Isabelle M Mansuy

Summary

Affiliation: University of Zurich
Country: Switzerland

Publications

  1. doi request reprint Epigenetic transmission of the impact of early stress across generations
    Tamara B Franklin
    Brain Research Institute, Medical Faculty of University of Zürich, Zurich, Switzerland
    Biol Psychiatry 68:408-15. 2010
  2. ncbi request reprint [Forgetting : theories and potential mechanisms]
    Isabelle M Mansuy
    Ecole Fédérale Polytechnique de Zurich Université de Zurich, Winterthurerstrasse 190, CH 8057 Zurich, Suisse
    Med Sci (Paris) 21:83-8. 2005
  3. ncbi request reprint Protein serine/threonine phosphatases in neuronal plasticity and disorders of learning and memory
    Isabelle M Mansuy
    Brain Research Institute, Medical Faculty of the University Zürich, Winterthurerstrasse 190, CH 8057 Zurich, Switzerland
    Trends Neurosci 29:679-86. 2006
  4. doi request reprint Protein phosphatase 1-dependent transcriptional programs for long-term memory and plasticity
    Johannes Graff
    Brain Research Institute, Medical Faculty of University Zürich and Department of Biology of Swiss Federal Institute of Technology, CH 8057 Zurich, Switzerland
    Learn Mem 17:355-63. 2010
  5. doi request reprint Protein phosphatase 1 regulates the histone code for long-term memory
    Kyoko Koshibu
    Brain Research Institute, University of Zurich, Swiss Federal Institute of Technology, CH 8057 Zurich, Switzerland
    J Neurosci 29:13079-89. 2009
  6. doi request reprint [Epigenetics and memory]
    Johannes Graff
    Brain Research Institute, University of Zurich, Zurich, Switzerland
    Biol Aujourdhui 204:131-7. 2010
  7. doi request reprint Dynamic histone marks in the hippocampus and cortex facilitate memory consolidation
    Johannes Graff
    Brain Research Institute, Medical Faculty of the University of Zurich, Zurich, Switzerland
    Nat Commun 3:991. 2012
  8. doi request reprint Changes in the proteome after neuronal zif268 overexpression
    Karsten Baumgärtel
    Brain Research Institute, Medical Faculty of the University of Zurich, Switzerland
    J Proteome Res 8:3298-316. 2009
  9. pmc Selective regulation of NR2B by protein phosphatase-1 for the control of the NMDA receptor in neuroprotection
    Mélissa Farinelli
    Brain Research Institute, University of Zurich, Zurich, Switzerland
    PLoS ONE 7:e34047. 2012
  10. pmc Identification of combinatorial patterns of post-translational modifications on individual histones in the mouse brain
    Ry Y Tweedie-Cullen
    Medical Faculty, Brain Research Institute, University of Zurich and Department of Biology, ETH Zurich, Zurich, Switzerland
    PLoS ONE 7:e36980. 2012

