H P Mattle

Summary

Affiliation: University Hospital
Country: Switzerland

Publications

  1. pmc Atorvastatin added to interferon beta for relapsing multiple sclerosis: 12-month treatment extension of the randomized multicenter SWABIMS trial
    Christian P Kamm
    Department of Neurology, Inselspital, University Hospital Bern and University of Bern, Bern, Switzerland
    PLoS ONE 9:e86663. 2014
  2. pmc Atorvastatin added to interferon β for relapsing multiple sclerosis: a randomized controlled trial
    Christian Philipp Kamm
    University Department of Neurology, Inselspital, Bern University Hospital and University of Bern, Freiburgstrasse, 3010, Bern, Switzerland
    J Neurol 259:2401-13. 2012
  3. doi request reprint National Institutes of Health stroke scale score and vessel occlusion in 2152 patients with acute ischemic stroke
    Mirjam R Heldner
    Department of Neurology, University of Bern, Bern, Switzerland
    Stroke 44:1153-7. 2013
  4. doi request reprint European Stroke Science Workshop
    Heinrich P Mattle
    Department of Neurology, Inselspital, University of Bern, Bern, Switzerland
    Cerebrovasc Dis 34:95-105. 2012
  5. pmc European stroke science workshop
    Heinrich P Mattle
    Department of Neurology, Inselspital, Freiburgstrasse 10, 3010 Bern, Switzerland
    Stroke 43:e81-8. 2012
  6. doi request reprint Endovascular therapy of 623 patients with anterior circulation stroke
    Aekaterini Galimanis
    Department of Neurology, University of Bern, Inselspital, Freiburgstrasse 10, 3010 Bern, Switzerland
    Stroke 43:1052-7. 2012
  7. pmc Randomized clinical trial comparing percutaneous closure of patent foramen ovale (PFO) using the Amplatzer PFO Occluder with medical treatment in patients with cryptogenic embolism (PC-Trial): rationale and design
    Ahmed A Khattab
    Cardiology Department, Bern University Hospital, Bern, Switzerland
    Trials 12:56. 2011
  8. pmc SWiss Atorvastatin and interferon Beta-1b trial In Multiple Sclerosis (SWABIMS)--rationale, design and methodology
    Christian P Kamm
    Department of Neurology, Inselspital, Bern University Hospital, and University of Bern, Switzerland
    Trials 10:115. 2009
  9. doi request reprint Basilar artery occlusion
    Heinrich P Mattle
    Department of Neurology, Inselspital, University of Bern, Bern, Switzerland
    Lancet Neurol 10:1002-14. 2011
  10. ncbi request reprint [Multiple sclerosis--update]
    H P Mattle
    Neurologische Klinik und Poliklinik der Universität, Inselspital, Bern
    Praxis (Bern 1994) 94:1167-70. 2005

Detail Information

Publications92

  1. pmc Atorvastatin added to interferon beta for relapsing multiple sclerosis: 12-month treatment extension of the randomized multicenter SWABIMS trial
    Christian P Kamm
    Department of Neurology, Inselspital, University Hospital Bern and University of Bern, Bern, Switzerland
    PLoS ONE 9:e86663. 2014
    ..Statins have anti-inflammatory and immunomodulatory properties in addition to lipid-lowering effects...
  2. pmc Atorvastatin added to interferon β for relapsing multiple sclerosis: a randomized controlled trial
    Christian Philipp Kamm
    University Department of Neurology, Inselspital, Bern University Hospital and University of Bern, Freiburgstrasse, 3010, Bern, Switzerland
    J Neurol 259:2401-13. 2012
    ..02). In conclusion, atorvastatin 40 mg/day in addition to interferon beta-1b did not have a beneficial effect on relapsing-remitting MS compared to interferon beta-1b monotherapy over a 12-month period...
  3. doi request reprint National Institutes of Health stroke scale score and vessel occlusion in 2152 patients with acute ischemic stroke
    Mirjam R Heldner
    Department of Neurology, University of Bern, Bern, Switzerland
    Stroke 44:1153-7. 2013
    ..There is some controversy on the association of the National Institutes of Health Stroke Scale (NIHSS) score to predict arterial occlusion on MR arteriography and CT arteriography in acute stroke...
  4. doi request reprint European Stroke Science Workshop
    Heinrich P Mattle
    Department of Neurology, Inselspital, University of Bern, Bern, Switzerland
    Cerebrovasc Dis 34:95-105. 2012
    ..The following sections summarize the content of the workshop...
  5. pmc European stroke science workshop
    Heinrich P Mattle
    Department of Neurology, Inselspital, Freiburgstrasse 10, 3010 Bern, Switzerland
    Stroke 43:e81-8. 2012
    ..The following sections summarize the content of the workshop...
