Oliver Mühlemann

Summary

Affiliation: University of Bern
Country: Switzerland

Publications

  1. doi request reprint Recognition and elimination of nonsense mRNA
    Oliver Mühlemann
    Institute of Cell Biology, University of Berne, Baltzerstrasse 4, CH 3012 Bern, Switzerland
    Biochim Biophys Acta 1779:538-49. 2008
  2. doi request reprint Recognition of nonsense mRNA: towards a unified model
    Oliver Mühlemann
    Institute of Cell Biology, University of Berne, Baltzerstrasse 4, CH 3012 Berne, Switzerland
    Biochem Soc Trans 36:497-501. 2008
  3. ncbi request reprint How and where are nonsense mRNAs degraded in mammalian cells?
    Oliver Mühlemann
    Institute of Cell Biology, University of Bern, Bern, Switzerland
    RNA Biol 7:28-32. 2010
  4. ncbi request reprint EJC-independent degradation of nonsense immunoglobulin-mu mRNA depends on 3' UTR length
    Marc Buhler
    Institute of Cell Biology, University of Bern, Baltzerstrasse 4, CH 3012 Bern, Switzerland
    Nat Struct Mol Biol 13:462-4. 2006
  5. ncbi request reprint Transcriptional silencing of nonsense codon-containing immunoglobulin minigenes
    Marc Buhler
    Institute of Cell Biology, University of Bern, Baltzerstrasse 4, CH 3012 Bern, Switzerland
    Mol Cell 18:307-17. 2005
  6. pmc Efficient downregulation of immunoglobulin mu mRNA with premature translation-termination codons requires the 5'-half of the VDJ exon
    Marc Buhler
    Institute of Cell Biology, University of Bern, Baltzerstrasse 4, CH 3012 Bern, Switzerland
    Nucleic Acids Res 32:3304-15. 2004
  7. pmc Alternative splicing induced by nonsense mutations in the immunoglobulin mu VDJ exon is independent of truncation of the open reading frame
    Marc Buhler
    Institute of Cell Biology, University of Bern, Baltzerstrasse 4, CH 3012 Bern, Switzerland
    RNA 11:139-46. 2005
  8. pmc Intranuclear degradation of nonsense codon-containing mRNA
    Marc Buhler
    Institute of Cell Biology, University of Bern, Baltzerstrasse 4, Switzerland
    EMBO Rep 3:646-51. 2002
  9. doi request reprint Nonsense-mediated mRNA decay in human cells: mechanistic insights, functions beyond quality control and the double-life of NMD factors
    Pamela Nicholson
    Institute of Cell Biology, University of Bern, Baltzerstrasse 4, 3012, Bern, Switzerland
    Cell Mol Life Sci 67:677-700. 2010
  10. doi request reprint Nonsense-mediated mRNA decay - mechanisms of substrate mRNA recognition and degradation in mammalian cells
    Christoph Schweingruber
    Dept of Chemistry and Biochemistry, University of Bern, Bern, Switzerland
    Biochim Biophys Acta 1829:612-23. 2013

