Jean Claude Martinou

Summary

Affiliation: University of Geneva
Country: Switzerland

Publications

  1. pmc Mitochondria in apoptosis: Bcl-2 family members and mitochondrial dynamics
    Jean Claude Martinou
    Department of Cell Biology, University of Geneva, Faculty of Sciences, 30 Quai Ernest Ansermet, Geneva 4, Switzerland
    Dev Cell 21:92-101. 2011
  2. ncbi request reprint Direct addition of BimL to mitochondria does not lead to cytochrome c release
    Olivier Terradillos
    Departement de Biologie Cellulaire, Sciences III, 30 quai E Ansermet, 1211 Geneve 4, Switzerland
    FEBS Lett 522:29-34. 2002
  3. pmc Inhibiting the mitochondrial fission machinery does not prevent Bax/Bak-dependent apoptosis
    Philippe A Parone
    Department of Cell Biology, University of Geneva, Quai Ernest Ansermet 30, 1211 Geneva 4, Switzerland
    Mol Cell Biol 26:7397-408. 2006
  4. pmc Bid induces cytochrome c-impermeable Bax channels in liposomes
    Xavier Roucou
    Departement de Biologie Cellulaire, Sciences III, 30 Quai Ernest Ansermet, CH 1211 Geneva 4, Switzerland
    Biochem J 363:547-52. 2002
  5. ncbi request reprint Newcomers in the process of mitochondrial permeabilization
    Safa Lucken-Ardjomande
    Department of Cell Biology, University of Geneva, 30 Quai Ernest Ansermet, 1211 Geneva 4, Switzerland
    J Cell Sci 118:473-83. 2005
  6. doi request reprint SLP-2 negatively modulates mitochondrial sodium-calcium exchange
    Sandrine Da Cruz
    Department of Cell Biology, University of Geneva, Switzerland
    Cell Calcium 47:11-8. 2010
  7. ncbi request reprint hFis1, a novel component of the mammalian mitochondrial fission machinery
    Dominic I James
    Department of Cell Biology, University of Geneva, Quai Ernest Ansermet 30, 1211 Geneva, Switzerland
    J Biol Chem 278:36373-9. 2003
  8. doi request reprint SLP-2 interacts with prohibitins in the mitochondrial inner membrane and contributes to their stability
    Sandrine Da Cruz
    Department of Cell Biology, University of Geneva, Geneva, Switzerland
    Biochim Biophys Acta 1783:904-11. 2008
  9. ncbi request reprint Proteomic analysis of the mouse liver mitochondrial inner membrane
    Sandrine Da Cruz
    University of Geneva, Department of Cellular Biology, 30 quai E Ansermet, 1205 Geneva, Switzerland
    J Biol Chem 278:41566-71. 2003
  10. ncbi request reprint Membrane remodeling induced by the dynamin-related protein Drp1 stimulates Bax oligomerization
    Sylvie Montessuit
    Department of Cell Biology, University of Geneva, Sciences III, 30 Quai Ernest Ansermet, 1211 Geneva 4, Switzerland
    Cell 142:889-901. 2010

