H Mohler

Summary

Affiliation: University of Zurich
Country: Switzerland

Publications

  1. ncbi A new benzodiazepine pharmacology
    H Mohler
    Institute of Pharmacology and Toxicology, University of Zurich, Zurich, Switzerland
    J Pharmacol Exp Ther 300:2-8. 2002
  2. ncbi GABA(A)-receptor subtypes: a new pharmacology
    H Mohler
    Institute of Pharmacology and Toxicology, University of Zurich, Switzerland
    Curr Opin Pharmacol 1:22-5. 2001
  3. ncbi GABA(A) receptor diversity and pharmacology
    H Mohler
    Institute of Pharmacology and Department of Chemistry and Applied Biosciences, University and ETH Zurich, Winterthurerstrasse 190, Zurich, CH 8057, Switzerland
    Cell Tissue Res 326:505-16. 2006
  4. ncbi GABAA receptors in central nervous system disease: anxiety, epilepsy, and insomnia
    Hanns Mohler
    Institute of Pharmacology, University of Zurich, Zurich, Switzerland
    J Recept Signal Transduct Res 26:731-40. 2006
  5. ncbi Molecular regulation of cognitive functions and developmental plasticity: impact of GABAA receptors
    Hanns Mohler
    Institute of Pharmacology, University of Zurich, Zurich, Switzerland
    J Neurochem 102:1-12. 2007
  6. doi The rise of a new GABA pharmacology
    Hanns Mohler
    Institute of Pharmacology, University of Zurich and Department of Chemistry and Applied Biosciences, Swiss Federal Institute of Technology ETH Zurich, Winterthurerstr 190, CH 8057 Zurich, Switzerland
    Neuropharmacology 60:1042-9. 2011
  7. ncbi Molecular and neuronal substrate for the selective attenuation of anxiety
    K Low
    Institute of Pharmacology and Toxicology, University of Zurich, and Swiss Federal Institute of Technology Zürich ETH, Winterthurerstrasse 190, CH 8057 Zurich, Switzerland
    Science 290:131-4. 2000
  8. ncbi Benzodiazepine actions mediated by specific gamma-aminobutyric acid(A) receptor subtypes
    U Rudolph
    Institute of Pharmacology, University of Zurich, Switzerland
    Nature 401:796-800. 1999
  9. pmc Single-channel properties of neuronal GABAA receptors from mice lacking the 2 subunit
    M Lorez
    Institute of Pharmacology and Toxicology, University of Zurich, Winterthurerstrasse 190, 8057 Zurich, Switzerland
    J Physiol 527:11-31. 2000
  10. pmc A schizophrenia-related sensorimotor deficit links alpha 3-containing GABAA receptors to a dopamine hyperfunction
    B K Yee
    Institute of Pharmacology and Toxicology, University of Zurich, Winterthurerstrasse 190, CH 8057 Zurich, Switzerland
    Proc Natl Acad Sci U S A 102:17154-9. 2005

