Beat Mueller

Summary

Affiliation: University of Basel
Country: Switzerland

Publications

  1. doi request reprint Biomarkers: past, present, and future
    Christian Mueller
    Department of Internal Medicine, University Hospital, Basel, Switzerland
    Swiss Med Wkly 138:225-9. 2008
  2. ncbi request reprint What cardiologists do need to know about procalcitonin
    Christian Mueller
    Department of Internal Medicine, University Hospital Basel, Switzerland
    Clin Lab 51:1-4. 2005
  3. pmc Biomarker-enhanced triage in respiratory infections: a proof-of-concept feasibility trial
    Werner C Albrich
    University of Basel, Kantonsspital Aarau, Aarau
    Eur Respir J 42:1064-75. 2013
  4. pmc Optimizing triage and hospitalization in adult general medical emergency patients: the triage project
    Philipp Schuetz
    University Department of Internal Medicine, Kantonsspital Aarau, Tellstrasse, Aarau CH 5001, Switzerland
    BMC Emerg Med 13:12. 2013
  5. pmc Targeting AMP-activated protein kinase in adipocytes to modulate obesity-related adipokine production associated with insulin resistance and breast cancer cell proliferation
    Jean Grisouard
    Department of Biomedicine, University Hospital Basel, Basel, CH 4031, Switzerland
    Diabetol Metab Syndr 3:16. 2011
  6. pmc Mid-regional pro-adrenomedullin as a prognostic marker in sepsis: an observational study
    Mirjam Christ-Crain
    Department of Internal Medicine, University Hospital Basel, Petersgraben 4, 4031 Basel, Switzerland
    Crit Care 9:R816-24. 2005
  7. pmc When once is not enough--further evidence of procalcitonin-guided antibiotic stewardship
    Stephan Harbarth
    Infection Control Program, Department of Internal Medicine, University of Geneva Hospitals and Medical School, CH 1211 Geneva 14, Switzerland
    Crit Care 13:165. 2009
  8. pmc Which patients with lower respiratory tract infections need inpatient treatment? Perceptions of physicians, nurses, patients and relatives
    Claudia Baehni
    Department of Internal Medicine, University Hospital Basel, Basel, Switzerland
    BMC Pulm Med 10:12. 2010
  9. pmc Clinical predictors for Legionella in patients presenting with community-acquired pneumonia to the emergency department
    Rico Fiumefreddo
    Department of Internal Medicine, Kantonsspital Aarau, Tellstrasse, CH 5001 Aarau, Switzerland
    BMC Pulm Med 9:4. 2009
  10. pmc Effect of a 14-day course of systemic corticosteroids on the hypothalamic-pituitary-adrenal-axis in patients with acute exacerbation of chronic obstructive pulmonary disease
    Philipp Schuetz
    Division of Endocrinology, Diabetes and Clinical Nutrition, University Hospital Basel, Petersgraben 4, CH 4031 Basel, Switzerland
    BMC Pulm Med 8:1. 2008

Detail Information

Publications112 found, 100 shown here

  1. doi request reprint Biomarkers: past, present, and future
    Christian Mueller
    Department of Internal Medicine, University Hospital, Basel, Switzerland
    Swiss Med Wkly 138:225-9. 2008
    ..Although these may look like unrelated medical challenges, recent clinical research in these areas by our groups and others has opened up opportunities and challenges that seem fundamental for biomarkers in general...
  2. ncbi request reprint What cardiologists do need to know about procalcitonin
    Christian Mueller
    Department of Internal Medicine, University Hospital Basel, Switzerland
    Clin Lab 51:1-4. 2005
    ..49 (p < 0.001), as compared to the standard group. Thus, using a sensitive assay, procalcitonin-guidance substantially and safely reduced antibiotic usage in LRTI...
  3. pmc Biomarker-enhanced triage in respiratory infections: a proof-of-concept feasibility trial
    Werner C Albrich
    University of Basel, Kantonsspital Aarau, Aarau
    Eur Respir J 42:1064-75. 2013
    ..13). There were no differences in adverse outcomes or readmission. Logistic obstacles and overruling are major challenges to implement biomarker-enhanced algorithms in clinical settings and need to be addressed to shorten length of stay...
  4. pmc Optimizing triage and hospitalization in adult general medical emergency patients: the triage project
    Philipp Schuetz
    University Department of Internal Medicine, Kantonsspital Aarau, Tellstrasse, Aarau CH 5001, Switzerland
    BMC Emerg Med 13:12. 2013
    ....
  5. pmc Targeting AMP-activated protein kinase in adipocytes to modulate obesity-related adipokine production associated with insulin resistance and breast cancer cell proliferation
    Jean Grisouard
    Department of Biomedicine, University Hospital Basel, Basel, CH 4031, Switzerland
    Diabetol Metab Syndr 3:16. 2011
    ..abstract:..
  6. pmc Mid-regional pro-adrenomedullin as a prognostic marker in sepsis: an observational study
    Mirjam Christ-Crain
    Department of Internal Medicine, University Hospital Basel, Petersgraben 4, 4031 Basel, Switzerland
    Crit Care 9:R816-24. 2005
    ..The aim of the present study was to evaluate the prognostic value of mid-regional pro-adrenomedullin (MR-proADM) levels in a cohort of medical intensive care patients and to compare it with other biomarkers and physiological scores...
  7. pmc When once is not enough--further evidence of procalcitonin-guided antibiotic stewardship
    Stephan Harbarth
    Infection Control Program, Department of Internal Medicine, University of Geneva Hospitals and Medical School, CH 1211 Geneva 14, Switzerland
    Crit Care 13:165. 2009
    ....