Collaborators

Detail Information

Publications25

  1. doi request reprint Recognition and elimination of nonsense mRNA
    Oliver Mühlemann
    Institute of Cell Biology, University of Berne, Baltzerstrasse 4, CH 3012 Bern, Switzerland
    Biochim Biophys Acta 1779:538-49. 2008
    ..Sci. 31 (2006) 639-646.[1]]. In this review, we focus on recent results from different model organisms that indicate an evolutionarily conserved mechanism for PTC identification...
  2. doi request reprint Recognition of nonsense mRNA: towards a unified model
    Oliver Mühlemann
    Institute of Cell Biology, University of Berne, Baltzerstrasse 4, CH 3012 Berne, Switzerland
    Biochem Soc Trans 36:497-501. 2008
    ....
  3. ncbi request reprint How and where are nonsense mRNAs degraded in mammalian cells?
    Oliver Mühlemann
    Institute of Cell Biology, University of Bern, Bern, Switzerland
    RNA Biol 7:28-32. 2010
    ..It therefore remains an open question whether NMD in human cells is restricted to a particular cellular location or whether it can be initiated wherever translation of the NMD substrate takes place...
  4. ncbi request reprint EJC-independent degradation of nonsense immunoglobulin-mu mRNA depends on 3' UTR length
    Marc Buhler
    Institute of Cell Biology, University of Bern, Baltzerstrasse 4, CH 3012 Bern, Switzerland
    Nat Struct Mol Biol 13:462-4. 2006
    ..As in yeast, this exon junction complex-independent NMD of Ig-mu mRNAs depends on the distance between the termination codon and the poly(A) tail and suggests an evolutionarily conserved mode of PTC recognition...
  5. ncbi request reprint Transcriptional silencing of nonsense codon-containing immunoglobulin minigenes
    Marc Buhler
    Institute of Cell Biology, University of Bern, Baltzerstrasse 4, CH 3012 Bern, Switzerland
    Mol Cell 18:307-17. 2005
    ..Remarkably, NMTGS is inhibited by overexpression of the putative siRNase 3'hExo, suggesting that siRNA-like molecules are involved in NMTGS...
  6. pmc Efficient downregulation of immunoglobulin mu mRNA with premature translation-termination codons requires the 5'-half of the VDJ exon
    Marc Buhler
    Institute of Cell Biology, University of Bern, Baltzerstrasse 4, CH 3012 Bern, Switzerland
    Nucleic Acids Res 32:3304-15. 2004
    ..Moreover, deletion of this NMD-promoting element from the Ig-micro minigene results in loss of strong NMD...
  7. pmc Alternative splicing induced by nonsense mutations in the immunoglobulin mu VDJ exon is independent of truncation of the open reading frame
    Marc Buhler
    Institute of Cell Biology, University of Bern, Baltzerstrasse 4, CH 3012 Bern, Switzerland
    RNA 11:139-46. 2005
    ....
  8. pmc Intranuclear degradation of nonsense codon-containing mRNA
    Marc Buhler
    Institute of Cell Biology, University of Bern, Baltzerstrasse 4, Switzerland
    EMBO Rep 3:646-51. 2002
    ..Our results are fully consistent with recently reported evidence for nuclear translation and suggest that an important biological role for nuclear ribosomes is the early elimination of nonsense mRNA during a pioneer round of translation...
  9. doi request reprint Nonsense-mediated mRNA decay in human cells: mechanistic insights, functions beyond quality control and the double-life of NMD factors
    Pamela Nicholson
    Institute of Cell Biology, University of Bern, Baltzerstrasse 4, 3012, Bern, Switzerland
    Cell Mol Life Sci 67:677-700. 2010
    ..In recent years, the discovery of additional functions played by several of the NMD factors has further complicated the picture. Therefore, we also review the reported roles of UPF1, SMG1 and SMG6 in other cellular processes...
  10. doi request reprint Nonsense-mediated mRNA decay - mechanisms of substrate mRNA recognition and degradation in mammalian cells
    Christoph Schweingruber
    Dept of Chemistry and Biochemistry, University of Bern, Bern, Switzerland
    Biochim Biophys Acta 1829:612-23. 2013
    ..This article is part of a Special Issue entitled: RNA Decay mechanisms...
  11. pmc Processing bodies are not required for mammalian nonsense-mediated mRNA decay
    Lukas Stalder
    Institute of Cell Biology, University of Berne, 3012 Berne, Switzerland
    RNA 15:1265-73. 2009
    ..Consistent with the recently reported decapping-independent SMG6-mediated endonucleolytic decay of human nonsense mRNAs, our results imply that microscopically detectable P-bodies are not required for mammalian NMD...
  12. doi request reprint SMG6 promotes endonucleolytic cleavage of nonsense mRNA in human cells
    Andrea B Eberle
    Institute of Cell Biology, University of Bern, Baltzerstrasse 4, CH 3012 Bern, Switzerland
    Nat Struct Mol Biol 16:49-55. 2009
    ..Our data lead to a revised mechanistic model for degradation of nonsense mRNA in human cells and suggest that endonucleolytic cleavage is a conserved feature in metazoan NMD...
  13. doi request reprint The meaning of nonsense
    Lukas Stalder
