Peter J Meier

Summary

Affiliation: University of Zurich
Country: Switzerland

Publications

  1. ncbi request reprint Identification and localization of sodium-phosphate cotransporters in hepatocytes and cholangiocytes of rat liver
    Pascal Frei
    Division of Clinical Pharmacology and Toxicology, Dept of Medicine, Univ Hospital Zurich, Ramistrasse 100, CH 8091 Zurich, Switzerland
    Am J Physiol Gastrointest Liver Physiol 288:G771-8. 2005
  2. ncbi request reprint Bile salt transporters
    Peter J Meier
    Division of Clinical Pharmacology and Toxicology, Department of Medicine, University Hospital, Zurich, 8091 Switzerland
    Annu Rev Physiol 64:635-61. 2002
  3. ncbi request reprint Differential expression of bile salt and organic anion transporters in developing rat liver
    Bo Gao
    Division of Clinical Pharmacology and Toxicology, Department of Medicine, University Hospital, CH 8091 Zurich, Switzerland
    J Hepatol 41:201-8. 2004
  4. pmc Increased susceptibility for intrahepatic cholestasis of pregnancy and contraceptive-induced cholestasis in carriers of the 1331T>C polymorphism in the bile salt export pump
    Yvonne Meier
    Division of Clinical Pharmacology and Toxicology, Department of Internal Medicine, University Hospital Zurich, Zurich, Switzerland
    World J Gastroenterol 14:38-45. 2008
  5. ncbi request reprint Hepatobiliary transporters and drug-induced cholestasis
    Christiane Pauli-Magnus
    Division of Clinical Pharmacology and Toxicology, University Hospital Zurich, Zurich, Switzerland
    Hepatology 44:778-87. 2006
  6. ncbi request reprint The bile salt export pump
    Bruno Stieger
    Department of Medicine, Institute of Clinical Pharmacology and Toxicology, University Hospital, Zurich, Switzerland
    Pflugers Arch 453:611-20. 2007
  7. doi request reprint Pharmacogenetics of drug transporters in the enterohepatic circulation
    Bruno Stieger
    Division of Clinical Pharmacology and Toxicology, University Hospital, 8091 Zurich, Switzerland
    Pharmacogenomics 12:611-31. 2011
  8. ncbi request reprint Interindividual variability of canalicular ATP-binding-cassette (ABC)-transporter expression in human liver
    Yvonne Meier
    Division of Clinical Pharmacology and Toxicology, Department of Medicine, University Hospital, Zurich, Switzerland
    Hepatology 44:62-74. 2006
  9. ncbi request reprint Localization of organic anion transporting polypeptides in the rat and human ciliary body epithelium
    Bo Gao
    Division of Clinical Pharmacology and Toxicology, Department of Medicine, University Hospital Zurich, CH 8091 Zurich, Switzerland
    Exp Eye Res 80:61-72. 2005
  10. ncbi request reprint Incidence of drug-induced liver injury in medical inpatients
    Yvonne Meier
    Division of Clinical Pharmacology and Toxicology, Department of Medicine, University Hospital Zurich, CH 8091, Zurich, Switzerland
    Eur J Clin Pharmacol 61:135-43. 2005

Collaborators

Detail Information

Publications59

  1. ncbi request reprint Identification and localization of sodium-phosphate cotransporters in hepatocytes and cholangiocytes of rat liver
    Pascal Frei
    Division of Clinical Pharmacology and Toxicology, Dept of Medicine, Univ Hospital Zurich, Ramistrasse 100, CH 8091 Zurich, Switzerland
    Am J Physiol Gastrointest Liver Physiol 288:G771-8. 2005
    ..We conclude that NaPi-IIb is most probably involved in the reabsorption of P(i) from primary hepatic bile and thus might play an important role in the regulation of biliary P(i) concentration...
  2. ncbi request reprint Bile salt transporters
    Peter J Meier
    Division of Clinical Pharmacology and Toxicology, Department of Medicine, University Hospital, Zurich, 8091 Switzerland
    Annu Rev Physiol 64:635-61. 2002
    ..Furthermore, defective expression and function of bile salt transporters have been recognized as important causes for various cholestatic liver diseases...