  8. pmc Which patients with lower respiratory tract infections need inpatient treatment? Perceptions of physicians, nurses, patients and relatives
    Claudia Baehni
    Department of Internal Medicine, University Hospital Basel, Basel, Switzerland
    BMC Pulm Med 10:12. 2010
    ..This survey analyzed perceptions of physicians, nurses, patients and relatives about feasibility of outpatient management and required duration of hospital stay...
  9. pmc Clinical predictors for Legionella in patients presenting with community-acquired pneumonia to the emergency department
    Rico Fiumefreddo
    Department of Internal Medicine, Kantonsspital Aarau, Tellstrasse, CH 5001 Aarau, Switzerland
    BMC Pulm Med 9:4. 2009
    ..Accurate clinical predictors to assess the likelihood of Legionella community-acquired pneumonia (CAP) in patients presenting to the emergency department are lacking...
  10. pmc Effect of a 14-day course of systemic corticosteroids on the hypothalamic-pituitary-adrenal-axis in patients with acute exacerbation of chronic obstructive pulmonary disease
    Philipp Schuetz
    Division of Endocrinology, Diabetes and Clinical Nutrition, University Hospital Basel, Petersgraben 4, CH 4031 Basel, Switzerland
    BMC Pulm Med 8:1. 2008
    ....
  11. pmc Procalcitonin for diagnosis of infection and guide to antibiotic decisions: past, present and future
    Philipp Schuetz
    Harvard School of Public Health, 667 Huntington Ave, 02115 Boston MA, USA
    BMC Med 9:107. 2011
    ..The aim of this review is to summarize the current evidence for PCT in different infections and clinical settings, and discuss the reliability of this marker when used with validated diagnostic algorithms...
  12. pmc Enhancement of CURB65 score with proadrenomedullin (CURB65-A) for outcome prediction in lower respiratory tract infections: derivation of a clinical algorithm
    Werner C Albrich
    Medical University Department of the University of Basel, Kantonsspital Aarau, Switzerland
    BMC Infect Dis 11:112. 2011
    ..We aimed to derive a practical algorithm combining the CURB65 score with ProADM-levels in patients with community-acquired pneumonia (CAP) and non-CAP-LRTI...
  13. pmc Procalcitonin guided antibiotic therapy and hospitalization in patients with lower respiratory tract infections: a prospective, multicenter, randomized controlled trial
    Philipp Schuetz
    Department of Internal Medicine, Diabetes and Clinical Nutrition, University Hospital Basel, Petersgraben 4, Basel, Switzerland
    BMC Health Serv Res 7:102. 2007
    ....
  14. pmc Diagnostic and prognostic accuracy of clinical and laboratory parameters in community-acquired pneumonia
    Beat Muller
    Departments of Internal Medicine, University Hospital, Petersgraben 4, CH 4031, Basel, Switzerland
    BMC Infect Dis 7:10. 2007
    ..This study aims to evaluate the diagnostic and prognostic accuracy of clinical signs and symptoms and laboratory biomarkers for CAP...
  15. ncbi request reprint Endocrine aspects of critical illness
    B Muller
    Clinic of Endocrinology, Diabetes and Clinical Nutrition, University Hospital Basel Petersgraben 4, 4031 Basel, Switzerland
    Ann Endocrinol (Paris) 68:290-8. 2007
    ..In several animal models the modulation and neutralization of hormokines during infection was shown to improve survival and thus might open new treatment options for severe infections, especially of the respiratory tract...
  16. ncbi request reprint Circulating biomarkers as surrogates for bloodstream infections
    Beat Muller
    Department of Internal Medicine, University Hospital Basel, Petersgraben 4, CH 4031 Basel, Switzerland
    Int J Antimicrob Agents 30:S16-23. 2007
    ..Specific cut-off ranges must be proposed and intervention studies conducted to tackle the existing vicious cycle of diagnostic uncertainty, antibiotic overuse and emerging multi-resistance...
  17. pmc Prohormones for prediction of adverse medical outcome in community-acquired pneumonia and lower respiratory tract infections
    Philipp Schuetz
    Department of Internal Medicine, Division of Endocrinology, Diabetes and Clinical Nutrition, University Hospital Basel, Petersgraben 4, 4031 Basel, Switzerland
    Crit Care 14:R106. 2010
    ..Measurement of prohormones representing different pathophysiological pathways could enhance risk stratification in patients with community-acquired pneumonia (CAP) and other lower respiratory tract infections (LRTI)...
  18. pmc Endothelin-1 precursor peptides correlate with severity of disease and outcome in patients with community acquired pneumonia
    Philipp Schuetz
    Department of Internal Medicine, University Hospital Basel, Switzerland
    BMC Infect Dis 8:22. 2008
    ..The objective of this study was to assess the diagnostic and prognostic value of proET-1 in a prospective cohort of mainly septic patients with community-acquired pneumonia...
  19. doi request reprint Stress markers predict mortality in patients with nonspecific complaints presenting to the emergency department and may be a useful risk stratification tool to support disposition planning
    Christian H Nickel
    Emergency Department, University Hospital, Basel, Switzerland
    Acad Emerg Med 20:670-9. 2013
    ....
  20. doi request reprint Procalcitonin levels predict bacteremia in patients with community-acquired pneumonia: a prospective cohort trial
    Fabian Müller
    Department of Internal Medicine, Division of Endocrinology, Diabetes and Clinical Nutrition, University Hospital Basel, Basel, Switzerland
    Chest 138:121-9. 2010
    ..However, the yield of true-positive results is low. We investigated the benefit of procalcitonin (PCT) on hospital admission to predict blood culture positivity in CAP...
