Xiu Fen Ming

Summary

Affiliation: University of Fribourg
Country: Switzerland

Publications

  1. pmc p38 mitogen-activated protein kinase is involved in arginase-II-mediated eNOS-uncoupling in obesity
    Yi Yu
    Laboratory of Vascular Biology, Department of Medicine, Division of Physiology, University of Fribourg, Chemin du Musee 5, CH 1700, Fribourg, Switzerland
    Cardiovasc Diabetol 13:113. 2014
  2. pmc Arginase-I enhances vascular endothelial inflammation and senescence through eNOS-uncoupling.
    Cuicui Zhu
    BMC Res Notes 10:82. 2017
  3. pmc Arginase II Promotes Macrophage Inflammatory Responses Through Mitochondrial Reactive Oxygen Species, Contributing to Insulin Resistance and Atherogenesis
    Xiu Fen Ming
    Laboratory of Vascular Biology, Department of Medicine, Division of Physiology, Faculty of Science, University of Fribourg, Switzerland X F M, A G R, G Y, Y X, J M C, J R, I S, Z W, K P, J P M, Z Y
    J Am Heart Assoc 1:e000992. 2012
  4. pmc Inhibition of S6K1 accounts partially for the anti-inflammatory effects of the arginase inhibitor L-norvaline
    Xiu Fen Ming
    Vascular Biology, Department of Medicine, Division of Physiology, University of Fribourg, Switzerland
    BMC Cardiovasc Disord 9:12. 2009
  5. doi request reprint Opposing and uncoupling effects of mTOR and S6K1 in the regulation of endothelial tissue factor expression
    Xiu Fen Ming
    Division of Physiology, Department of Medicine, University of Fribourg, Fribourg, Switzerland
    FEBS Lett 584:135-40. 2010
  6. ncbi request reprint Reconstituted high-density lipoprotein inhibits thrombin-induced endothelial tissue factor expression through inhibition of RhoA and stimulation of phosphatidylinositol 3-kinase but not Akt/endothelial nitric oxide synthase
    Hema Viswambharan
    Department of Medicine, Divisions of Physiology, University of Fribourg, Fribourg, Switzerland
    Circ Res 94:918-25. 2004
  7. ncbi request reprint Thrombin stimulates human endothelial arginase enzymatic activity via RhoA/ROCK pathway: implications for atherosclerotic endothelial dysfunction
    Xiu Fen Ming
    Vascular Biology, Department of Medicine, Division of Physiology, University of Fribourg, Fribourg, Switzerland
    Circulation 110:3708-14. 2004
  8. pmc Hyperactive S6K1 mediates oxidative stress and endothelial dysfunction in aging: inhibition by resveratrol
    Angana G Rajapakse
    Department of Medicine, Division of Physiology, University of Fribourg, Fribourg, Switzerland
    PLoS ONE 6:e19237. 2011
  9. pmc Arginase-II induces vascular smooth muscle cell senescence and apoptosis through p66Shc and p53 independently of its l-arginine ureahydrolase activity: implications for atherosclerotic plaque vulnerability
    Yuyan Xiong
    Vascular Biology, Department of Medicine, Division of Physiology, Faculty of Science, University of Fribourg, Chemin du Musee 5, Fribourg, CH 1700, Switzerland
    J Am Heart Assoc 2:e000096. 2013
  10. ncbi request reprint PKC is required for activation of ROCK by RhoA in human endothelial cells
    Christine Barandier
    Vascular Biology, Department of Medicine, Division of Physiology, University of Fribourg, Rue du Musee 5, CH 1700 Fribourg, Switzerland
    Biochem Biophys Res Commun 304:714-9. 2003