  6. doi request reprint Endovascular therapy of 623 patients with anterior circulation stroke
    Aekaterini Galimanis
    Department of Neurology, University of Bern, Inselspital, Freiburgstrasse 10, 3010 Bern, Switzerland
    Stroke 43:1052-7. 2012
    ..The purpose of this study is to determine predictors of outcome in a large cohort of patients treated with intra-arterial thrombolysis, mechanical revascularization techniques, or both...
  7. pmc Randomized clinical trial comparing percutaneous closure of patent foramen ovale (PFO) using the Amplatzer PFO Occluder with medical treatment in patients with cryptogenic embolism (PC-Trial): rationale and design
    Ahmed A Khattab
    Cardiology Department, Bern University Hospital, Bern, Switzerland
    Trials 12:56. 2011
    ..The PC-Trial was set up to compare endovascular closure and best medical treatment for prevention of recurrent events...
  8. pmc SWiss Atorvastatin and interferon Beta-1b trial In Multiple Sclerosis (SWABIMS)--rationale, design and methodology
    Christian P Kamm
    Department of Neurology, Inselspital, Bern University Hospital, and University of Bern, Switzerland
    Trials 10:115. 2009
    ....
  9. doi request reprint Basilar artery occlusion
    Heinrich P Mattle
    Department of Neurology, Inselspital, University of Bern, Bern, Switzerland
    Lancet Neurol 10:1002-14. 2011
    ..The goal of thrombolysis is to restore blood flow in the occluded artery and salvage brain tissue; however, the best treatment approach to improve clinical outcome still needs to be ascertained...
  10. ncbi request reprint [Multiple sclerosis--update]
    H P Mattle
    Neurologische Klinik und Poliklinik der Universität, Inselspital, Bern
    Praxis (Bern 1994) 94:1167-70. 2005
    ..Very active forms can be treated with immunosuppression using mitoxantrone. Individual manifestations such as urinary tract infections or paroxysmal phenomena should be treated accordingly with medication...
  11. ncbi request reprint Comparison of intraarterial and intravenous thrombolysis for ischemic stroke with hyperdense middle cerebral artery sign
    Heinrich P Mattle
    University Hospital Bern, Department of Neurology, Inselspital, Freiburgstrasse, CH 3010 Bern, Switzerland
    Stroke 39:379-83. 2008
    ..The aim of this study was to compare IAT and IVT in stroke patients with HMCAS...
  12. ncbi request reprint Blood pressure and vessel recanalization in the first hours after ischemic stroke
    Heinrich P Mattle
    Department of Neurology, University of Berne, Freiburgstrasse, Inselspital, CH 3010 Berne, Switzerland
    Stroke 36:264-8. 2005
    ..Transient elevation of arterial blood pressure (BP) is frequent in acute ischemic stroke and may help to increase perfusion of tissue jeopardized by ischemia. If this is true, recanalization may eliminate the need for this BP elevation...
  13. ncbi request reprint [Atrial fibrillation and stroke]
    H P Mattle
    Neurologische Universitatsklinik, Inselspital, Bern
    Ther Umsch 60:527-34. 2003
    ..Antiplatelet agents should be used only for young (< 65 years) AF patients at low risk...
  14. ncbi request reprint [Pathophysiology, etiology and diagnosis of stroke]
    H P Mattle
    Neurologische Klinik und Poliklinik, Universitat Bern, Inselspital, Bern
    Ther Umsch 60:499-507. 2003
    ..In addition, recognition and modification of individual vascular risk factors are of paramount importance...
  15. ncbi request reprint [The comatose patient]
    H P Mattle
    Neurologische Klinik und Poliklinik, Universitat Bern, Inselspital, Bern
    Ther Umsch 62:331-7. 2005
    ..Ancillary tests are used to answer specific diagnostic questions. The treatment of coma depends on its etiology...
  16. doi request reprint Prevention of stroke in patients with patent foramen ovale
    H P Mattle
    Department of Neurology, Inselspital, University of Bern, Bern, Switzerland
    Int J Stroke 5:92-102. 2010
    ..Transcatheter device closure has therefore become an intriguing addition to medical treatment, but its therapeutic value still needs to be confirmed by randomised-controlled trials...
  17. ncbi request reprint Long-term outcome after stroke due to atrial fibrillation
    Heinrich P Mattle
    Department of Neurology, Inselspital, University of Bern, Bern, Switzerland
    Cerebrovasc Dis 16:3-8. 2003
    ..The benefit of dual antiplatelet regimens in AF patients is unknown, and combining antiplatelet agents with different mechanisms of action is an important topic for future investigation...
  18. ncbi request reprint [International Stroke Trial Switzerland: some epidemiologic data]
    H P Mattle
    Neurologische Universitatsklinik, Inselspital, Bern
    Schweiz Med Wochenschr 129:1964-9. 1999
    ....