  21. doi request reprint Use of B-type natriuretic peptide in the risk stratification of acute exacerbations of COPD
    Daiana Stolz
    Clinic for Pneumology and Respiratory Cell Research, University Hospital Basel, Switzerland
    Chest 133:1088-94. 2008
    ..In patients with COPD, prognosis might be determined at least in part by the extent of cardiac stress induced by hypoxia and pulmonary arterial hypertension...
  22. pmc Copeptin, procalcitonin and routine inflammatory markers-predictors of infection after stroke
    Felix Fluri
    Department of Neurology, University Hospital Basel, Basel, Switzerland
    PLoS ONE 7:e48309. 2012
    ..Early predictors for the development of stroke-associated infection may identify patients at high risk and reduce post-stroke infection and mortality...
  23. doi request reprint Prognostic value of procalcitonin in Legionella pneumonia
    J Haeuptle
    Department of Internal Medicine, University Hospital Basel, Basel, Switzerland
    Eur J Clin Microbiol Infect Dis 28:55-60. 2009
    ..5 had a significantly higher risk of death and/or ICU admission (log rank p = 0.003) during the hospital stay. In patients with CAP due to Legionella, PCT levels on admission might be an interesting predictor for adverse medical outcomes...
  24. doi request reprint Guidance of antibiotic therapy with procalcitonin in lower respiratory tract infections: insights into the ProHOSP study
    Philipp Schuetz
    Department of Internal Medicine, Division of Endocrinology, Diabetes and Clinical Nutrition, University Hospital Basel, Basel, Switzerland
    Virulence 1:88-92. 2010
    ..In lower respiratory tract infections, PCT guidance had a differential effect on antibiotic exposure depending on the underlying type and severity of respiratory tract infection...
  25. ncbi request reprint Biomarkers in respiratory tract infections: diagnostic guides to antibiotic prescription, prognostic markers and mediators
    M Christ-Crain
    Department of Internal Medicine, University Hospital Basel, Petersgraben 4, CH 4031 Basel, Switzerland
    Eur Respir J 30:556-73. 2007
    ..In several animal models the modulation and neutralisation of hormokines during infection was shown to improve survival, and thus might open new treatment options for severe infections, especially of the respiratory tract...
  26. ncbi request reprint Calcitonin precursors are reliable markers of sepsis in a medical intensive care unit
    B Muller
    Division of Medical Intensive Care, University Hospitals, Basel, Switzerland
    Crit Care Med 28:977-83. 2000
    ....
  27. doi request reprint Prognostic impact of plasma lipids in patients with lower respiratory tract infections - an observational study
    Maja Gruber
    Clinic of Endocrinology, Diabetology and Clinical Nutrition, University Hospital, Basel, Switzerland
    Swiss Med Wkly 139:166-72. 2009
    ..Whether lipids have prognostic implications or could help to differentiate community-acquired pneumonia from other lower respiratory tract infections remains unknown...
  28. pmc Predictors for length of hospital stay in patients with community-acquired pneumonia: results from a Swiss multicenter study
    Isabelle Suter-Widmer
    Department of Internal Medicine, Division of Endocrinology, Diabetes and Metabolism, University Hospital Basel, Basel, Switzerland
    BMC Pulm Med 12:21. 2012
    ..Accurate estimation of LOS on admission and during follow-up may result in earlier and more efficient discharge strategies...
  29. doi request reprint Procalcitonin-guided antibiotic use vs a standard approach for acute respiratory tract infections in primary care
    Matthias Briel
    Department of Internal Medicine, University Hospital Basel, Petersgraben 4, 4031 Basel, Switzerland
    Arch Intern Med 168:2000-7; discussion 2007-8. 2008
    ..We consider whether antibiotic therapy guided by procalcitonin reduces the use of antibiotics without increasing the restrictions experienced by patients by more than 1 day...
  30. pmc Predicting mortality with pneumonia severity scores: importance of model recalibration to local settings
    P Schuetz
    University Hospital Basel, Department of Internal Medicine, Basel, Switzerland
    Epidemiol Infect 136:1628-37. 2008
    ....
  31. pmc Association of adrenal function and disease severity in community-acquired pneumonia
    Cornelia Mueller
    Department of Endocrinology, Diabetology and Metabolism, UniversityHospital, Basel, Switzerland
    PLoS ONE 9:e99518. 2014
    ..We herein validatedthe prognostic value of the adrenal hormones DHEA, DHEA-Sulfate (DHEAS),cortisol/DHEA-, cortisol/DHEAS- and DHEA/DHEAS -ratios in patients with CAP...
  32. ncbi request reprint Head-to-head comparison of length of stay, patients' outcome and satisfaction in Switzerland before and after SwissDRG-Implementation in 2012 in 2012: an observational study in two tertiary university centers
    Désirée Thommen
    Division of Internal Medicine, University Hospital Basel, Switzerland
    Swiss Med Wkly 144:w13972. 2014
    ..With the introduction of the new payment system we aim to answer questions raised regarding length of stay as well as patients' outcome and satisfaction...
  33. doi request reprint Effectiveness of a procalcitonin algorithm to guide antibiotic therapy in respiratory tract infections outside of study conditions: a post-study survey
    P Schuetz
    Division of Internal Medicine, University Hospital Basel, 4031 Basel, Switzerland
    Eur J Clin Microbiol Infect Dis 29:269-77. 2010
    ..The integration of the PCT algorithm into daily practice requires ongoing reinforcement and involves a learning process of the prescribing physicians...
