P Moreillon

Summary

Affiliation: University of Lausanne
Country: Switzerland

Publications

  1. ncbi Infective endocarditis
    Philippe Moreillon
    Institute of Fundamental Microbiology, Centre Hospitalier Universitaire, University of Lausanne, Switzerland
    Lancet 363:139-49. 2004
  2. ncbi Proinflammatory activity of cell-wall constituents from gram-positive bacteria
    P Moreillon
    Institute of Fundamental Microbiology, University of Lausanne, Switzerland
    Scand J Infect Dis 35:632-41. 2003
  3. pmc A single mutation in enzyme I of the sugar phosphotransferase system confers penicillin tolerance to Streptococcus gordonii
    A Bizzini
    Department of Fundamental Microbiology, Faculty of Biology and Medicine, Biophore Building, University of Lausanne, Lausanne 1015, Switzerland
    Antimicrob Agents Chemother 54:259-66. 2010
  4. doi A positive interaction between inhibitors of protein synthesis and cefepime in the fight against methicillin-resistant Staphylococcus aureus
    B Guignard
    Department of Fundamental Microbiology, Biophore Building, University of Lausanne, 1015 Lausanne, Switzerland
    Eur J Clin Microbiol Infect Dis 32:899-907. 2013
  5. doi New and emerging treatment of Staphylococcus aureus infections in the hospital setting
    P Moreillon
    Department of Medicine, University of Lausanne, Lausanne, Switzerland
    Clin Microbiol Infect 14:32-41. 2008
  6. pmc Failure of vancomycin continuous infusion against experimental endocarditis due to vancomycin-intermediate Staphylococcus aureus
    J M Entenza
    Department of Fundamental Microbiology, Biophore University of Lausanne, Lausanne, Switzerland
    Antimicrob Agents Chemother 55:385-7. 2011
  7. pmc Induction of experimental endocarditis by continuous low-grade bacteremia mimicking spontaneous bacteremia in humans
    T R Veloso
    Department of Fundamental Microbiology, Biophore Building, University of Lausanne, CH 1015 Lausanne, Switzerland
    Infect Immun 79:2006-11. 2011
  8. doi Tigecycline in combination with other antimicrobials: a review of in vitro, animal and case report studies
    J M Entenza
    Department of Fundamental Microbiology, Faculty of Biology and Medicine, University of Lausanne, CH 1015 Lausanne, Switzerland
    Int J Antimicrob Agents 34:8.e1-9. 2009
  9. ncbi Loss of penicillin tolerance by inactivating the carbon catabolite repression determinant CcpA in Streptococcus gordonii
    A Bizzini
    Faculty of Biology and Medicine, Department of Fundamental Microbiology, Biophore Building, University of Lausanne, 1015 Lausanne, Switzerland
    J Antimicrob Chemother 59:607-15. 2007
  10. pmc Teichoic acids are not required for Streptococcus pneumoniae and Staphylococcus aureus cell walls to trigger the release of tumor necrosis factor by peripheral blood monocytes
    P A Majcherczyk
    Institute of Fundamental Microbiology, University of Lausanne, 1015 Lausanne, Switzerland
    Infect Immun 71:3707-13. 2003

Collaborators

Detail Information

Publications40

  1. ncbi Infective endocarditis
    Philippe Moreillon
    Institute of Fundamental Microbiology, Centre Hospitalier Universitaire, University of Lausanne, Switzerland
    Lancet 363:139-49. 2004
    ..New ideas for antimicrobial agents are being developed. These novel insights should help redefine preventive and therapeutic strategies against infective endocarditis...
  2. ncbi Proinflammatory activity of cell-wall constituents from gram-positive bacteria
    P Moreillon
    Institute of Fundamental Microbiology, University of Lausanne, Switzerland
    Scand J Infect Dis 35:632-41. 2003
    ..This high specificity underlines the importance of using well-characterized microbial material in investigating the system...
  3. pmc A single mutation in enzyme I of the sugar phosphotransferase system confers penicillin tolerance to Streptococcus gordonii
    A Bizzini
    Department of Fundamental Microbiology, Faculty of Biology and Medicine, Biophore Building, University of Lausanne, Lausanne 1015, Switzerland
    Antimicrob Agents Chemother 54:259-66. 2010
    ....
