Bernhard Moser

Summary

Affiliation: University of Bern
Country: Switzerland

Publications

  1. pmc A skin-selective homing mechanism for human immune surveillance T cells
    Patrick Schaerli
    Theodor Kocher Institute, University of Bern, P O Box 99, CH 3000 Bern 9, Switzerland
    J Exp Med 199:1265-75. 2004
  2. pmc Monocyte selectivity and tissue localization suggests a role for breast and kidney-expressed chemokine (BRAK) in macrophage development
    I Kurth
    Theodor Kocher Institute, University of Bern, CH 3000 Bern 9, Switzerland
    J Exp Med 194:855-61. 2001
  3. ncbi Chemokines: role in immune cell traffic
    Bernhard Moser
    Theodor Kocher Institute, University of Bern, Bern, Switzerland
    Eur Cytokine Netw 14:204-10. 2003
  4. pmc Chemokines: role in inflammation and immune surveillance
    B Moser
    Theodor Kocher Institute, University of Bern, Freiestrasse 1, CH 3012 Bern, Switzerland
    Ann Rheum Dis 63:ii84-ii89. 2004
  5. ncbi Lymphocyte traffic control by chemokines: follicular B helper T cells
    Bernhard Moser
    Theodor Kocher Institute, University of Bern, 3012 Bern, Switzerland
    Immunol Lett 85:105-12. 2003
  6. ncbi CXCR5(+) T cells: follicular homing takes center stage in T-helper-cell responses
    Bernhard Moser
    Theodor Kocher Institute, University of Bern, Freiestrasse 1, 3000 Bern 9, Switzerland
    Trends Immunol 23:250-4. 2002
  7. ncbi Lymphocyte traffic control by chemokines
    B Moser
    Theodor Kocher Institute, University of Bern, CH 3000 Bern 9, Switzerland
    Nat Immunol 2:123-8. 2001
  8. ncbi Chemokines: multiple levels of leukocyte migration control
    Bernhard Moser
    Theodor Kocher Institute, University of Bern, Freiestrasse 1, CH 3012 Bern, Switzerland
    Trends Immunol 25:75-84. 2004
  9. ncbi Chemokine-mediated control of T cell traffic in lymphoid and peripheral tissues
    Lisa M Ebert
    Theodor Kocher Institute, University of Bern, Freiestrasse 1, CH 3012 Bern, Switzerland
    Mol Immunol 42:799-809. 2005
  10. ncbi Cutaneous CXCL14 targets blood precursors to epidermal niches for Langerhans cell differentiation
    Patrick Schaerli
    Institute of Cell Biology, University of Bern, CH 3012 Bern, Switzerland
    Immunity 23:331-42. 2005

Collaborators

Detail Information

Publications54

  1. pmc A skin-selective homing mechanism for human immune surveillance T cells
    Patrick Schaerli
    Theodor Kocher Institute, University of Bern, P O Box 99, CH 3000 Bern 9, Switzerland
    J Exp Med 199:1265-75. 2004
    ..For the first time, these findings define a chemokine system for homeostatic T cell traffic in normal human skin...
  2. pmc Monocyte selectivity and tissue localization suggests a role for breast and kidney-expressed chemokine (BRAK) in macrophage development
    I Kurth
    Theodor Kocher Institute, University of Bern, CH 3000 Bern 9, Switzerland
    J Exp Med 194:855-61. 2001
    ..We propose that BRAK is involved in the generation of tissue macrophages by recruiting extravasated precursors to fibroblasts, which are known to secrete essential cytokines for macrophage development...
  3. ncbi Chemokines: role in immune cell traffic
    Bernhard Moser
    Theodor Kocher Institute, University of Bern, Bern, Switzerland
    Eur Cytokine Netw 14:204-10. 2003
  4. pmc Chemokines: role in inflammation and immune surveillance
    B Moser
    Theodor Kocher Institute, University of Bern, Freiestrasse 1, CH 3012 Bern, Switzerland
    Ann Rheum Dis 63:ii84-ii89. 2004
    ..Emphasis is placed on a concept describing distinct subsets of memory T cells according to their primary residence in peripheral blood, secondary lymphoid tissues, or peripheral (extralymphoid) tissues...