  34. doi request reprint Effect of procalcitonin-based guidelines vs standard guidelines on antibiotic use in lower respiratory tract infections: the ProHOSP randomized controlled trial
    Philipp Schuetz
    Department of Internal Medicine, Kantonsspital Aarau, Tellstrasse, CH 5001 Aarau, Switzerland
    JAMA 302:1059-66. 2009
    ..In previous smaller trials, a procalcitonin (PCT) algorithm reduced antibiotic use in patients with lower respiratory tract infections (LRTIs)...
  35. doi request reprint Do sepsis biomarkers in the emergency room allow transition from bundled sepsis care to personalized patient care?
    Philipp Schuetz
    Department of Internal Medicine, Kantonsspital Aarau, Switzerland
    Curr Opin Crit Care 18:341-9. 2012
    ....
  36. ncbi request reprint Procalcitonin and the early diagnosis of infective endocarditis
    Christian Mueller
    Department of Internal Medicine, University Hospital Basel, Basel, Switzerland
    Circulation 109:1707-10. 2004
    ..Variability in the clinical presentation of infective endocarditis (IE) makes the diagnosis a clinical challenge. We hypothesized that serum procalcitonin, a marker of systemic bacterial infection, might be helpful in its diagnosis...
  37. doi request reprint Anterior pituitary axis hormones and outcome in acute ischaemic stroke
    S Neidert
    Department of Endocrinology, University Hospital Basel, Basel, Switzerland
    J Intern Med 269:420-32. 2011
    ..We therefore evaluated the prognostic value of cortisol, triiodothyronine (T3), free thyroxine (fT4), thyroid-stimulating hormone (TSH) and growth hormone (GH) in patients with an acute ischaemic stroke...
  38. ncbi request reprint Blood biomarkers for personalized treatment and patient management decisions in community-acquired pneumonia
    Philipp Schuetz
    Medical University Clinic, Department of Internal Medicine, Kantonsspital Aarau, Aarau, Switzerland
    Curr Opin Infect Dis 26:159-67. 2013
    ....
  39. doi request reprint The value of serum procalcitonin level for differentiation of infectious from noninfectious causes of fever after orthopaedic surgery
    Sabina Hunziker
    Department of Internal Medicine, University Hospital Basel, Petersgraben 4, CH 4031 Basel, Switzerland
    J Bone Joint Surg Am 92:138-48. 2010
    ..There are currently no reliable diagnostic markers to differentiate infectious from noninfectious causes of postoperative fever. We investigated the value of the serum procalcitonin level in febrile patients after orthopaedic surgery...
  40. pmc Corticosteroid treatment for community-acquired pneumonia - the STEP trial: study protocol for a randomized controlled trial
    Claudine A Blum
    Endocrinology, Diabetology and Metabolism, Department of Internal Medicine, University Hospital Basel, Petersgraben 4, 4031 Basel, Switzerland
    Trials 15:257. 2014
    ..Available studies show controversial results, and the question about benefits and harms of adjunct corticosteroid therapy has not been conclusively resolved, particularly in the non-critical care setting...
  41. doi request reprint Low triiodothyronine syndrome: a prognostic marker for outcome in sepsis?
    Stefanie Meyer
    Department of Internal Medicine, Division of Endocrinology Diabetes and Clinical Nutrition, University Hospital Basel, Basel, Switzerland
    Endocrine 39:167-74. 2011
    ..04 and P = 0.02). T3 and fT4 levels on admission were not prognostic in this cohort of critically ill patients. A decrease in fT4 levels in the course of disease, however, may point to adverse outcome...
  42. pmc Mannose-binding lectin deficiency is associated with smaller infarction size and favorable outcome in ischemic stroke patients
    Michael Osthoff
    Laboratory of Clinical Immunology, Department of Biomedicine and Clinic for Internal Medicine, University Hospital Basel, Basel, Switzerland
    PLoS ONE 6:e21338. 2011
    ....
  43. doi request reprint Stress hormones predict cerebrovascular re-events after transient ischemic attacks
    M Katan
    Department of Endocrinology, University Hospital Basel, Petersgraben 4, 4031 Basel, Switzerland
    Neurology 76:563-6. 2011
    ..This study assessed prognostic reliability of 2 distinct stress hormones, copeptin and cortisol, for the risk stratification of re-events in patients with TIA...
  44. doi request reprint Inflammatory responses predict long-term mortality risk in community-acquired pneumonia
    C Guertler
    Department of Internal Medicine, University Hospital Basel, Basel, Switzerland
    Eur Respir J 37:1439-46. 2011
    ..Further studies should address whether closer monitoring of high-risk CAP patients after hospital discharge favourably impacts long-term mortality...
  45. pmc Procalcitonin guidance to reduce antibiotic treatment of lower respiratory tract infection in children and adolescents (ProPAED): a randomized controlled trial
    Gurli Baer
    Department of Pediatrics, University Basel, Basel, Switzerland
    PLoS ONE 8:e68419. 2013
    ..Antibiotics are overused in children and adolescents with lower respiratory tract infection (LRTI). Serum-procalcitonin (PCT) can be used to guide treatment when bacterial infection is suspected. Its role in pediatric LRTI is unclear...
