N J Mueller

Summary

Affiliation: University Hospital
Country: Switzerland

Publications

  1. ncbi request reprint Herpesvirus infections in xenotransplantation: pathogenesis and approaches
    Nicolas J Mueller
    Division of Infectious Diseases and Hospital Epidemiology, University Hospital Zurich, CH 8091 Zurich, Switzerland
    Xenotransplantation 11:486-90. 2004
  2. doi request reprint Donor-derived aspergillosis from use of a solid organ recipient as a multiorgan donor
    N J Mueller
    Department of Medicine, Division of Infectious Diseases and Hospital Epidemiology, University Hospital Zurich, Zurich, Switzerland
    Transpl Infect Dis 12:54-9. 2010
  3. doi request reprint New immunosuppressive strategies and the risk of infection
    N J Mueller
    Department of Medicine, Division of Infectious Diseases and Hospital Epidemiology, University Hospital, Zurich, Switzerland
    Transpl Infect Dis 10:379-84. 2008
  4. ncbi request reprint How should we evaluate organ donors with active or prior infections?
    Nicolas J Mueller
    Division of Infectious Diseases and Hospital Epidemiology, University Hospital Zurich, Switzerland
    J Hepatol 45:507-13. 2006
  5. doi request reprint High prevalence of severe vitamin D deficiency in combined antiretroviral therapy-naive and successfully treated Swiss HIV patients
    Nicolas J Mueller
    Division of Infectious Diseases and Hospital Epidemiology, Department of Medicine, University Hospital of Zurich, Zurich, Switzerland
    AIDS 24:1127-34. 2010
  6. doi request reprint A stringent preemptive protocol reduces cytomegalovirus disease in the first 6 months after kidney transplantation
    M Greiner
    Division of Infectious Diseases and Hospital Epidemiology, University Hospital Zurich, Rämistrasse 100 RAE U 70, 8091, Zurich, Switzerland
    Infection 40:669-75. 2012
  7. doi request reprint Association of noncirrhotic portal hypertension in HIV-infected persons and antiretroviral therapy with didanosine: a nested case-control study
    Helen Kovari
    Divisions of Infectious Diseases and Hospital Epidemiology, University Hospital, Zurich CH 8091, Switzerland
    Clin Infect Dis 49:626-35. 2009
  8. doi request reprint Incidence and risk factors for chronic elevation of alanine aminotransferase levels in HIV-infected persons without hepatitis b or c virus co-infection
    Helen Kovari
    Division of Infectious Diseases and Hospital Epidemiology, University Hospital, Zurich, Switzerland
    Clin Infect Dis 50:502-11. 2010
  9. doi request reprint Effect of high-dosage cholecalciferol and extended physiotherapy on complications after hip fracture: a randomized controlled trial
    Heike A Bischoff-Ferrari
    Centre on Aging and Mobility, University of Zurich, University Hospital Zurich, Gloriastrasse 25, 8091 Zurich, Switzerland
    Arch Intern Med 170:813-20. 2010
  10. doi request reprint Fatal outcome after heart transplantation caused by Aspergillus lentulus
    A Zbinden
    Institute of Medical Microbiology, University of Zurich, Zurich, Switzerland
    Transpl Infect Dis 14:E60-3. 2012

