Research Topics
Genomes and Genes
| Karin MoellingSummaryAffiliation: University of Zurich Country: Switzerland Publications
| Collaborators
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Detail Information
Publications
Regulation of Raf-Akt Cross-talkKarin Moelling
Institute of Medical Virology, University of Zurich, Gloriastrasse 30, 8028 Zurich, Switzerland
J Biol Chem 277:31099-106. 2002..This is highly relevant to understanding cellular transformation and may be of use in areas like tissue engineering...- Silencing of HIV by hairpin-loop-structured DNA oligonucleotideKarin Moelling
Institute of Medical Virology, University of Zurich, Switzerland
FEBS Lett 580:3545-50. 2006..The ODN against HIV-IIIB was effective preferentially against its homologous PPT and less against the PPT of HIV-BaL differing in two of 24 nucleotides and vice versa. It may be interesting mechanistically as an antiviral drug... - Regulation of epithelial wound closure and intercellular adhesion by interaction of AF6 with actin cytoskeletonMihaela Lorger
Institute of Medical Virology, University of Zurich, Gloriastrasse 30, CH 8006 Zurich, Switzerland
J Cell Sci 119:3385-98. 2006.... - Anti-tumor activity of mesenchymal stem cells producing IL-12 in a mouse melanoma modelLina Elzaouk
Institute of Medical Virology, University of Zurich, Zurich, Switzerland
Exp Dermatol 15:865-74. 2006..The presented data demonstrate that these two different strategies can induce a similar therapeutic anti-tumor efficacy in the mouse melanoma tumor model... - WD-repeat-propeller-FYVE protein, ProF, binds VAMP2 and protein kinase CzetaThorsten Fritzius
Institute of Medical Virology, University of Zurich, Gloriastrasse 30, Zurich CH 8006, Switzerland
FEBS J 274:1552-66. 2007..VAMP2 is known to regulate docking and fusion of vesicles and to play a role in targeting vesicles to the plasma membrane. The complex may be involved in vesicle cycling in various secretory pathways... 
c-Src-mediated epithelial cell migration and invasion regulated by PDZ binding siteMartin Baumgartner
Institute of Medical Virology, University of Zurich, Gloriastrasse 30, CH 8006 Zurich, Switzerland
Mol Cell Biol 28:642-55. 2008..We propose that the C terminus of c-Src via its GENL sequence presents a mechanism that restricts c-Src in epithelia and prevents progression toward an invasive phenotype...- Akt- and Foxo1-interacting WD-repeat-FYVE protein promotes adipogenesisThorsten Fritzius
Institute of Medical Virology, University of Zurich, Zurich, Switzerland
EMBO J 27:1399-410. 2008..Thus, ProF modulates Foxo1 phosphorylation by Akt, promoting adipocyte differentiation. Furthermore, ProF might be involved in metabolic disorders such as diabetes... 
Oligonucleotide-mediated retroviral RNase H activation leads to reduced HIV-1 titer in patient-derived plasmaJochen Heinrich
Institute of Medical Virology, University of Zurich, Zurich, Switzerland
AIDS 23:213-21. 2009..The retroviral RNase H is essential for viral replication. This component has not yet been extensively studied for antiviral therapy. It can be activated by an oligodeoxynucleotide (ODN) resulting in self-destruction of the virions...- IP-10-encoding plasmid DNA therapy exhibits anti-tumor and anti-metastatic efficiencyJohanna Keyser
Institute of Medical Virology, University of Zurich, Gloriastr, Zurich, Switzerland
Exp Dermatol 13:380-90. 2004..Interestingly, treatment of nude mice lacking T lymphocytes with DNA-encoding IP-10 or IL-12 still resulted in a pronounced reduction of tumor growth or metastasis formation... - The PDZ protein MPP2 interacts with c-Src in epithelial cellsMartin Baumgartner
Institute of Medical Virology, University of Zurich, Zurich, Switzerland
Exp Cell Res 315:2888-98. 2009..In conclusion we demonstrate here that MPP2 interacts with c-Src in cells to control c-Src activity and morphological function... - Intratumoral injection of DNA encoding human interleukin 12 into patients with metastatic melanoma: clinical efficacyLucie Heinzerling
Department of Dermatology, University of Zurich, CH-8091 Zurich, Switzerland