  4. doi A positive interaction between inhibitors of protein synthesis and cefepime in the fight against methicillin-resistant Staphylococcus aureus
    B Guignard
    Department of Fundamental Microbiology, Biophore Building, University of Lausanne, 1015 Lausanne, Switzerland
    Eur J Clin Microbiol Infect Dis 32:899-907. 2013
    ..Further studies are necessary in order to provide a mechanism for this positive interaction...
  5. doi New and emerging treatment of Staphylococcus aureus infections in the hospital setting
    P Moreillon
    Department of Medicine, University of Lausanne, Lausanne, Switzerland
    Clin Microbiol Infect 14:32-41. 2008
    ....
  6. pmc Failure of vancomycin continuous infusion against experimental endocarditis due to vancomycin-intermediate Staphylococcus aureus
    J M Entenza
    Department of Fundamental Microbiology, Biophore University of Lausanne, Lausanne, Switzerland
    Antimicrob Agents Chemother 55:385-7. 2011
    ..Vancomycin continuous infusion was unsuccessful, as 20 mg/liter was barely active against PC1 (6 of 13 sterile vegetations) and 40 mg/liter failed against PC3 (2 of 9 sterile vegetations)...
  7. pmc Induction of experimental endocarditis by continuous low-grade bacteremia mimicking spontaneous bacteremia in humans
    T R Veloso
    Department of Fundamental Microbiology, Biophore Building, University of Lausanne, CH 1015 Lausanne, Switzerland
    Infect Immun 79:2006-11. 2011
    ..05). These results show that high-level bacteremia is not required to induce experimental endocarditis and support the hypothesis that cumulative exposure to low-grade bacteremia represents a genuine risk of IE in humans...
  8. doi Tigecycline in combination with other antimicrobials: a review of in vitro, animal and case report studies
    J M Entenza
    Department of Fundamental Microbiology, Faculty of Biology and Medicine, University of Lausanne, CH 1015 Lausanne, Switzerland
    Int J Antimicrob Agents 34:8.e1-9. 2009
    ..pneumoniae bacteraemia and P. aeruginosa osteomyelitis. Antagonism was extremely rare in vitro and was not reported in vivo. Thus, tigecycline may be combined with a second antimicrobial as part of a combination regimen...
  9. ncbi Loss of penicillin tolerance by inactivating the carbon catabolite repression determinant CcpA in Streptococcus gordonii
    A Bizzini
    Faculty of Biology and Medicine, Department of Fundamental Microbiology, Biophore Building, University of Lausanne, 1015 Lausanne, Switzerland
    J Antimicrob Chemother 59:607-15. 2007
    ..arc was not directly responsible for tolerance, but is controlled by the global regulator CcpA. Therefore, we sought whether CcpA might be implicated in tolerance...
  10. pmc Teichoic acids are not required for Streptococcus pneumoniae and Staphylococcus aureus cell walls to trigger the release of tumor necrosis factor by peripheral blood monocytes
    P A Majcherczyk
    Institute of Fundamental Microbiology, University of Lausanne, 1015 Lausanne, Switzerland
    Infect Immun 71:3707-13. 2003
    ..01 microg/ml (P. A. Majcherczyk, H. Langen, et al., J. Biol. Chem. 274:12537-12543,1999). Thus, although TA is an important part of gram-positive walls, it did not participate to the TNF-releasing activity of PGN...
  11. pmc Therapeutic effects of bacteriophage Cpl-1 lysin against Streptococcus pneumoniae endocarditis in rats
    J M Entenza
    Department of Fundamental Microbiology, Biology Building, University of Lausanne, CH 1015 Lausanne, Switzerland
    Antimicrob Agents Chemother 49:4789-92. 2005
    ..Rapid bacterial lysis induced by Cpl-1 treatment increased cytokine secretion noticeably...
  12. ncbi Pathogenesis of streptococcal and staphylococcal endocarditis
    Philippe Moreillon
    Division of Infectious Diseases, Centre Hospitalier Universitaire Vaudois, BH19 Rue du Bugnon, 1011 Lausanne, Switzerland
    Infect Dis Clin North Am 16:297-318. 2002
    ..Streptococci produce surface glucans (gtf and ftf), ECM adhesins (e.g., fibronectin-binding proteins, FimA), and platelet aggregating factors (phase I and phase II antigens, pblA, pblB, and pblT), all of which have been...
