Research Topics
| Joachim MullerSummaryAffiliation: University of Bern Country: Switzerland Publications
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Publications
Identification of differentially expressed genes in a Giardia lamblia WB C6 clone resistant to nitazoxanide and metronidazoleJoachim Muller
Institute of Parasitology, University of Berne, Langgass strasse 122, CH 3012 Berne, Switzerland
J Antimicrob Chemother 62:72-82. 2008..The characterization of differential gene expression in Giardia lamblia WB C6 strain C4 resistant to metronidazole and nitazoxanide using microarray technology and quantitative real-time PCR...
A novel Giardia lamblia nitroreductase, GlNR1, interacts with nitazoxanide and other thiazolidesJoachim Muller
Institute of Parasitology, University of Berne, Langgass strasse 122, CH 3012 Berne, Switzerland
Antimicrob Agents Chemother 51:1979-86. 2007..In this assay system, NR activity was severely inhibited by NTZ and other thiazolides, demonstrating that the antigiardial activity of these drugs could be, at least partially, mediated through inhibition of GlNR1...- Stable expression of Escherichia coli beta-glucuronidase A (GusA) in Giardia lamblia: application to high-throughput drug susceptibility testingJoachim Muller
Institute of Parasitology, University of Berne, Berne, Switzerland
J Antimicrob Chemother 64:1187-91. 2009.... 
Characterization of Giardia lamblia WB C6 clones resistant to nitazoxanide and to metronidazoleJoachim Muller
Institute of Parasitology, University of Berne, Langgass strasse 122, CH 3012 Berne, Switzerland
J Antimicrob Chemother 60:280-7. 2007....- Neospora caninum: functional inhibition of protein disulfide isomerase by the broad-spectrum anti-parasitic drug nitazoxanide and other thiazolidesJoachim Muller
Institute of Parasitology, University of Berne, Langgass strasse 122, CH 3012 Berne, Switzerland
Exp Parasitol 118:80-8. 2008..Thus, thiazolides readily interfere with NcPDI, and possibly also with PDIs from other microorganisms susceptible to thiazolides... - Identification of a host cell target for the thiazolide class of broad-spectrum anti-parasitic drugsJoachim Muller
Institute of Parasitology, University of Berne, Langgass strasse 122, CH 3012 Berne, Switzerland
Exp Parasitol 128:145-50. 2011..The thiazolides NTZ, tizoxanide and RM4847 inhibited recQR activity on menadione in a concentration-dependent manner. Moreover, a small residual reducing activity was observed when these thiazolides were offered as substrates... - Thioureides of 2-(phenoxymethyl)benzoic acid 4-R substituted: a novel class of anti-parasitic compoundsJoachim Muller
Institute of Parasitology, University of Berne, Langgass strasse 122, CH 3012 Berne, Switzerland
Parasitol Int 58:128-35. 2009..Thioureides may thus present a promising class of anti-infective agents... - Nitroreductase (GlNR1) increases susceptibility of Giardia lamblia and Escherichia coli to nitro drugsDorothea Nillius
Institute of Parasitology, University of Berne, Berne, Switzerland
J Antimicrob Chemother 66:1029-35. 2011..lamblia nitroreductase 1 (GlNR1) was identified as a nitazoxanide-binding protein. The aim of the present project was to elucidate the role of this enzyme in the mode of action of the nitro drugs nitazoxanide and metronidazole... - Characterization of a Giardia lamblia WB C6 clone resistant to the isoflavone formononetinMaaike Sterk
Institute of Parasitology, University of Berne, Langgass strasse 122, CH 3012 Berne, Switzerland
Microbiology 153:4150-8. 2007..However, the capacity of Giardia to develop resistance to isoflavones can potentially interfere with this alternative treatment of the disease... - In vitro effects of thiazolides on Giardia lamblia WB clone C6 cultured axenically and in coculture with Caco2 cellsJoachim Muller
Institute of Parasitology, University of Bern, Langgass strasse 122, CH 3012 Bern, Switzerland
Antimicrob Agents Chemother 50:162-70. 2006..Trophozoites treated with NTZ showed distinct lesions on the ventral disk as soon as 2 to 3 h after treatment, whereas treatment with metronidazole resulted in severe damage to the dorsal surface membrane at later time points... - Drug target identification in intracellular and extracellular protozoan parasitesJoachim Muller
Institute of Parasitology, University of Berne, Länggass Strasse, Switzerland