Hum Gene Ther 16:35-48. 2005..Serum levels revealed fluctuations. The results show that intratumoral injection of DNA produced some beneficial clinical effect. DNA encoding a cytokine may be useful as a therapeutic or adjuvant against various human cancers... - A short hairpin DNA analogous to miR-125b inhibits C-Raf expression, proliferation, and survival of breast cancer cellsMarco H Hofmann
University of Zurich, Zurich, Switzerland
Mol Cancer Res 7:1635-44. 2009..Both features may be useful to interfere with tumor growth... - Role of AF6 protein in cell-to-cell spread of Herpes simplex virus 1Johanna Keyser
Institute of Medical Virology, University of Zurich, Gloriastrasse 30, CH 8006 Zurich, Switzerland
FEBS Lett 581:5349-54. 2007..Thus, AF6 protein is important for spreading of HSV-1 in epithelial cells, independently of nectin clustering, possibly by stabilization of the E-cadherin-dependent cell adhesion... - Antitumor activity of small double-stranded oligodeoxynucleotides targeting telomerase RNA in malignant melanoma cellsFaiza Noreen
Institute of Medical Virology, University of Zurich, Zurich, Switzerland
Oligonucleotides 19:169-78. 2009..Our study demonstrates the potential utility of these hairpin-loop-structured ODNs as a different group of nucleic acids for telomerase-based antiproliferative strategies... - Reduction of gene expression by a hairpin-loop structured oligodeoxynucleotide: alternative to siRNA and antisenseTerry Kwok
Institute of Medical Virology, University of Zurich, Gloriastrasse 30, CH 8006 Zurich, Switzerland
Biochim Biophys Acta 1790:1170-8. 2009..ODN A was shown to lead to reduced viral RNA in virions or early during infection... - Inhibition of influenza A virus replication by short double-stranded oligodeoxynucleotidesTerry Kwok
Institute of Medical Virology, University of Zurich, Zurich, Switzerland
Arch Virol 154:109-14. 2009..Thus, dsODNs may be developed as an additional class of nucleic acids for the inhibition of influenza virus replication... - A WD-FYVE protein binds to the kinases Akt and PKCzeta/lambdaThorsten Fritzius
Institute of Medical Virology, University of Zurich, Gloriastrasse 30, CH 8006 Zurich, Switzerland
Biochem J 399:9-20. 2006..In summary, we describe a new binding partner for kinases, located on vesicular structures in specialized cells, which may play a role for the spatial organization of signalling cascades... - Regulation of c-Src by binding to the PDZ domain of AF-6Gerald Radziwill
Institute of Medical Virology, University of Zurich, Zurich, Switzerland
EMBO J 26:2633-44. 2007..c-Src is recruited by AF-6 to cell-cell contact sites, suggesting that c-Src is regulated by a PDZ protein in special cellular locations. We identified a novel type of c-Src regulation by interaction with a PDZ protein... - A combination of plasmid DNAs encoding murine fetal liver kinase 1 extracellular domain, murine interleukin-12, and murine interferon-gamma inducible protein-10 leads to tumor regression and survival in melanoma-bearing miceKristin Ladell
Institute of Medical Virology, University of Zurich, Gloriastrasse 30, 8028, Zurich, Switzerland
J Mol Med 81:271-8. 2003..A combination of Flk-1 ECD and DNA encoding murine interleukin-12 or murine interferon-gamma inducible protein-10 improved the effect, leading to tumor regression and long-term survival of the mice... - Retroviral self-inactivation in the mouse vagina induced by short DNALina Wittmer-Elzaouk
Institute of Medical Virology, University of Zurich, Gloriastrasse 30 32, CH 8006 Zurich, Switzerland
Antiviral Res 82:22-8. 2009..Our finding may have some relevance for the design of other viral self-destruction approaches. It may lead to a microbicide for reduction of sexual and mother-to-child transmission... - Short hairpin-loop-structured oligodeoxynucleotides reduce HSV-1 replicationAlexander Falkenhagen
University of Zurich, Gloriastrasse 30 32, CH 8006 Zurich, Switzerland
Virol J 6:43. 2009..The results underline the potential of partially double-stranded hairpin loop-structured ODNs as antiviral agents... - Vero cells as a model to study the effects of adenoviral gene delivery vectors on the RNAi system in context of viral infectionAlexey A Matskevich
