Zora Markovic-Housley

Summary

Affiliation: University of Basel
Country: Switzerland

Publications

  1. ncbi Crystal structure of hyaluronidase, a major allergen of bee venom
    Z Markovic-Housley
    Division of Structural Biology Biozentrum University of Basel CH 4056, Basel, Switzerland
    Structure 8:1025-35. 2000
  2. ncbi Crystal structure of a hypoallergenic isoform of the major birch pollen allergen Bet v 1 and its likely biological function as a plant steroid carrier
    Zora Markovic-Housley
    Department of Structural Biology, Biozentrum, University of Basel, CH 4056 Basel, Switzerland
    J Mol Biol 325:123-33. 2003
  3. doi Structure of the major carrot allergen Dau c 1
    Zora Markovic-Housley
    Core Program of Structural Biology and Biophysics, Biozentrum, University of Basel, CH 4056 Basel, Switzerland
    Acta Crystallogr D Biol Crystallogr 65:1206-12. 2009
  4. ncbi Identification of a B-cell epitope of hyaluronidase, a major bee venom allergen, from its crystal structure in complex with a specific Fab
    Sivaraman Padavattan
    Division of Structural Biology, Biozentrum, University of Basel, CH 4056 Basel, Switzerland
    J Mol Biol 368:742-52. 2007
  5. ncbi Crystal structure of the major celery allergen Api g 1: molecular analysis of cross-reactivity
    Tilman Schirmer
    Department of Structural Biology, Biozentrum, University of Basel, CH 4056 Basel, Switzerland
    J Mol Biol 351:1101-9. 2005
  6. doi Crystal structure of Sol I 2: a major allergen from fire ant venom
    Aline S Borer
    Department of Structural Biology, Biozentrum, University of Basel, Basel, Switzerland
    J Mol Biol 415:635-48. 2012
  7. doi Crystal structure of the major allergen from fire ant venom, Sol i 3
    Sivaraman Padavattan
    Department of Structural Biology, Biozentrum, University of Basel, CH 4056 Basel, Switzerland
    J Mol Biol 383:178-85. 2008
  8. doi High-affinity IgE recognition of a conformational epitope of the major respiratory allergen Phl p 2 as revealed by X-ray crystallography
    Sivaraman Padavattan
    Division of Structural Biology, Biozentrum, University of Basel, Basel, Switzerland
    J Immunol 182:2141-51. 2009

Collaborators

Detail Information

Publications8

  1. ncbi Crystal structure of hyaluronidase, a major allergen of bee venom
    Z Markovic-Housley
    Division of Structural Biology Biozentrum University of Basel CH 4056, Basel, Switzerland
    Structure 8:1025-35. 2000
    ..On the basis of sequence similarity, mammalian enzymes and Hya are assigned to glycosidase family 56 for which no structure has been reported yet...
  2. ncbi Crystal structure of a hypoallergenic isoform of the major birch pollen allergen Bet v 1 and its likely biological function as a plant steroid carrier
    Zora Markovic-Housley
    Department of Structural Biology, Biozentrum, University of Basel, CH 4056 Basel, Switzerland
    J Mol Biol 325:123-33. 2003
    ..The role of BRs transport in PR-10 proteins may be of crucial importance in the plant defense response to pathological situations as well as in growth and development...
  3. doi Structure of the major carrot allergen Dau c 1
    Zora Markovic-Housley
    Core Program of Structural Biology and Biophysics, Biozentrum, University of Basel, CH 4056 Basel, Switzerland
    Acta Crystallogr D Biol Crystallogr 65:1206-12. 2009
    ..This is in agreement with the observation that the majority of carrot-allergic patients have Bet v 1 cross-reactive IgE antibodies, whereas others have Dau c 1-specific IgE antibodies which do not recognize Bet v 1...
  4. ncbi Identification of a B-cell epitope of hyaluronidase, a major bee venom allergen, from its crystal structure in complex with a specific Fab
    Sivaraman Padavattan
    Division of Structural Biology, Biozentrum, University of Basel, CH 4056 Basel, Switzerland
    J Mol Biol 368:742-52. 2007
    ..The structure of the complex provides the basis for the rational design of Hyal derivatives with reduced allergenic activity, which could be used in the development of safer allergen-specific immunotherapy...
  5. ncbi Crystal structure of the major celery allergen Api g 1: molecular analysis of cross-reactivity
    Tilman Schirmer
    Department of Structural Biology, Biozentrum, University of Basel, CH 4056 Basel, Switzerland
    J Mol Biol 351:1101-9. 2005
    ..The structure of Api g 1 and the related epitope analysis provides a molecular basis for a better understanding of allergen cross-reactivity and may lead to the development of hypoallergens which would allow a safer immunotherapy...
  6. doi Crystal structure of Sol I 2: a major allergen from fire ant venom
    Aline S Borer
    Department of Structural Biology, Biozentrum, University of Basel, Basel, Switzerland
    J Mol Biol 415:635-48. 2012
    ..Molecular surface analysis, in combination with sequence alignment, can explain the serological cross-reactivity observed between some ant species...
  7. doi Crystal structure of the major allergen from fire ant venom, Sol i 3
    Sivaraman Padavattan
    Department of Structural Biology, Biozentrum, University of Basel, CH 4056 Basel, Switzerland
    J Mol Biol 383:178-85. 2008
    ..Indeed, the molecular area in Sol i 3 covered by non-conserved residues is large enough to accommodate four unique Sol i 3 epitopes...
  8. doi High-affinity IgE recognition of a conformational epitope of the major respiratory allergen Phl p 2 as revealed by X-ray crystallography
    Sivaraman Padavattan
    Division of Structural Biology, Biozentrum, University of Basel, Basel, Switzerland
    J Immunol 182:2141-51. 2009
    ..Our results indicate that IgE Abs recognize conformational epitopes with high affinity and provide a structural basis for the highly efficient effector cell activation by allergen/IgE immune complexes...