Collaborators

Detail Information

Publications36

  1. pmc Mitochondria in apoptosis: Bcl-2 family members and mitochondrial dynamics
    Jean Claude Martinou
    Department of Cell Biology, University of Geneva, Faculty of Sciences, 30 Quai Ernest Ansermet, Geneva 4, Switzerland
    Dev Cell 21:92-101. 2011
    ..However, in these organisms, mitochondrial membrane permeabilization does not occur and the mechanism by which mitochondrial dynamics participates in cell death remains elusive...
  2. ncbi request reprint Direct addition of BimL to mitochondria does not lead to cytochrome c release
    Olivier Terradillos
    Departement de Biologie Cellulaire, Sciences III, 30 quai E Ansermet, 1211 Geneve 4, Switzerland
    FEBS Lett 522:29-34. 2002
    ....
  3. pmc Inhibiting the mitochondrial fission machinery does not prevent Bax/Bak-dependent apoptosis
    Philippe A Parone
    Department of Cell Biology, University of Geneva, Quai Ernest Ansermet 30, 1211 Geneva 4, Switzerland
    Mol Cell Biol 26:7397-408. 2006
    ..Therefore, the fission of mitochondria is a dispensable event in Bax/Bak-dependent apoptosis...
  4. pmc Bid induces cytochrome c-impermeable Bax channels in liposomes
    Xavier Roucou
    Departement de Biologie Cellulaire, Sciences III, 30 Quai Ernest Ansermet, CH 1211 Geneva 4, Switzerland
    Biochem J 363:547-52. 2002
    ..Cut Bid by itself is unable to induce Bax oligomerization in lipid membranes. It is suggested that another factor that might be present in mitochondria is required for Bax oligomerization...
  5. ncbi request reprint Newcomers in the process of mitochondrial permeabilization
    Safa Lucken-Ardjomande
    Department of Cell Biology, University of Geneva, 30 Quai Ernest Ansermet, 1211 Geneva 4, Switzerland
    J Cell Sci 118:473-83. 2005
    ..The important rearrangements mitochondrial lipids undergo during apoptosis play a role in the permeabilization process and this role is probably more central than first envisioned...
  6. doi request reprint SLP-2 negatively modulates mitochondrial sodium-calcium exchange
    Sandrine Da Cruz
    Department of Cell Biology, University of Geneva, Switzerland
    Cell Calcium 47:11-8. 2010
    ..These data show that SLP-2 modulates mitochondrial calcium extrusion, thereby altering the ability of mitochondria to buffer Ca(2+) and to shape cytosolic Ca(2+) signals...
  7. ncbi request reprint hFis1, a novel component of the mammalian mitochondrial fission machinery
    Dominic I James
    Department of Cell Biology, University of Geneva, Quai Ernest Ansermet 30, 1211 Geneva, Switzerland
    J Biol Chem 278:36373-9. 2003
    ..Our studies show that hFis1 is part of the mammalian fission machinery and suggest that regulation of the fission processes might be involved in apoptotic mechanisms...
  8. doi request reprint SLP-2 interacts with prohibitins in the mitochondrial inner membrane and contributes to their stability
    Sandrine Da Cruz
    Department of Cell Biology, University of Geneva, Geneva, Switzerland
    Biochim Biophys Acta 1783:904-11. 2008
    ..These data indicate that SLP-2 plays a role in regulating the stability of mitochondrial proteins including prohibitins and subunits of respiratory chain complexes...
  9. ncbi request reprint Proteomic analysis of the mouse liver mitochondrial inner membrane
    Sandrine Da Cruz
    University of Geneva, Department of Cellular Biology, 30 quai E Ansermet, 1205 Geneva, Switzerland
    J Biol Chem 278:41566-71. 2003
    ..This study provides the first proteome of the MIM and provides a basis for a more detailed study of the newly characterized proteins of this membrane...
  10. ncbi request reprint Membrane remodeling induced by the dynamin-related protein Drp1 stimulates Bax oligomerization
    Sylvie Montessuit
    Department of Cell Biology, University of Geneva, Sciences III, 30 Quai Ernest Ansermet, 1211 Geneva 4, Switzerland
    Cell 142:889-901. 2010
    ..In cells, overexpression of Drp1 R247A/E delays Bax oligomerization and cell death. Our findings uncover a function of Drp1 and provide insight into the mechanism of Bax oligomerization...
  11. ncbi request reprint Regulation of Bcl-2 proteins and of the permeability of the outer mitochondrial membrane
    Safa Lucken-Ardjomande
    Department of Cell Biology, University of Geneva, 30, Quai Ernest Ansermet, 1211 Geneve 4, Switzerland
    C R Biol 328:616-31. 2005
    ..Here, we attempt to summarize our current view of the mechanisms that lead to these events, regarding both additional proteins that were recently suggested to be involved, and the roles of lipids...
  12. ncbi request reprint Mitochondrial dynamics: to be in good shape to survive
    Sébastien Herzig
    Department of Cell Biology, University of Geneva, Quai Ernest Ansermet 30, 1211 Geneva 4, Switzerland
    Curr Mol Med 8:131-7. 2008
    ..In this review, we present the latest progress in the field of mitochondrial dynamics with a particular emphasis on its implication in apoptosis and in diseases...