Curr Top Med Chem 11:2029-38. 2011..In this review, we provide an overview of strategies for target identification, and present examples of selected drug targets, ranging from proteins to nucleic acids to intermediary metabolism... - Echinococcus multilocularis phosphoglucose isomerase (EmPGI): a glycolytic enzyme involved in metacestode growth and parasite-host cell interactionsBritta Stadelmann
Institute of Parasitology, Vetsuisse Faculty, University of Berne, Berne, Switzerland
Int J Parasitol 40:1563-74. 2010..Thus, besides its role in glycolysis, EmPGI could also act as a factor that stimulates parasite growth and potentially induces the formation of novel blood vessels around the developing metacestode in vivo... - Tritrichomonas foetus isolates from cats and cattle show minor genetic differences in unrelated loci ITS-2 and EF-1αKarin Reinmann
Institute of Parasitology, Vetsuisse Faculty, University of Berne, Langgassstrasse 122, 3012 Berne, Switzerland
Vet Parasitol 185:138-44. 2012..foetus from feline isolates and also from other trichomonads. The implications these minor genetic differences may have on the biological properties of the distinct isolates remain to be investigated... - Hepatic gene expression profile in mice perorally infected with Echinococcus multilocularis eggsBruno Gottstein
Vetsuisse Faculty, Institute of Parasitology, University of Bern, Bern, Switzerland
PLoS ONE 5:e9779. 2010..Despite this severe course and outcome of disease, the genetic program that regulates the host response leading to organ damage as a consequence of hepatic alveolar echinococcosis is largely unknown... - Application of an in vitro drug screening assay based on the release of phosphoglucose isomerase to determine the structure-activity relationship of thiazolides against Echinococcus multilocularis metacestodesBritta Stadelmann
Institute of Parasitology, Vetsuisse Faculty, University of Berne, Langgass strasse 122, CH 3012 Berne, Switzerland
J Antimicrob Chemother 65:512-9. 2010..multilocularis metacestode cultivation, we aimed to develop a rapid and reliable drug screening test, which enables efficient screening of a large number of compounds in a relatively short time frame... - Vaccination with recombinant NcROP2 combined with recombinant NcMIC1 and NcMIC3 reduces cerebral infection and vertical transmission in mice experimentally infected with Neospora caninum tachyzoitesKarim Debache
Institute of Parasitology, Vetsuisse Faculty, University of Berne, Langgass strasse 122, CH 3012 Berne, Switzerland
Int J Parasitol 39:1373-84. 2009..In conclusion, a mixture of recombinant antigens representing important secretory micronemal and rhoptry proteins leads to a significant protection against vertical transmission of N. caninum in mice... - Induction of tachyzoite egress from cells infected with the protozoan Neospora caninum by nitro- and bromo-thiazolides, a class of broad-spectrum anti-parasitic drugsMarco Esposito
Institute of Parasitology, Vetsuisse Faculty, University of Berne, Langgass strasse 122, CH 3012 Berne, Switzerland
Int J Parasitol 37:1143-52. 2007..This demonstrated that bromo- and nitro-thiazolides exhibit differential effects against the intracellular protozoan N. caninum and bromo-thiazolides could represent a valuable alternative to the nitro-thiazolyl-salicylamide drugs... - Thiazolides inhibit growth and induce glutathione-S-transferase Pi (GSTP1)-dependent cell death in human colon cancer cellsJoachim Muller
Institute of Parasitology, University of Berne, Langgass strasse 122, CH 3012 Berne, Switzerland
Int J Cancer 123:1797-806. 2008..Thiazolides may thus represent an interesting novel class of future cancer therapeutics... - In vitro and in vivo effects of 2-methoxyestradiol, either alone or combined with albendazole, against Echinococcus metacestodesMartin Spicher
Institute of Parasitology, Vetsuisse Faculty, University of Berne, Langgass strasse 122, CH 3012 Berne, Switzerland
Exp Parasitol 119:475-82. 2008.... - In vitro culture systems for the study of apicomplexan parasites in farm animalsJoachim Muller
Institute of Parasitology, Vetsuisse Faculty, University of Berne, Langgass strasse 122, CH 3012 Berne, Switzerland
Int J Parasitol 43:115-24. 2013.... - New approaches for the identification of drug targets in protozoan parasitesJoachim Muller
Institute of Parasitology, University of Berne, Langgass strasse 122, Berne, Switzerland
Int Rev Cell Mol Biol 301:359-401. 2013..Target-based drug design supported by genomics and proteomics of protozoan parasites has not produced any antiparasitic drug so far. The reason for this is discussed and a synthesis of both methods is proposed...