Research Topics
Genomes and Genes | Peter J MeierSummaryAffiliation: University of Zurich Country: Switzerland Publications
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Publications
Identification and localization of sodium-phosphate cotransporters in hepatocytes and cholangiocytes of rat liverPascal Frei
Division of Clinical Pharmacology and Toxicology, Dept of Medicine, Univ Hospital Zurich, Ramistrasse 100, CH 8091 Zurich, Switzerland
Am J Physiol Gastrointest Liver Physiol 288:G771-8. 2005..We conclude that NaPi-IIb is most probably involved in the reabsorption of P(i) from primary hepatic bile and thus might play an important role in the regulation of biliary P(i) concentration...- Bile salt transportersPeter J Meier
Division of Clinical Pharmacology and Toxicology, Department of Medicine, University Hospital, Zurich, 8091 Switzerland
Annu Rev Physiol 64:635-61. 2002..Furthermore, defective expression and function of bile salt transporters have been recognized as important causes for various cholestatic liver diseases... - Differential expression of bile salt and organic anion transporters in developing rat liverBo Gao
Division of Clinical Pharmacology and Toxicology, Department of Medicine, University Hospital, CH 8091 Zurich, Switzerland
J Hepatol 41:201-8. 2004..Here, we investigated the ontogenesis of the polar expression of hepatocellular organic anion and bile salt transport systems in rat liver... 
Increased susceptibility for intrahepatic cholestasis of pregnancy and contraceptive-induced cholestasis in carriers of the 1331T>C polymorphism in the bile salt export pumpYvonne Meier
Division of Clinical Pharmacology and Toxicology, Department of Internal Medicine, University Hospital Zurich, Zurich, Switzerland
World J Gastroenterol 14:38-45. 2008....- Hepatobiliary transporters and drug-induced cholestasisChristiane Pauli-Magnus
Division of Clinical Pharmacology and Toxicology, University Hospital Zurich, Zurich, Switzerland
Hepatology 44:778-87. 2006..This review summarizes current knowledge about the function of hepatobiliary uptake and efflux systems and discusses factors that might predispose to drug-induced cholestasis... - The bile salt export pumpBruno Stieger
Department of Medicine, Institute of Clinical Pharmacology and Toxicology, University Hospital, Zurich, Switzerland
Pflugers Arch 453:611-20. 2007..Furthermore, many genetic variants of Bsep are known, some of which potentially render individuals susceptible to acquired forms of liver disease... 
Pharmacogenetics of drug transporters in the enterohepatic circulationBruno Stieger
Division of Clinical Pharmacology and Toxicology, University Hospital, 8091 Zurich, Switzerland
Pharmacogenomics 12:611-31. 2011..This will require a combination of pharmacogenetics of drug transporters, drug metabolism and pharmacodynamics of the respective drugs...- Interindividual variability of canalicular ATP-binding-cassette (ABC)-transporter expression in human liverYvonne Meier
Division of Clinical Pharmacology and Toxicology, Department of Medicine, University Hospital, Zurich, Switzerland
Hepatology 44:62-74. 2006..Furthermore, data suggest a polymorphic transporter expression pattern, which might constitute a risk factor for the development of acquired forms of cholestatic liver diseases... - Localization of organic anion transporting polypeptides in the rat and human ciliary body epitheliumBo Gao
Division of Clinical Pharmacology and Toxicology, Department of Medicine, University Hospital Zurich, CH 8091 Zurich, Switzerland
Exp Eye Res 80:61-72. 2005.... - Incidence of drug-induced liver injury in medical inpatientsYvonne Meier
Division of Clinical Pharmacology and Toxicology, Department of Medicine, University Hospital Zurich, CH-8091, , Switzerland