  3. ncbi request reprint Differential expression of bile salt and organic anion transporters in developing rat liver
    Bo Gao
    Division of Clinical Pharmacology and Toxicology, Department of Medicine, University Hospital, CH 8091 Zurich, Switzerland
    J Hepatol 41:201-8. 2004
    ..Here, we investigated the ontogenesis of the polar expression of hepatocellular organic anion and bile salt transport systems in rat liver...
  4. pmc Increased susceptibility for intrahepatic cholestasis of pregnancy and contraceptive-induced cholestasis in carriers of the 1331T>C polymorphism in the bile salt export pump
    Yvonne Meier
    Division of Clinical Pharmacology and Toxicology, Department of Internal Medicine, University Hospital Zurich, Zurich, Switzerland
    World J Gastroenterol 14:38-45. 2008
    ....
  5. ncbi request reprint Hepatobiliary transporters and drug-induced cholestasis
    Christiane Pauli-Magnus
    Division of Clinical Pharmacology and Toxicology, University Hospital Zurich, Zurich, Switzerland
    Hepatology 44:778-87. 2006
    ..This review summarizes current knowledge about the function of hepatobiliary uptake and efflux systems and discusses factors that might predispose to drug-induced cholestasis...
  6. ncbi request reprint The bile salt export pump
    Bruno Stieger
    Department of Medicine, Institute of Clinical Pharmacology and Toxicology, University Hospital, Zurich, Switzerland
    Pflugers Arch 453:611-20. 2007
    ..Furthermore, many genetic variants of Bsep are known, some of which potentially render individuals susceptible to acquired forms of liver disease...
  7. doi request reprint Pharmacogenetics of drug transporters in the enterohepatic circulation
    Bruno Stieger
    Division of Clinical Pharmacology and Toxicology, University Hospital, 8091 Zurich, Switzerland
    Pharmacogenomics 12:611-31. 2011
    ..This will require a combination of pharmacogenetics of drug transporters, drug metabolism and pharmacodynamics of the respective drugs...
  8. ncbi request reprint Interindividual variability of canalicular ATP-binding-cassette (ABC)-transporter expression in human liver
    Yvonne Meier
    Division of Clinical Pharmacology and Toxicology, Department of Medicine, University Hospital, Zurich, Switzerland
    Hepatology 44:62-74. 2006
    ..Furthermore, data suggest a polymorphic transporter expression pattern, which might constitute a risk factor for the development of acquired forms of cholestatic liver diseases...
  9. ncbi request reprint Localization of organic anion transporting polypeptides in the rat and human ciliary body epithelium
    Bo Gao
    Division of Clinical Pharmacology and Toxicology, Department of Medicine, University Hospital Zurich, CH 8091 Zurich, Switzerland
    Exp Eye Res 80:61-72. 2005
    ....
  10. ncbi request reprint Incidence of drug-induced liver injury in medical inpatients
    Yvonne Meier
    Division of Clinical Pharmacology and Toxicology, Department of Medicine, University Hospital Zurich, CH 8091, Zurich, Switzerland
    Eur J Clin Pharmacol 61:135-43. 2005
    ..Drug-induced liver injury (DILI) is a common concern. However, data on DILI epidemiology in inpatients are sparse...
  11. doi request reprint ABC-transporters are localized in caveolin-1-positive and reggie-1-negative and reggie-2-negative microdomains of the canalicular membrane in rat hepatocytes
    Manfred G Ismair
    Division of Clinical Pharmacology and Toxicology, Department of Medicine, University Hospital, Zurich, Switzerland
    Hepatology 49:1673-82. 2009
    ..quot;Lubrol-microdomains" contain the machinery for canalicular bile formation and may be the starting place for canalicular lipid secretion...
  12. ncbi request reprint Pharmacogenetics of hepatocellular transporters
    Christiane Pauli-Magnus
    Department of Medicine, University Hospital, Zurich, Switzerland
    Pharmacogenetics 13:189-98. 2003
    ....
  13. ncbi request reprint Hepatocyte transplantation: potential of hepatocyte progenitor cells and bone marrow derived stem cells
    Bruno Stieger
    Division of Clinical Pharmacology and Toxicology, Department of Medicine, University Hospital, Zurich, Switzerland
    Swiss Med Wkly 136:552-6. 2006
    ..Such cells may be a source for hepatocyte transplantation and hence have the potential to offer a novel therapy for liver failure...