Detail Information

Publications29

  1. ncbi request reprint Herpesvirus infections in xenotransplantation: pathogenesis and approaches
    Nicolas J Mueller
    Division of Infectious Diseases and Hospital Epidemiology, University Hospital Zurich, CH 8091 Zurich, Switzerland
    Xenotransplantation 11:486-90. 2004
    ....
  2. doi request reprint Donor-derived aspergillosis from use of a solid organ recipient as a multiorgan donor
    N J Mueller
    Department of Medicine, Division of Infectious Diseases and Hospital Epidemiology, University Hospital Zurich, Zurich, Switzerland
    Transpl Infect Dis 12:54-9. 2010
    ..Despite the pressure to extend the use of organs by lowering the acceptance criteria, organs should only be accepted if the cause of death of the donors is unequivocally explained...
  3. doi request reprint New immunosuppressive strategies and the risk of infection
    N J Mueller
    Department of Medicine, Division of Infectious Diseases and Hospital Epidemiology, University Hospital, Zurich, Switzerland
    Transpl Infect Dis 10:379-84. 2008
    ..It is important to remain vigilant for unexpected infections, not only in the context of clinical studies with selected patients, but also in the routine follow-up of our transplant patients...
  4. ncbi request reprint How should we evaluate organ donors with active or prior infections?
    Nicolas J Mueller
    Division of Infectious Diseases and Hospital Epidemiology, University Hospital Zurich, Switzerland
    J Hepatol 45:507-13. 2006
  5. doi request reprint High prevalence of severe vitamin D deficiency in combined antiretroviral therapy-naive and successfully treated Swiss HIV patients
    Nicolas J Mueller
    Division of Infectious Diseases and Hospital Epidemiology, Department of Medicine, University Hospital of Zurich, Zurich, Switzerland
    AIDS 24:1127-34. 2010
    ..To evaluate the prevalence of 25-hydroxyvitamin D [25(OH)D] deficiency in HIV-positive patients, a population at risk for osteoporosis...
  6. doi request reprint A stringent preemptive protocol reduces cytomegalovirus disease in the first 6 months after kidney transplantation
    M Greiner
    Division of Infectious Diseases and Hospital Epidemiology, University Hospital Zurich, Rämistrasse 100 RAE U 70, 8091, Zurich, Switzerland
    Infection 40:669-75. 2012
    ..The optimal strategy to prevent cytomegalovirus (CMV) disease after kidney transplantation continues to be open to debate. The preemptive approach requires regular determination of CMV viremia and prompt initiation of therapy...
  7. doi request reprint Association of noncirrhotic portal hypertension in HIV-infected persons and antiretroviral therapy with didanosine: a nested case-control study
    Helen Kovari
    Divisions of Infectious Diseases and Hospital Epidemiology, University Hospital, Zurich CH 8091, Switzerland
    Clin Infect Dis 49:626-35. 2009
    ..Postulated pathogenesis includes prolonged exposure to antiretroviral therapy, particularly didanosine...
  8. doi request reprint Incidence and risk factors for chronic elevation of alanine aminotransferase levels in HIV-infected persons without hepatitis b or c virus co-infection
    Helen Kovari
    Division of Infectious Diseases and Hospital Epidemiology, University Hospital, Zurich, Switzerland
    Clin Infect Dis 50:502-11. 2010
    ..Chronic liver disease in human immunodeficiency virus (HIV)-infected patients is mostly caused by hepatitis virus co-infection. Other reasons for chronic alanine aminotransferase (ALT) elevation are more difficult to diagnose...
  9. doi request reprint Effect of high-dosage cholecalciferol and extended physiotherapy on complications after hip fracture: a randomized controlled trial
    Heike A Bischoff-Ferrari
    Centre on Aging and Mobility, University of Zurich, University Hospital Zurich, Gloriastrasse 25, 8091 Zurich, Switzerland
    Arch Intern Med 170:813-20. 2010
    ..Care of elderly patients after hip fracture is not well established...
  10. doi request reprint Fatal outcome after heart transplantation caused by Aspergillus lentulus
    A Zbinden
    Institute of Medical Microbiology, University of Zurich, Zurich, Switzerland
    Transpl Infect Dis 14:E60-3. 2012
    ..This is the first report, to our knowledge, of a proven pulmonary invasive fungal infection caused by A. lentulus after heart transplantation...
  11. ncbi request reprint Methadone-induced Torsade de pointes after stopping lopinavir-ritonavir
    B Lüthi