Eur J Clin Pharmacol 61:135-43. 2005..Incidences of DILI were highest for antineoplastic agents and tuberculostatics. DILI is frequently missed and, therefore, DILI detection by diagnoses will result in misleadingly low incidence rates... - ABC-transporters are localized in caveolin-1-positive and reggie-1-negative and reggie-2-negative microdomains of the canalicular membrane in rat hepatocytesManfred G Ismair
Division of Clinical Pharmacology and Toxicology, Department of Medicine, University Hospital, Zurich, Switzerland
Hepatology 49:1673-82. 2009..quot;Lubrol-microdomains" contain the machinery for canalicular bile formation and may be the starting place for canalicular lipid secretion... - Pharmacogenetics of hepatocellular transportersChristiane Pauli-Magnus
Department of Medicine, University Hospital, Zurich, Switzerland
Pharmacogenetics 13:189-98. 2003.... - Hepatocyte transplantation: potential of hepatocyte progenitor cells and bone marrow derived stem cellsBruno Stieger
Division of Clinical Pharmacology and Toxicology, Department of Medicine, University Hospital, Zurich, Switzerland
Swiss Med Wkly 136:552-6. 2006..Such cells may be a source for hepatocyte transplantation and hence have the potential to offer a novel therapy for liver failure... - Hepatocellular transporters and cholestasisChristiane Pauli-Magnus
Division of Clinical Pharmacology and Toxicology, University Hospital Zurich, Zurich, Switzerland
J Clin Gastroenterol 39:S103-10. 2005..This overview summarizes the physiologic function and regulation of human hepatobiliary transport systems and discusses the impact of their genetic variations for the pathophysiology of different cholestatic syndromes... - Small hepatocytes in culture develop polarized transporter expression and differentiationMarguerite Anne Sidler Pfändler
Division of Clinical Pharmacology and Toxicology, Department of Medicine, University Hospital, 8091 Zurich, Switzerland
J Cell Sci 117:4077-87. 2004.... - Enterohepatic bile salt transporters in normal physiology and liver diseaseGerd A Kullak-Ublick
Division of Clinical Pharmacology and Toxicology, Department of Internal Medicine, University Hospital, Zurich, Switzerland
Gastroenterology 126:322-42. 2004..Finally, dysfunction of individual bile salt transporters such as BSEP, on account of genetic mutations, steric inhibition, suppression of gene expression, or disturbed signaling, is an important cause of cholestatic liver disease... - No clinically relevant drug interaction between paracetamol and phenprocoumon based on a pharmacoepidemiological cohort study in medical inpatientsKarin Fattinger
Dept of Medicine, University Hospital, Zurich, Switzerland
Eur J Clin Pharmacol 57:863-7. 2002..In many European countries, phenprocoumon and not warfarin is used as an anticoagulant. However, the effects of paracetamol on the anticoagulant effects of phenprocoumon have so far not been evaluated... - The human organic anion transporter 2 gene is transactivated by hepatocyte nuclear factor-4 alpha and suppressed by bile acidsKatrin Popowski
Laboratory of Molecular Gastroenterology and Hepatology, University Hospital, Zurich, Switzerland
Mol Pharmacol 67:1629-38. 2005..Hepatic uptake of hOAT2 substrates may thus be decreased in disease conditions associated with elevated intracellular levels of bile acids... - Adverse drug events caused by medication errors in medical inpatientsBeat Hardmeier
Division of Clinical Pharmacology and Toxicology, Department of Medicine, University Hospital, , Switzerland
Swiss Med Wkly 134:664-70. 2004..In contrast, eADEs accounted for 30% of ADE-related hospital admissions. Hence, in medical inpatients, eADEs represented a small fraction of total incident ADEs, whereas they contributed significantly to hospital admissions... - Interactions of rifamycin SV and rifampicin with organic anion uptake systems of human liverStephan R Vavricka