  13. ncbi Efficacy of daptomycin in the treatment of experimental endocarditis due to susceptible and multidrug-resistant enterococci
    Jacques Vouillamoz
    Department of Fundamental Microbiology, University of Lausanne, CH 1015 Lausanne, Switzerland
    J Antimicrob Chemother 58:1208-14. 2006
    ....
  14. ncbi Lack of in vitro biofilm formation does not attenuate the virulence of Streptococcus gordonii in experimental endocarditis
    Alain Bizzini
    Department of Fundamental Microbiology, Faculty of Biology and Medicine, University of Lausanne, Lausanne, Switzerland
    FEMS Immunol Med Microbiol 48:419-23. 2006
    ..These strains were clearly impaired (>75% reduction) in biofilm production in vitro. However, this did not result in a decreased severity of infection in vivo...
  15. ncbi Effects of alpha-phosphoglucomutase deficiency on cell wall properties and fitness in Streptococcus gordonii
    Alain Bizzini
    Département de Microbiologie Fondamentale, Bâtiment Biophore, Universite de Lausanne, Quartier UNIL Sorge, CH 1015 Lausanne, Switzerland
    Microbiology 153:490-8. 2007
    ..In vitro, the reduced fitness included reduced growth, reduced viability in the stationary phase and increased autolytic activity. In vivo, the pgm-deficient strain had a lower virulence in a rat model of experimental endocarditis...
  16. ncbi Fibronectin-binding proteins and clumping factor A in Staphylococcus aureus experimental endocarditis: FnBPA is sufficient to activate human endothelial cells
    Ruth Heying
    Department of Paediatric Cardiology, University Children s Hospital, Duesseldorf, Germany
    Thromb Haemost 97:617-26. 2007
    ..lactis organisms indicating that bacterium-EC interactions mediated by these adhesins are sufficient to evoke inflammation as well as procoagulant activity at infected endovascular sites...
  17. ncbi Infectivity of Lactobacillus rhamnosus and Lactobacillus paracasei isolates in a rat model of experimental endocarditis
    Vanessa Vankerckhoven
    Laboratory of Medical Microbiology, University of Antwerp, Belgium
    J Med Microbiol 56:1017-24. 2007
    ..Other disease-promoting factors may exist in these organisms and warrant further investigation...
  18. pmc Granular layer in the periplasmic space of gram-positive bacteria and fine structures of Enterococcus gallinarum and Streptococcus gordonii septa revealed by cryo-electron microscopy of vitreous sections
    Benoit Zuber
    Laboratory of Ultrastructural Analysis, Biophore Building, University of Lausanne, CH 1015 Lausanne, Switzerland
    J Bacteriol 188:6652-60. 2006
    ....
  19. pmc Role of sigmaB in the expression of Staphylococcus aureus cell wall adhesins ClfA and FnbA and contribution to infectivity in a rat model of experimental endocarditis
    Jose Manuel Entenza
    Department of Medical Microbiology, University of Zurich, Gloriastrasse 32, CH 8028 Zurich, Switzerland
    Infect Immun 73:990-8. 2005
    ..Sigma(B) appears to have a transient enhancing effect on bacterial density in the early stages of infection that is lost during progression...
  20. pmc Fibrinogen and fibronectin binding cooperate for valve infection and invasion in Staphylococcus aureus experimental endocarditis
    Yok Ai Que
    Department of Fundamental Microbiology, University of Lausanne, 1015 Lausanne, Switzerland
    J Exp Med 201:1627-35. 2005
    ..Thus, fibrinogen and fibronectin binding could cooperate for S. aureus valve colonization and endothelial invasion in vivo...
  21. pmc LB11058, a new cephalosporin with high penicillin-binding protein 2a affinity and activity in experimental endocarditis due to homogeneously methicillin-resistant Staphylococcus aureus
    Jacques Vouillamoz
    Department of Fundamental Microbiology University of Lausanne Biology Building CH 1015 Lausanne, Switzerland
    Antimicrob Agents Chemother 48:4322-7. 2004
    ..At appropriate doses, LB11058 was highly effective both in vitro and in vivo. This finding supports the development of this beta-lactam with high PBP2a affinity for the treatment of MRSA infections...