  19. ncbi request reprint Thrombolysis in patients with acute stroke caused by cervical artery dissection: analysis of 9 patients and review of the literature
    Marcel Arnold
    Department of Neurology, University of Berne, Inselspital, CH 3010 Berne, Switzerland
    Arch Neurol 59:549-53. 2002
    ..Results of recently published studies suggest that intravenous thrombolysis (IVT) and local intra-arterial thrombolysis (LIT) are feasible procedures in acute stroke after cervical artery dissection (CAD)...
  20. ncbi request reprint Dilemmas in the management of patients with arteriovenous malformations
    H P Mattle
    Department of Neurology, Inselspital, 3010 Bern, Switzerland
    J Neurol 247:917-28. 2000
    ..Prospective randomised trials on the optimal management of AVMs are lacking. All our knowledge on AVMs stems from open series and indirect comparisons...
  21. pmc Clinical and radiological predictors of recanalisation and outcome of 40 patients with acute basilar artery occlusion treated with intra-arterial thrombolysis
    M Arnold
    Department of Neurology, University of Berne, Switzerland
    J Neurol Neurosurg Psychiatry 75:857-62. 2004
    ..To define predictors of recanalisation and clinical outcome of patients with acute basilar artery occlusions treated with local intra-arterial thrombolysis (IAT)...
  22. pmc Symptomatic intracranial haemorrhage after intra-arterial thrombolysis in acute ischaemic stroke: assessment of 294 patients treated with urokinase
    C Brekenfeld
    Institute of Diagnostic and Interventional Neuroradiology, Inselspital, University of Berne, CH 3010 Berne, Switzerland
    J Neurol Neurosurg Psychiatry 78:280-5. 2007
    ..The PROACT II trial showed that intra-arterial thrombolysis (IAT) is effective for treatment of acute ischaemic stroke attributable to M1 and M2 segment occlusions. Incidence of symptomatic intracranial haemorrhage (sICH) was 10%...
  23. ncbi request reprint [Anticoagulation and antiaggregation in neurological patients]
    M Arnold
    Neurologische Universitätsklinik und Poliklinik, Inselspital, Bern
    Ther Umsch 60:33-5. 2003
    ....
  24. ncbi request reprint Prevalence and size of directly detected patent foramen ovale in migraine with aura
    M Schwerzmann
    Department of Cardiology, University Hospital, Inselspital, CH 3010 Bern, Switzerland
    Neurology 65:1415-8. 2005
    ..The anatomy and size of these right-to-left shunts have never been directly assessed...
  25. doi request reprint Endovascular therapy in 201 patients with acute symptomatic occlusion of the internal carotid artery
    U Fischer
    Department of Neurology, Inselspital, University Hospital Bern, University of Bern, Bern, Switzerland
    Eur J Neurol 20:1017-24, e87. 2013
    ..Endovascular therapy is used increasingly for treatment of acute symptomatic internal carotid artery (ICA) occlusion, although randomized trials are lacking. Predictors of outcome are therefore of special interest...
  26. pmc Recanalisation of middle cerebral artery occlusion after intra-arterial thrombolysis: different recanalisation grading systems and clinical functional outcome
    M Arnold
    Department of Neurology, University of Berne, Freiburgstrasse, Inselspital, CH 3010 Berne, Switzerland
    J Neurol Neurosurg Psychiatry 76:1373-6. 2005
    ..Different grading systems of arterial recanalisation have never been compared in large series of stroke patients treated with intra-arterial thrombolysis (IAT)...
  27. doi request reprint Diagnostic workup of patients with acute transverse myelitis: spectrum of clinical presentation, neuroimaging and laboratory findings
    J Sellner
    Department of Neurology, Inselspital, Bern University Hospital, University of Bern, Bern, Switzerland
    Spinal Cord 47:312-7. 2009
    ..Retrospective 9-year survey...
  28. doi request reprint Aspirin vs anticoagulation in carotid artery dissection: a study of 298 patients
    D Georgiadis
    Department of Neurology, Frauenklinikstrasse 26, CH 8091 Zurich, Switzerland
    Neurology 72:1810-5. 2009
    ..No randomized study has yet compared efficacy and safety of aspirin and anticoagulants in patients with spontaneous dissection of the cervical carotid artery (sICAD)...
  29. ncbi request reprint Percutaneous closure of patent foramen ovale reduces the frequency of migraine attacks
    M Schwerzmann
    Department of Cardiology, University Hospital, Bern, Switzerland
    Neurology 62:1399-401. 2004
    ..2 +/- 0.7 vs 0.4 +/- 0.4 per month; p = 0.006). PFO closure did not have an effect on headache frequency in patients with nonmigraine headaches (1.4 +/- 0.9 vs 1.0 +/- 0.9 per month; p = NS)...
  30. doi request reprint Atorvastatin decreases high-sensitivity C-reactive protein in multiple sclerosis
    J Sellner
    Department of Neurology, Inselspital Bern University Hospital, and University of Bern, Bern, Switzerland
    Mult Scler 14:981-4. 2008
    ..05), indicating an anti-inflammatory action of atorvastatin in MS. However, whether add-on treatment with atorvastatin modifies the course of MS remains to be investigated...