  14. ncbi request reprint Hepatocellular transporters and cholestasis
    Christiane Pauli-Magnus
    Division of Clinical Pharmacology and Toxicology, University Hospital Zurich, Zurich, Switzerland
    J Clin Gastroenterol 39:S103-10. 2005
    ..This overview summarizes the physiologic function and regulation of human hepatobiliary transport systems and discusses the impact of their genetic variations for the pathophysiology of different cholestatic syndromes...
  15. ncbi request reprint Small hepatocytes in culture develop polarized transporter expression and differentiation
    Marguerite Anne Sidler Pfändler
    Division of Clinical Pharmacology and Toxicology, Department of Medicine, University Hospital, 8091 Zurich, Switzerland
    J Cell Sci 117:4077-87. 2004
    ....
  16. ncbi request reprint Enterohepatic bile salt transporters in normal physiology and liver disease
    Gerd A Kullak-Ublick
    Division of Clinical Pharmacology and Toxicology, Department of Internal Medicine, University Hospital, Zurich, Switzerland
    Gastroenterology 126:322-42. 2004
    ..Finally, dysfunction of individual bile salt transporters such as BSEP, on account of genetic mutations, steric inhibition, suppression of gene expression, or disturbed signaling, is an important cause of cholestatic liver disease...
  17. ncbi request reprint No clinically relevant drug interaction between paracetamol and phenprocoumon based on a pharmacoepidemiological cohort study in medical inpatients
    Karin Fattinger
    Dept of Medicine, University Hospital, Zurich, Switzerland
    Eur J Clin Pharmacol 57:863-7. 2002
    ..In many European countries, phenprocoumon and not warfarin is used as an anticoagulant. However, the effects of paracetamol on the anticoagulant effects of phenprocoumon have so far not been evaluated...
  18. ncbi request reprint The human organic anion transporter 2 gene is transactivated by hepatocyte nuclear factor-4 alpha and suppressed by bile acids
    Katrin Popowski
    Laboratory of Molecular Gastroenterology and Hepatology, University Hospital, Zurich, Switzerland
    Mol Pharmacol 67:1629-38. 2005
    ..Hepatic uptake of hOAT2 substrates may thus be decreased in disease conditions associated with elevated intracellular levels of bile acids...
  19. ncbi request reprint Adverse drug events caused by medication errors in medical inpatients
    Beat Hardmeier
    Division of Clinical Pharmacology and Toxicology, Department of Medicine, University Hospital, Zurich, Switzerland
    Swiss Med Wkly 134:664-70. 2004
    ..In view of growing concern in recent years regarding medication errors as causes of adverse drug events (ADEs), we explore the frequency and characteristics of error-associated ADEs in medical inpatients...
  20. ncbi request reprint Interactions of rifamycin SV and rifampicin with organic anion uptake systems of human liver
    Stephan R Vavricka
    Division of Clinical Pharmacology and Toxicology, Department of Medicine, University Hospital, CH 8091 Zurich, Switzerland
    Hepatology 36:164-72. 2002
    ..Inhibition of human liver OATPs can explain the previously observed effects of rifamycin SV and rifampicin on hepatic organic anion elimination...
  21. ncbi request reprint Organic anion transporting polypeptides of the OATP/ SLC21 family: phylogenetic classification as OATP/ SLCO superfamily, new nomenclature and molecular/functional properties
    Bruno Hagenbuch
    Division of Clinical Pharmacology and Toxicology, Department of Medicine, University Hospital, 8091, Zurich, Switzerland
    Pflugers Arch 447:653-65. 2004
    ....
  22. ncbi request reprint Functional expression of the canalicular bile salt export pump of human liver
    Johannes Noe
    Division of Clinical Pharmacology and Toxicology, Department of Medicine, University Hospital, Zurich, Switzerland
    Gastroenterology 123:1659-66. 2002
    ..Therefore, the aim of this study was to functionally characterize human BSEP...