Division of Clinical Pharmacology and Toxicology, Department of Medicine, University Hospital, , Switzerland
Hepatology 36:164-72. 2002..Inhibition of human liver OATPs can explain the previously observed effects of rifamycin SV and rifampicin on hepatic organic anion elimination... - Organic anion transporting polypeptides of the OATP/ SLC21 family: phylogenetic classification as OATP/ SLCO superfamily, new nomenclature and molecular/functional propertiesBruno Hagenbuch
Division of Clinical Pharmacology and Toxicology, Department of Medicine, University Hospital, 8091, Zurich, Switzerland
Pflugers Arch 447:653-65. 2004.... - Functional expression of the canalicular bile salt export pump of human liverJohannes Noe
Division of Clinical Pharmacology and Toxicology, Department of Medicine, University Hospital, Zurich, Switzerland
Gastroenterology 123:1659-66. 2002..Therefore, the aim of this study was to functionally characterize human BSEP... - Pharmacokinetics of high doses of intramuscular and oral heroin in narcotic addictsFrançois Girardin
Division of Clinical Pharmacology and Toxicology, Department of Medicine, University Hospital, Zurich, Switzerland
Clin Pharmacol Ther 74:341-52. 2003..Therefore we characterized the pharmacokinetics of intramuscular and oral diacetylmorphine in the high dose range usually required in narcotic addicts... - Human organic anion transporting polypeptide 8 promoter is transactivated by the farnesoid X receptor/bile acid receptorDiana Jung
Division of Clinical Pharmacology and Toxicology, University Hospital, Zurich, Switzerland
Gastroenterology 122:1954-66. 2002..We investigated whether OATP8 gene expression is regulated by the nuclear receptors farnesoid X receptor/bile acid receptor (FXR/BAR; NR1H4), pregnane X receptor (PXR), or liver X receptor (LXR)... - Localization of organic anion transport protein 2 in the apical region of rat retinal pigment epitheliumBo Gao
Clinical Pharmacology and Toxicology, Department of Medicine, University Hospital, , Switzerland
Invest Ophthalmol Vis Sci 43:510-4. 2002..A2E is a competitive inhibitor of Oatp2-mediated substrate transport, suggesting that A2E or A2E-like compounds and some retinoids may be substrates for Oatp2 transport... - Functional characterization of the mouse organic-anion-transporting polypeptide 2Jessica E van Montfoort
Division of Clinical Pharmacology and Toxicology, Department of Medicine, University Hospital, Ramistr 100, CH 8091 Zurich, Switzerland
Biochim Biophys Acta 1564:183-8. 2002..Northern blot analysis demonstrated a predominant expression in the liver with additional signals in kidney and brain. Using fluorescence in situ hybridization, the Oatp2 gene (gene symbol Slc21a5) was mapped to chromosome 6G1-G3... - Regulation of rat organic anion transporters in bile salt-induced cholestatic hepatitis: effect of ursodeoxycholateDaniel Rost
Department of Gastroenterology, University Hospital, Heidelberg, Germany
Hepatology 38:187-95. 2003..In conclusion, we show that CA feeding may cause cholestasis associated with a posttranscriptional down-regulation of Oatp4. UDCA may prevent impairment of hepatic function by restoring hepatic transporter expression... - Expression of rat hepatic multidrug resistance-associated proteins and organic anion transporters in pregnancyJingsong Cao
Graduate Center for Toxicology, Chandler Medical Center, University of Kentucky, Lexington, Kentucky 40536 - 0305, USA
Am J Physiol Gastrointest Liver Physiol 283:G757-66. 2002..These data also demonstrate that decreased Mrp2 expression is not necessarily accompanied by increased Mrp3 expression... - Mechanisms of impaired biliary excretion of acetaminophen glucuronide after acute phenobarbital treatment or phenobarbital pretreatmentHao Xiong
Division of Drug Delivery and Disposition, School of Pharmacy, CB 7360, Beard Hall, University of North Carolina, Chapel Hill, North Carolina 27599-7360, USA