    Institute of Cell Biology, University of Berne, Baltzerstrabetae 4, 3012 Berne, Switzerland
    Trends Cell Biol 18:315-21. 2008
    ..Here, we summarize the latest results and discuss an emerging model for NMD and its implications for the regulation of gene expression...
  14. pmc Posttranscriptional gene regulation by spatial rearrangement of the 3' untranslated region
    Andrea B Eberle
    Institute of Cell Biology, University of Berne, Berne, Switzerland
    PLoS Biol 6:e92. 2008
    ..Most importantly, our results demonstrate that spatial rearrangements of the 3' untranslated region can modulate the NMD pathway and thereby provide a novel mechanism for posttranscriptional gene regulation...
  15. doi request reprint Analysis of nonsense-mediated mRNA decay in mammalian cells
    Pamela Nicholson
    Department for Chemistry, University of Bern, Bern, Switzerland
    Curr Protoc Cell Biol . 2012
    ....
  16. doi request reprint mRNP quality control goes regulatory
    Oliver Mühlemann
    Department of Chemistry and Biochemistry, University of Bern, Freiestrasse 3, CH 3012 Bern, Switzerland
    Trends Genet 28:70-7. 2012
    ..From this perspective, QC and gene regulation represent two outcomes of the same molecular process...
  17. doi request reprint Cutting the nonsense: the degradation of PTC-containing mRNAs
    Pamela Nicholson
    Department of Chemistry and Biochemistry, University of Bern, Freiestrasse 3, CH 3012 Bern, Switzerland
    Biochem Soc Trans 38:1615-20. 2010
    ....
  18. pmc tRNASec is transcribed by RNA polymerase II in Trypanosoma brucei but not in humans
    Eric Aeby
    Department of Chemistry and Biochemistry, University of Bern, Freiestrasse 3, CH 3012 Bern, Switzerland
    Nucleic Acids Res 38:5833-43. 2010
    ..Moreover, intron-encoded tRNAs are present in a number of eukaryotic genomes indicating that Pol-II transcription of tRNAs may not be restricted to trypanosomatids...
  19. doi request reprint eIF4E-bound mRNPs are substrates for nonsense-mediated mRNA decay in mammalian cells
    Simone C Rufener
    Department of Chemistry and Biochemistry, University of Bern, Bern, Switzerland
    Nat Struct Mol Biol 20:710-7. 2013
    ..These results corroborate an emerging unified model for NMD substrate recognition, according to which NMD can ensue at every aberrant translation termination event...
  20. pmc Autoregulation of the nonsense-mediated mRNA decay pathway in human cells
    Hasmik Yepiskoposyan
    Department of Chemistry and Biochemistry, University of Bern, Bern, Switzerland
    RNA 17:2108-18. 2011
    ..Using reporter gene assays, we demonstrated that the long 3' UTRs of UPF1, SMG5, and SMG7 mRNAs are the main NMD-inducing features of these mRNAs, suggesting that long 3' UTRs might be a frequent trigger of NMD...
  21. pmc Equal transcription rates of productively and nonproductively rearranged immunoglobulin mu heavy chain alleles in a pro-B cell line
    Andrea B Eberle
    Institute of Cell Biology, University of Bern, 3012 Bern, Switzerland
    RNA 15:1021-8. 2009
    ..Altogether, we found no evidence for transcriptional silencing of the PTC+ allele in this pro-B cell line; hence, the efficient down-regulation of the PTC+ Ig-mu mRNA results entirely from NMD...
  22. ncbi request reprint Transcriptional silencing of nonsense codon-containing immunoglobulin micro genes requires translation of its mRNA
    Lukas Stalder
    Institute of Cell Biology, University of Berne, Baltzerstrasse 4, CH 3012 Bern, Switzerland
    J Biol Chem 282:16079-85. 2007
    ..Collectively, our data indicate that NMTGS and NMD are linked, relying on the same mechanism for PTC recognition, and that the NMTGS pathway branches from the NMD pathway at a step after Upf1 function...
  23. doi request reprint Translation-dependent displacement of UPF1 from coding sequences causes its enrichment in 3' UTRs
    David Zünd
    1 Department of Chemistry and Biochemistry, University of Bern, Bern, Switzerland 2 Graduate School for Cellular and Biomedical Sciences, University of Bern, Bern, Switzerland
    Nat Struct Mol Biol 20:936-43. 2013
    ....
  24. pmc A GFP-based reporter system to monitor nonsense-mediated mRNA decay
    Alexandra Paillusson
    Institute of Cell Biology, University of Bern CH 3012 Bern, Switzerland
    Nucleic Acids Res 33:e54. 2005
    ..With these properties, our GFP-based NMD reporter system could be used for large-scale screenings to identify NMD-inhibiting drugs or NMD-deficient mutant cells...
  25. pmc Nonsense-associated alternative splicing of T-cell receptor beta genes: no evidence for frame dependence
    Fabio Mohn
    Institute of Cell Biology, University of Bern, Baltzerstrasse 4, CH 3012 Bern, Switzerland
    RNA 11:147-56. 2005
    ..Our study thus contradicts the previously reported PTC specificity of TCR-beta NAS and points out the need for systematically testing the PTC specificity in other cases where NAS has been observed...