  23. ncbi request reprint Pharmacokinetics of high doses of intramuscular and oral heroin in narcotic addicts
    François Girardin
    Division of Clinical Pharmacology and Toxicology, Department of Medicine, University Hospital, Zurich, Switzerland
    Clin Pharmacol Ther 74:341-52. 2003
    ..Therefore we characterized the pharmacokinetics of intramuscular and oral diacetylmorphine in the high dose range usually required in narcotic addicts...
  24. ncbi request reprint Human organic anion transporting polypeptide 8 promoter is transactivated by the farnesoid X receptor/bile acid receptor
    Diana Jung
    Division of Clinical Pharmacology and Toxicology, University Hospital, Zurich, Switzerland
    Gastroenterology 122:1954-66. 2002
    ..We investigated whether OATP8 gene expression is regulated by the nuclear receptors farnesoid X receptor/bile acid receptor (FXR/BAR; NR1H4), pregnane X receptor (PXR), or liver X receptor (LXR)...
  25. ncbi request reprint Localization of organic anion transport protein 2 in the apical region of rat retinal pigment epithelium
    Bo Gao
    Clinical Pharmacology and Toxicology, Department of Medicine, University Hospital, Zurich, Switzerland
    Invest Ophthalmol Vis Sci 43:510-4. 2002
    ..Its exact localization and function in the retina are unknown. Therefore, the purposes of the present study were to determine the cellular and subcellular localization and the potential functional aspects of Oatp2 in the retina...
  26. ncbi request reprint Functional characterization of the mouse organic-anion-transporting polypeptide 2
    Jessica E van Montfoort
    Division of Clinical Pharmacology and Toxicology, Department of Medicine, University Hospital, Ramistr 100, CH 8091 Zurich, Switzerland
    Biochim Biophys Acta 1564:183-8. 2002
    ..Northern blot analysis demonstrated a predominant expression in the liver with additional signals in kidney and brain. Using fluorescence in situ hybridization, the Oatp2 gene (gene symbol Slc21a5) was mapped to chromosome 6G1-G3...
  27. ncbi request reprint Regulation of rat organic anion transporters in bile salt-induced cholestatic hepatitis: effect of ursodeoxycholate
    Daniel Rost
    Department of Gastroenterology, University Hospital, Heidelberg, Germany
    Hepatology 38:187-95. 2003
    ..In conclusion, we show that CA feeding may cause cholestasis associated with a posttranscriptional down-regulation of Oatp4. UDCA may prevent impairment of hepatic function by restoring hepatic transporter expression...
  28. ncbi request reprint Expression of rat hepatic multidrug resistance-associated proteins and organic anion transporters in pregnancy
    Jingsong Cao
    Graduate Center for Toxicology, Chandler Medical Center, University of Kentucky, Lexington, Kentucky 40536 0305, USA
    Am J Physiol Gastrointest Liver Physiol 283:G757-66. 2002
    ..These data also demonstrate that decreased Mrp2 expression is not necessarily accompanied by increased Mrp3 expression...
  29. ncbi request reprint Mechanisms of impaired biliary excretion of acetaminophen glucuronide after acute phenobarbital treatment or phenobarbital pretreatment
    Hao Xiong
    Division of Drug Delivery and Disposition, School of Pharmacy, CB 7360, Beard Hall, University of North Carolina, Chapel Hill, North Carolina 27599 7360, USA
    Drug Metab Dispos 30:962-9. 2002
    ..However, impaired biliary excretion of AG after PB pretreatment may be attributed primarily to the induction of hepatic Mrp3 by PB...
  30. ncbi request reprint Functional analysis of the rat bile salt export pump gene promoter
    Thomas Gerloff
    Institute of Clinical Pharmacology, Charite University Medical Center, Humboldt University, Berlin, Germany
    Eur J Biochem 269:3495-503. 2002
    ..FXR was a major regulatory factor, mediating bile acid feed-back stimulation of Bsep transcription...
  31. ncbi request reprint Canalicular bile formation: beyond single transporter functions
    Peter J Meier
    J Hepatol 37:272-3. 2002
  32. ncbi request reprint Enterohepatic transport of bile salts and genetics of cholestasis
    Christiane Pauli-Magnus
    Division of Clinical Pharmacology and Toxicology, University Hospital Zurich, Ramistrasse 100, E RAE 09, 8091 Zurich, Switzerland
    J Hepatol 43:342-57. 2005
  33. ncbi request reprint Impaired expression and function of the bile salt export pump due to three novel ABCB11 mutations in intrahepatic cholestasis
    Johannes Noe
    Division of Clinical Pharmacology and Toxicology, Department of Internal Medicine, University Hospital Zurich, Ramistrasse 100, E RAE 09, 8091 Zurich, Switzerland
    J Hepatol 43:536-43. 2005
    ..We functionally characterized novel ABCB11 mutations encountered in two patients with a PFIC2 and a BRIC2 phenotype, respectively...