Institute of Medical Virology, University of Zurich, Zurich, Switzerland
J Innate Immun 1:389-94. 2009..Thus, the Vero cell line could serve as an interesting model for studying the effects of gene delivery vectors on the RNAi system in the context of virus-related disorders... - Heteromeric complex formation of ASK2 and ASK1 regulates stress-induced signalingElisabeth Ortner
Institute of Medical Virology, University of Zurich, Gloriastrasse 30, CH 8006 Zurich, Switzerland
Biochem Biophys Res Commun 362:454-9. 2007..We propose that ASK2 regulates stress-induced caspase-3 and PARP cleavage in a dose-dependent manner by heteromeric complex formation with ASK1... - c-Src is a PDZ interaction partner and substrate of the E3 ubiquitin ligase Ligand-of-Numb protein X1Andreas Weiss
Institute of Medical Virology, University of Zurich, Gloriastrasse 30, 8006 Zurich, Switzerland
FEBS Lett 581:5131-6. 2007..Furthermore, we show that c-Src phosphorylates LNX1. Moreover, c-Src itself is ubiquitinated by LNX1, suggesting an interdependent regulation of c-Src and LNX1... - RNase H-mediated retrovirus destruction in vivo triggered by oligodeoxynucleotidesKathrin Matzen
Institute of Medical Virology, University of Zurich, Gloriastrasse 30, 8006 Zurich, Switzerland
Nat Biotechnol 25:669-74. 2007..As it targets events common to the replication cycle of all retroviruses, this approach may be broadly applicable to retroviruses of medical and agricultural importance... - Analysis of antitumor activity elicited by vaccination with combinations of interleukin-12 DNA with gp100 DNA or the chemokine CCL21 in vivoLina Elzaouk
Institute of Medical Virology, University of Zurich, CH-8006 Zurich, Switzerland
Hum Gene Ther 17:859-70. 2006..These findings open a new route of investigation of IL-12 and gp100 or other tumor-associated antigens in the immunotherapy of a variety of tumors... - Linear closed mini DNA generated by the prokaryotic cleaving-joining enzyme TelN is functional in mammalian cellsJochen Heinrich
, , Gloriastrasse 30, , Switzerland
J Mol Med 80:648-54. 2002..Therefore, the TelN/ telRL system is well suited to generate linear closed mini DNA with high stability and a minimum of foreign nucleotide sequences... - Dicer is involved in protection against influenza A virus infectionAlexey A Matskevich
Institute of Medical Virology, University of Zurich, Gloriastrasse 30 32, CH 8006 Zurich, Switzerland
J Gen Virol 88:2627-35. 2007..Thus, RNAi is involved in antiviral response, and Dicer is important for protection against influenza A virus infection... - CNK1 is a scaffold protein that regulates Src-mediated Raf-1 activationAlgirdas Ziogas
Institute of Medical Virology, University of Zurich, Gloriastrasse 30, CH 8006 Zurich, Switzerland
J Biol Chem 280:24205-11. 2005..Down-regulation of endogenously expressed CNK1 by small inhibitory RNA interferes with Src-dependent activation of ERK. Thus, CNK1 allows cross-talk between Src and Raf-1 and is essential for the full activation of Raf-1... - JM4 is a four-transmembrane protein binding to the CCR5 receptorMarc Schweneker
Institute of Medical Virology, University Zurich, Gloriastr 30, 8028 Zurich, Switzerland
FEBS Lett 579:1751-8. 2005..In conclusion, we describe a CCR5-interacting protein, which is suggested to function in trafficking and membrane localisation of the receptor, possibly also other receptors or amino acid transporters... - RIP2 mediates LPS-induced p38 and IkappaBalpha signaling including IL-12 p40 expression in human monocyte-derived dendritic cellsNurguel Usluoglu
Institute of Medical Virology, University of Zurich, Zurich, Switzerland
Eur J Immunol 37:2317-25. 2007..Thus, in human DC LPS stimulates a signal cascade that involves the Raf-dependent activation of RIP2 leading to expression of IL-12 p40... - A short hairpin loop-structured oligodeoxynucleotide targeting the virion-associated RNase H of HIV inhibits HIV production in cell culture and in huPBL-SCID miceJochen Heinrich
University of Zurich, Zurich, Switzerland
Intervirology 55:242-6. 2012..This mechanism has been described previously in a mouse model using an oncogenic retrovirus and was commented as driving HIV into suicide. The RNase H is one of four retrovirus-specific enzymes and not yet targeted by antiviral drugs... - Bcr interferes with beta-catenin-Tcf1 interactionAngelika Ress