  5. ncbi Lymphocyte traffic control by chemokines: follicular B helper T cells
    Bernhard Moser
    Theodor Kocher Institute, University of Bern, 3012 Bern, Switzerland
    Immunol Lett 85:105-12. 2003
    ..Special emphasis is placed on the potential involvement of T(FH) cells in the humoral immune response within B cell follicles, as well as the differentiation potential of these non-polarized cells...
  6. ncbi CXCR5(+) T cells: follicular homing takes center stage in T-helper-cell responses
    Bernhard Moser
    Theodor Kocher Institute, University of Bern, Freiestrasse 1, 3000 Bern 9, Switzerland
    Trends Immunol 23:250-4. 2002
  7. ncbi Lymphocyte traffic control by chemokines
    B Moser
    Theodor Kocher Institute, University of Bern, CH 3000 Bern 9, Switzerland
    Nat Immunol 2:123-8. 2001
    ..Thus, the chemokine system assures that cell traffic during inflammatory responses occurs in the proper spatial and temporal fashion and disturbance of this system, therefore, can lead to inflammatory disease...
  8. ncbi Chemokines: multiple levels of leukocyte migration control
    Bernhard Moser
    Theodor Kocher Institute, University of Bern, Freiestrasse 1, CH 3012 Bern, Switzerland
    Trends Immunol 25:75-84. 2004
    ....
  9. ncbi Chemokine-mediated control of T cell traffic in lymphoid and peripheral tissues
    Lisa M Ebert
    Theodor Kocher Institute, University of Bern, Freiestrasse 1, CH 3012 Bern, Switzerland
    Mol Immunol 42:799-809. 2005
    ..Here, we propose that the tissue distribution of T(PS) cells is determined by a distinct set of chemokines and corresponding receptors that differs from those operating in secondary lymphoid tissues and inflammatory sites...
  10. ncbi Cutaneous CXCL14 targets blood precursors to epidermal niches for Langerhans cell differentiation
    Patrick Schaerli
    Institute of Cell Biology, University of Bern, CH 3012 Bern, Switzerland
    Immunity 23:331-42. 2005
    ..Our model assigns unprecedented roles to CXCL14 and epidermal tissue as attractant and niche of differentiation, respectively, in the renewal of Langerhans cells under steady-state conditions...
  11. pmc Cross-presenting human gammadelta T cells induce robust CD8+ alphabeta T cell responses
    Marlene Brandes
    Institute of Cell Biology, University of Bern, CH 3000 Bern 9, Switzerland
    Proc Natl Acad Sci U S A 106:2307-12. 2009
    ..Our study reveals unexpected properties of human gammadelta T-APCs in the induction of CD8(+) alphabeta T effector cells, and justifies their further exploration in immunotherapy research...
  12. doi Constitutive expression of CXCL14 in healthy human and murine epithelial tissues
    Simone Meuter
    Institute of Cell Biology, University of Bern, Balzerstrasse 4, 3012 Bern, Switzerland
    Cytokine 44:248-55. 2008
    ..Therefore, despite the remarkable structural homology and the broad similarity in the tissue distribution of human and murine CXCL14, distinct differences point to diverse, species-specific needs for CXCL14 in epithelial immunity...
  13. ncbi Flexible migration program regulates gamma delta T-cell involvement in humoral immunity
    Marlene Brandes
    Theodor Kocher Institute, University of Bern, CH 3000 Bern 9, Switzerland
    Blood 102:3693-701. 2003
    ..Collectively, our findings agree with a role for gamma delta T cells in humoral immunity during the early phase of antimicrobial responses...
  14. ncbi Characterization of human T cells that regulate neutrophilic skin inflammation
    Patrick Schaerli
    Division of Allergology, Clinic of Rheumatology and Clinical Immunology Allergology, Inselspital, and Theodor Kocher Institute, University of Bern, Switzerland
    J Immunol 173:2151-8. 2004
    ..This mechanism may be relevant for other T cell-mediated diseases with a neutrophilic inflammation such as Behçet's disease and pustular psoriasis...
