M H Mohajeri

Summary

Affiliation: University of Zurich
Country: Switzerland

Publications

  1. ncbi Antibody-based approaches in Alzheimer's research: safety, pharmacokinetics, metabolism, and analytical tools
    Peter Lichtlen
    ESBATech AG, Zurich Schlieren, Switzerland
    J Neurochem 104:859-74. 2008
  2. ncbi Transgenic BACE expression in mouse neurons accelerates amyloid plaque pathology
    M H Mohajeri
    Division of Psychiatry Research, University of Zurich, Zurich, Switzerland
    J Neural Transm 111:413-25. 2004
  3. ncbi Passive immunization against beta-amyloid peptide protects central nervous system (CNS) neurons from increased vulnerability associated with an Alzheimer's disease-causing mutation
    M Hasan Mohajeri
    Division of Psychiatry Research, University of Zurich, August Forel Strasse 1, 8008 Zurich, Switzerland
    J Biol Chem 277:33012-7. 2002
  4. ncbi Abeta 42-induced increase in neprilysin is associated with prevention of amyloid plaque formation in vivo
    M Hasan Mohajeri
    Division of Psychiatry Research, University of Zurich, August Forel Strasse 1, 8008 Zurich, Switzerland
    J Biol Chem 277:35460-5. 2002
  5. ncbi The impact of genetic background on neurodegeneration and behavior in seizured mice
    M H Mohajeri
    Division of Psychiatry Research and Institute of Anatomy, University of Zurich, Switzerland
    Genes Brain Behav 3:228-39. 2004
  6. ncbi Intact spatial memory in mice with seizure-induced partial loss of hippocampal pyramidal neurons
    M Hasan Mohajeri
    Division of Psychiatry Research, University of Zurich, Switzerland
    Neurobiol Dis 12:174-81. 2003
  7. ncbi Assessment of the bioactivity of antibodies against beta-amyloid peptide in vitro and in vivo
    M Hasan Mohajeri
    Division of Psychiatry Research, University of Zurich, Zurich, Switzerland
    Neurodegener Dis 1:160-7. 2004
  8. ncbi Anti-amyloid activity of neprilysin in plaque-bearing mouse models of Alzheimer's disease
    M Hasan Mohajeri
    Division of Psychiatry Research, University of Zurich, August Forel Str 1, 8008 Zurich, Switzerland
    FEBS Lett 562:16-21. 2004
  9. ncbi Active immunization trial in Abeta42-injected P301L tau transgenic mice
    Luka Kulic
    Division of Psychiatry Research, University of Zurich, August Forel Str 1, 8008 Zurich, Switzerland
    Neurobiol Dis 22:50-6. 2006
  10. ncbi Antibodies from a DNA peptide vaccination decrease the brain amyloid burden in a mouse model of Alzheimer's disease
    Jan G Schiltz
    Institute if Medical Virology, University of Zurich, Gloriastrasse 30, 8028 Zurich, Switzerland
    J Mol Med (Berl) 82:706-14. 2004