  13. pmc Selective actions of mitochondrial fission/fusion genes on metabolism-secretion coupling in insulin-releasing cells
    Kyu Sang Park
    Department of Cell Physiology and Metabolism, University of Geneva, CH 1211, Geneva 4, Switzerland
    J Biol Chem 283:33347-56. 2008
    ..Through their impact on mitochondrial bioenergetics and distribution, hFis1 and Mfn1 activities influence mitochondrial signal generation thereby insulin exocytosis...
  14. ncbi request reprint Building the mitochondrial proteome
    Sandrine Da Cruz
    Department of Cellular Biology, University of Geneva, 30 quai E Ansermet, 1205 Geneva, Switzerland
    Expert Rev Proteomics 2:541-51. 2005
    ..Altogether, it is becoming clear that proteomics is a powerful tool not only to identify currently unknown components of the mitochondrion, but also to study the different roles of the organelle in cellular homeostasis...
  15. pmc Bax oligomerization in mitochondrial membranes requires tBid (caspase-8-cleaved Bid) and a mitochondrial protein
    Xavier Roucou
    Departement de Biologie Cellulaire, University of Geneva, 30 quai E Ansermet, 1211 Geneva 4, Switzerland
    Biochem J 368:915-21. 2002
    ..These findings imply that tBid is necessary but not sufficient for Bax oligomerization; a mitochondrial protein is also required...
  16. doi request reprint Identification and functional expression of the mitochondrial pyruvate carrier
    Sébastien Herzig
    Department of Cell Biology, University of Geneva, Geneva, Switzerland
    Science 337:93-6. 2012
    ..Coexpression of mouse MPC1 and MPC2 in Lactococcus lactis promoted transport of pyruvate across the membrane. These observations firmly establish these proteins as essential components of the MPC...
  17. ncbi request reprint Mechanisms of mitochondrial outer membrane permeabilization
    Dominic James
    Department of Cell Biology, University of Geneva, Quai Ernest Ansermet 30, Geneva, Switzerland
    Novartis Found Symp 287:170-6; discussion 176-82. 2007
    ..The mechanisms that lead to the oligomerization of proapoptotic members of the Bcl-2 family and to MOMP are still unclear and the role of mitochondrial fission in these events remains elusive...
  18. ncbi request reprint Apoptosis: bombarding the mitochondria
    Philippe Parone
    Department of Cell Biology, University of Geneva, 30 quai Ansermet, 1211 Geneva 4, Switzerland
    Essays Biochem 39:41-51. 2003
    ..The release of these proteins is the result of the outer mitochondrial membrane becoming permeable. In addition, mitochondria can initiate apoptosis through the production of reactive oxygen species...
  19. pmc Mitochondrial dynamics: quantifying mitochondrial fusion in vitro
    Alexis Jourdain
    Department of Cell Biology, University of Geneva, Switzerland
    BMC Biol 8:99. 2010
    ..In this issue of BMC Biology, Schauss and colleagues describe a simple, reliable, and robust novel assay that allows fusion of mammalian mitochondria to be quantified in vitro...
  20. doi request reprint Expression of mitofusin 2(R94Q) in a transgenic mouse leads to Charcot-Marie-Tooth neuropathy type 2A
    Romain Cartoni
    Department of Cell Biology, University of Geneva, 30 Quai Ernest Ansermet, 1211 Geneve 4, Switzerland
    Brain 133:1460-9. 2010
    ..5 microm. Together these data suggest a link between an increased number of mitochondria in axons and a shift in axonal size distribution in mitofusin 2(R94Q) transgenic animals that may contribute to their neurological phenotype...
  21. doi request reprint Life without the mitochondrial calcium uniporter
    Sébastien Herzig
    Department of Cell Biology, University of Geneva, 1211 Geneva 4, Switzerland
    Nat Cell Biol 15:1398-400. 2013
    ..These mice are fully viable and show defects limited to performance of high-energy-demanding exercises. Strikingly, no protection against necrosis is observed following ischaemia-reperfusion in the heart. ..
  22. ncbi request reprint Mitochondrial dynamics and cancer
    Stéphanie Grandemange
    Department of Cell Biology, University of Geneva, Switzerland
    Semin Cancer Biol 19:50-6. 2009
    ....
  23. pmc Preventing mitochondrial fission impairs mitochondrial function and leads to loss of mitochondrial DNA
    Philippe A Parone
    Department of Cell Biology, University of Geneva, Geneva, Switzerland
    PLoS ONE 3:e3257. 2008
    ..In conclusion, we propose that mitochondrial fission is required for preservation of mitochondrial function and thereby for maintenance of cellular homeostasis...
  24. doi request reprint Granzyme a, a stealth killer in the mitochondrion
    Safa Lucken-Ardjomande
    Department of Cell Biology, University of Geneva, 30 Quai Ernest Ansermet, Geneva CH 1211, Switzerland
    Cell 133:568-70. 2008
    ..In the mitochondrial matrix, GzmA cleaves NDUFS3 (a component of the electron transport chain) leading to production of reactive oxygen species and ultimately to cell death...
  25. doi request reprint Purification and proteomic analysis of the mouse liver mitochondrial inner membrane