  15. ncbi T-cell memory: the importance of chemokine-mediated cell attraction
    Bernhard Moser
    Institute of Cell Biology, University of Bern, Baltzerstrasse 4, CH 3012 Bern, Switzerland
    Curr Biol 16:R504-7. 2006
    ..A recent study demonstrates the involvement of certain chemokines in immune response initiation and CD8+ T-cell memory formation. These seminal findings broaden our understanding of the role of chemokines in adaptive immune processes...
  16. ncbi Gammadelta T cells: an alternative type of professional APC
    Bernhard Moser
    Institute of Cell Biology, University of Bern, Baltzerstrasse 4, CH 3012 Bern, Switzerland
    Trends Immunol 27:112-8. 2006
    ....
  17. ncbi Professional antigen-presentation function by human gammadelta T Cells
    Marlene Brandes
    Institute of Cell Biology, University of Bern, CH 3012, Switzerland
    Science 309:264-8. 2005
    ..We suggest that, upon microbial activation, Vdelta2+ T cells participate in the induction of adaptive immune responses and that these cells may be a useful tool in vaccine development and immunotherapy...
  18. ncbi gammadelta T cells: novel initiators of adaptive immunity
    Bernhard Moser
    Institute of Cell Biology, University of Bern, Bern, Switzerland
    Immunol Rev 215:89-102. 2007
    ..This unexpected finding is discussed with regards to microbial sensing by human gammadelta T cells and a possible role for these cells in anti-microbial immunity...
  19. ncbi Chemokines: control of primary and memory T-cell traffic
    Patrick Schaerli
    Theodor Kocher Institute, University of Bern, Freiestrasse 1, CH 3012 Bern, Switzerland
    Immunol Res 31:57-74. 2005
    ..Localization and relocation of memory T cells is strictly related to their function in recall responses. Therefore, detailed knowledge of their generation and tissue distribution may help to design better vaccination strategies...
  20. ncbi B cells alter the phenotype and function of follicular-homing CXCR5+ T cells
    Lisa M Ebert
    Theodor Kocher Institute, University of Bern, Bern, Switzerland
    Eur J Immunol 34:3562-71. 2004
    ..Thus, B cells directly modulate the B cell helper phenotype in T(FH) cells and actively promote their prolonged co-localization with these cells...
  21. ncbi Homing and function of human skin gammadelta T cells and NK cells: relevance for tumor surveillance
    Lisa M Ebert
    Institute of Cell Biology, University of Bern, Switzerland
    J Immunol 176:4331-6. 2006
    ..We therefore propose that gammadelta T cells and NK cells are regular constituents of normal human skin with potential function in the clearance of tumor and otherwise stressed tissue cells...
  22. pmc Chemokine receptor specific for IP10 and mig: structure, function, and expression in activated T-lymphocytes
    M Loetscher
    Theodor Kocher Institute, University of Bern, Switzerland
    J Exp Med 184:963-9. 1996
    ..g., MCP-1, MCP-2, MCP-3, MIP-1 alpha, MIP-1 beta, and RANTES, are also found in monocytes and granulocytes. The present observations suggest that the IP10/Mig receptor is involved in the selective recruitment of effector T cells...
  23. pmc Homing chemokines in rheumatoid arthritis
    Pius Loetscher
    Theodor Kocher Institute, University of Bern, Switzerland
    Arthritis Res 4:233-6. 2002
    ..Here, we comment on recent studies highlighting the importance of chemokines in rheumatoid arthritis, in particular of B-cell-activating chemokine-1 in lymphoid neogenesis in the inflamed synovium...
  24. pmc B cell-attracting chemokine 1, a human CXC chemokine expressed in lymphoid tissues, selectively attracts B lymphocytes via BLR1/CXCR5
    D F Legler
    Theodor Kocher Institute, University of Bern, CH 3000 Bern 9, Switzerland
    J Exp Med 187:655-60. 1998
    ....
