Markus G Manz

Summary

Affiliation: University Hospital
Country: Switzerland

Publications

  1. doi request reprint Renaissance for mouse models of human hematopoiesis and immunobiology
    Markus G Manz
    Division of Hematology, University Hospital Zurich, Zurich, Switzerland
    Nat Immunol 10:1039-42. 2009
  2. pmc Dynamic variation in cycling of hematopoietic stem cells in steady state and inflammation
    Hitoshi Takizawa
    Institute for Research in Biomedicine, Bellinzona, Switzerland
    J Exp Med 208:273-84. 2011
  3. doi request reprint In vivo divisional tracking of hematopoietic stem cells
    Hitoshi Takizawa
    Division of Hematology, University Hospital Zurich, Zurich, Switzerland
    Ann N Y Acad Sci 1266:40-6. 2012
  4. ncbi request reprint The concerted action of GM-CSF and Flt3-ligand on in vivo dendritic cell homeostasis
    Dior Kingston
    Institute for Research in Biomedicine, Bellinzona, Switzerland
    Blood 114:835-43. 2009
  5. doi request reprint Instructive cytokine signals in dendritic cell lineage commitment
    Michael A Schmid
    Institute for Research in Biomedicine IRB, Bellinzona, Switzerland
    Immunol Rev 234:32-44. 2010
  6. doi request reprint Dendritic cell homeostasis is maintained by nonhematopoietic and T-cell-produced Flt3-ligand in steady state and during immune responses
    Yasuyuki Saito
    Division of Hematology, University Hospital Zurich, Zurich, Switzerland
    Eur J Immunol 43:1651-8. 2013
  7. doi request reprint Bone marrow dendritic cell progenitors sense pathogens via Toll-like receptors and subsequently migrate to inflamed lymph nodes
    Michael A Schmid
    Institute for Research in Biomedicine IRB, Bellinzona, Switzerland
    Blood 118:4829-40. 2011
  8. doi request reprint Cutting edge: LPS-induced emergency myelopoiesis depends on TLR4-expressing nonhematopoietic cells
    Steffen Boettcher
    Institute for Research in Biomedicine, 6500 Bellinzona, Switzerland
    J Immunol 188:5824-8. 2012
  9. doi request reprint Ex vivo expansion of hematopoietic stem cells: mission accomplished?
    Hitoshi Takizawa
    Division of Hematology, University Hospital Zurich, 8091 Zurich, Switzerland
    Swiss Med Wkly 141:w13316. 2011
  10. ncbi request reprint Emergency granulopoiesis
    Markus G Manz
    Division of Hematology, University Hospital Zurich, Raemistrasse 100, CH 8091 Zurich, Switzerland
    Nat Rev Immunol 14:302-14. 2014