Institute of Medical Virology, University of Zurich, Gloriastrasse 30, CH 8006 Zurich, Switzerland
FEBS Lett 580:1227-30. 2006..Thus two independent mechanisms may regulate Tcf/beta-catenin-mediated transcription via Bcr: binding to beta-catenin as we have previously shown and to Tcf1 as shown here... - Interaction partners of the PDZ domain of erbinAngelika Ress
Institute of Medical Virology, University of Zurich, Gloriastrasse 30, CH 8006 Zurich, Switzerland
Protein Pept Lett 13:877-81. 2006..The interactions were verified by co-immunoprecipitation experiments. These findings demonstrate the promiscuity of the PDZ domain of Erbin... - Antibodies from a DNA peptide vaccination decrease the brain amyloid burden in a mouse model of Alzheimer's diseaseJan G Schiltz
Institute if Medical Virology, University of Zurich, Gloriastrasse 30, 8028 Zurich, Switzerland
J Mol Med 82:706-14. 2004..The monoclonal antibodies are applicable for passive immunization studies and may lead to a therapy of AD... - Stimuli-dependent cleavage of Dicer during apoptosisAlexey A Matskevich
Institute of Medical Virology, University of Zurich, Gloriastrasse 30 32, CH 8006 Zurich, Switzerland
Biochem J 412:527-34. 2008..Thus the apoptotic machinery may regulate the miRNA pathway by affecting individual proteins, such as Dicer... - Short partially double-stranded oligodeoxynucleotide induces reverse transcriptase/RNase H-mediated cleavage of HIV RNA and contributes to abrogation of infectivity of virionsAlexey A Matskevich
Institute of Medical Virology, University of Zurich, CH-8006 Zurich, Switzerland
AIDS Res Hum Retroviruses 22:1220-30. 2006..The pretreatment with ODN A strongly reduced the infectivity of virions in cell culture in the absence of any DNA carriers or detergents... - The HIV-1 co-receptor CCR5 binds to alpha-catenin, a component of the cellular cytoskeletonMarc Schweneker
Institute of Medical Virology, University of Zurich, 8028 Zurich, Switzerland Institute of Biochemistry, Freie Universitat Berlin, 14195 Berlin, Germany
Biochem Biophys Res Commun 325:751-7. 2004..Our results suggest that alpha-catenin links CCR5 and CXCR4 to the cytoskeleton and is involved in the organization of these receptors at the membrane, thereby possibly affecting HIV-1 infection... - Bcr is a negative regulator of the Wnt signalling pathwayAngelika Ress
Institute of Medical Virology, University of Zurich, Gloriastrasse 30, 8006 Zurich, Switzerland
EMBO Rep 6:1095-100. 2005..The inhibitor of the Bcr-Abl tyrosine kinase, STI-571 or Gleevec, a drug against CML, reverses this effect. Our data contribute to the understanding of Bcr as a tumour suppressor in the Wnt signalling pathway, as well as in CML... - Tumor regression of human and murine melanoma after intratumoral injection of IL-12-encoding plasmid DNA in miceLucie Heinzerling
Institute of Medical Virology, University of Zurich, Zurich, Switzerland
Exp Dermatol 11:232-40. 2002..These results suggest that intratumoral plasmid DNA coding for IL-12 holds some promise as a new therapeutic tool for accessible melanoma lesions and should be tested in clinical trial... - Cooperation of Ras- and c-Myc-dependent pathways in regulating the growth and invasiveness of synovial fibroblasts in rheumatoid arthritisThomas Pap
Center of Internal Medicine, University Hospital Magdeburg, Magdeburg, Germany
Arthritis Rheum 50:2794-802. 2004..To study the specific contribution of MAP kinase activator c-Raf-1 and one of its downstream transcription factors, c-Myc, to the growth and invasive behavior of rheumatoid arthritis synovial fibroblasts (RASFs)... - Characterization of a putative phosphorylation switch: adaptation of SPOT synthesis to analyze PDZ domain regulation mechanismsPrisca Boisguerin
Institut fur Medizinische Immunologie, Charite Universitatsmedizin Berlin, Hessische Strasse 3 4, 10115 Berlin, Germany
Chembiochem 8:2302-7. 2007..This should ultimately help in the identification of phosphorylation-dependent regulation mechanisms in vivo...