  25. ncbi Potent and broad-spectrum antimicrobial activity of CXCL14 suggests an immediate role in skin infections
    Christa Maerki
    Theodor Kocher Institute, University of Bern, Bern, Switzerland
    J Immunol 182:507-14. 2009
    ..We propose that CXCL14 fights bacteria at the earliest stage of infection, well before the establishment of inflammation, and thus fulfills a unique role in antimicrobial immunity...
  26. ncbi The chemokine SDF-1, stromal cell-derived factor 1, attracts early stage B cell precursors via the chemokine receptor CXCR4
    M D'Apuzzo
    Theodor Kocher Institute, University of Bern, Switzerland
    Eur J Immunol 27:1788-93. 1997
    ....
  27. ncbi Lymphocyte responses to chemokines
    B Moser
    Theodor Kocher Institute, University of Bern, Switzerland
    Int Rev Immunol 16:323-44. 1998
    ..The involvement of chemokine receptors in HIV infection is briefly mentioned, while other interesting areas in chemokine research, such as hematopoiesis and angiogenesis, are not discussed...
  28. ncbi The chemokine receptor CXCR3 mediates rapid and shear-resistant adhesion-induction of effector T lymphocytes by the chemokines IP10 and Mig
    L Piali
    Theodor Kocher Institute, University of Bern, Switzerland
    Eur J Immunol 28:961-72. 1998
    ..The critical role of IFN-gamma as inducer of IP10/Mig production in HUVEC indicates that these chemokines are essential mediators of effector T cell recruitment to IFN-gamma-dependent pathologies...
  29. pmc CXC chemokine receptor 5 expression defines follicular homing T cells with B cell helper function
    P Schaerli
    Theodor Kocher Institute, University of Bern, CH 3000 Bern 9, Switzerland
    J Exp Med 192:1553-62. 2000
    ..These properties portray CXCR5(+) T cells as a distinct memory T cell subset with B cell helper function, designated here as follicular B helper T cells (T(FH))...
  30. ncbi Human chemokines: an update
    M Baggiolini
    Theodor Kocher Institute, University of Bern, Switzerland
    Annu Rev Immunol 15:675-705. 1997
    ..Of considerable interest is the recent discovery that some chemokines function as HIV-suppressive factors by interacting with chemokine receptors which, together with CD4, were recognized as the binding sites for HIV-1...
  31. ncbi Cutting edge: induction of follicular homing precedes effector Th cell development
    P Schaerli
    Theodor Kocher Institute, University of Bern, Bern, Switzerland
    J Immunol 167:6082-6. 2001
    ..Together, CXCR5 unequivocally defines pre-effector memory CD4+ T cells generated during ongoing immune responses...
  32. ncbi Cloning of a human seven-transmembrane domain receptor, LESTR, that is highly expressed in leukocytes
    M Loetscher
    Theodor Kocher Institute, University of Bern, Switzerland
    J Biol Chem 269:232-7. 1994
    ....
  33. ncbi Identification of CCR8, the receptor for the human CC chemokine I-309
    R S Roos
    Theodor Kocher Institute, University of Bern, CH 3000 Bern 9, Switzerland
    J Biol Chem 272:17251-4. 1997
    ..Identification of the receptor for I-309 represents a significant progress in determining the function of I-309 in inflammation and disease...
  34. pmc Sequence variation of a novel heptahelical leucocyte receptor through alternative transcript formation
    L Barella
    Theodor Kocher Institute, University of Bern, Switzerland
    Biochem J 309:773-9. 1995
    ..Alternative transcript formation affecting the 5'-terminal part of the coding region may be a way to modify ligand-binding selectivity...
  35. pmc Efficient interaction of HIV-1 with purified dendritic cells via multiple chemokine coreceptors
    A Granelli-Piperno
    Theodor Kocher Institute, Bern, Switzerland
    J Exp Med 184:2433-8. 1996
    ..DCs express more CCR5 and CXCR4 mRNA than T cells. Therefore, while HIV-1 does not replicate efficiently in mature DCs, viral entry can be active and can be blocked by chemokines that act on known receptors for M- and T-tropic virus...