  34. ncbi request reprint Carriers involved in targeting the cytostatic bile acid-cisplatin derivatives cis-diammine-chloro-cholylglycinate-platinum(II) and cis-diammine-bisursodeoxycholate-platinum(II) toward liver cells
    Oscar Briz
    Department of Physiology and Pharmacology, University of Salamanca, Salamanca, Spain
    Mol Pharmacol 61:853-60. 2002
    ..These results suggest a role for carriers of organic anions and cations in Bamet-R2 and Bamet-UD2 uptake, which may determine their ability to accumulate in liver tumor cells and/or be taken up and efficiently excreted by hepatocytes...
  35. ncbi request reprint Prediction of in vivo biliary clearance from the in vitro transcellular transport of organic anions across a double-transfected Madin-Darby canine kidney II monolayer expressing both rat organic anion transporting polypeptide 4 and multidrug resistance as
    Makoto Sasaki
    Department of Biopharmaceutics, School of Pharmaceutical Sciences, The University of Tokyo, 7 3 1 Hongo, Bunkyo ku, Tokyo 113 0033, Japan
    Mol Pharmacol 66:450-9. 2004
    ..The double-transfected MDCK II monolayer may be useful in analyzing the hepatic vectorial transport of organic anions and in predicting in vivo biliary clearance...
  36. ncbi request reprint P-glycoprotein expression, localization, and function in sandwich-cultured primary rat and human hepatocytes: relevance to the hepatobiliary disposition of a model opioid peptide
    Keith A Hoffmaster
    Division of Drug Delivery and Disposition, School of Pharmacy, University of North Carolina, Chapel Hill, North Carolina 27599, USA
    Pharm Res 21:1294-302. 2004
    ..These studies examined repolarization, localization of P-glycoprotein (P-gp) to the canalicular domain of the hepatocyte, and re-establishment of vectorial transport in sandwich-cultured (SC) rat and human primary hepatocytes...
  37. ncbi request reprint Role of liver-enriched transcription factors and nuclear receptors in regulating the human, mouse, and rat NTCP gene
    Diana Jung
    Division of Gastroenterology and Hepatology, Dept of Internal Medicine, Univ Hospital, CH 8091 Zurich, Switzerland
    Am J Physiol Gastrointest Liver Physiol 286:G752-61. 2004
    ..Bile acids may regulate NTCP/Ntcp indirectly by modulating the capacity of nuclear factors to activate gene expression...
  38. ncbi request reprint Physiological characteristics of allo-cholic acid
    Maria E Mendoza
    Department of Physiology and Pharmacology, University of Salamanca, Spain
    J Lipid Res 44:84-92. 2003
    ....
  39. ncbi request reprint Gd-BOPTA transport into rat hepatocytes: pharmacokinetic analysis of dynamic magnetic resonance images using a hollow-fiber bioreactor
    Corinne Planchamp
    Geneva University Hospitals, Radiology Department, Geneva, Switzerland
    Invest Radiol 39:506-15. 2004
    ..To investigate the transport of the hepatobiliary magnetic resonance (MR) imaging contrast agent Gd-BOPTA into rat hepatocytes...
  40. ncbi request reprint Phenobarbital alters hepatic Mrp2 function by direct and indirect interactions
    Nita J Patel
    Division of Drug Delivery and Disposition, School of Pharmacy, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina, USA
    Mol Pharmacol 64:154-9. 2003
    ....
  41. ncbi request reprint Characterization of two splice variants of human organic anion transporting polypeptide 3A1 isolated from human brain
    Robert D Huber
    Univ Hospital, Dept of Internal Medicine, Institute of Clinical Pharmacology and Toxicology, 8091 Zurich, Switzerland
    Am J Physiol Cell Physiol 292:C795-806. 2007
    ....