    Department of Internal Medicine, Division of Infectious Diseases and Hospital Epidemiology, University Hospital of Zurich, Raemistrasse 100 RAE U 74, 8091, Zurich, Switzerland
    Eur J Clin Microbiol Infect Dis 26:367-9. 2007
  12. doi request reprint Molecular evidence of interhuman transmission in an outbreak of Pneumocystis jirovecii pneumonia among renal transplant recipients
    S Gianella
    Division of Infectious Diseases and Hospital Epidemiology, University Hospital Zurich, Zurich, Switzerland
    Transpl Infect Dis 12:1-10. 2010
    ..Our findings have epidemiological implications and suggest that prolonged chemoprophylaxis for PCP may be warranted in an era of more intense immunosuppression...
  13. ncbi request reprint Retrospective analysis of varicella zoster virus (VZV) copy DNA numbers in plasma of immunocompetent patients with herpes zoster, of immunocompromised patients with disseminated VZV disease, and of asymptomatic solid organ transplant recipients
    A Kronenberg
    Division of Infectious Diseases and Hospital Epidemiology, Department of Internal Medicine, University Hospital of Zurich, Zurich, Switzerland
    Transpl Infect Dis 7:116-21. 2005
    ..Newer studies assessing the prevalence and impact of subclinical VZV reactivation in solid organ transplant (SOT) recipients are lacking...
  14. doi request reprint Incidence and outcome of progressive multifocal leukoencephalopathy over 20 years of the Swiss HIV Cohort Study
    Nina Khanna
    Division of Infectious Diseases and Hospital Epidemiology, University Hospital, University of Basel, Basel, Switzerland
    Clin Infect Dis 48:1459-66. 2009
    ..We investigated the incidence and outcome of progressive multifocal leukoencephalopathy (PML) in human immunodeficiency virus (HIV)-infected individuals before and after the introduction of combination antiretroviral therapy (cART) in 1996...
  15. doi request reprint Impact of enterococcal colonization and infection in solid organ transplantation recipients from the Swiss Transplant Cohort Study
    E Bucheli
    Division of Infectious Diseases and Hospital Epidemiology, University Hospital Basel, Basel, Switzerland
    Transpl Infect Dis 16:26-36. 2014
    ..Solid organ transplantation is considered as a risk factor. However, little is known about the relevance of enterococci in solid organ transplantation recipients in areas with a low VRE prevalence...
  16. doi request reprint Skin lesions, malaise, and heart failure in a renal transplant recipient
    C Kocher
    Division of Infectious Diseases and Hospital Epidemiology, University Hospital of Zurich, Zurich, Switzerland
    Transpl Infect Dis 14:391-7. 2012
    ..Given the rising numbers of transplantations in patients with a migration background and extensive travel histories, specific screening procedures have to be considered...
  17. doi request reprint Significance of Staphylococcus lugdunensis bacteremia: report of 28 cases and review of the literature
    A S Zinkernagel
    Division of Infectious Diseases and Hospital Epidemiology, Dept of Internal Medicine, University Hospital Zurich, Rämistrasse 100 RAE U 74, CH 8091, Zurich, Switzerland
    Infection 36:314-21. 2008
    ..Staphylococcus lugdunensis endocarditis has been associated with an aggressive course. The aim of this study was to determine factors associated with the development of endocarditis in patients with S. lugdunensis bacteremia...
  18. doi request reprint Human CMV infection of porcine endothelial cells increases adhesion receptor expression and human leukocyte recruitment
    Maddalena Ghielmetti
    Division of Infectious Diseases and Hospital Epidemiology, University Hospital Zurich, Zurich, Switzerland
    Transplantation 87:1792-800. 2009
    ..Therefore, we investigated the effects of HCMV infection of porcine endothelial cells (pEC) on cell surface molecule expression and human leukocyte recruitment...
  19. pmc JC virus-specific immune responses in human immunodeficiency virus type 1 patients with progressive multifocal leukoencephalopathy
    Nina Khanna
    Division of Infectious Diseases and Hospital Epidemiology, University Hospital Basel, CH 4031 Basel, Switzerland
    J Virol 83:4404-11. 2009
    ..JCV-specific T-cell and IgG responses may serve as prognostic markers for patients at risk...
  20. doi request reprint Critical issues related to porcine xenograft exposure to human viruses: lessons from allotransplantation
    Anne Laure Millard