  46. doi request reprint Head-to-head comparison of fee-for-service and diagnosis related groups in two tertiary referral hospitals in Switzerland: an observational study
    Noemi Weissenberger
    Division of Internal Medicine, University Hospital Basel, Switzerland
    Swiss Med Wkly 143:w13790. 2013
    ..We compared length of hospital stay (LOS), patient satisfaction and quality of life between the two systems before a nation-wide implementation of DRG...
  47. doi request reprint Dynamics and association of different acute stress markers with performance during a simulated resuscitation
    Sabina Hunziker
    Intensive Care Unit, University Hospital Basel and University Basel, Basel, Switzerland
    Resuscitation 83:572-8. 2012
    ..Our aim was to compare self-reported, biochemical and physiological stress measures in regard to CPR performance...
  48. pmc Copeptin is associated with mortality and outcome in patients with acute intracerebral hemorrhage
    Christian Zweifel
    Department of Neurosurgery, University Hospital of Basel, Spitalstrasse 21, 4031 Basel, Switzerland
    BMC Neurol 10:34. 2010
    ..Copeptin, the C-terminal part of provasopressin, has emerged as a new prognostic marker in a variety of diseases, but its prognostic value in ICH is unknown...
  49. doi request reprint Single and multiple viral infections in lower respiratory tract infection
    Mikael Gencay
    Pulmonary Cell Research, Department of Biomedicine, University Hospital Basel and University of Basel, Basel, Switzerland
    Respiration 80:560-7. 2010
    ..Lower respiratory tract infection (LRTI) often leads to hospitalization, and it was indicated that causative viral infections are underestimated...
  50. ncbi request reprint Disordered calcium homeostasis of sepsis: association with calcitonin precursors
    B Muller
    University Hospitals, CH 4031 Basel, Switzerland
    Eur J Clin Invest 30:823-31. 2000
    ..Hypocalcemia and increased serum levels of calcitonin precursors are common in critically ill patients, especially in those with sepsis. We investigated calcium homeostasis in such patients...
  51. ncbi request reprint Procalcitonin: how a hormone became a marker and mediator of sepsis
    B Muller
    Division of Endocrinology, Diabetology and Clinical Nutrition, Department of Internal Medicine, University Hospitals, Basel, Switzerland
    Swiss Med Wkly 131:595-602. 2001
    ..The aim of this review is to describe this metamorphosis of an endocrine hormone to a new class of hormokine mediators in infectious diseases...
  52. doi request reprint Dexamethasone suppression test predicts later development of an impaired adrenal function after a 14-day course of prednisone in healthy volunteers
    Stefanie Neidert
    Division of Endocrinology, Diabetes and Clinical Nutrition, Department of Internal Medicine, University Hospital Basel, Basel, Switzerland
    Eur J Endocrinol 162:943-9. 2010
    ..Identification of patients at risk is of clinical importance. We hypothesized that the dexamethasone suppression test predicts the development of corticosteroid-induced impaired adrenal function...
  53. doi request reprint Metformin induces glucose uptake in human preadipocyte-derived adipocytes from various fat depots
    M Fischer
    Department of Biomedicine, University Hospital Basel, CH 4031 Basel, Switzerland
    Diabetes Obes Metab 12:356-9. 2010
    ..In adipocytes, metformin seems to induce glucose uptake independent of insulin suggesting an alternative mechanism of action of this drug...
  54. ncbi request reprint Is there a clinical relevance of partial androgen deficiency of the aging male?
    Mirjam Christ-Crain
    Division of Endocrinology, Diabetes and Clinical Nutrition, Department of Medicine, University Hospitals, Basel, Switzerland
    J Urol 172:624-7. 2004
    ..We investigate the association between various T measures and clinical and biochemical parameters of the aging male...
  55. doi request reprint Increase in high molecular weight adiponectin by bariatric surgery-induced weight loss
    P Linscheid
    Department of Research, University Hospital, Basel, Switzerland
    Diabetes Obes Metab 10:1266-70. 2008
    ..To determine the changes in adiponectin multimers upon marked weight loss...
  56. ncbi request reprint Effects of infectious disease on plasma lipids and their diagnostic significance in critical illness
    S Lüthold
    Division of Endocrinology, Diabetology and Clinical Nutrition, Department of Internal Medicine, University Hospital, Basel, Switzerland
    Eur J Clin Invest 37:573-9. 2007
    ..It also aims to determine the value of plasma lipid routine measurements in the diagnosis of infection in critical illness in comparison to markers of infection and acute phase reactants...
  57. doi request reprint Early diagnosis of myocardial infarction with sensitive cardiac troponin assays
    Tobias Reichlin
    Department of Internal Medicine, University Hospital, Basel, Switzerland
    N Engl J Med 361:858-67. 2009
    ..The rapid and reliable diagnosis of acute myocardial infarction is a major unmet clinical need...
  58. doi request reprint Use of changes in B-type natriuretic peptides to detect ischemia in selected patients
    Daniel Staub
    Department of Internal Medicine, University Hospital Basel, Switzerland
    Int J Cardiol 136:40-6. 2009
    ..The aim of this study was to either confirm or refute a previous investigation suggesting that myocardial ischemia can reliably be detected by exercise-induced changes in BNP or NT-proBNP levels in selected patients...
  59. pmc Copeptin Levels Remain Unchanged during the Menstrual Cycle
    Claudine A Blum
    Endocrinology, Medical University Clinic, Kantonsspital Aarau, Aarau, Switzerland Endocrinology, Diabetology and Metabolism, University Hospital Basel, Basel, Switzerland
    PLoS ONE 9:e98240. 2014
    ..We investigated copeptin during the menstrual cycle and its relationship to sex hormones, markers of subclinical inflammation and estimates of body fluid...