  22. pmc Structure-function characterization and optimization of a plant-derived antibacterial peptide
    Mougli Suarez
    Institute of Biotechnology, University of Lausanne, Switzerland
    Antimicrob Agents Chemother 49:3847-57. 2005
    ..Sedimentation may result from coupled flocculation and coagulation effects, while the bactericidal activity would require bacterial membrane destabilization by a hydrophobic loop...
  23. pmc Genometrics as an essential tool for the assembly of whole genome sequences: the example of the chromosome of Bifidobacterium longum NCC2705
    Lionel Guy
    Département de Microbiologie Fondamentale, Faculté de Biologie et Médecine, Universite de Lausanne, CH 1015 Lausanne, Switzerland
    BMC Microbiol 5:60. 2005
    ..However, a rapid scrutiny by genometric methods revealed a genome organization totally different from all so far sequenced high-GC Gram-positive chromosomes...
  24. ncbi The discriminatory power of MALDI-TOF mass spectrometry to differentiate between isogenic teicoplanin-susceptible and teicoplanin-resistant strains of methicillin-resistant Staphylococcus aureus
    Paul A Majcherczyk
    Department of Fundamental Microbiology, University of Lausanne, Lausanne, Switzerland
    FEMS Microbiol Lett 255:233-9. 2006
    ..MALDI-TOF MS might be useful to detect subtle strain-specific differences in ionizable components released from bacterial surfaces and not from their peptidoglycan network...
  25. pmc Efficacy of garenoxacin in treatment of experimental endocarditis due to Staphylococcus aureus or viridans group streptococci
    Jose M Entenza
    Institute of Fundamental Microbiology, UNIL, Dorigny, 1015 Lausanne, Switzerland
    Antimicrob Agents Chemother 48:86-92. 2004
    ..The fact that the activity of garenoxacin was equal or superior to those of the standard comparators against staphylococci and VGS indicates that it is a potential alternative for the treatment of infections caused by such bacteria...
  26. ncbi Innate sensors for Gram-positive bacteria
    Joerg R Weber
    Dept of Neurology, Humboldt University, Charite Hospital, Berlin, Germany
    Curr Opin Immunol 15:408-15. 2003
    ..It is these breakthrough studies that have finally confirmed the paradigm of innate sensors for Gram-positive bacteria...
  27. ncbi [Infective endocarditis: update]
    Yok Ai Que
    Division des Soins Intensifs de Médecine, Departement de Medecine Interne, CHUV Lausanne
    Rev Med Suisse Romande 124:341-6. 2004
    ..The epidemiology, pathogenesis, diagnosis, prevention and treatment of IE are being reviewed in this article...
  28. pmc The fibrinogen- and fibronectin-binding domains of Staphylococcus aureus fibronectin-binding protein A synergistically promote endothelial invasion and experimental endocarditis
    Lionel Piroth
    Department of Fundamental Microbiology, University of Lausanne, CH 1015 Lausanne, Switzerland
    Infect Immun 76:3824-31. 2008
    ..This unforeseen FnBPA subtlety might bear importance for the development of antiadhesin strategies...
  29. pmc Comparative analysis of the roles of HtrA-like surface proteases in two virulent Staphylococcus aureus strains
    Candice Rigoulay
    Unité de Recherches Laitières et Génétique Appliquée, INRA, 78352 Jouy en Josas Cedex, France
    Infect Immun 73:563-72. 2005
    ..We speculate that HtrA proteins act in the agr-dependent regulation pathway by assuring folding and/or maturation of some surface components of the agr system...
  30. ncbi ANIBAL, stable isotope-based quantitative proteomics by aniline and benzoic acid labeling of amino and carboxylic groups
    Alexandre Panchaud
    Département de Microbiologie Fondamentale, Universite de Lausanne, Quartier UNIL Sorge, Bâtiment Biophore, CH 1015 Lausanne, Switzerland
    Mol Cell Proteomics 7:800-12. 2008
    ..A milk fraction was used for dynamic range assessment of protein quantification, and a bacterial lysate was used for the evaluation of relative protein quantification in a complex sample in two different biological states...
  31. ncbi In vitro activities of tigecycline combined with other antimicrobials against multiresistant gram-positive and gram-negative pathogens
    Jacques Vouillamoz
    Laboratory of Infectious Diseases and Department of Fundamental Microbiology, Faculty of Biology and Medicine, University of Lausanne, CH 1015 Lausanne, Switzerland
    J Antimicrob Chemother 61:371-4. 2008
    ..To test the activity of tigecycline combined with 16 antimicrobials in vitro against 22 gram-positive and 55 gram-negative clinical isolates...
