Zora Markovic-Housley

Summary

Affiliation: University of Basel
Country: Switzerland

Publications

  1. ncbi request reprint Crystal structure of hyaluronidase, a major allergen of bee venom
    Z Markovic-Housley
    Division of Structural Biology Biozentrum University of Basel CH 4056, Basel, Switzerland
    Structure 8:1025-35. 2000
  2. ncbi request reprint Crystal structure of a hypoallergenic isoform of the major birch pollen allergen Bet v 1 and its likely biological function as a plant steroid carrier
    Zora Markovic-Housley
    Department of Structural Biology, Biozentrum, University of Basel, CH 4056 Basel, Switzerland
    J Mol Biol 325:123-33. 2003
  3. doi request reprint Structure of the major carrot allergen Dau c 1
    Zora Markovic-Housley
    Core Program of Structural Biology and Biophysics, Biozentrum, University of Basel, CH 4056 Basel, Switzerland
    Acta Crystallogr D Biol Crystallogr 65:1206-12. 2009
  4. ncbi request reprint Identification of a B-cell epitope of hyaluronidase, a major bee venom allergen, from its crystal structure in complex with a specific Fab
    Sivaraman Padavattan
    Division of Structural Biology, Biozentrum, University of Basel, CH 4056 Basel, Switzerland
    J Mol Biol 368:742-52. 2007
  5. ncbi request reprint Crystal structure of the major celery allergen Api g 1: molecular analysis of cross-reactivity
    Tilman Schirmer
    Department of Structural Biology, Biozentrum, University of Basel, CH 4056 Basel, Switzerland
    J Mol Biol 351:1101-9. 2005
  6. doi request reprint Crystal structure of Sol I 2: a major allergen from fire ant venom
    Aline S Borer
    Department of Structural Biology, Biozentrum, University of Basel, Basel, Switzerland
    J Mol Biol 415:635-48. 2012
  7. doi request reprint Crystal structure of the major allergen from fire ant venom, Sol i 3
    Sivaraman Padavattan
    Department of Structural Biology, Biozentrum, University of Basel, CH 4056 Basel, Switzerland
    J Mol Biol 383:178-85. 2008
  8. doi request reprint High-affinity IgE recognition of a conformational epitope of the major respiratory allergen Phl p 2 as revealed by X-ray crystallography
    Sivaraman Padavattan
    Division of Structural Biology, Biozentrum, University of Basel, Basel, Switzerland
    J Immunol 182:2141-51. 2009

Collaborators

Detail Information

Publications8

  1. ncbi request reprint Crystal structure of hyaluronidase, a major allergen of bee venom
    Z Markovic-Housley
    Division of Structural Biology Biozentrum University of Basel CH 4056, Basel, Switzerland
    Structure 8:1025-35. 2000
    ..On the basis of sequence similarity, mammalian enzymes and Hya are assigned to glycosidase family 56 for which no structure has been reported yet...
  2. ncbi request reprint Crystal structure of a hypoallergenic isoform of the major birch pollen allergen Bet v 1 and its likely biological function as a plant steroid carrier
    Zora Markovic-Housley
    Department of Structural Biology, Biozentrum, University of Basel, CH 4056 Basel, Switzerland
    J Mol Biol 325:123-33. 2003
    ..The role of BRs transport in PR-10 proteins may be of crucial importance in the plant defense response to pathological situations as well as in growth and development...
  3. doi request reprint Structure of the major carrot allergen Dau c 1
    Zora Markovic-Housley
    Core Program of Structural Biology and Biophysics, Biozentrum, University of Basel, CH 4056 Basel, Switzerland
    Acta Crystallogr D Biol Crystallogr 65:1206-12. 2009
    ..This is in agreement with the observation that the majority of carrot-allergic patients have Bet v 1 cross-reactive IgE antibodies, whereas others have Dau c 1-specific IgE antibodies which do not recognize Bet v 1...
  4. ncbi request reprint Identification of a B-cell epitope of hyaluronidase, a major bee venom allergen, from its crystal structure in complex with a specific Fab
    Sivaraman Padavattan
    Division of Structural Biology, Biozentrum, University of Basel, CH 4056 Basel, Switzerland
    J Mol Biol 368:742-52. 2007
    ..The structure of the complex provides the basis for the rational design of Hyal derivatives with reduced allergenic activity, which could be used in the development of safer allergen-specific immunotherapy...
  5. ncbi request reprint Crystal structure of the major celery allergen Api g 1: molecular analysis of cross-reactivity
    Tilman Schirmer
    Department of Structural Biology, Biozentrum, University of Basel, CH 4056 Basel, Switzerland
    J Mol Biol 351:1101-9. 2005
    ..The structure of Api g 1 and the related epitope analysis provides a molecular basis for a better understanding of allergen cross-reactivity and may lead to the development of hypoallergens which would allow a safer immunotherapy...
  6. doi request reprint Crystal structure of Sol I 2: a major allergen from fire ant venom
    Aline S Borer
    Department of Structural Biology, Biozentrum, University of Basel, Basel, Switzerland
    J Mol Biol 415:635-48. 2012
    ..Molecular surface analysis, in combination with sequence alignment, can explain the serological cross-reactivity observed between some ant species...
  7. doi request reprint Crystal structure of the major allergen from fire ant venom, Sol i 3
    Sivaraman Padavattan
    Department of Structural Biology, Biozentrum, University of Basel, CH 4056 Basel, Switzerland
    J Mol Biol 383:178-85. 2008
    ..Indeed, the molecular area in Sol i 3 covered by non-conserved residues is large enough to accommodate four unique Sol i 3 epitopes...
  8. doi request reprint High-affinity IgE recognition of a conformational epitope of the major respiratory allergen Phl p 2 as revealed by X-ray crystallography
    Sivaraman Padavattan
    Division of Structural Biology, Biozentrum, University of Basel, Basel, Switzerland
    J Immunol 182:2141-51. 2009
    ..Our results indicate that IgE Abs recognize conformational epitopes with high affinity and provide a structural basis for the highly efficient effector cell activation by allergen/IgE immune complexes...