Collaborators

Detail Information

Publications32

  1. ncbi A new benzodiazepine pharmacology
    H Mohler
    Institute of Pharmacology and Toxicology, University of Zurich, Zurich, Switzerland
    J Pharmacol Exp Ther 300:2-8. 2002
    ..Only restricted neuronal networks will be modulated by the new subtype-selective drugs. Promising new anxiolytics have already been developed. A new pharmacology of the benzodiazepine site is on the horizon...
  2. ncbi GABA(A)-receptor subtypes: a new pharmacology
    H Mohler
    Institute of Pharmacology and Toxicology, University of Zurich, Switzerland
    Curr Opin Pharmacol 1:22-5. 2001
    ..These drug actions have now been attributed to defined receptor subtypes. Thus, precise guidelines are available for the development of novel drugs with more selective action and less side effects than those currently in clinical use...
  3. ncbi GABA(A) receptor diversity and pharmacology
    H Mohler
    Institute of Pharmacology and Department of Chemistry and Applied Biosciences, University and ETH Zurich, Winterthurerstrasse 190, Zurich, CH 8057, Switzerland
    Cell Tissue Res 326:505-16. 2006
    ..These achievements are of obvious relevance for the pharmacotherapy of certain brain disorders, in particular sleep dysfunctions, anxiety disorders, schizophrenia and diseases associated with memory deficits...
  4. ncbi GABAA receptors in central nervous system disease: anxiety, epilepsy, and insomnia
    Hanns Mohler
    Institute of Pharmacology, University of Zurich, Zurich, Switzerland
    J Recept Signal Transduct Res 26:731-40. 2006
    ..In this article, the contribution of GABAA receptor deficits to central nervous system disorders, in particular anxiety disorders, epilepsy, schizophrenia and insomnia, is reviewed...
  5. ncbi Molecular regulation of cognitive functions and developmental plasticity: impact of GABAA receptors
    Hanns Mohler
    Institute of Pharmacology, University of Zurich, Zurich, Switzerland
    J Neurochem 102:1-12. 2007
    ..These developments are reviewed with regard to the regulation of sleep, anxiety, memory, sensorimotor processing and post-natal developmental plasticity...
  6. doi The rise of a new GABA pharmacology
    Hanns Mohler
    Institute of Pharmacology, University of Zurich and Department of Chemistry and Applied Biosciences, Swiss Federal Institute of Technology ETH Zurich, Winterthurerstr 190, CH 8057 Zurich, Switzerland
    Neuropharmacology 60:1042-9. 2011
    ..Today, the GABA pharmacology comprises selective hypnotics, non-sedative anxiolytics, memory enhancers and powerful analgesics. This article is part of a Special Issue entitled 'Trends in neuropharmacology: in memory of Erminio Costa'...
  7. ncbi Molecular and neuronal substrate for the selective attenuation of anxiety
    K Low
    Institute of Pharmacology and Toxicology, University of Zurich, and Swiss Federal Institute of Technology Zürich ETH, Winterthurerstrasse 190, CH 8057 Zurich, Switzerland
    Science 290:131-4. 2000
    ....
  8. ncbi Benzodiazepine actions mediated by specific gamma-aminobutyric acid(A) receptor subtypes
    U Rudolph
    Institute of Pharmacology, University of Zurich, Switzerland
    Nature 401:796-800. 1999
    ..Thus, benzodiazepine-induced behavioural responses are mediated by specific GABA(A) receptor subtypes in distinct neuronal circuits, which is of interest for drug design...
  9. pmc Single-channel properties of neuronal GABAA receptors from mice lacking the 2 subunit
    M Lorez
    Institute of Pharmacology and Toxicology, University of Zurich, Winterthurerstrasse 190, 8057 Zurich, Switzerland
    J Physiol 527:11-31. 2000
    ..8. We conclude that the gamma2 subunit enhances the efficacy of GABA by determining open conformations of high conductance and long lifetime, and by prolonging the time receptors remain in the activated bursting state...
  10. pmc A schizophrenia-related sensorimotor deficit links alpha 3-containing GABAA receptors to a dopamine hyperfunction
    B K Yee
    Institute of Pharmacology and Toxicology, University of Zurich, Winterthurerstrasse 190, CH 8057 Zurich, Switzerland
    Proc Natl Acad Sci U S A 102:17154-9. 2005
    ..Hence, agonists acting at alpha3-containing GABA(A) receptors may constitute an avenue for an effective treatment of sensorimotor-gating deficits in various psychiatric conditions...
  11. pmc Trace fear conditioning involves hippocampal alpha5 GABA(A) receptors
    F Crestani
    Institute of Pharmacology, University of Zurich, Winterthurerstrasse 190, 8057 Zurich, Switzerland
    Proc Natl Acad Sci U S A 99:8980-5. 2002