  60. pmc Impact of concomitant thyroid pathology on preoperative workup for primary hyperparathyroidism
    Oleg Heizmann
    Allgemeinchirurgische Klinik, Universitatsspital Basel, Spitalstr 21, CH 4031 Basel, Switzerland
    Eur J Med Res 14:37-41. 2009
    ..The aim of the present study is to evaluate the value of MIP in respect to coexisting thyroid findings and their impact on preoperative workup for primary hyperparathyroidism...
  61. ncbi request reprint Circulating levels of copeptin, a novel biomarker, in lower respiratory tract infections
    B Muller
    University Hospital Basel, Switzerland
    Eur J Clin Invest 37:145-52. 2007
    ..Lower respiratory tract infections (LRTI) are a precursor of sepsis. Thus, we investigated circulating levels and the prognostic use of copeptin for the severity and outcome in patients with LRTI...
  62. doi request reprint Different strategies to overcome the effect of carbimazole on high- and low-dose radioiodine therapy: results from continuous dose-effect models
    M A Walter
    Institute of Nuclear Medicine, University Hospital Basel, Basel, Switzerland
    Eur J Clin Invest 39:51-7. 2009
    ....
  63. doi request reprint B-type natriuretic peptide-guided management and outcome in patients with obesity and dyspnea--results from the BASEL study
    Markus Noveanu
    Department of Internal Medicine, University Hospital Basel, Basel, Switzerland
    Am Heart J 158:488-95. 2009
    ..Obesity may reduce diagnostic accuracy of B-type natriuretic peptide (BNP) and affect long-term outcome...
  64. doi request reprint Accuracy of chest radiographs in the emergency diagnosis of heart failure
    Ueli Studler
    Department of Radiology, University Hospital Basel, Petersgraben 4, 4031, Basel, Switzerland
    Eur Radiol 18:1644-52. 2008
    ..In our study, the combination of radiographic features provided valuable information and was of comparable accuracy as BNP-testing for the diagnosis of HF...
  65. doi request reprint Diagnostic and prognostic value of uric acid in patients with acute dyspnea
    Tobias Reichlin
    Department of Internal Medicine, University Hospital Basel, Switzerland
    Am J Med 122:1054.e7-1054.e14. 2009
    ..Uric acid was shown to predict outcome in patients with stable chronic heart failure. Its impact in patients admitted in the Emergency Department with acute dyspnea, however, remains unknown...
  66. ncbi request reprint Multimarker strategy for risk prediction in patients presenting with acute dyspnea to the emergency department
    Michael Christ
    Department of Internal Medicine, University Hospital, Petersgraben 4, CH 4031 Basel, Switzerland
    Int J Cardiol 126:73-8. 2008
    ....
  67. ncbi request reprint Incidence, risk factors, and outcome of aspiration pneumonitis in ICU overdose patients
    Andreas Christ
    Department of Internal Medicine, University of Basel, University Hospital, Petersgraben 4, 4031 Basel, Switzerland
    Intensive Care Med 32:1423-7. 2006
    ..To assess the incidence and outcome of clinically significant aspiration pneumonitis in intensive care unit (ICU) overdose patients and to identify its predisposing factors...
  68. ncbi request reprint Inflammation and long-term mortality in acute congestive heart failure
    Christian Mueller
    Department of Internal Medicine, University of Basel, University Hospital, Basel, Switzerland
    Am Heart J 151:845-50. 2006
    ..Systemic inflammation has long been recognized as a precipitator of acute congestive heart failure (CHF). The impact of inflammation on prognosis in acute CHF, however, is unknown...
  69. ncbi request reprint Prognostic value of the admission electrocardiogram in patients with unstable angina/non-ST-segment elevation myocardial infarction treated with very early revascularization
    Christian Mueller
    University Hospital, Basel, Switzerland
    Am J Med 117:145-50. 2004
    ..The goals of this study were to determine if very early revascularization might ameliorate the adverse prognosis associated with ST-segment depression in patients with unstable angina/non-ST-segment elevation myocardial infarction...
  70. pmc Midregional pro-adrenomedullin in addition to b-type natriuretic peptides in the risk stratification of patients with acute dyspnea: an observational study
    Mihael Potocki
    Department of Internal Medicine, University Hospital, Petersgraben 4, 4031 Basel, Switzerland
    Crit Care 13:R122. 2009
    ....
  71. doi request reprint Risk stratification in acute decompensated heart failure: the role of cardiac troponin
    Christian Mueller
    University of Basel and Internal Medicine at University Hospital Basel, Basel, Switzerland
    Nat Clin Pract Cardiovasc Med 5:680-1. 2008
    ..0% vs 2.7%; P<0.001). Future studies need to define which treatment changes could improve outcome in troponin-positive patients with acute decompensated heart failure...
  72. doi request reprint Percutaneous coronary intervention versus coronary artery bypass grafting as primary revascularization in patients with acute coronary syndrome
    Willibald Hochholzer
    Herz Zentrum, Bad Krozingen, Germany Department of Internal Medicine, University Hospital, Basel, Switzerland
    Am J Cardiol 102:173-9. 2008
    ....
  73. doi request reprint Impact of history of heart failure on diagnostic and prognostic value of BNP: results from the B-type Natriuretic Peptide for Acute Shortness of Breath Evaluation (BASEL) study
    Tujana Boldanova
    Department of Internal Medicine, University of Basel, University Hospital, Switzerland
    Int J Cardiol 142:265-72. 2010
    ....