Collaborators

Detail Information

Publications24

  1. ncbi Antibody-based approaches in Alzheimer's research: safety, pharmacokinetics, metabolism, and analytical tools
    Peter Lichtlen
    ESBATech AG, Zurich Schlieren, Switzerland
    J Neurochem 104:859-74. 2008
    ....
  2. ncbi Transgenic BACE expression in mouse neurons accelerates amyloid plaque pathology
    M H Mohajeri
    Division of Psychiatry Research, University of Zurich, Zurich, Switzerland
    J Neural Transm 111:413-25. 2004
    ..We suggest that BACE overexpression is not sufficient to produce beta-amyloid plaques, but simultaneous expression of BACE and its substrate (SwAPP) leads to an accelerated amyloid plaque formation...
  3. ncbi Passive immunization against beta-amyloid peptide protects central nervous system (CNS) neurons from increased vulnerability associated with an Alzheimer's disease-causing mutation
    M Hasan Mohajeri
    Division of Psychiatry Research, University of Zurich, August Forel Strasse 1, 8008 Zurich, Switzerland
    J Biol Chem 277:33012-7. 2002
    ....
  4. ncbi Abeta 42-induced increase in neprilysin is associated with prevention of amyloid plaque formation in vivo
    M Hasan Mohajeri
    Division of Psychiatry Research, University of Zurich, August Forel Strasse 1, 8008 Zurich, Switzerland
    J Biol Chem 277:35460-5. 2002
    ..In addition, astrogliosis normally associated with amyloidosis was significantly reduced. Our results suggest that up-regulation of neprilysin in brain may represent an opportunity to reduce or prevent amyloid plaque formation in vivo...
  5. ncbi The impact of genetic background on neurodegeneration and behavior in seizured mice
    M H Mohajeri
    Division of Psychiatry Research and Institute of Anatomy, University of Zurich, Switzerland
    Genes Brain Behav 3:228-39. 2004
    ....
  6. ncbi Intact spatial memory in mice with seizure-induced partial loss of hippocampal pyramidal neurons
    M Hasan Mohajeri
    Division of Psychiatry Research, University of Zurich, Switzerland
    Neurobiol Dis 12:174-81. 2003
    ..Our data suggest that normal spatial learning and memory can be achieved without the full number of hippocampal pyramidal neurons in partially lesioned hippocampus...
  7. ncbi Assessment of the bioactivity of antibodies against beta-amyloid peptide in vitro and in vivo
    M Hasan Mohajeri
    Division of Psychiatry Research, University of Zurich, Zurich, Switzerland
    Neurodegener Dis 1:160-7. 2004
    ..This protocol may prove useful for the rapid validation of the activity of antibodies designed to be used in immune therapy of AD...
  8. ncbi Anti-amyloid activity of neprilysin in plaque-bearing mouse models of Alzheimer's disease
    M Hasan Mohajeri
    Division of Psychiatry Research, University of Zurich, August Forel Str 1, 8008 Zurich, Switzerland
    FEBS Lett 562:16-21. 2004
    ..Therefore, we suggest that the potential of NEP for AD therapy is age-dependent and most effective early in the course of AD pathophysiology...
  9. ncbi Active immunization trial in Abeta42-injected P301L tau transgenic mice
    Luka Kulic
    Division of Psychiatry Research, University of Zurich, August Forel Str 1, 8008 Zurich, Switzerland
    Neurobiol Dis 22:50-6. 2006
    ..Further studies are required to determine whether modifications of our protocol could affect the Abeta42-mediated induction of NFT formation...
  10. ncbi Antibodies from a DNA peptide vaccination decrease the brain amyloid burden in a mouse model of Alzheimer's disease
    Jan G Schiltz
    Institute if Medical Virology, University of Zurich, Gloriastrasse 30, 8028 Zurich, Switzerland
    J Mol Med (Berl) 82:706-14. 2004
    ..The monoclonal antibodies are applicable for passive immunization studies and may lead to a therapy of AD...
  11. ncbi Neuronal neprilysin overexpression is associated with attenuation of Abeta-related spatial memory deficit
    Raphael Poirier
    Division of Psychiatry Research, University of Zurich, August Forel Strasse 1, Zurich 8008, Switzerland
    Neurobiol Dis 24:475-83. 2006
    ....
  12. ncbi Increased cystatin C in astrocytes of transgenic mice expressing the K670N-M671L mutation of the amyloid precursor protein and deposition in brain amyloid plaques
    T Steinhoff
    Division of Psychiatry Research, University of Zurich, August Forel Strasse 1, 8008 Zurich, Switzerland
    Neurobiol Dis 8:647-54. 2001
    ..These results show that expression of SweAPP is associated with increased cystatin C in reactive astrocytes, and they suggest an early role of cystatin C in appositional amyloid plaque growth...
  13. pmc The role of seladin-1/DHCR24 in cholesterol biosynthesis, APP processing and Abeta generation in vivo
    Arames Crameri