  36. ncbi TYMSTR, a putative chemokine receptor selectively expressed in activated T cells, exhibits HIV-1 coreceptor function
    M Loetscher
    Theodor Kocher Institute University of Bern P O Box 99, CH 3000 Bern 9, Switzerland
    Curr Biol 7:652-60. 1997
    ..Here, we describe the isolation of a novel, putative chemokine receptor...
  37. pmc Antimicrobial activities of chemokines: not just a side-effect?
    Marlene Wolf
    Theodor Kocher Institute, University of Bern Bern, Switzerland
    Front Immunol 3:213. 2012
    ..e., chemokines that are produced in tissue cells in response to microbial antigens (such as pathogen-associated molecular patterns) may be more important in orchestrating the cellular arm in antimicrobial immunity...
  38. pmc Murine CXCL14 is dispensable for dendritic cell function and localization within peripheral tissues
    Simone Meuter
    Department of Medical Biochemistry and Immunology, Henry Wellcome Building, School of Medicine, Cardiff University, Heath Park, Cardiff CF14 4XN, United Kingdom
    Mol Cell Biol 27:983-92. 2007
    ..Overall, our data indicate that murine CXCL14 is dispensable for the homeostatic recruitment of antigen-presenting cells toward the periphery and for LC functionality...
  39. ncbi Comment on "The vast majority of CLA+ T cells are resident in normal skin"
    Patrick Schaerli
    J Immunol 177:1375-6; author reply 1376-7. 2006
  40. ncbi Susceptibility to programmed cell death in T-lymphocytes from septic patients: a mechanism for lymphopenia and Th2 predominance
    Georg Roth
    Department of Surgery, General Hospital of Vienna Medical School, Vienna, Austria
    Biochem Biophys Res Commun 308:840-6. 2003
    ..These findings strongly suggest that in septic patients Th1 T-cells are selectively susceptible to undergo apoptosis. This observation provides an additional pathophysiological concept in the genesis of Th2 dominance...
  41. ncbi Soluble ST2 protein in cardiac surgery: a possible negative feedback loop to prevent uncontrolled inflammatory reactions
    Tamas Szerafin
    Department of Cardiac Surgery, University of Debrecen, Debrecen, Hungary
    Clin Lab 51:657-63. 2005
    ..The relation of soluble ST2 and secretion of IL-10, markers of TH2 T-cell activation, and IL-13 in relation to immunoglobulin isotope production is not known in patients undergoing On- versus Off-pump (CABG) procedure...
  42. ncbi Follicular B helper T cells in antibody responses and autoimmunity
    Carola G Vinuesa
    Division of Immunology and Genetics, John Curtin School of Medical Research, The Australian National University, Canberra 2601, Australia
    Nat Rev Immunol 5:853-65. 2005
    ..Here, we outline the central role of this subset in normal and pathological immune responses...
  43. ncbi Aberrant T cell activation and heightened apoptotic turnover in end-stage renal failure patients: a comparative evaluation between non-dialysis, haemodialysis, and peritoneal dialysis
    Bernhard Moser
    Department of Surgery, General Hospital of Vienna, Austria
    Biochem Biophys Res Commun 308:581-5. 2003
    ..These findings strongly suggest that in ESRD patients Th1 T cells are selectively susceptible to undergo apoptosis. This observation provides an additional pathophysiological concept in the genesis of Th2 dominance...
  44. pmc RAGE ligation affects T cell activation and controls T cell differentiation
    Yali Chen
    Department of Immunobiology, Yale University School of Medicine, New Haven, CT 06520, USA
    J Immunol 181:4272-8. 2008
    ..We conclude that activation of RAGE on T cells is involved in early events that lead to differentiation of Th1(+) T cells...
