Research Topics
Genomes and Genes | Isabelle M MansuySummaryAffiliation: University of Zurich Country: Switzerland Publications
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Publications
[Forgetting : theories and potential mechanisms]Isabelle M Mansuy
Ecole Fédérale Polytechnique de Zurich Université de Zurich, Winterthurerstrasse 190, CH 8057 Zurich, Suisse
Med Sci (Paris) 21:83-8. 2005..This review provides a brief account of the main features of forgetting and a summary of the most recent findings on its potential mechanisms...
Epigenetic transmission of the impact of early stress across generationsTamara B Franklin
Brain Research Institute, Medical Faculty of University of Zürich, Zurich, Switzerland
Biol Psychiatry 68:408-15. 2010..Traumatic experiences in early life are risk factors for the development of behavioral and emotional disorders. Such disorders can persist through adulthood and have often been reported to be transmitted across generations...- Protein serine/threonine phosphatases in neuronal plasticity and disorders of learning and memoryIsabelle M Mansuy
Brain Research Institute, Medical Faculty of the University Zürich, Winterthurerstrasse 190, CH 8057 Zurich, Switzerland
Trends Neurosci 29:679-86. 2006..Here, we review key modes of regulation of neuronal protein serine/threonine phosphatases and their contribution to disorders of learning and memory... - Protein phosphatase 1-dependent transcriptional programs for long-term memory and plasticityJohannes Graff
Brain Research Institute, Medical Faculty of University Zürich and Department of Biology of Swiss Federal Institute of Technology, CH 8057 Zurich, Switzerland
Learn Mem 17:355-63. 2010..These findings highlight an important role for PP1 in the regulation of gene transcription in LTM and synaptic plasticity in the adult brain... - Protein phosphatase 1 regulates the histone code for long-term memoryKyoko Koshibu
Brain Research Institute, University of Zurich, Swiss Federal Institute of Technology, CH 8057 Zurich, Switzerland
J Neurosci 29:13079-89. 2009..Together, these findings reveal a novel mechanism for the epigenetic control of gene transcription and long-term memory in the adult brain that depends on PP1... - [Epigenetics and memory]Johannes Graff
Brain Research Institute, University of Zurich, Zurich, Switzerland
Biol Aujourdhui 204:131-7. 2010..Their study in animal models has demonstrated their importance, and revealed some of their modes of function... - Dynamic histone marks in the hippocampus and cortex facilitate memory consolidationJohannes Graff
Brain Research Institute, Medical Faculty of the University of Zurich, Zurich, Switzerland
Nat Commun 3:991. 2012..These findings reveal the spatiotemporal dynamics of histone marks during memory consolidation, and demonstrate their inherent 'mnemonic' property... - Changes in the proteome after neuronal zif268 overexpressionKarsten Baumgärtel
Brain Research Institute, Medical Faculty of the University of Zurich, Switzerland
J Proteome Res 8:3298-316. 2009..The results provide a comprehensive and quantitative data set characterizing the Zif268-dependent proteome in the adult mouse brain and offers biologically important new insight into activity-dependent pathways downstream of IEGs... 
Selective regulation of NR2B by protein phosphatase-1 for the control of the NMDA receptor in neuroprotectionMélissa Farinelli
Brain Research Institute, University of Zurich, Zurich, Switzerland
PLoS ONE 7:e34047. 2012..They provide a new target for the development of potential therapeutic treatment of neurodegeneration...- Identification of combinatorial patterns of post-translational modifications on individual histones in the mouse brainRy Y Tweedie-Cullen
Medical Faculty, Brain Research Institute, University of Zurich and Department of Biology, ETH Zurich, Zurich, Switzerland
PLoS ONE 7:e36980. 2012..Overall, the present data newly identify a specific histone code in the mouse brain and reveal its level of complexity, suggesting its potential relevance for higher-order brain functions... - The prevalence of epigenetic mechanisms in the regulation of cognitive functions and behaviourTamara B Franklin
Brain Research Institute, University and ETH Zurich, Zurich, Switzerland
Curr Opin Neurobiol 20:441-9. 2010..Thus, both pharmacological and environmental interventions that act on epigenetic mechanisms provide a promising tool for the treatment of a wide variety of cognitive and behavioural disorders... - Comprehensive mapping of post-translational modifications on synaptic, nuclear, and histone proteins in the adult mouse brainRy Y Tweedie-Cullen
Brain Research Institute, Medical Faculty, University of Zurich, Zurich, Switzerland
J Proteome Res 8:4966-82. 2009..Overall, our data demonstrates the complexity of PTMs in the brain and the prevalence of histone PTMs, and reveals potentially important regulatory sites on proteins involved in synaptic plasticity and brain functions... - Epigenetic dysregulation in cognitive disordersJohannes Graff
Brain Research Institute, Medical Faculty of the University of Zurich, Zurich, Switzerland
Eur J Neurosci 30:1-8. 2009..This review outlines major cognitive disorders known to be associated with epigenetic dysregulation, and discusses the potential of 'epigenetic medicine' as a promising cure... - Control of the establishment of aversive memory by calcineurin and Zif268Karsten Baumgärtel
Brain Research Institute, Medical Faculty of the University of Zürich and Department of Biology, Swiss Federal Institute of Technology, Winterthurerstrasse 190, 8057 Zurich, Switzerland