Drug Metab Dispos 30:962-9. 2002..However, impaired biliary excretion of AG after PB pretreatment may be attributed primarily to the induction of hepatic Mrp3 by PB... - Functional analysis of the rat bile salt export pump gene promoterThomas Gerloff
Institute of Clinical Pharmacology, Charite University Medical Center, Humboldt University, Berlin, Germany
Eur J Biochem 269:3495-503. 2002..FXR was a major regulatory factor, mediating bile acid feed-back stimulation of Bsep transcription... - Canalicular bile formation: beyond single transporter functionsPeter J Meier
J Hepatol 37:272-3. 2002 - Enterohepatic transport of bile salts and genetics of cholestasisChristiane Pauli-Magnus
Division of Clinical Pharmacology and Toxicology, University Hospital Zurich, , E RAE 09, 8091 Zurich, Switzerland
J Hepatol 43:342-57. 2005 - Impaired expression and function of the bile salt export pump due to three novel ABCB11 mutations in intrahepatic cholestasisJohannes Noe
Division of Clinical Pharmacology and Toxicology, Department of Internal Medicine, University Hospital Zurich, Ramistrasse 100, E RAE 09, 8091 Zurich, Switzerland
J Hepatol 43:536-43. 2005..We functionally characterized novel ABCB11 mutations encountered in two patients with a PFIC2 and a BRIC2 phenotype, respectively... - Carriers involved in targeting the cytostatic bile acid-cisplatin derivatives cis-diammine-chloro-cholylglycinate-platinum(II) and cis-diammine-bisursodeoxycholate-platinum(II) toward liver cellsOscar Briz
Department of Physiology and Pharmacology, University of Salamanca, Salamanca, Spain
Mol Pharmacol 61:853-60. 2002..These results suggest a role for carriers of organic anions and cations in Bamet-R2 and Bamet-UD2 uptake, which may determine their ability to accumulate in liver tumor cells and/or be taken up and efficiently excreted by hepatocytes... - Prediction of in vivo biliary clearance from the in vitro transcellular transport of organic anions across a double-transfected Madin-Darby canine kidney II monolayer expressing both rat organic anion transporting polypeptide 4 and multidrug resistance asMakoto Sasaki
Department of Biopharmaceutics, School of Pharmaceutical Sciences, The University of Tokyo, 7-3-1 Hongo, Bunkyo-ku, Tokyo 113-0033, Japan
Mol Pharmacol 66:450-9. 2004..The double-transfected MDCK II monolayer may be useful in analyzing the hepatic vectorial transport of organic anions and in predicting in vivo biliary clearance... - P-glycoprotein expression, localization, and function in sandwich-cultured primary rat and human hepatocytes: relevance to the hepatobiliary disposition of a model opioid peptideKeith A Hoffmaster
Division of Drug Delivery and Disposition, School of Pharmacy, University of North Carolina, Chapel Hill, North Carolina 27599, USA
Pharm Res 21:1294-302. 2004..CONCLUSIONS: These studies indicate that SC hepatocytes repolarize and traffic functional canalicular transport proteins to the appropriate cellular domain... - Role of liver-enriched transcription factors and nuclear receptors in regulating the human, mouse, and rat NTCP geneDiana Jung
Division of Gastroenterology and Hepatology, Dept of Internal Medicine, Univ Hospital, CH 8091 Zurich, Switzerland
Am J Physiol Gastrointest Liver Physiol 286:G752-61. 2004..Bile acids may regulate NTCP/Ntcp indirectly by modulating the capacity of nuclear factors to activate gene expression... - Physiological characteristics of allo-cholic acidMaria E Mendoza
Department of Physiology and Pharmacology, University of Salamanca, Spain
J Lipid Res 44:84-92. 2003.... - Gd-BOPTA transport into rat hepatocytes: pharmacokinetic analysis of dynamic magnetic resonance images using a hollow-fiber bioreactorCorinne Planchamp
Geneva University Hospitals, Radiology Department, Geneva, Switzerland