  31. ncbi request reprint Prognosis after percutaneous closure of patent foramen ovale for paradoxical embolism
    A Wahl
    Department of Cardiology, University Hospital Bern, Switzerland
    Neurology 57:1330-2. 2001
    ..3; 95% CI 1.3 to 21.0; p = 0.02). Randomized trials comparing medical treatment with percutaneous PFO closure in the prevention of recurrent embolism are in progress...
  32. ncbi request reprint Reasons to withhold intra-arterial thrombolysis in clinical practice
    J Isenegger
    Department of Internal Medicine, University of Bern, Inselspital, Bern, 3010, Bern, Switzerland
    J Neurol 253:1552-6. 2006
    ..However, data about eligibility of acute stroke patients for IAT in clinical practice are very scarce...
  33. pmc Comparison of intra-arterial thrombolysis with conventional treatment in patients with acute central retinal artery occlusion
    M Arnold
    Department of Neurology, University of Berne, Freiburgstrasse, Inselspital, CH 3010 Berne, Switzerland
    J Neurol Neurosurg Psychiatry 76:196-9. 2005
    ..Several case series and a recent meta-analysis indicate that intra-arterial thrombolysis (IAT) is effective for the treatment of acute central retinal artery occlusion (CRAO)...
  34. doi request reprint Age-dependent differences in demographics, risk factors, co-morbidity, etiology, management, and clinical outcome of acute ischemic stroke
    M Arnold
    Department of Neurology, University Hospital, Inselspital, Freiburgstrasse, 3010 Berne, Switzerland
    J Neurol 255:1503-7. 2008
    ..Comparisons between younger and older stroke patients including comorbidities are limited...
  35. ncbi request reprint Acute stenting and thromboaspiration in basilar artery occlusions due to embolism from the dominating vertebral artery
    K Nedeltchev
    Institute of Diagnostic and Interventional Neuroradiology, University of Bern, Inselspital, Freiburgstrasse 4, 3010 Bern, Switzerland
    Neuroradiology 46:686-91. 2004
    ..A stent was deployed at the site of the stenosis in the VA either prior to or immediately after BA recanalization...
  36. doi request reprint Thrombolysis in patients with prior stroke within the last 3 months
    M R Heldner
    Department of Neurology and Stroke Center, Inselspital, University of Bern, Bern, Switzerland
    Eur J Neurol 21:1493-9. 2014
    ..The aim of this study was to compare baseline characteristics and clinical outcome of thrombolyzed patients who had a previous stroke within the last 3 months with those not fulfilling this criterion (comparison group)...
  37. pmc Ischaemic stroke in young adults: predictors of outcome and recurrence
    K Nedeltchev
    Department of Neurology, University Hospital of Bern, Switzerland
    J Neurol Neurosurg Psychiatry 76:191-5. 2005
    ..There is limited information about predictors of outcome and recurrence of ischaemic stroke affecting young adults...
  38. ncbi request reprint Long-term results after fluoroscopy-guided closure of patent foramen ovale for secondary prevention of paradoxical embolism
    A Wahl
    Cardiology Department, University Hospital Bern, Switzerland
    Heart 94:336-41. 2008
    ..To carry out long-term follow-up after percutaneous closure of patent foramen ovale (PFO) in patients with cryptogenic stroke...
  39. pmc Intra-arterial thrombolysis in 24 consecutive patients with internal carotid artery T occlusions
    M Arnold
    Department of Neurology, University Hospital of Berne, Switzerland
    J Neurol Neurosurg Psychiatry 74:739-42. 2003
    ..To determine the safety, efficacy, and predictors of favourable outcome of intra-arterial thrombolysis in acute stroke attributable to internal carotid "T"occlusion..
  40. ncbi request reprint Passing the thrombus in endovascular treatment of acute ischemic stroke: do we penetrate the thrombus?
    P Mordasini
    Department of Diagnostic and Interventional Neuroradiology, Inselspital, University of Berne Berne, Switzerland
    Neuroradiol J 25:243-50. 2012
    ..This route of passing has implications on deployment and transmission of force in relation to the thrombus in mechanical approaches and consequently on the development of retrieval devices. ..
  41. doi request reprint Outcome of intravenous thrombolysis in stroke patients weighing over 100 kg
    H Sarikaya
    Department of Neurology, University Hospital of Zurich, Zurich, Switzerland
    Cerebrovasc Dis 32:201-6. 2011
    ..Little is known about the clinical outcomes of stroke patients weighing >100 kg, who may benefit less from thrombolysis due to this dose limitation...
  42. ncbi request reprint Assessment of >/=50% and <50% intracranial stenoses by transcranial color-coded duplex sonography
    R W Baumgartner
    Department of Neurology, University Hospital of Zurich, Switzerland
    Stroke 30:87-92. 1999
    ....