  42. ncbi request reprint Sequence analysis of bile salt export pump (ABCB11) and multidrug resistance p-glycoprotein 3 (ABCB4, MDR3) in patients with intrahepatic cholestasis of pregnancy
    Christiane Pauli-Magnus
    Department of Internal Medicine, University Hospital Zurich, Zurich Switzerland
    Pharmacogenetics 14:91-102. 2004
    ....
  43. ncbi request reprint Gender difference in the Oatp1-mediated tubular reabsorption of estradiol 17beta-D-glucuronide in rats
    Yasumasa Gotoh
    Graduate School of Pharmaceutical Sciences, University of Tokyo, Tokyo 113 0033, Japan
    Am J Physiol Endocrinol Metab 282:E1245-54. 2002
    ..These results suggest that urinary E(2)-17betaG excretion is subject to hormonal regulation and that the large gender difference can be explained by regulation in Oatp1-mediated reabsorption...
  44. ncbi request reprint Linkage between a new splicing site mutation in the MDR3 alias ABCB4 gene and intrahepatic cholestasis of pregnancy
    Gudrun Schneider
    Department of Internal Medicine I, University of Bonn, Bonn, Germany
    Hepatology 45:150-8. 2007
    ..00341). CONCLUSION: This study demonstrates that splicing mutations in the MDR3 gene can cause ICP with normal gamma-GT and may be associated with stillbirths and gallstone disease...
  45. ncbi request reprint Mutations and polymorphisms in the bile salt export pump and the multidrug resistance protein 3 associated with drug-induced liver injury
    Carmen Lang
    Division of Clinical Pharmacology and Toxicology, University Hospital Zurich, Switzerland
    Pharmacogenet Genomics 17:47-60. 2007
    ..The aim of this study was therefore to describe the extent of genetic variability in ABCB11 and ABCB4 in patients with drug-induced liver injury and to in vitro functionally characterize newly detected ABCB11 mutations and polymorphisms...
  46. ncbi request reprint Comparative inhibitory effects of different compounds on rat oatpl (slc21a1)- and Oatp2 (Slc21a5)-mediated transport
    Yoshihisa Shitara
    School of Pharmaceutical Sciences, Kitasato University, Tokyo, Japan
    Pharm Res 19:147-53. 2002
    ..Methods: The inhibitory effects of 20 compounds on the Oatpl-mediated transport of estradiol 17beta-D-glucuronide and on the Oatp2-mediated transport of digoxin were examined in cDNA-transfected LLC-PK1cells...
  47. ncbi request reprint Organic anion transporting polypeptides, cholestasis, and nuclear receptors
    Gerd A Kullak-Ublick
    Hepatology 35:732-4. 2002
  48. ncbi request reprint Vectorial transport of bile salts across MDCK cells expressing both rat Na+-taurocholate cotransporting polypeptide and rat bile salt export pump
    Sachiko Mita
    Graduate School of Pharmaceutical Sciences, The University of Tokyo, Bunkyo ku, Tokyo 113 0033, Japan
    Am J Physiol Gastrointest Liver Physiol 288:G159-67. 2005
    ..This double-expressing system can be used as a model to clarify vectorial transport of bile salts across hepatocytes under physiological conditions...
  49. ncbi request reprint Functional analysis of the extracellular cysteine residues in the human organic anion transporting polypeptide, OATP2B1
    Emanuel Hänggi
    Division of Clinical Pharmacology and Toxicology, University Hospital Zurich, 100 Ramistrasse, Zurich 8091, Switzerland
    Mol Pharmacol 70:806-17. 2006
    ..Our findings show that the trafficking and function of OATP2B1 is vulnerable to changes in the cysteine residues of extracellular loop IX-X...
  50. ncbi request reprint Coordinate transcriptional regulation of transport and metabolism
    Jyrki J Eloranta
    Division of Gastroenterology and Hepatology, University Hospital, Zurich, Switzerland
    Methods Enzymol 400:511-30. 2005
    ..The fine-tuning of transcriptional control of drug and bile acid homeostasis depends on regulated interactions of specific nuclear receptors with their target genes...