Invest Radiol 39:506-15. 2004..To investigate the transport of the hepatobiliary magnetic resonance (MR) imaging contrast agent Gd-BOPTA into rat hepatocytes... - Phenobarbital alters hepatic Mrp2 function by direct and indirect interactionsNita J Patel
Division of Drug Delivery and Disposition, School of Pharmacy, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina, USA
Mol Pharmacol 64:154-9. 2003.... - Characterization of two splice variants of human organic anion transporting polypeptide 3A1 isolated from human brainRobert D Huber
Univ Hospital, Dept of Internal Medicine, Institute of Clinical Pharmacology and Toxicology, 8091 Zurich, Switzerland
Am J Physiol Cell Physiol 292:C795-806. 2007.... - Sequence analysis of bile salt export pump (ABCB11) and multidrug resistance p-glycoprotein 3 (ABCB4, MDR3) in patients with intrahepatic cholestasis of pregnancyChristiane Pauli-Magnus
Department of Internal Medicine, University Hospital Zurich, Zurich Switzerland
Pharmacogenetics 14:91-102. 2004.... - Gender difference in the Oatp1-mediated tubular reabsorption of estradiol 17beta-D-glucuronide in ratsYasumasa Gotoh
Graduate School of Pharmaceutical Sciences, University of Tokyo, Tokyo 113 0033, Japan
Am J Physiol Endocrinol Metab 282:E1245-54. 2002..These results suggest that urinary E(2)-17betaG excretion is subject to hormonal regulation and that the large gender difference can be explained by regulation in Oatp1-mediated reabsorption... - Linkage between a new splicing site mutation in the MDR3 alias ABCB4 gene and intrahepatic cholestasis of pregnancyGudrun Schneider
Department of Internal Medicine I, University of Bonn, Bonn, Germany
Hepatology 45:150-8. 2007..00341). CONCLUSION: This study demonstrates that splicing mutations in the MDR3 gene can cause ICP with normal gamma-GT and may be associated with stillbirths and gallstone disease... - Mutations and polymorphisms in the bile salt export pump and the multidrug resistance protein 3 associated with drug-induced liver injuryCarmen Lang
Division of Clinical Pharmacology and Toxicology, University Hospital Zurich, Switzerland
Pharmacogenet Genomics 17:47-60. 2007..The aim of this study was therefore to describe the extent of genetic variability in ABCB11 and ABCB4 in patients with drug-induced liver injury and to in vitro functionally characterize newly detected ABCB11 mutations and polymorphisms... - Comparative inhibitory effects of different compounds on rat oatpl (slc21a1)- and Oatp2 (Slc21a5)-mediated transportYoshihisa Shitara
School of Pharmaceutical Sciences, Kitasato University, Tokyo, Japan
Pharm Res 19:147-53. 2002..These selective inhibitors may be used at appropriate concentrations to estimate the maximum contribution of Oatp1 or Oatp2 to the total substrate uptake into rat hepatocytes... - Organic anion transporting polypeptides, cholestasis, and nuclear receptorsGerd A Kullak-Ublick
Hepatology 35:732-4. 2002 - Vectorial transport of bile salts across MDCK cells expressing both rat Na+-taurocholate cotransporting polypeptide and rat bile salt export pumpSachiko Mita
Graduate School of Pharmaceutical Sciences, The University of Tokyo, Bunkyo ku, Tokyo 113 0033, Japan
Am J Physiol Gastrointest Liver Physiol 288:G159-67. 2005..This double-expressing system can be used as a model to clarify vectorial transport of bile salts across hepatocytes under physiological conditions... - Functional analysis of the extracellular cysteine residues in the human organic anion transporting polypeptide, OATP2B1Emanuel Hänggi
Division of Clinical Pharmacology and Toxicology, University Hospital Zurich, 100 Ramistrasse, Zurich 8091, Switzerland
Mol Pharmacol 70:806-17. 2006..Our findings show that the trafficking and function of OATP2B1 is vulnerable to changes in the cysteine residues of extracellular loop IX-X... - Coordinate transcriptional regulation of transport and metabolismJyrki J Eloranta