Collaborators

Detail Information

Publications28

  1. pmc p38 mitogen-activated protein kinase is involved in arginase-II-mediated eNOS-uncoupling in obesity
    Yi Yu
    Laboratory of Vascular Biology, Department of Medicine, Division of Physiology, University of Fribourg, Chemin du Musee 5, CH 1700, Fribourg, Switzerland
    Cardiovasc Diabetol 13:113. 2014
    ....
  2. pmc Arginase-I enhances vascular endothelial inflammation and senescence through eNOS-uncoupling.
    Cuicui Zhu
    BMC Res Notes 10:82. 2017
    ..Our study demonstrates that Arg-I promotes endothelial senescence and inflammatory responses through eNOS-uncoupling unrelated to activation of the S6K1 pathway...
  3. pmc Arginase II Promotes Macrophage Inflammatory Responses Through Mitochondrial Reactive Oxygen Species, Contributing to Insulin Resistance and Atherogenesis
    Xiu Fen Ming
    Laboratory of Vascular Biology, Department of Medicine, Division of Physiology, Faculty of Science, University of Fribourg, Switzerland X F M, A G R, G Y, Y X, J M C, J R, I S, Z W, K P, J P M, Z Y
    J Am Heart Assoc 1:e000992. 2012
    ..This study characterizes the role of Arg-II in macrophage inflammatory responses and its impact on obesity-linked type II diabetes mellitus and atherosclerosis...
  4. pmc Inhibition of S6K1 accounts partially for the anti-inflammatory effects of the arginase inhibitor L-norvaline
    Xiu Fen Ming
    Vascular Biology, Department of Medicine, Division of Physiology, University of Fribourg, Switzerland
    BMC Cardiovasc Disord 9:12. 2009
    ..We investigated whether the endothelial arginase II is involved in inflammatory responses in endothelial cells...
  5. doi request reprint Opposing and uncoupling effects of mTOR and S6K1 in the regulation of endothelial tissue factor expression
    Xiu Fen Ming
    Division of Physiology, Department of Medicine, University of Fribourg, Fribourg, Switzerland
    FEBS Lett 584:135-40. 2010
    ..The results reveal an opposing and uncoupling effect of mTOR and S6K1 in regulating TF expression...
  6. ncbi request reprint Reconstituted high-density lipoprotein inhibits thrombin-induced endothelial tissue factor expression through inhibition of RhoA and stimulation of phosphatidylinositol 3-kinase but not Akt/endothelial nitric oxide synthase
    Hema Viswambharan
    Department of Medicine, Divisions of Physiology, University of Fribourg, Fribourg, Switzerland
    Circ Res 94:918-25. 2004
    ..In conclusion, rHDL inhibits thrombin-induced human endothelial TF expression through inhibition of RhoA and activation of PI3K but not Akt/eNOS. These findings implicate a novel mechanism of antiatherothrombotic effects of HDL...
  7. ncbi request reprint Thrombin stimulates human endothelial arginase enzymatic activity via RhoA/ROCK pathway: implications for atherosclerotic endothelial dysfunction
    Xiu Fen Ming
    Vascular Biology, Department of Medicine, Division of Physiology, University of Fribourg, Fribourg, Switzerland
    Circulation 110:3708-14. 2004
    ..This study investigated regulatory mechanisms of arginase activity in endothelial cells and its role in atherosclerosis...
  8. pmc Hyperactive S6K1 mediates oxidative stress and endothelial dysfunction in aging: inhibition by resveratrol
    Angana G Rajapakse
    Department of Medicine, Division of Physiology, University of Fribourg, Fribourg, Switzerland
    PLoS ONE 6:e19237. 2011
    ..Resveratrol improves endothelial function in aging, at least in part, through inhibition of S6K1. Targeting S6K1 may thus represent a novel therapeutic approach for aging-associated vascular disease...
  9. pmc Arginase-II induces vascular smooth muscle cell senescence and apoptosis through p66Shc and p53 independently of its l-arginine ureahydrolase activity: implications for atherosclerotic plaque vulnerability
    Yuyan Xiong
    Vascular Biology, Department of Medicine, Division of Physiology, Faculty of Science, University of Fribourg, Chemin du Musee 5, Fribourg, CH 1700, Switzerland
    J Am Heart Assoc 2:e000096. 2013
    ..The function of Arg-II in VSMCs with respect to plaque vulnerability is unknown. This study investigated the functions of Arg-II in VSMCs linking to plaque vulnerability...
  10. ncbi request reprint PKC is required for activation of ROCK by RhoA in human endothelial cells
    Christine Barandier