  43. ncbi request reprint Impact of comorbidity on ischemic stroke outcome
    U Fischer
    Neurology Department, University Hospital, Bern, Switzerland
    Acta Neurol Scand 113:108-13. 2006
    ..To evaluate the impact of comorbidity on stroke outcome of patients admitted to a general ward (GW) and a stroke unit (SU)...
  44. doi request reprint Safety of endovascular treatment beyond the 6-h time window in 205 patients
    S Jung
    Department of Neurology, Inselspital, University Hospital Bern and University of Berne, Berne, Switzerland
    Eur J Neurol 20:865-71. 2013
    ..In this study we compared the safety of IAT in these four patient groups...
  45. doi request reprint Technical feasibility and application of mechanical thrombectomy with the Solitaire FR Revascularization Device in acute basilar artery occlusion
    P Mordasini
    Institute of Diagnostic and Interventional Neuroradiology, Inselspital, University of Bern, Switzerland
    AJNR Am J Neuroradiol 34:159-63. 2013
    ..Therefore, the purpose of this study was to evaluate technical feasibility, safety, and efficacy of mechanical thrombectomy using retrievable stent in the treatment of acute BAO...
  46. ncbi request reprint Cerebrovascular response to repetitive visual stimulation in interictal migraine with aura
    K Nedeltchev
    Department of Neurology, University Hospital of Bern, Bern, Switzerland
    Cephalalgia 24:700-6. 2004
    ..A reduced adaptation to environmental stimuli in migraine is suggested, since there was no habituation in migraineurs in contrast to healthy controls...
  47. pmc Atorvastatin does not alter serum levels of sCD95 and sCD95L in multiple sclerosis
    J Sellner
    Department of Neurology, Inselspital, Bern University Hospital, University of Bern, Bern, Switzerland
    Clin Exp Immunol 152:280-4. 2008
    ..Our study suggests that atorvastatin does not affect IFN-beta-induced increases of the soluble death receptors in the serum of patients with MS...
  48. ncbi request reprint Anti-myelin antibodies in clinically isolated syndrome indicate the risk of multiple sclerosis in a Swiss cohort
    I Greeve
    Department of Neurology, Inselspital, University Hospital Bern, Bern, Switzerland
    Acta Neurol Scand 116:207-10. 2007
    ..Individual and geographical prognostic factors remain to be determined. Whether anti-myelin antibodies may predict the risk of conversion to CDMS in Swiss CIS patients of the canton Berne was the subject of the study...
  49. doi request reprint Acute partial transverse myelitis: risk factors for conversion to multiple sclerosis
    J Sellner
    Department of Neurology, Inselspital, Bern University Hospital and University of Bern, Bern, Switzerland corrected
    Eur J Neurol 15:398-405. 2008
    ..In patients with a first-ever APTM, a family history of MS, high EDSS at presentation, lesions on brain MRI, CSF-specific oligoclonal bands or abnormal IgG-index may indicate an increased risk for conversion to MS...
  50. ncbi request reprint Protein Z in ischaemic stroke
    K Kobelt
    Central Haematology Laboratory, Inselspital, University of Bern, Switzerland
    Br J Haematol 114:169-73. 2001
    ..04) after adjustment for established risk factors. Our data indicated that a high plasma level of protein Z is an independent risk factor for ischaemic stroke...
  51. doi request reprint Triple and quadruple spontaneous cervical artery dissection: presenting characteristics and long-term outcome
    M Arnold
    Assistance Publique, Hopitaux de Paris, Department of Neurology, University Hospital Lariboisiere, Paris
    J Neurol Neurosurg Psychiatry 80:171-4. 2009
    ..Spontaneous cervicocephalic artery dissection (sCAD) of more than two cervical arteries is rare...
  52. doi request reprint [Thrombolysis of the middle cerebral artery]
    C Brekenfeld
    Institut für Diagnostische und Interventionelle Neuroradiologie, Inselspital Bern, Freiburgstr 4, CH 3010, Bern, Schweiz
    Radiologe 49:312-8. 2009
    ..However, intra-arterial thrombolysis (IAT) results in higher recanalization rates of the middle cerebral artery compared to IVT. Therefore it seems reasonable to apply IAT in addition or instead of IVT up to 6 h after symptom onset...
  53. ncbi request reprint [Uric acid and multiple sclerosis]
    H P Mattle
    Neurologische Klinik und Poliklinik, Universitatsspital Bern, Inselspital, Bern
    Ther Umsch 61:553-5. 2004
    ..At present, uric acid can solely be regarded as a marker of disease activity in MS. In addition, the current knowledge of uric acid and MS supports hypotheses which predict a positive effect of radical scavengers in MS...
  54. pmc Outcome of patients with cryptogenic stroke and patent foramen ovale
    K Nedeltchev
    Department of Neurology, Inselspital, University of Bern, 3010 Bern, Switzerland
    J Neurol Neurosurg Psychiatry 72:347-50. 2002
    ..The aim was to estimate the recurrence rate and to define subgroups at increased risk for recurrent cerebral ischaemia in patients with patent foramen ovale (PFO) and so called cryptogenic stroke due to paradoxical embolism...