  51. ncbi request reprint Regulation of basolateral organic anion transporters in ethinylestradiol-induced cholestasis in the rat
    Andreas Geier
    Department of Internal Medicine III, University of Technology Aachen, Pauwelsstrasse 30, 52074 Aachen, Germany
    Biochim Biophys Acta 1609:87-94. 2003
    ..In addition, known transactivators of Oatp2 and Ntcp were studied to further characterize transcriptional regulation of these transporter genes...
  52. ncbi request reprint Effect of dexamethasone treatment on the expression and function of transport proteins in sandwich-cultured rat hepatocytes
    Ryan Z Turncliff
    Division of Drug Delivery and Disposition, School of Pharmacy, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599 7360, USA
    Drug Metab Dispos 32:834-9. 2004
    ..Modest alterations in hepatic transport protein function were consistent with changes in protein expression...
  53. ncbi request reprint Metal-responsive transcription factor-1 (MTF-1) is essential for embryonic liver development and heavy metal detoxification in the adult liver
    Ying Wang
    Institute of Molecular Biology, University of Zurich, Switzerland
    FASEB J 18:1071-9. 2004
    ..Together, these findings point to a critical role of MTF-1 in embryonic liver formation, heavy metal toxicity, and hematopoiesis...
  54. ncbi request reprint Gender difference in the urinary excretion of organic anions in rats
    Yukio Kato
    Graduate School of Pharmaceutical Sciences, University of Tokyo, 7 3 1 Hongo, Bunkyoi ku, Tokyo 113 0033, Japan
    J Pharmacol Exp Ther 302:483-9. 2002
    ....
  55. ncbi request reprint Expression and functional involvement of organic anion transporting polypeptide subtype 3 (Slc21a7) in rat choroid plexus
    Hiroyuki Kusuhara
    Department of Biopharmaceutics, Graduate School of Pharmaceutical Sciences, The University of Tokyo, 7 3 1 Hongo, Bunkyo ku, Tokyo 113 0033, Japan
    Pharm Res 20:720-7. 2003
    ..The purpose of this study is to compare the substrate specificity of the transporter in the CP with those of rat organic anion transporting polypeptide 1 (rOatp1) and rOatp3...
  56. ncbi request reprint Hepatobiliary organic anion transporters are differentially regulated in acute toxic liver injury induced by carbon tetrachloride
    Andreas Geier
    Department of Internal Medicine III, University of Technology, Pauwelsstrasse 30, 52074 Aachen, Germany
    J Hepatol 37:198-205. 2002
    ..Maintained binding activity of RXRalpha:RARalpha may explain differences in Mrp2 expression...
  57. ncbi request reprint BSEP and MDR3 haplotype structure in healthy Caucasians, primary biliary cirrhosis and primary sclerosing cholangitis
    Christiane Pauli-Magnus
    Division of Clinical Pharmacology and Toxicology, University Hospital Zurich, Ramistrasse 100, A 8091 Zurich, Switzerland
    Hepatology 39:779-91. 2004
    ..Although an impact of rare variants on BSEP and MDR3 function cannot be ruled out, our data do not support a strong role of BSEP and MDR3 genetic variations in the pathogenesis of PBC and PSC...
  58. ncbi request reprint The human organic anion transporting polypeptide 8 (SLCO1B3) gene is transcriptionally repressed by hepatocyte nuclear factor 3beta in hepatocellular carcinoma
    Stephan R Vavricka
    Laboratory of Molecular Gastroenterology and Hepatology, Division of Gastroenterology and Hepatology, University Hospital, CH 8091 Zurich, Switzerland
    J Hepatol 40:212-8. 2004
    ..Our aim was to study the expression and regulation of OATP8 (OATP1B3, SLC21A8/SLCO1B3) and OATP-C (OATP1B1, SLC21A6/SLCO1B1) in hepatocellular carcinomas (HCC)...
  59. ncbi request reprint Magnetic resonance imaging with hepatospecific contrast agents in cirrhotic rat livers
    Corinne Planchamp
    Département de Radiologie and Division de Gastroentérologie, Hopitaux Universitaires de Geneve, Geneva, Switzerland
    Invest Radiol 40:187-94. 2005
    ..Consequently, the aim of our study was to measure the hepatic SI enhancement during Gd-BOPTA perfusion as well as the Oatp and Mrp2 expression in normal and cirrhotic livers...