  45. pmc Macrophages exposed to Mycobacterium tuberculosis release chemokines able to recruit selected leucocyte subpopulations: focus on gammadelta cells
    Elisabetta Ferrero
    Laboratory of Tumour Immunology, Universita Vita e Salute, Scientific Institute H San Raffaele, Via Olgettina 60, I 20132 Milan, Italy
    Immunology 108:365-74. 2003
    ....
  46. ncbi Receptor for advanced glycation end products expression on T cells contributes to antigen-specific cellular expansion in vivo
    Bernhard Moser
    Department of Medicine, Columbia University College of Physicians and Surgeons, New York, NY 10032, USA
    J Immunol 179:8051-8. 2007
    ..These data indicate that RAGE expressed on T cells is required for efficient priming of T cells and elucidate critical roles for RAGE engagement during cognate dendritic cell-T cell interactions...
  47. ncbi Receptor for AGE (RAGE): weaving tangled webs within the inflammatory response
    Raphael Clynes
    Division of Surgical Science, Department of Surgery, Columbia University Medical Center, 630 West 168th Street, P and S 17 501, New York, NY 10032, USA
    Curr Mol Med 7:743-51. 2007
    ..Ultimately, drawing the fine line between antagonism versus stimulation of the receptor in health and disease will depend on the full characterization of RAGE in repair versus injury...
  48. ncbi Receptor for advanced glycation end products (RAGE) in a dash to the rescue: inflammatory signals gone awry in the primal response to stress
    Kevan Herold
    Department of Medicine, Yale University School of Medicine, New Haven, Connecticut, USA
    J Leukoc Biol 82:204-12. 2007
    ..Identification of the threshold beyond which ligands of RAGE mediate repair versus injury is a central component in delineating optimal strategies to target RAGE in the clinic...
  49. ncbi Increased levels of soluble ST2 protein and IgG1 production in patients with sepsis and trauma
    Markus Brunner
    Department of Surgery, University of Vienna, AKH, Wahringer Gurtel 18 20, 1090 Vienna, Austria
    Intensive Care Med 30:1468-73. 2004
    ..The relation of soluble ST2, Th1-Th2 cytokine profile, and immunoglobulin (Ig) production in sepsis and trauma patients is not well known...
  50. ncbi Receptor for advanced glycation end products and its ligands: a journey from the complications of diabetes to its pathogenesis
    William Kim
    Division of Surgical Science, Department of Surgery, Columbia University Medical Center, 630 West 168th St, P and S 17 501, New York, New York 10032, USA
    Ann N Y Acad Sci 1043:553-61. 2005
    ..Studies are in progress to test the premise that antagonism of this interaction is a logical strategy for the prevention and treatment of diabetes...
  51. pmc Soluble RAGE: a hot new biomarker for the hot joint?
    Bernhard Moser
    Department of Surgery, College of Physicians and Surgeons, Columbia University, New York, NY, USA
    Arthritis Res Ther 7:142-4. 2005
    ..Nevertheless, although 'cause or effect' relationships may not be established in this report, fascinating insights into RAGE, inflammation and human arthritis emerge from these studies...
  52. ncbi RAGE blockade stabilizes established atherosclerosis in diabetic apolipoprotein E-null mice
    Loredana G Bucciarelli
    Division of Surgical Science, College of Physicians and Surgeons, Department of Surgery, Columbia University, New York, NY 10032, USA
    Circulation 106:2827-35. 2002
    ..In this study, we tested the hypothesis that RAGE contributed to lesion progression in established atherosclerosis in diabetic apoE-null mice...
  53. pmc RAGE drives the development of glomerulosclerosis and implicates podocyte activation in the pathogenesis of diabetic nephropathy
    Thoralf M Wendt
    Department of Pathology, College of Physicians and Surgeons, Columbia University, New York, New York 10032, USA
    Am J Pathol 162:1123-37. 2003
    ....
  54. ncbi Infection with a periodontal pathogen increases mononuclear cell adhesion to human aortic endothelial cells
    Georg A Roth
    Division of Surgical Science, Department of Surgery, College of Physicians and Surgeons, Columbia University, New York, NY 10032, USA
    Atherosclerosis 190:271-81. 2007
    ....