    Vascular Biology, Department of Medicine, Division of Physiology, University of Fribourg, Rue du Musee 5, CH 1700 Fribourg, Switzerland
    Biochem Biophys Res Commun 304:714-9. 2003
    ..These results indicate that RhoA/ROCK complex formation alone is not sufficient and PKC is required for RhoA-induced ROCK activation leading to eNOS gene suppression...
  11. pmc Role of p38 mitogen-activated protein kinase in vascular endothelial aging: interaction with Arginase-II and S6K1 signaling pathway
    Zongsong Wu
    Laboratory of Vascular Biology, Department of Medicine, Division of Physiology, University of Fribourg, CH 1700 Fribourg, Switzerland
    Aging (Albany NY) 7:70-81. 2015
    ..Silencing Arg-II or p38a or S6K1 inhibits each other in senescence endothelial cells. Thus, Arg-II, p38, and S6K1 form a positive circuit which regulates endothelial senescence and cardiovascular aging...
  12. ncbi request reprint p38 Mitogen-activated protein kinase is required for glucosamine-induced endothelial nitric oxide synthase uncoupling and plasminogen-activator inhibitor expression
    Zongsong Wu
    Department of Medicine, Division of Physiology, University of Fribourg, Switzerland
    Circ J 76:2015-22. 2012
    ..The aim of the present study was to investigate the role of p38mapk in GlcN-induced endothelial PAI-1 expression and eNOS dysfunction...
  13. doi request reprint Positive crosstalk between arginase-II and S6K1 in vascular endothelial inflammation and aging
    Gautham Yepuri
    Vascular Biology, Department of Medicine, Division of Physiology, University of Fribourg, Fribourg, Switzerland
    Aging Cell 11:1005-16. 2012
    ..Targeting S6K1 and/or Arg-II may decelerate vascular aging and age-associated cardiovascular disease development...
  14. pmc En Face Detection of Nitric Oxide and Superoxide in Endothelial Layer of Intact Arteries
    Yi Yu
    Cardiovascular and Aging Research, Department of Medicine, Division of Physiology, Faculty of Science, University of Fribourg Kidney Control of Homeostasis, Swiss National Centre of Competence in Research
    J Vis Exp . 2016
    ..in the intact blood vessels and can be widely applied for investigation of endothelial (dys)function under (physio)pathological conditions. ..
  15. pmc Rho GTPase/Rho kinase negatively regulates endothelial nitric oxide synthase phosphorylation through the inhibition of protein kinase B/Akt in human endothelial cells
    Xiu Fen Ming
    Vascular Biology, Institute of Physiology, University of Fribourg, CH 1700 Fribourg, Switzerland
    Mol Cell Biol 22:8467-77. 2002
    ..Taken together, these data demonstrate that Rho/ROCK pathway negatively regulates eNOS phosphorylation through inhibition of PKB, whereas it downregulates eNOS expression independent of PKB...
  16. doi request reprint The hexosamine biosynthesis inhibitor azaserine prevents endothelial inflammation and dysfunction under hyperglycemic condition through antioxidant effects
    Angana Gupta Rajapakse
    Division of Physiology, Department of Medicine, Faculty of Science, University of Fribourg, Fribourg, Switzerland
    Am J Physiol Heart Circ Physiol 296:H815-22. 2009
    ..Azaserine protects against hyperglycemic endothelial damage through its antioxidant effect independently of inhibiting HBP pathway...
  17. ncbi request reprint Mutation of the circadian clock gene Per2 alters vascular endothelial function
    Hema Viswambharan
    Department of Medicine, Division of Physiology, University of Fribourg, Rue du Musee 5, CH 1700 Fribourg, Switzerland
    Circulation 115:2188-95. 2007
    ..The circadian clock regulates biological processes including cardiovascular function and metabolism. In the present study, we investigated the role of the circadian clock gene Period2 (Per2) in endothelial function in a mouse model...
  18. pmc Period2 gene mutant mice show compromised insulin-mediated endothelial nitric oxide release and altered glucose homeostasis
    João M Carvas
    Faculty of Science, Division of Physiology, Department of Medicine, University of Fribourg Fribourg, Switzerland
    Front Physiol 3:337. 2012
    ..Thus, mice with Per2 gene mutation show altered glucose homeostasis and compromised insulin-stimulated NO release, independently of obesity...
  19. pmc Targeting arginase-II protects mice from high-fat-diet-induced hepatic steatosis through suppression of macrophage inflammation
    Chang Liu