    ..Thus, the largely extrasynaptic alpha5GABA(A) receptors in hippocampal pyramidal cells are implicated as control elements of the temporal association of threat cues in trace fear conditioning...
  12. pmc Mechanism of action of the hypnotic zolpidem in vivo
    F Crestani
    Institute of Pharmacology and Toxicology, University of Zurich, Switzerland
    Br J Pharmacol 131:1251-4. 2000
    ..These results establish that the sedative-hypnotic and anticonvulsant activities of zolpidem are due to its action on alpha(1)-GABA(A) receptors and not on alpha(2)- or alpha(3)-GABA(A) receptors...
  13. ncbi Decreased GABAA-receptor clustering results in enhanced anxiety and a bias for threat cues
    F Crestani
    Institute of Pharmacology, Swiss Federal Institute of Technology ETH and University of Zurich, Winterthurerstrasse 190, 8057 Zurich, Switzerland
    Nat Neurosci 2:833-9. 1999
    ..This model implicates GABAA-receptor dysfunction in patients as a causal predisposition to anxiety disorders...
  14. ncbi GABAB-receptor splice variants GB1a and GB1b in rat brain: developmental regulation, cellular distribution and extrasynaptic localization
    J M Fritschy
    Institute of Pharmacology, Swiss Federal Institute of Technology ETH, University of Zurich, Switzerland
    Eur J Neurosci 11:761-8. 1999
    ..This subcellular localization is unrelated to GABAergic inputs, indicating that the role of GABAB-receptors in vivo extends beyond synaptic GABAergic neurotransmission and may, in the cerebellum, involve taurine as a ligand...
  15. ncbi Independent assembly and subcellular targeting of GABA(A)-receptor subtypes demonstrated in mouse hippocampal and olfactory neurons in vivo
    J M Fritschy
    Institute of Pharmacology, University of Zurich, Switzerland
    Neurosci Lett 249:99-102. 1998
    ..These findings indicate that the assembly of distinct GABA(A)-receptor subtypes in the same neuron is regulated independently. Furthermore, the alpha-subunit is a prime candidate for providing domains which direct subcellular targeting...
  16. ncbi Specific GABA(A) circuits in brain development and therapy
    H Mohler
    Institute of Pharmacology, University of Zurich, Winterthurerstrasse 190, CH 8057 Zurich, Switzerland
    Biochem Pharmacol 68:1685-90. 2004
    ....
  17. ncbi The rat beta 1-subunit of the GABAA receptor forms a picrotoxin-sensitive anion channel open in the absence of GABA
    E Sigel
    Institute of Pharmacology, University of Bern, Switzerland
    FEBS Lett 257:377-9. 1989
    ..Since this channel could be shunt by the GABA-channel blocker picrotoxin, we conclude that the beta 1-subunit of the GABAA receptor is sufficient to form binding sites for picrotoxin...
  18. ncbi GABA(A) receptor subtypes: dissecting their pharmacological functions
    U Rudolph
    Institute of Pharmacology and Toxicology, University of Zürich and Swiss Federal Institut of Technology ETH Zürich, Winterthurerstrasse 190, CH 8057, Zurich, Switzerland
    Trends Pharmacol Sci 22:188-94. 2001
    ..Such discoveries could open up new avenues for drug development...
  19. ncbi GABAA-receptor alpha-subunit is an essential prerequisite for receptor formation in vivo
    J M Fritschy
    Institute of Pharmacology, University of Zurich, Switzerland
    Neuroscience 81:1043-53. 1997
    ..Thus, the alpha-subunit, unlike the gamma 2-subunit, might play a major role in the assembly or targeting of GABAA-receptor complexes...
  20. ncbi GABA-based therapeutic approaches: GABAA receptor subtype functions
    Uwe Rudolph
    Institute of Pharmacology and Toxicology, University of Zurich, Winterthurerstrasse 190, CH 8057 Zurich, Switzerland, and Laboratory of Genetic Neuropharmacology, McLean Hospital, Harvard Medical School, Belmont, MA 02478, USA
    Curr Opin Pharmacol 6:18-23. 2006
    ..Thus, a new pharmacology based on GABAA receptor subtype-specific actions is emerging...
  21. pmc Neonatal hepatic steatosis by disruption of the adenosine kinase gene
    Detlev Boison
    Institute of Pharmacology and Toxicology, University of Zurich, CH 8057 Zurich, Switzerland
    Proc Natl Acad Sci U S A 99:6985-90. 2002
    ..Thus, a deficiency in adenosine metabolism is identified as a powerful contributor to the development of neonatal hepatic steatosis, providing a model for the rapid development of postnatally lethal fatty liver...
  22. doi The alpha5(H105R) mutation impairs alpha5 selective binding properties by altered positioning of the alpha5 subunit in GABAA receptors containing two distinct types of alpha subunits
    Ela Balic