    Sandrine Da Cruz
    Department of Cell Biology, University of Geneva, Geneva, Switzerland
    Methods Mol Biol 432:101-16. 2008
    ..Altogether, this study demonstrates that the proteomics-based approach we have used is a powerful technique to identify new mitochondrial membrane proteins...
  26. ncbi request reprint TRAIL promotes membrane blebbing, detachment and migration of cells displaying a dysfunctional intrinsic pathway of apoptosis
    Syam Prakash Somasekharan
    Department of Cell Biology, University of Geneva, Sciences III, 30 Quai Ernest Ansermet, 1211 Geneva 4, Switzerland
    Apoptosis 18:324-36. 2013
    ..These findings may have important consequences for TRAIL anti-cancer therapy...
  27. ncbi request reprint Mitochondrial fission and apoptosis: an ongoing trial
    Philippe A Parone
    Department of Cell Biology, University of Geneva, Quai Ernest Ansermet 30, 1211 Geneva 4, Switzerland
    Biochim Biophys Acta 1763:522-30. 2006
    ..Here, we discuss how this mitochondrial morphological transition occurs during cell death and the role that it may have in apoptosis...
  28. doi request reprint Mitochondrial outer membrane permeabilization during apoptosis: the role of mitochondrial fission
    Thomas Landes
    Department of Cell Biology, University of Geneva, Sciences III, 30 Quai Ernest Ansermet, 1211 Geneva 4, Switzerland
    Biochim Biophys Acta 1813:540-5. 2011
    ..This article is part of a Special Issue entitled Mitochondria: the deadly organelle...
  29. pmc GRSF1 regulates RNA processing in mitochondrial RNA granules
    Alexis A Jourdain
    Department of Cell Biology, University of Geneva, 30 Quai Ernest Ansermet, 1211 Geneve 4, Switzerland
    Cell Metab 17:399-410. 2013
    ..Our findings suggest that the foci containing GRSF1 and RNase P correspond to sites where primary RNA transcripts converge to be processed. We have termed these large ribonucleoprotein structures "mitochondrial RNA granules."..
  30. ncbi request reprint Ca(2+) homeostasis during mitochondrial fragmentation and perinuclear clustering induced by hFis1
    Maud Frieden
    Department of Physiology, University of Geneva Medical Center, Geneva 4, Switzerland
    J Biol Chem 279:22704-14. 2004
    ..These observations indicate that close contact to Ca(2+) influx channels is not required for CCE modulation and that the formation of a mitochondrial network facilitates Ca(2+) propagation within interconnected mitochondria...
  31. doi request reprint Involvement of cardiolipin in tBID-induced activation of BAX during apoptosis
    Etienne Raemy
    Department of Cell Biology, University of Geneva, 30 Quai Ernest Ansermet, 1211 Geneva 4, Switzerland
    Chem Phys Lipids 179:70-4. 2014
    ..Here we review the evidence for and against a role for cardiolipin in BAX and BAK activation and in the subsequent onset of apoptosis. ..
  32. pmc Where killers meet--permeabilization of the outer mitochondrial membrane during apoptosis
    Tom Bender
    Department of Cell Biology, University of Geneva, 1211 Geneva 4, Switzerland
    Cold Spring Harb Perspect Biol 5:a011106. 2013
    ..Besides the Bcl-2 proteins, the mitochondrial organelle contributes to and possibly regulates MOMP, because mitochondrial resident proteins and membrane lipids are prominently involved in the process...
  33. doi request reprint Role of mitofusin 2 mutations in the physiopathology of Charcot-Marie-Tooth disease type 2A
    Romain Cartoni
    Department of Cell Biology, Geneve, Switzerland
    Exp Neurol 218:268-73. 2009
    ..In this review, we will describe the physiological role of Mfn2, the pathophysiology of CMT2A and current hypotheses about the deleterious role of mutant Mfn2 in neuronal function...
  34. ncbi request reprint Fusion of mitochondria in mammalian cells is dependent on the mitochondrial inner membrane potential and independent of microtubules or actin
    Yves Mattenberger
    Department of Cell Biology, University of Geneva, Quai Ernest Ansermet 30, Geneva, Switzerland
    FEBS Lett 538:53-9. 2003
    ..We report that the fusion of mitochondria requires an intact mitochondrial inner membrane potential but is independent of a functional cytoskeleton...
  35. doi request reprint Mitochondrial outer-membrane permeabilization and remodelling in apoptosis
    Alexis Jourdain
    Department of Cell Biology, University of Geneva, Quai Ernest Ansermet 30, 1211 Geneva 4, Switzerland
    Int J Biochem Cell Biol 41:1884-9. 2009
    ..In this review, we will discuss the link that could exist between mitochondrial fission and fusion machinery, Bcl-2 family members and MOMP...
  36. pmc SLP-2 is required for stress-induced mitochondrial hyperfusion
    Daniel Tondera
    Department of Cell Biology, University of Geneva, Geneva, Switzerland
    EMBO J 28:1589-600. 2009
    ..In the absence of SLP-2, L-OPA1 is lost and SIMH is prevented. SIMH is accompanied by increased mitochondrial ATP production and represents a novel adaptive pro-survival response against stress...