  55. ncbi request reprint Determination of language dominance: Wada test confirms functional transcranial Doppler sonography
    F Rihs
    Department of Neurology, University of Berne, Inselspital, Switzerland
    Neurology 52:1591-6. 1999
    ..To determine the efficacy of the invasive Wada test in determining language dominance, and to validate the functional transcranial Doppler sonography (fTCD) examination in patients...
  56. ncbi request reprint Cerebral hemodynamic response induced by the Tower of Hanoi puzzle and the Wisconsin Card Sorting test
    D Schuepbach
    Psychiatric Services of the University of Berne, 3010, Bern, Switzerland
    Neuropsychologia 40:39-53. 2002
    ..These findings showed a different CBFV pattern during the TOH task and WCST than during the visuomotor test. In conclusion, TCD was able to assess CBFV in prefrontal functions, using a high resolution in time...
  57. ncbi request reprint Mitochondrial neurogastrointestinal encephalomyopathy in three siblings: clinical, genetic and neuroradiological features
    W M M Schüpbach
    Department of Neurology, University Hospital Inselspital, 3010 Bern, Switzerland
    J Neurol 254:146-53. 2007
    ..Urinary thymidine is for the first time reported to be detectable in a heterozygous carrier. MRS findings indicate loss of neurons, axons, and glial cells in patients with MNGIE, but not in heterozygous carriers...
  58. doi request reprint Patent foramen ovale may be causal for the first stroke but unrelated to subsequent ischemic events
    Marie Luise Mono
    Department of Neurology, Inselspital, University Hospital and University of Bern, Freiburgstrasse, CH 3010 Bern, Switzerland
    Stroke 42:2891-5. 2011
    ..Studies with very long follow-up are scarce in patients with cryptogenic stroke and patent foramen ovale (PFO). Little is known about the etiology of recurrent cerebrovascular events (CVE) in PFO patients...
  59. doi request reprint What is a minor stroke?
    Urs Fischer
    Department of Neurology, Inselspital, University Hospital Bern and University of Bern, Switzerland
    Stroke 41:661-6. 2010
    ..The term "minor stroke" is often used; however a consensus definition is lacking. We explored the relationship of 6 "minor stroke" definitions and outcome and tested their validity in subgroups of patients...
  60. ncbi request reprint Hemostatic risk factors in ischemic stroke
    Franziska Demarmels Biasiutti
    Central Hematology Laboratory, Inselspital, Universitiy of Bern, CH 3010 Bern, Switzerland
    Thromb Haemost 90:1094-9. 2003
    ..2%-38%). In conclusion, we found a high plasma level of FV:C to be a prevalent (FV:C > 130% in 20/157 patients) and independent risk factor for ischemic stroke...
  61. ncbi request reprint Comparison of medical treatment with percutaneous closure of patent foramen ovale in patients with cryptogenic stroke
    Stephan Windecker
    Department of Cardiology, University Hospital, Bern, Switzerland
    J Am Coll Cardiol 44:750-8. 2004
    ..The purpose of this study was to compare the efficacy of medical treatment with percutaneous closure of patent foramen ovale (PFO)...
  62. ncbi request reprint Intra-arterial thrombolysis in 100 patients with acute stroke due to middle cerebral artery occlusion
    Marcel Arnold
    Department of Neurology, Inselspital, University of Berne, Switzerland
    Stroke 33:1828-33. 2002
    ..The purpose of this study was to evaluate the safety and efficacy of local intra-arterial thrombolysis (LIT) using urokinase in patients with acute stroke due to middle cerebral artery (MCA) occlusion...
  63. ncbi request reprint Long-term effect of intra-arterial thrombolysis in stroke
    Krassen Nedeltchev
    Department of Neurology, University of Bern, Inselspital, Freiburgstrasse 4, 3010 Bern, Switzerland
    Stroke 37:3002-7. 2006
    ..Thrombolysis has been shown to improve the 3-month outcome of patients with ischemic stroke, but knowledge of the long-term effect of thrombolysis is limited...
  64. ncbi request reprint Pre- and in-hospital delays from stroke onset to intra-arterial thrombolysis
    Krassen Nedeltchev
    Department of Neurology, University Hospital of Bern, Bern, Switzerland
    Stroke 34:1230-4. 2003
    ..The aim of this study was to examine, in our tertiary care center, the time intervals preceding intra-arterial thrombolysis in order to accelerate and optimize the management of acute strokes...
  65. ncbi request reprint [Cerebral ischemia]
    Heinrich P Mattle
    Ther Umsch 60:497-8. 2003
  66. ncbi request reprint Long-term outcome of acute spinal cord ischemia syndrome
    Krassen Nedeltchev
    Department of Neurology, University Hospital of Bern, Inselspital, Bern, Switzerland
    Stroke 35:560-5. 2004
    ..Therefore, we analyzed clinical features and outcome of all types of ASCIS to define predictors of recovery...