  74. doi request reprint Impact of body temperature on in-hospital and long-term mortality in patients with acute heart failure
    Theresia Klima
    Department of Internal Medicine, Institute of Social and Preventive Medicine, University Hospital Basel, Basel, Switzerland
    Swiss Med Wkly 138:299-304. 2008
    ..Body temperature (BT) was shown to have impact on outcome in several medical conditions. This study investigated the prognostic impact of BT in patients with acute heart failure (HF)...
  75. doi request reprint Use of B-type natriuretic peptide outside of the emergency department
    Micha T Maeder
    Division of Cardiology, University Hospital Basel, Switzerland
    Int J Cardiol 127:5-16. 2008
    ..Despite active research in many additional fields, the use of BNP/NT-proBNP in other settings is not yet based on solid evidence and, therefore, seems not to be useful...
  76. ncbi request reprint Clinical application of sensitive cardiac troponin assays: potential and limitations
    Raphael Twerenbold
    Department of Internal Medicine, University Hospital Basel, Petersgraben 4, CH 4031 Basel, Switzerland
    Biomark Med 4:395-401. 2010
    ..The aim of this article is to guide clinicians in the use of sensitive cTn...
  77. ncbi request reprint Neurohormonal activation and left ventricular ejection fraction in patients with suspected myocardial ischemia
    Juerg Wermuth
    Department of Internal Medicine, Medical Division A, University Hospital, Petersgraben 4, CH 4031 Basel, Switzerland
    Int J Cardiol 120:248-53. 2007
    ..Unfortunately, there is very limited data regarding the association between BNP and LVEF...
  78. ncbi request reprint Operator experience and long term outcome after percutaneous coronary intervention
    Christian Mueller
    Medizinische Universitätsklinik Basel, Basel, Switzerland
    Can J Cardiol 19:1047-51. 2003
    ..To investigate the impact of operator experience on long term outcome of patients undergoing percutaneous coronary intervention (PCI)...
  79. ncbi request reprint Use of B-type natriuretic peptide in the evaluation and management of acute dyspnea
    Christian Mueller
    Department of Internal Medicine, Medical Division A, University of Basel, University Hospital, Basel, Switzerland
    N Engl J Med 350:647-54. 2004
    ..B-type natriuretic peptide levels are higher in patients with congestive heart failure than in patients with dyspnea from other causes...
  80. ncbi request reprint Use of B-type natriuretic peptide for the management of women with dyspnea
    Christian Mueller
    Department of Internal Medicine, Medical Division, University of Basel, University Hospital, Basel, Switzerland
    Am J Cardiol 94:1510-4. 2004
    ..165). Thus, used in conjunction with other clinical information, rapid measurement of BNP decreased time to discharge and total cost of treatment in women who presented with acute dyspnea...
  81. ncbi request reprint Use of B-type natriuretic peptide in the management of acute dyspnea in patients with pulmonary disease
    Christian Mueller
    Medical Division A, Department of Internal Medicine, University Hospital, University of Basel, Basel, Switzerland
    Am Heart J 151:471-7. 2006
    ..The impact of B-type natriuretic peptide (BNP) measurements on the management of patients with pulmonary disease and acute dyspnea remains to be defined...
  82. doi request reprint Incidence of contrast-induced nephropathy with volume supplementation--insights from a large cohort
    Nicole Mueller-Lenke
    University Hospital Basel, Basel, Switzerland
    Med Princ Pract 17:409-14. 2008
    ..The present study was performed to determine the effect of combined intravenous and oral volume supplementation on the incidence of contrast-induced nephropathy (CIN) in patients undergoing percutaneous coronary intervention (PCI)...
  83. ncbi request reprint Use of N-terminal pro-B-type natriuretic peptide to detect myocardial ischemia
    Daniel Staub
    Department of Internal Medicine, University Hospital Basel, Basel, Switzerland
    Am J Med 118:1287. 2005
    ..To evaluate the utility of plasma N-terminal pro-B-type natriuretic peptide (NT-proBNP) levels to detect myocardial ischemia...
  84. ncbi request reprint The integration of BNP and NT-proBNP into clinical medicine
    Christian Mueller
    Department of Internal Medicine, University Hospital, Petersgraben 4, CH 4031 Basel, Switzerland
    Swiss Med Wkly 137:4-12. 2007
    ....
  85. doi request reprint Use of copeptin in the detection of myocardial ischemia
    Daniel Staub
    Department of Internal Medicine, University Hospital Basel, Switzerland
    Clin Chim Acta 399:69-73. 2009
    ..The role of the arginine-vasopressin (AVP) system in the response to myocardial ischemia is unclear. Copeptin, the C-terminal part of the AVP prohormone is secreted stoichiometrically with AVP...
  86. ncbi request reprint The use of B-type natriuretic peptide in the diagnosis of acute dyspnoea
    Christian Mueller
    Department of Internal Medicine, University Hospital Basel, Switzerland
    Clin Lab 51:5-9. 2005
    ....
  87. ncbi request reprint Incremental value of copeptin for rapid rule out of acute myocardial infarction
    Tobias Reichlin
    Department of Internal Medicine, University Hospital, Basel, Switzerland
    J Am Coll Cardiol 54:60-8. 2009
    ..The purpose of this study was to examine the incremental value of copeptin for rapid rule out of acute myocardial infarction (AMI)...
  88. doi request reprint Cardiovascular biomarkers in the ICU
    Markus Noveanu
    Department of Internal Medicine, University Hospital Basel, Basel, Switzerland
    Curr Opin Crit Care 15:377-83. 2009
    ..This review focuses on recently published articles relating to the use of natriuretic peptides and cTn in critically ill patients...