Nat Neurosci 11:572-8. 2008..Together, these findings reveal a previously unknown mechanism for the control of emotional memory that depends on CaN and Zif268... - Epigenetic modifications of the neuroproteomeAndrea M Brunner
Brain Research Institute, University of Zurich and Department of Biology, ETH Zurich, Zurich, Switzerland
Proteomics 12:2404-20. 2012.... - Influence of early stress on social abilities and serotonergic functions across generations in miceTamara B Franklin
Brain Research Institute, Medical Faculty of the University of Zurich, Zurich, Switzerland
PLoS ONE 6:e21842. 2011..These findings underscore the susceptibility of social behaviors and serotonergic pathways to early stress, and the persistence of their perturbation across generations... - The involvement of epigenetic defects in mental retardationTamara B Franklin
Brain Research Institute, Swiss Federal Institute of Technology, Zurich, Switzerland
Neurobiol Learn Mem 96:61-7. 2011..This review will discuss the epigenetic abnormalities associated with mental retardation, and will highlight their importance for diagnosis, treatment, and prevention of these disorders... - Inheritable effect of unpredictable maternal separation on behavioral responses in miceIsabelle C Weiss
Brain Research Institute, University of Zurich Swiss Federal Institute of Technology Zurich, Switzerland
Front Behav Neurosci 5:3. 2011..These results suggest a non-genomic mode of transmission of the impact of early stress in mice... - Epigenetic codes in cognition and behaviourJohannes Graff
Brain Research Institute, Medical Faculty of the University of Zürich and Department of Biology, Swiss Federal Institute of Technology, Winterthurerstrasse 190, Zurich, Switzerland
Behav Brain Res 192:70-87. 2008.... - Protein phosphatase 1-dependent bidirectional synaptic plasticity controls ischemic recovery in the adult brainGaël F Hédou
Brain Research Institute, Medical Faculty, University of Zurich and Department of Biology, Swiss Federal Institute of Technology, CH 8057 Zurich, Switzerland
J Neurosci 28:154-62. 2008.... - Epigenetic inheritance in mammals: evidence for the impact of adverse environmental effectsTamara B Franklin
Brain Research Institute, Medical Faculty of the University of Zürich and Department of Biology, Swiss Federal Institute of Technology, Winterthurerstrasse 190, CH 8057 Zurich, Switzerland
Neurobiol Dis 39:61-5. 2010..Environmental factors examined include exposure to toxicants, diet, and postnatal care, and DNA methylation is the main mechanism discussed in this review... - Inducible molecular switches for the study of long-term potentiationGael Hedou
Institute of Cell Biology, Swiss Federal Institute of Technology, ETH Hönggerberg CH 8093, Zurich, Switzerland
Philos Trans R Soc Lond B Biol Sci 358:797-804. 2003..Further technical developments are, however, awaited for an even higher level of finesse... - Calcineurin in memory and bidirectional plasticityIsabelle M Mansuy
Department of Biology, Swiss Federal Institute of Technology, , CH-8093, Zurich, Switzerland
Biochem Biophys Res Commun 311:1195-208. 2003..This review outlines some of CN neuronal targets and their implication in synaptic functions, and describes the role of CN in the acquisition, storage, retrieval, and extinction of memory, as well as in bidirectional plasticity... - The role of protein phosphatase-1 in the modulation of synaptic and structural plasticityRichard P Munton
Department of Biology, HPM D24, , CH-8093 Zurich, Switzerland
FEBS Lett 567:121-8. 2004..This review examines one such phosphatase, PP1, and highlights recent advances in the understanding of its intervention in synaptic and structural plasticity and the mechanisms of learning and memory... - Reversible blockade of experience-dependent plasticity by calcineurin in mouse visual cortexYupeng Yang
Department of Ophthalmology and Visual Science, Yale University School of Medicine, New Haven, Connecticut 06520, USA
Nat Neurosci 8:791-6. 2005..These results imply that the balance between protein kinases and phosphatases is critical for visual cortex plasticity... - The reinforcing effects of chronic D-amphetamine and morphine are impaired in a line of memory-deficient mice overexpressing calcineurinGrazyna Biala
INSERM U513, , , France
Eur J Neurosci 21:3089-96. 2005..The present results emphasize the essential role of hippocampal-dependent learning and memory in the development of drug addiction... - Partial inhibition of PP1 alters bidirectional synaptic plasticity in the hippocampusAnne Jouvenceau
INSERM, U549, Paris, F 75014, France
Eur J Neurosci 24:564-72. 2006.... - Proteolytic degradation of SCOP in the hippocampus contributes to activation of MAP kinase and memoryKimiko Shimizu
Department of Pharmacology, The University of Washington, Seattle, WA 98195, USA
Cell 128:1219-29. 2007..Overexpression of SCOP completely blocked memory for novel objects. We conclude that degradation of SCOP by calpain contributes to activation of MAPK during memory formation... - Abeta oligomer-mediated long-term potentiation impairment involves protein phosphatase 1-dependent mechanismsMarlen Knobloch
Division of Psychiatry Research, University of Zurich, 8008 Zurich, Switzerland
J Neurosci 27:7648-53. 2007..Overall, these results reveal that PP1 is a key player in the mechanisms of AD pathology... - Protein phosphatase 1 is a molecular constraint on learning and memoryDavid Genoux
Institute of Cell Biology, Swiss Federal Institute of Technology, Department of Biology, , , Switzerland
Nature 418:970-5. 2002..Our findings emphasize the physiological importance of PP1 as a suppressor of learning and memory, and as a potential mediator of cognitive decline during ageing...