  67. doi request reprint Sex differences in cryptogenic stroke with patent foramen ovale
    Krassen Nedeltchev
    Department of Neurology, University Hospital of Bern, Bern, Switzerland
    Am Heart J 156:461-5. 2008
    ..We aimed to determine sex influences on demographics, vascular risk factors, clinical manifestations, stroke location, and clinical outcome...
  68. ncbi request reprint [Clopidogrel as basic therapy in high-risk stroke patients]
    Heinrich P Mattle
    Inselspital Bern
    Praxis (Bern 1994) 93:1364. 2004
  69. ncbi request reprint Vascular risk factors in the Swiss population
    Krassen Nedeltchev
    Dept of Neurology, University Hospital of Bern, Freiburgstrasse 4, Switzerland
    J Neurol 252:1210-6. 2005
    ..Identification of the population at risk of stroke remains the best approach to assess the burden of cardiovascular morbidity and mortality...
  70. ncbi request reprint Practice parameter: recurrent stroke with patent foramen ovale and atrial septal aneurysm: report of the Quality Standards Subcommittee of the American Academy of Neurology
    Heinrich P Mattle
    Neurology 63:2198-9; author reply 2198-9. 2004
  71. ncbi request reprint Vertebral artery dissection: presenting findings and predictors of outcome
    Marcel Arnold
    Department of Neurology, Assistance Publique, Hopitaux de Paris, Lariboisiere, Paris, France
    Stroke 37:2499-503. 2006
    ..Few data exist about clinical, radiologic findings, clinical outcome, and its predictors in patients with spontaneous vertebral artery dissection (sVAD)...
  72. ncbi request reprint Contrast-enhanced 3-D MRA in decision making for carotid endarterectomy: a 6-year experience
    Alain Barth
    Department of Neurosurgery, University Hospital of Bern, Bern, Switzerland
    Cerebrovasc Dis 21:393-400. 2006
    ..In this study, we present the radiological characteristics and clinical results of a series of patients operated on the basis of combined ultrasonography (US)/MRA...
  73. ncbi request reprint Time to admission in acute ischemic stroke and transient ischemic attack
    Osei Agyeman
    Department of Neurology, University of Bern, Inselspital, 3010 Bern, Switzerland
    Stroke 37:963-6. 2006
    ..This study was designed to analyze the variables that influence the time from symptom onset to admission (TTA) to the stroke unit...
  74. ncbi request reprint Therapy of basilar artery occlusion: a systematic analysis comparing intra-arterial and intravenous thrombolysis
    Perttu J Lindsberg
    Department of Neurology, Neurosciences Program, Biomedicum Helsinki, Helsinki, Finland
    Stroke 37:922-8. 2006
    ....
  75. ncbi request reprint Internal carotid artery stent implantation in 25 patients with acute stroke: preliminary results
    Krassen Nedeltchev
    Institute of Diagnostic and Interventional Neuroradiology, University of Bern, Inselspital, Freiburgstrasse 4, 3010 Bern, Switzerland
    Radiology 237:1029-37. 2005
    ....
  76. ncbi request reprint Endovascular neuroradiological treatment of acute ischemic stroke: techniques and results in 350 patients
    Caspar Brekenfeld
    Institute of Diagnostic and Interventional Neuroradiology, University of Bern, Inselspital, Switzerland
    Neurol Res 27:S29-35. 2005
    ..Randomized trials have demonstrated the benefit of intra-arterial thrombolysis (IAT) for treatment of acute ischemic stroke, if performed within 6 hours of symptom onset...
  77. ncbi request reprint Transcatheter treatment of atrial septal aneurysm associated with patent foramen ovale for prevention of recurrent paradoxical embolism in high-risk patients
    Andreas Wahl
    Department of Cardiology, Swiss Cardiovascular Center, Bern University Hospital, CH 3010 Bern, Switzerland
    J Am Coll Cardiol 45:377-80. 2005
    ..This study sought to investigate the safety and efficacy of transcatheter treatment of atrial septal aneurysm (ASA) associated with patent foramen ovale (PFO)...
  78. ncbi request reprint NIHSS score and arteriographic findings in acute ischemic stroke
    Urs Fischer
    Department of Neurology, University of Bern, Inselspital, 3010 Bern, Switzerland
    Stroke 36:2121-5. 2005
    ..To test the hypothesis that the National Institutes of Health Stroke Scale (NIHSS) score is associated with the findings of arteriography performed within the first hours after ischemic stroke...
  79. ncbi request reprint Contrast-enhanced transcranial Doppler ultrasound for diagnosis of patent foramen ovale
    Krassen Nedeltchev
    Institute of Diagnostic and Interventional Neuroradiology, University of Bern, Bern, Switzerland
    Front Neurol Neurosci 21:206-15. 2006
    ..However, c-TCD cannot localize the site of the RLS. Therefore, TEE and TCD are complementary methods and should be applied jointly in order to increase the diagnostic accuracy for detecting PFO and other types of RLS...