    Vascular Biology, Department of Medicine, Division of Physiology, University of Fribourg, Chemin du Musee 5, CH 1700 Fribourg, Switzerland
    Sci Rep 6:20405. 2016
    ..These effects of BMM conditioned medium can be neutralized by neutralizing antibodies against TNF-α and IL-6. Thus, Arg-II-expressing macrophages facilitate diet-induced NAFLD through TNF-α and IL-6 in obesity. ..
  20. pmc O-linked beta-N-acetylglucosamine during hyperglycemia exerts both anti-inflammatory and pro-oxidative properties in the endothelial system
    Angana Gupta Rajapakse
    Vascular Biology, Department of Medicine, Division of Physiology, Faculty of Science, University of Fribourg, Switzerland
    Oxid Med Cell Longev 2:172-5. 2009
    ..Further work should delineate the exact role of HPB pathway in different aspects of cardiovascular functions, especially those of diabetic cardiovascular complications...
  21. pmc Long term exposure to L-arginine accelerates endothelial cell senescence through arginase-II and S6K1 signaling
    Yuyan Xiong
    Vascular Biology, Department of Medicine, Division of Physiology, University of Fribourg, CH 1700, Fribourg Switzerland
    Aging (Albany NY) 6:369-79. 2014
    ..These results demonstrate that S6K1 and arginase-II form a positive circuit mediating the detrimental effects of chronic L-arginine supplementation on endothelial cells. ..
  22. ncbi request reprint Endothelial arginase: a new target in atherosclerosis
    Zhihong Yang
    Vascular Biology, Department of Medicine, Division of Physiology, University of Fribourg, Rue du Musee 5, CH 1700 Fribourg, Switzerland
    Curr Hypertens Rep 8:54-9. 2006
    ..Thus, endothelial arginase may represent a new therapeutic target in atherosclerosis...
  23. pmc Sirolimus increases tissue factor expression but not activity in cultured human vascular smooth muscle cells
    Shengsi Zhu
    Vascular Biology, Department of Medicine, Division of Physiology, University of Fribourg, Rue du Musee 5, CH 1700 Fribourg, Switzerland
    BMC Cardiovasc Disord 5:22. 2005
    ..There is a concern of sub-acute and late stent thrombosis. Tissue factor (TF) is critical in thrombosis. This study investigated the effect of sirolimus on TF expression and activity in cultured human vascular smooth muscle cells (SMCs)...
  24. pmc Recent advances in understanding endothelial dysfunction in atherosclerosis
    Zhihong Yang
    Vascular Biology Laboratory, Department of Medicine, Division of Physiology, University of Fribourg, Rue du Musee 5, CH 1700 Fribourg, Switzerland
    Clin Med Res 4:53-65. 2006
    ....
  25. pmc Genetic Targeting of Arginase-II in Mouse Prevents Renal Oxidative Stress and Inflammation in Diet-Induced Obesity
    Ji Huang
    Cardiovascular and Aging Research, Division of Physiology, Department of Medicine, University of FribourgFribourg, Switzerland Swiss National Centre of Competence in Research NCCR Kidney Control of Homeostasis Kidney CH Zurich, Switzerland
    Front Physiol 7:560. 2016
    ..Genetic targeting of Arg-II prevents renal damage associated with obesity, suggesting an important role of Arg-II in obesity-associated renal disease development...
  26. ncbi request reprint Small G proteins as novel therapeutic targets in cardiovascular medicine
    Christine Barandier
    Vascular Biology, Department of Medicine, Division of Physiology, University of Fribourg, CH 1700 Fribourg, Switzerland
    News Physiol Sci 18:18-22. 2003
    ..Targeting small G proteins and their downstream signaling could constitute promising therapeutic approaches in cardiovascular disorders such as atherosclerosis, restenosis, hypertension, vasospasm, and cardiac hypertrophy...
  27. pmc Perspectives of Targeting mTORC1-S6K1 in Cardiovascular Aging
    Xiu Fen Ming
    Laboratory of Vascular Biology, Division of Physiology, Department of Medicine, Faculty of Science, University of Fribourg Fribourg, Switzerland
    Front Physiol 3:5. 2012
    ....
  28. pmc Arginase: the emerging therapeutic target for vascular oxidative stress and inflammation
    Zhihong Yang
    Vascular Biology, Division of Physiology, Department of Medicine, University of Fribourg, Fribourg, Switzerland
    Front Immunol 4:149. 2013
    ..Moreover, regulatory mechanisms of arginases in the vasculature are reviewed and the future perspectives of targeting arginases as therapeutic options in vascular diseases are discussed...