    Division of Infectious Diseases and Hospital Epidemiology, University Hospital Zurich, Zurich, Switzerland
    Curr Opin Organ Transplant 15:230-5. 2010
    ..Recent data are reviewed that assess the susceptibility of porcine cells to human viruses. On the basis of the experience in allotransplantation, potential consequences for the xenograft are discussed...
  21. doi request reprint Can human viruses infect porcine xenografts?
    Anne Laure Millard
    Division of Infectious Diseases and Hospital Epidemiology, Department of Medicine, University Hospital Zurich, Zurich, Switzerland
    Xenotransplantation 17:6-10. 2010
    ..This review focuses on human or recipient-derived pathogens and their potential harmful role in xenograft infection...
  22. doi request reprint Efficiency of porcine endothelial cell infection with human cytomegalovirus depends on both virus tropism and endothelial cell vascular origin
    Anne Laure Millard
    Division of Infectious Diseases and Hospital Epidemiology, University Hospital, Zurich, Switzerland
    Xenotransplantation 17:274-87. 2010
    ..We investigated the susceptibility of porcine endothelial cells (pEC) to HCMV infection...
  23. ncbi request reprint Porcine cytomegalovirus and coagulopathy in pig-to-primate xenotransplantation
    Bernd Gollackner
    Transplantation Biology Research Center, Massachusetts General Hospital Harvard Medical School, Boston, MA 02114, USA
    Transplantation 75:1841-7. 2003
    ..The activation of porcine (P) cytomegalovirus (PCMV) and baboon (B) CMV infections has been documented in pig-to-primate xenotransplantation. The purpose of this study was to determine the contribution of PCMV and BCMV to CC...
  24. ncbi request reprint Reduced efficacy of ganciclovir against porcine and baboon cytomegalovirus in pig-to-baboon xenotransplantation
    Nicolas J Mueller
    Infectious Diseases Division, Massachusetts General Hospital, Harvard Medical School, Boston, MA 02114, USA
    Am J Transplant 3:1057-64. 2003
    ..GCV and other antiviral agents have limited activities against PCMV in vitro. Breeding of PCMV-free xenograft donors may be necessary to prevent PCMV infections in clinical trials...
  25. ncbi request reprint Correlation of biochemical and hematological changes with graft failure following pig heart and kidney transplantation in baboons
    Christoph Knosalla
    Transplantation Biology Research Center, Massachusetts General Hospital Harvard Medical School, Boston, MA, USA
    Am J Transplant 3:1510-9. 2003
    ..Noninvasive parameters were identified that have predictive potential for AHXR. Monitoring of these might enable therapeutic intervention to reverse rejection...
  26. ncbi request reprint Activation of porcine cytomegalovirus, but not porcine lymphotropic herpesvirus, in pig-to-baboon xenotransplantation
    Nicolas J Mueller
    Infectious Disease Division, Massachusetts General Hospital, Harvard Medical School, Boston, Massachusetts 02114, USA
    J Infect Dis 189:1628-33. 2004
    ..Control immunosuppressed swine coinfected with PCMV and PLHV-1 had activation of PCMV but not PLHV-1. PCMV, but not PLHV-1, is activated in solid-organ xenotransplantation...
  27. ncbi request reprint Early weaning of piglets fails to exclude porcine lymphotropic herpesvirus
    Nicolas J Mueller
    Infectious Diseases Division, Massachusetts General Hospital, Harvard Medical School, Massachusetts General Hospital, Boston, MA 02114, USA
    Xenotransplantation 12:59-62. 2005
    ..MATERIAL and..
  28. ncbi request reprint Reduction of consumptive coagulopathy using porcine cytomegalovirus-free cardiac porcine grafts in pig-to-primate xenotransplantation
    Nicolas J Mueller
    Infectious Diseases Division, Massachusetts General Hospital, Harvard Medical School, 55 Fruit Street, GRJ 504, Boston, MA 02114, USA
    Transplantation 78:1449-53. 2004
    ..Activation of porcine cytomegalovirus (PCMV) in pig-to-baboon xenotransplantation is associated with xenograft injury and possibly an increased incidence of consumptive coagulopathy (CC)...
  29. pmc Activation of cytomegalovirus in pig-to-primate organ xenotransplantation
    Nicolas J Mueller
    Infectious Diseases Division, Massachusetts General Hospital and Harvard Medical School, Boston 02114, USA
    J Virol 76:4734-40. 2002
    ..The observation of graft injury by PCMV demonstrates that CMV will be an important pathogen in immunosuppressed xenograft recipients. Strategies must be developed to exclude CMV from porcine organ donors...