    Institute of Pharmacology and Toxicology, University of Zurich, Winterhurerstrasse, Zurich, Switzerland
    J Neurochem 110:244-54. 2009
    ..These findings imply an important role of histidine 105 in determining the position of the alpha5 subunit within the receptor complex by determining the affinity for assembly with the gamma2 subunit...
  23. ncbi Analysis of the presence and abundance of GABAA receptors containing two different types of alpha subunits in murine brain using point-mutated alpha subunits
    Dietmar Benke
    Institute of Pharmacology and Toxicology, University of Zurich, Winterthurerstrasse 190, CH 8057, Switzerland
    J Biol Chem 279:43654-60. 2004
    ..This experimental approach provides the basis for a detailed analysis of the abundance of GABAA receptors containing heterologous alpha subunits on a brain regional level...
  24. ncbi Genetically modified animals in pharmacological research: future trends
    U Rudolph
    Institute of Pharmacology, Swiss Federal Institute of Technology ETH, University of Zurich
    Eur J Pharmacol 375:327-37. 1999
    ..Techniques which permit the time- and tissue-specific inducible regulation of gene expression present an important methodological advance...
  25. doi GABA A receptors as in vivo substrate for the anxiolytic action of valerenic acid, a major constituent of valerian root extracts
    Dietmar Benke
    Institute of Pharmacology and Toxicology, University of Zurich, Winterthurerstrasse 190, CH 8057 Zurich, Switzerland
    Neuropharmacology 56:174-81. 2009
    ..In beta3 (N265M) point-mutated mice the anxiolytic activity of valerenic acid was absent. Thus, neurons expressing beta3 containing GABA(A) receptors are a major cellular substrate for the anxiolytic action of valerian extracts...
  26. doi Regulation of cognition and symptoms of psychosis: focus on GABA(A) receptors and glycine transporter 1
    Hanns Mohler
    University of Zurich and Swiss Federal Institute of Technology, Zurich, Institute of Pharmacology, Winterthurerstrasse 190, CH 8057 Zurich, Switzerland
    Pharmacol Biochem Behav 90:58-64. 2008
    ..Taken together, these results qualify distinct GABA-A receptor subtypes and GlyT1 as molecular targets for the development of a new pharmacology in the treatment of cognitive decline and psychotic symptoms...
  27. ncbi Requirement of alpha5-GABAA receptors for the development of tolerance to the sedative action of diazepam in mice
    Carolien van Rijnsoever
    Institute of Pharmacology and Toxicology, University of Zurich, 8057 Zurich, Switzerland
    J Neurosci 24:6785-90. 2004
    ..Thus, the chronic activation of alpha(5)-GABA(A) receptors is crucial for the normal development of sedative tolerance to diazepam, which manifests itself in conjunction with alpha1-GABA(A) receptors...
  28. ncbi The gamma 3-subunit of the GABAA-receptor confers sensitivity to benzodiazepine receptor ligands
    F Knoflach
    Institute of Pharmacology, University of Zurich, Switzerland
    FEBS Lett 293:191-4. 1991
    ..The gamma 3-subunit could functionally replace the gamma 2-subunit with regard to the bi-directional allosteric drug modulation...
  29. ncbi gamma-aminobutyric acid type B receptor splice variant proteins GBR1a and GBR1b are both associated with GBR2 in situ and display differential regional and subcellular distribution
    D Benke
    Institute of Pharmacology, Swiss Federal Institute and Technology ETH and University of Zurich, CH 8057 Zurich, Switzerland
    J Biol Chem 274:27323-30. 1999
    ..Thus, GBR1a and GBR1b are both associated with GBR2 to form heterodimers at mainly different subcellular locations where they are expected to subserve different functions...
  30. ncbi Enhancement of the NMDA receptor function by reduction of glycine transporter-1 expression
    Laetitia Gabernet
    Institute of Pharmacology and Toxicology, University of Zurich, Winterthurerstr 190, CH 8057 Zurich, Switzerland
    Neurosci Lett 373:79-84. 2005
    ..Thus, GlyT1 function is a controlling factor for an enhancement of the NMDA receptor response. These findings are of relevance for the development of GlyT1 inhibitory drugs...
  31. doi GABAergic analgesia: new insights from mutant mice and subtype-selective agonists
    Hanns Ulrich Zeilhofer
    Institute of Pharmacology and Toxicology, University of Zurich, CH 8057 Zurich, Switzerland
    Trends Pharmacol Sci 30:397-402. 2009
    ..First results raise hopes that such compounds will be active against inflammatory and neuropathic pain but devoid of many of the side-effects of the established benzodiazepine-like drugs...