 3012 Berne, Switzerland
    Int J Cancer 123:1797-806. 2008
    ..Thiazolides may thus represent an interesting novel class of future cancer therapeutics...
  21. doi request reprint New approaches for the identification of drug targets in protozoan parasites
    Joachim Muller
    Institute of Parasitology, University of Berne, Berne, Switzerland
    Int Rev Cell Mol Biol 301:359-401. 2013
    ..Target-based drug design supported by genomics and proteomics of protozoan parasites has not produced any antiparasitic drug so far. The reason for this is discussed and a synthesis of both methods is proposed...
  22. doi request reprint In vitro culture systems for the study of apicomplexan parasites in farm animals
    Joachim Muller
    Institute of Parasitology, Vetsuisse Faculty, University of Berne, Langgass strasse 122, CH 3012 Berne, Switzerland
    Int J Parasitol 43:115-24. 2013
    ....