Collaborators

Detail Information

Publications13

  1. doi request reprint Renaissance for mouse models of human hematopoiesis and immunobiology
    Markus G Manz
    Division of Hematology, University Hospital Zurich, Zurich, Switzerland
    Nat Immunol 10:1039-42. 2009
    ....
  2. pmc Dynamic variation in cycling of hematopoietic stem cells in steady state and inflammation
    Hitoshi Takizawa
    Institute for Research in Biomedicine, Bellinzona, Switzerland
    J Exp Med 208:273-84. 2011
    ..These findings suggest a model in which all HSCs undergo dynamic and demand-adapted entry into and exit out of the cell cycle over time. This may facilitate a similar degree of turnover of the entire HSC pool at the end of life...
  3. doi request reprint In vivo divisional tracking of hematopoietic stem cells
    Hitoshi Takizawa
    Division of Hematology, University Hospital Zurich, Zurich, Switzerland
    Ann N Y Acad Sci 1266:40-6. 2012
    ..Here, we summarize these recent findings on HSC turnover from different experimental systems and discuss hypothetical models for HSC cycling and maintenance in steady-state and upon hematopoietic challenge...
  4. ncbi request reprint The concerted action of GM-CSF and Flt3-ligand on in vivo dendritic cell homeostasis
    Dior Kingston
    Institute for Research in Biomedicine, Bellinzona, Switzerland
    Blood 114:835-43. 2009
    ..These data thus show the concerted action of GM-CSF and Flt3-ligand on DC homeostasis in vivo...
  5. doi request reprint Instructive cytokine signals in dendritic cell lineage commitment
    Michael A Schmid
    Institute for Research in Biomedicine IRB, Bellinzona, Switzerland
    Immunol Rev 234:32-44. 2010
    ..Along this line, we emphasize the role that diverse microenvironments have in influencing the generation of DC subsets with specific functions throughout the body...
  6. doi request reprint Dendritic cell homeostasis is maintained by nonhematopoietic and T-cell-produced Flt3-ligand in steady state and during immune responses
    Yasuyuki Saito
    Division of Hematology, University Hospital Zurich, Zurich, Switzerland
    Eur J Immunol 43:1651-8. 2013
    ..Thus, Flt3L-mediated lymphoid tissue DC homeostasis is regulated by steady-state T cells as well as by proliferative T cells, fostering local development of lymphoid organ resident DCs. ..
  7. doi request reprint Bone marrow dendritic cell progenitors sense pathogens via Toll-like receptors and subsequently migrate to inflamed lymph nodes
    Michael A Schmid
    Institute for Research in Biomedicine IRB, Bellinzona, Switzerland
    Blood 118:4829-40. 2011
    ..This mechanism likely developed to support DC homeostasis on specific need at sites of inflammation...
  8. doi request reprint Cutting edge: LPS-induced emergency myelopoiesis depends on TLR4-expressing nonhematopoietic cells
    Steffen Boettcher
    Institute for Research in Biomedicine, 6500 Bellinzona, Switzerland
    J Immunol 188:5824-8. 2012
    ..Collectively, our findings reveal a key and nonredundant role for nonhematopoietic compartment pathogen sensing that is subsequently translated into cytokine release for enhanced, demand-adapted myeloid cell production...
  9. doi request reprint Ex vivo expansion of hematopoietic stem cells: mission accomplished?
    Hitoshi Takizawa
    Division of Hematology, University Hospital Zurich, 8091 Zurich, Switzerland
    Swiss Med Wkly 141:w13316. 2011
    ..Although the specific issue concerns only highly specialised medicine today, newly generated knowledge will be critical for the whole field of stem cell transplantation and regenerative medicine in the future...
  10. ncbi request reprint Emergency granulopoiesis
    Markus G Manz
    Division of Hematology, University Hospital Zurich, Raemistrasse 100, CH 8091 Zurich, Switzerland
    Nat Rev Immunol 14:302-14. 2014
    ..In this Review, we discuss the molecular and cellular events that regulate emergency granulopoiesis, a process that is crucial for host survival. ..
  11. doi request reprint Demand-adapted regulation of early hematopoiesis in infection and inflammation
    Hitoshi Takizawa
    Division of Hematology, University Hospital Zurich, Zurich, Switzerland
    Blood 119:2991-3002. 2012
    ..We also outline how chronic inflammatory processes might impinge on hematopoiesis, potentially fostering hematopoietic stem cell diseases, and, how clinical benefit is and could be achieved by learning from nature...
  12. ncbi request reprint Identification of clonogenic common Flt3+M-CSFR+ plasmacytoid and conventional dendritic cell progenitors in mouse bone marrow
    Nobuyuki Onai
    Institute for Research in Biomedicine, CH 6500 Bellinzona, Switzerland
    Nat Immunol 8:1207-16. 2007
    ..These clonogenic common DC progenitors thus define a cytokine-regulated DC developmental pathway that ensures the supply of various DC populations...
  13. ncbi request reprint Reversible skeletal disease and high fluoride serum levels in hematologic patients receiving voriconazole
    Bernhard Gerber
    Division of Hematology, University Hospital Zurich, Zurich, Switzerland
    Blood 120:2390-4. 2012
    ..Clinically relevant skeletal disease was associated with renal insufficiency and above 10-fold elevated fluoride levels, and was reversible on termination of voriconazole treatment...