  80. ncbi request reprint Implantation of a second closure device in patients with residual shunt after percutaneous closure of patent foramen ovale
    Markus Schwerzmann
    Swiss Cardiovascular Center Bern, Cardiology, University Hospital, Bern, Switzerland
    Catheter Cardiovasc Interv 63:490-5. 2004
    ..Therefore, implantation of a second closure device in patients with persistence of more than a residual shunt after percutaneous PFO closure appears safe and effective...
  81. ncbi request reprint Recanalization and outcome after intra-arterial thrombolysis in middle cerebral artery and internal carotid artery occlusion: does sex matter?
    Marcel Arnold
    Department of Neurology, University Hospital Berne, Bern, Switzerland
    Stroke 38:1281-5. 2007
    ..Recent studies have reported sex differences in recanalization and outcome after intravenous thrombolysis (IVT) in acute ischemic stroke...
  82. doi request reprint Atorvastatin does not alter interferon Beta-induced changes of serum matrix metalloproteinase 9 and tissue inhibitor of metalloproteinase 1 in patients with multiple sclerosis
    Johann Sellner
    Arch Neurol 65:672-4. 2008
  83. doi request reprint Intra-arterial thrombolysis of acute iatrogenic intracranial arterial occlusion attributable to neuroendovascular procedures or coronary angiography
    Marcel Arnold
    Department of Neurology, Inselspital, University Hospital Bern, University of Bern, Bern, Switzerland
    Stroke 39:1491-5. 2008
    ..However, knowledge of safety and efficacy of IAT in patients with acute stroke as a complication of arterial catheter interventions is limited...
  84. ncbi request reprint Ultrasound diagnosis of spontaneous carotid dissection with isolated Horner syndrome
    Marcel Arnold
    Assistance Publique, Hopitaux de Paris, Department of Neurology, University Hospitals Lariboisière, Paris, France
    Stroke 39:82-6. 2008
    ..Current knowledge on ultrasound findings in patients with sICAD presenting with isolated Horner syndrome is limited...
  85. ncbi request reprint Outcome of stroke with mild or rapidly improving symptoms
    Krassen Nedeltchev
    Department of Neurology, University Hospital of Bern, Bern, Switzerland
    Stroke 38:2531-5. 2007
    ..Therefore, thrombolysis with its potential risks does not seem to be justified in such patients. However, recent studies indicate that the outcome is not invariably benign...
  86. ncbi request reprint Frequent atrial premature beats predict paroxysmal atrial fibrillation in stroke patients: an opportunity for a new diagnostic strategy
    Dieter Wallmann
    Swiss Cardiovascular Center Bern, University Hospital, Bern, Switzerland
    Stroke 38:2292-4. 2007
    ..We hypothesized that patients with frequent atrial premature beats (APBs) recorded in 24-hour ECG will show more often atrial fibrillation when followed by repeated long-term ECG recordings than patients without or infrequent APBs...
  87. ncbi request reprint Intravenous or intra-arterial thrombolysis?: it's time to find the right approach for the right patient
    Heinrich P Mattle
    Stroke 38:2038-40. 2007
  88. ncbi request reprint Low awareness of transient ischemic attacks and risk factors of stroke in a Swiss urban community
    Krassen Nedeltchev
    Department of Neurology, Inselspital, University of Bern, Freiburgstrasse 10, 3010 Bern, Switzerland
    J Neurol 254:179-84. 2007
    ..In order to decrease the delays, educational campaigns try to inform the general public how to act optimally in case of stroke. To determine the content of such a campaign, we assessed the stroke knowledge in our population...
  89. ncbi request reprint Duplex sonographic criteria for measuring carotid stenoses
    Ivan N Staikov
    Department of Neurology, Inselspital, University of Bern, Switzerland
    J Clin Ultrasound 30:275-81. 2002
    ....
  90. doi request reprint Quality of life in stroke survivors after local intra-arterial thrombolysis
    Urs Fischer
    Department of Neurology, Inselspital, University Hospital Bern and University of Bern, Bern, Switzerland
    Cerebrovasc Dis 25:438-44. 2008
    ..We aimed to assess quality of life (QOL) and its predictors in stroke survivors after local intra-arterial thrombolysis (IAT) as well as to measure QOL according to the site of pretreatment vessel occlusion...
  91. doi request reprint Effect of interferon-beta and atorvastatin on Th1/Th2 cytokines in multiple sclerosis
    Johann Sellner
    Department of Neurology, Inselspital, Bern University Hospital, and University of Bern, Switzerland
    Neurochem Int 53:17-21. 2008
    ..Supplemental atorvastatin might promote a Th1-type response by raising IL-12p70. Further studies are required to support a Th2 cytokine shift by atorvastatin in patients with MS...