  32. pmc Fitness cost and impaired survival in penicillin-resistant Streptococcus gordonii isolates selected in the laboratory
    Marisa Haenni
    Department of Fundamental Microbiology, Quartier UNIL Sorge, Biophore Building, CH 1015 Lausanne, Switzerland
    Antimicrob Agents Chemother 52:337-9. 2008
    ..008 to 2 microg/ml. The 2-microg/ml MIC maximum was already reached after 36 passages but resulted in impaired fitness. Although the MIC did not increase further, fitness was partially recovered during the 79 additional cycles...
  33. pmc Prospective determination of plasma imipenem concentrations in critically ill children
    Eric Giannoni
    Department of Pediatrics, CHUV, CH 1011 Lausanne, Switzerland
    Antimicrob Agents Chemother 50:2563-8. 2006
    ..To avoid subtherapeutic drug levels, we recommend treatment with at least 100 mg/kg of body weight/day of imipenem-cilastatin for critically ill children requiring such therapy...
  34. pmc Promoter and transcription analysis of penicillin-binding protein genes in Streptococcus gordonii
    Marisa Haenni
    Department of Fundamental Microbiology, Quartier UNIL Sorge, Biophore Building, Lausanne, Switzerland
    Antimicrob Agents Chemother 51:2774-83. 2007
    ..Since penicillin-related induction of class A PBPs occurred in both susceptible and resistant cells, such a mutation-independent facilitating mechanism could be operative at each step of resistance development...
  35. pmc Single-dose oral amoxicillin or linezolid for prophylaxis of experimental endocarditis due to vancomycin-susceptible and vancomycin-resistant Enterococcus faecalis
    Philippe Moreillon
    Department of Fundamental Microbiology, Biophore Building, University of Lausanne, CH 1015 Lausanne, Switzerland
    Antimicrob Agents Chemother 51:1661-5. 2007
    ..Linezolid appears to be less reliable, at least against the vancomycin-resistant strain...
  36. ncbi Beta-lactams against methicillin-resistant Staphylococcus aureus
    Bertrand Guignard
    University of Lausanne, Department of Fundamental Microbiology, Biology Building, 1015 Lausanne, Switzerland
    Curr Opin Pharmacol 5:479-89. 2005
    ..Thus, clinically useful anti-MRSA beta-lactams are imminent...
  37. pmc Mutations in penicillin-binding protein (PBP) genes and in non-PBP genes during selection of penicillin-resistant Streptococcus gordonii
    Marisa Haenni
    Department of Fundamental Microbiology, University of Lausanne, Switzerland
    Antimicrob Agents Chemother 50:4053-61. 2006
    ..The results underline the complexity of penicillin resistance development and suggest that inhibition of transglycosylase might be an as yet underestimated way to interfere with early resistance development...
  38. ncbi Combining protein identification and quantification: C-terminal isotope-coded tagging using sulfanilic acid
    Alexandre Panchaud
    Department of Fundamental Microbiology, Faculty of Biology and Medicine, University of Lausanne, CH 1015 Lausanne, Switzerland
    Rapid Commun Mass Spectrom 20:1585-94. 2006
    ..Finally, the method is able to specifically identify the C-terminal peptide of a protein by using GluC as the proteolytic enzyme...
  39. pmc Detection of live and antibiotic-killed bacteria by quantitative real-time PCR of specific fragments of rRNA
    Steve Aellen
    Centre Hospitalier Universitaire Vaudois, Lausanne, Switzerland
    Antimicrob Agents Chemother 50:1913-20. 2006
    ..Thus, 16S rRNA was a marker of antibiotic-induced killing, but the size of the amplified fragment was critical for differentiation between live and dead bacteria...
  40. pmc Mutational analysis of class A and class B penicillin-binding proteins in Streptococcus gordonii
    Marisa Haenni
    Department of Fundamental Microbiology, University of Lausanne, Switzerland
    Antimicrob Agents Chemother 50:4062-9. 2006
    ..Thus, single deletion of four of the five HMW genes had a detectable effect on the bacterial morphology and/or physiology, and only PBP 1B seemed redundant a priori...