  89. doi request reprint B-type natriuretic peptides for the evaluation of exercise intolerance
    Christian Mueller
    Department of Internal Medicine, University Hospital Basel, Switzerland
    Am J Med 122:265-72. 2009
    ..This study sought to assess the utility of B-type natriuretic peptide (BNP) and N-terminal-pro-B-type natriuretic peptide (NT-proBNP) for the identification of a cardiocirculatory exercise limitation...
  90. doi request reprint Long-term benefit-risk balance of drug-eluting vs. bare-metal stents in daily practice: does stent diameter matter? Three-year follow-up of BASKET
    Matthias Pfisterer
    Department of Cardiology, University Hospital Basel, Petersgraben, Basel, Switzerland
    Eur Heart J 30:16-24. 2009
    ..To assess the long-term benefit-risk ratio of drug-eluting (DES) vs. bare-metal stents (BMS) relative to stent size...
  91. ncbi request reprint Prospective pilot study of recombinant granulocyte-macrophage colony-stimulating factor and interferon-gamma in patients with inoperable hepatocellular carcinoma
    Walter Reinisch
    Department of Internal Medicine IV, Division of Gastroenterology and Hepatology, University of Vienna, Waehringer Guertel 18 20, A 1090 Vienna, Austria
    J Immunother 25:489-99. 2002
    ..Immunotherapeutic approaches hold promise to prolong survival in selected patients with advanced HCC who respond by enhanced tumor immunogenicity...
  92. ncbi request reprint Brain natriuretic peptide for prediction of Cheyne-Stokes respiration in heart failure patients
    Michael Christ
    Klinik fur Innere Medizin, Kardiologie Philipps Universität Marburg, Germany
    Int J Cardiol 116:62-9. 2007
    ..Specifically, BNP levels are associated with the severity of cardiac and sleep-related disease, and may be helpful in the diagnosis of CSR and more appropriate use of polysomnography in CHF patients...
  93. ncbi request reprint Inflammation and long-term mortality after non-ST elevation acute coronary syndrome treated with a very early invasive strategy in 1042 consecutive patients
    Christian Mueller
    Herz Zentrum Bad Krozingen, Germany
    Circulation 105:1412-5. 2002
    ..This study sought to evaluate the predictive value of C-reactive protein (CRP) on long-term mortality in non-ST-elevation acute coronary syndromes (NSTACS) that were treated with a very early aggressive revascularization strategy...
  94. ncbi request reprint Prevention of contrast media-associated nephropathy: randomized comparison of 2 hydration regimens in 1620 patients undergoing coronary angioplasty
    Christian Mueller
    Herz Zentrum, Bad Krozingen, Germany
    Arch Intern Med 162:329-36. 2002
    ..The administration of radiographic contrast agents remains an important cause of acute renal failure. The optimal infusion for hydration has not been evaluated...
  95. ncbi request reprint Female sex and risk of contrast nephropathy after percutaneous coronary intervention
    Christian Mueller
    Herz Zentrum Bad Krozingen, Bad Krozingen, Germany
    Can J Cardiol 20:505-9. 2004
    ..The reason for this difference in outcome is unknown. Contrast nephropathy (CN) remains a major complication of PCI and a common cause of acute renal failure...
  96. pmc Molecular analysis of Phr peptide processing in Bacillus subtilis
    Sophie Stephenson
    Division of Cellular Biology, Department of Molecular and Experimental Medicine, The Scripps Research Institute, La Jolla, California 92037, USA
    J Bacteriol 185:4861-71. 2003
    ..subtilis (SipS, SipT, SipU, SipV, and SipW) are indispensable for Phr processing. However, we show that SipV and SipT have a previously undescribed role in sporulation, competence, and cell growth...
  97. ncbi request reprint Osteoporosis case finding in the general practice: phalangeal radiographic absorptiometry with and without risk factors for osteoporosis to select postmenopausal women eligible for lumbar spine and hip densitometry
    Katharina M Gasser
    Osteoporosis Policlinic, University Hospital of Berne, Switzerland
    Osteoporos Int 16:1353-62. 2005
    ..In the Swiss environment, RA is a valid case finding tool for patients with risk factors for osteoporosis, especially for those who do not qualify for DXA reimbursement...
  98. ncbi request reprint Women do have an improved long-term outcome after non-ST-elevation acute coronary syndromes treated very early and predominantly with percutaneous coronary intervention: a prospective study in 1,450 consecutive patients
    Christian Mueller
    Bad Krozingen Heart Center, Bad Krozingen, Germany
    J Am Coll Cardiol 40:245-50. 2002
    ..This study sought to assess gender-based differences in long-term outcome after very early aggressive revascularization for non-ST-elevation acute coronary syndromes (NSTACS)...
  99. ncbi request reprint Impact of intracoronary ultrasound guidance on long-term outcome of percutaneous coronary interventions in diabetics--insights from the randomized SIPS trial
    Christian Mueller
    Herz Zentrum Bad Krozingen, Germany
    Swiss Med Wkly 132:279-84. 2002
    ....
  100. doi request reprint New definition of myocardial infarction: impact on long-term mortality
    Willibald Hochholzer
    Herz Zentrum, Bad Krozingen, Germany
    Am J Med 121:399-405. 2008
    ....
  101. ncbi request reprint Differing definitions of contrast-induced nephropathy
    Omer Toprak
    Swiss Med Wkly 135:630; author reply 630. 2005