Division of Gastroenterology and Hepatology, University Hospital, , Switzerland
Methods Enzymol 400:511-30. 2005..The fine-tuning of transcriptional control of drug and bile acid homeostasis depends on regulated interactions of specific nuclear receptors with their target genes... - Regulation of basolateral organic anion transporters in ethinylestradiol-induced cholestasis in the ratAndreas Geier
Department of Internal Medicine III, University of Technology Aachen, Pauwelsstrasse 30, 52074 Aachen, Germany
Biochim Biophys Acta 1609:87-94. 2003..Reduction in transporter gene expression seems to be mediated by a diminished nuclear binding activity of transactivators such as HNF1, C/EBP and PXR by estrogens... - Effect of dexamethasone treatment on the expression and function of transport proteins in sandwich-cultured rat hepatocytesRyan Z Turncliff
Division of Drug Delivery and Disposition, School of Pharmacy, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599-7360, USA
Drug Metab Dispos 32:834-9. 2004..Modest alterations in hepatic transport protein function were consistent with changes in protein expression... - Metal-responsive transcription factor-1 (MTF-1) is essential for embryonic liver development and heavy metal detoxification in the adult liverYing Wang
Institute of Molecular Biology, University of Zurich, Switzerland
FASEB J 18:1071-9. 2004..Together, these findings point to a critical role of MTF-1 in embryonic liver formation, heavy metal toxicity, and hematopoiesis... - Gender difference in the urinary excretion of organic anions in ratsYukio Kato
Graduate School of Pharmaceutical Sciences, University of Tokyo, 7 3 1 Hongo, Bunkyoi ku, Tokyo 113 0033, Japan
J Pharmacol Exp Ther 302:483-9. 2002.... - Expression and functional involvement of organic anion transporting polypeptide subtype 3 (Slc21a7) in rat choroid plexusHiroyuki Kusuhara
Department of Biopharmaceutics, Graduate School of Pharmaceutical Sciences, The University of Tokyo, 7 3 1 Hongo, Bunkyo ku, Tokyo 113 0033, Japan
Pharm Res 20:720-7. 2003..The purpose of this study is to compare the substrate specificity of the transporter in the CP with those of rat organic anion transporting polypeptide 1 (rOatp1) and rOatp3... - Hepatobiliary organic anion transporters are differentially regulated in acute toxic liver injury induced by carbon tetrachlorideAndreas Geier
Department of Internal Medicine III, University of Technology, Pauwelsstrasse 30, 52074 Aachen, Germany
J Hepatol 37:198-205. 2002..Maintained binding activity of RXRalpha:RARalpha may explain differences in Mrp2 expression... - BSEP and MDR3 haplotype structure in healthy Caucasians, primary biliary cirrhosis and primary sclerosing cholangitisChristiane Pauli-Magnus
Division of Clinical Pharmacology and Toxicology, University Hospital Zurich, Ramistrasse 100, A 8091 Zurich, Switzerland
Hepatology 39:779-91. 2004..Although an impact of rare variants on BSEP and MDR3 function cannot be ruled out, our data do not support a strong role of BSEP and MDR3 genetic variations in the pathogenesis of PBC and PSC... - The human organic anion transporting polypeptide 8 (SLCO1B3) gene is transcriptionally repressed by hepatocyte nuclear factor 3beta in hepatocellular carcinomaStephan R Vavricka
Laboratory of Molecular Gastroenterology and Hepatology, Division of Gastroenterology and Hepatology, University Hospital, CH 8091 Zurich, Switzerland
J Hepatol 40:212-8. 2004..Our aim was to study the expression and regulation of OATP8 (OATP1B3, SLC21A8/SLCO1B3) and OATP-C (OATP1B1, SLC21A6/SLCO1B1) in hepatocellular carcinomas (HCC)... - Magnetic resonance imaging with hepatospecific contrast agents in cirrhotic rat liversCorinne Planchamp
, , Geneva, Switzerland
Invest Radiol 40:187-94. 2005..CONCLUSION: During biliary cirrhosis, Gd-BOPTA-induced SI enhancement could not be related to the hepatic expression of transporters...