    Division of Psychiatry Research, University of Zurich, Zurich, Switzerland
    EMBO J 25:432-43. 2006
    ..Pharmacological enhancement of seladin-1 activity may be a novel Abeta-lowering approach for the treatment of AD...
  14. doi Neprilysin deficiency-dependent impairment of cognitive functions in a mouse model of amyloidosis
    M Hasan Mohajeri
    Division of Psychiatry Research, University of Zurich, Zurich, Switzerland
    Neurochem Res 34:717-26. 2009
    ..These data suggest that even a partial neprilysin deficiency, as is found during aging, exacerbates amyloid pathology and may impair cognitive functions...
  15. ncbi Modulation of Alzheimer's pathology by cerebro-ventricular grafting of hybridoma cells expressing antibodies against Abeta in vivo
    Meret N M Gaugler
    Division of Psychiatry Research, University of Zurich, August Forel Str 1, 8008 Zurich, Switzerland
    FEBS Lett 579:753-6. 2005
    ....
  16. ncbi Active immunization of mice with an Abeta-Hsp70 vaccine
    Michael F Koller
    Institute of Biochemistry, Division of Psychiatry Research, University of Zurich, Zurich, Switzerland
    Neurodegener Dis 1:20-8. 2004
    ..These data emphasize the need for anti-Abeta antibodies that remove Abeta peptides from the central nervous system without negative side effects...
  17. ncbi Glucocorticoid-related genetic susceptibility for Alzheimer's disease
    Dominique J F de Quervain
    Division of Psychiatry Research, University of Zurich, Zurich, Switzerland
    Hum Mol Genet 13:47-52. 2004
    ..Our results indicate that a functional variation in the glucocorticoid system increases the risk for AD, which may have important implications for the diagnosis and treatment of this disease...
  18. ncbi Lack of neprilysin suffices to generate murine amyloid-like deposits in the brain and behavioral deficit in vivo
    Rime Madani
    Institute of Anatomy, University of Zurich, Zurich, Switzerland
    J Neurosci Res 84:1871-8. 2006
    ....
  19. ncbi The underestimated potential of the immune system in prevention of Alzheimer's disease pathology
    M Hasan Mohajeri
    Division of Psychiatry Research, University of Zurich, Zurich, Switzerland
    Bioessays 29:927-32. 2007
    ..Nonetheless, the physiological role of the immune system in preventing AD is not fully understood. This article summarizes crucial animal and clinical data underscoring the potential of the immune system for AD treatment...
  20. pmc Age-dependent increase in desmosterol restores DRM formation and membrane-related functions in cholesterol-free DHCR24-/- mice
    Katrin Kuehnle
    Division of Psychiatry Research, University of Zurich, Zurich, Switzerland
    Neurochem Res 34:1167-82. 2009
    ..These data indicate that desmosterol can replace cholesterol in membrane-related functions in the DHCR24(-/-) mouse...
  21. ncbi The immunoglobulin-superfamily molecule basigin is a binding protein for oligomannosidic carbohydrates: an anti-idiotypic approach
    Martin Heller
    Department of Neurobiology, Swiss Federal Institute of Technology, Zurich, Switzerland
    J Neurochem 84:557-65. 2003
    ..To our knowledge this is the first report that anti-idiotypic antibodies can be used to identify binding partners for carbohydrates...
  22. ncbi Neuronal and nonneuronal quantitative BACE immunocytochemical expression in the entorhinohippocampal and frontal regions in Alzheimer's disease
    Genevieve Leuba
    Center for Psychiatric Neuroscience and Service of Old Age Psychiatry, Department of Psychiatry CHUV, University of Lausanne, CH 1008 Lausanne, Switzerland
    Dement Geriatr Cogn Disord 19:171-83. 2005
    ..Moreover, the strong expression in controls and regions less vulnerable to AD puts forward the probable existence of alternate BACE functions...
  23. ncbi No influence of amyloid-beta-degrading neprilysin activity on prion pathogenesis
    Markus Glatzel
    Institute of Neuropathology, University Hospital of Zurich, Schmelzbergstrasse 12, CH 8091 Zurich, Switzerland
    J Gen Virol 86:1861-7. 2005
    ..Also, incubation times and clinical course of prion disease, as well as brain infectivity titres at terminal stage, were unaffected. These data rule out neprilysin as a major modulator of PrPSc accumulation and prion pathogenesis...
  24. pmc Prosurvival effect of DHCR24/Seladin-1 in acute and chronic responses to oxidative stress
    Katrin Kuehnle
    Swiss Academy of Medical Sciences, Petersplatz 13, 4051 Basel, Switzerland
    Mol Cell Biol 28:539-50. 2008
    ..Our findings reveal a dual capacity of DHCR24/seladin-1, which appears to be involved in two mechanistically independent prosurvival effects, exerting an acute response and a chronic response to oxidative stress...