Collaborators

Detail Information

Publications36

  1. doi request reprint Epigenetic transmission of the impact of early stress across generations
    Tamara B Franklin
    Brain Research Institute, Medical Faculty of University of Zürich, Zurich, Switzerland
    Biol Psychiatry 68:408-15. 2010
    ..Traumatic experiences in early life are risk factors for the development of behavioral and emotional disorders. Such disorders can persist through adulthood and have often been reported to be transmitted across generations...
  2. ncbi request reprint [Forgetting : theories and potential mechanisms]
    Isabelle M Mansuy
    Ecole Fédérale Polytechnique de Zurich Université de Zurich, Winterthurerstrasse 190, CH 8057 Zurich, Suisse
    Med Sci (Paris) 21:83-8. 2005
    ..This review provides a brief account of the main features of forgetting and a summary of the most recent findings on its potential mechanisms...
  3. ncbi request reprint Protein serine/threonine phosphatases in neuronal plasticity and disorders of learning and memory
    Isabelle M Mansuy
    Brain Research Institute, Medical Faculty of the University Zürich, Winterthurerstrasse 190, CH 8057 Zurich, Switzerland
    Trends Neurosci 29:679-86. 2006
    ..Here, we review key modes of regulation of neuronal protein serine/threonine phosphatases and their contribution to disorders of learning and memory...
  4. doi request reprint Protein phosphatase 1-dependent transcriptional programs for long-term memory and plasticity
    Johannes Graff
    Brain Research Institute, Medical Faculty of University Zürich and Department of Biology of Swiss Federal Institute of Technology, CH 8057 Zurich, Switzerland
    Learn Mem 17:355-63. 2010
    ..These findings highlight an important role for PP1 in the regulation of gene transcription in LTM and synaptic plasticity in the adult brain...
  5. doi request reprint Protein phosphatase 1 regulates the histone code for long-term memory
    Kyoko Koshibu
    Brain Research Institute, University of Zurich, Swiss Federal Institute of Technology, CH 8057 Zurich, Switzerland
    J Neurosci 29:13079-89. 2009
    ..Together, these findings reveal a novel mechanism for the epigenetic control of gene transcription and long-term memory in the adult brain that depends on PP1...
  6. doi request reprint [Epigenetics and memory]
    Johannes Graff
    Brain Research Institute, University of Zurich, Zurich, Switzerland
    Biol Aujourdhui 204:131-7. 2010
    ..Their study in animal models has demonstrated their importance, and revealed some of their modes of function...
  7. doi request reprint Dynamic histone marks in the hippocampus and cortex facilitate memory consolidation
    Johannes Graff
    Brain Research Institute, Medical Faculty of the University of Zurich, Zurich, Switzerland
    Nat Commun 3:991. 2012
    ..These findings reveal the spatiotemporal dynamics of histone marks during memory consolidation, and demonstrate their inherent 'mnemonic' property...
  8. doi request reprint Changes in the proteome after neuronal zif268 overexpression
    Karsten Baumgärtel
    Brain Research Institute, Medical Faculty of the University of Zurich, Switzerland
    J Proteome Res 8:3298-316. 2009
    ..The results provide a comprehensive and quantitative data set characterizing the Zif268-dependent proteome in the adult mouse brain and offers biologically important new insight into activity-dependent pathways downstream of IEGs...
  9. pmc Selective regulation of NR2B by protein phosphatase-1 for the control of the NMDA receptor in neuroprotection
    Mélissa Farinelli
    Brain Research Institute, University of Zurich, Zurich, Switzerland
    PLoS ONE 7:e34047. 2012
    ..They provide a new target for the development of potential therapeutic treatment of neurodegeneration...
  10. pmc Identification of combinatorial patterns of post-translational modifications on individual histones in the mouse brain
    Ry Y Tweedie-Cullen
    Medical Faculty, Brain Research Institute, University of Zurich and Department of Biology, ETH Zurich, Zurich, Switzerland
    PLoS ONE 7:e36980. 2012
    ..Overall, the present data newly identify a specific histone code in the mouse brain and reveal its level of complexity, suggesting its potential relevance for higher-order brain functions...
  11. doi request reprint The prevalence of epigenetic mechanisms in the regulation of cognitive functions and behaviour
    Tamara B Franklin
    Brain Research Institute, University and ETH Zurich, Zurich, Switzerland
    Curr Opin Neurobiol 20:441-9. 2010
    ..Thus, both pharmacological and environmental interventions that act on epigenetic mechanisms provide a promising tool for the treatment of a wide variety of cognitive and behavioural disorders...
  12. doi request reprint Transgenerational epigenetic effects on brain functions
    Johannes Bohacek
    Brain Research Institute, University of Zurich Swiss Federal Institute of Technology, Zurich, Switzerland
    Biol Psychiatry 73:313-20. 2013
    ..Possible routes and mechanisms of transgenerational transmission are proposed, and the major questions and challenges raised by this emerging field of research are considered...
  13. doi request reprint Comprehensive mapping of post-translational modifications on synaptic, nuclear, and histone proteins in the adult mouse brain
    Ry Y Tweedie-Cullen
    Brain Research Institute, Medical Faculty, University of Zurich, Zurich, Switzerland
    J Proteome Res 8:4966-82. 2009
    ..Overall, our data demonstrates the complexity of PTMs in the brain and the prevalence of histone PTMs, and reveals potentially important regulatory sites on proteins involved in synaptic plasticity and brain functions...
  14. doi request reprint A simple and fast method for tissue cryohomogenization enabling multifarious molecular extraction
    Lukas M von Ziegler
    Brain Research Institute, Faculty of Medicine, University of Zurich, Zurich, Switzerland
    J Neurosci Methods 216:137-41. 2013
    ..The method may be particularly advantageous for parallel molecular extraction from brain structures with known hemispheric lateralization, such as the hippocampus, parietal cortex, suprachiasmatic nucleus, and amygdala...
  15. pmc Epigenetic inheritance of disease and disease risk
    Johannes Bohacek
    Brain Research Institute, University of Zurich ETH Zurich, Zurich, Switzerland
    Neuropsychopharmacology 38:220-36. 2013
    ..Finally, the adaptive value of epigenetic inheritance, and the cost and benefit of allowing acquired epigenetic marks to persist across generations is critically evaluated...
  16. doi request reprint Epigenetic dysregulation in cognitive disorders
    Johannes Graff
    Brain Research Institute, Medical Faculty of the University of Zurich, Zurich, Switzerland
    Eur J Neurosci 30:1-8. 2009
    ..This review outlines major cognitive disorders known to be associated with epigenetic dysregulation, and discusses the potential of 'epigenetic medicine' as a promising cure...
  17. doi request reprint Control of the establishment of aversive memory by calcineurin and Zif268
    Karsten Baumgärtel
    Brain Research Institute, Medical Faculty of the University of Zürich and Department of Biology, Swiss Federal Institute of Technology, Winterthurerstrasse 190, 8057 Zurich, Switzerland
    Nat Neurosci 11:572-8. 2008
    ..Together, these findings reveal a previously unknown mechanism for the control of emotional memory that depends on CaN and Zif268...
  18. doi request reprint Calcineurin interacts with the serotonin transporter C-terminus to modulate its plasma membrane expression and serotonin uptake
    Mathieu Seimandi
    Centre National de la Recherche Scientifique, UMR 5203, Institut de Genomique Fonctionnelle, F 34094 Montpellier, France, Institut National de la Sante et de la Recherche Medicale, U661, F 34094 Montpellier, France, Universite Montpellier 1, F 34094 Montpellier, France, Universite Montpellier 2, F 34094 Montpellier, France, and Brain Research Institute, Medical Faculty of the University of Zürich and Department of Health Science and Technology of the Swiss Federal Institute of Technology, CH 8057 Zurich, Switzerland
    J Neurosci 33:16189-99. 2013
    ....
  19. doi request reprint Epigenetic modifications of the neuroproteome
    Andrea M Brunner
    Brain Research Institute, University of Zurich and Department of Biology, ETH Zurich, Zurich, Switzerland
    Proteomics 12:2404-20. 2012
    ....
  20. pmc Inheritable effect of unpredictable maternal separation on behavioral responses in mice
    Isabelle C Weiss
    Brain Research Institute, University of Zurich Swiss Federal Institute of Technology Zurich, Switzerland
    Front Behav Neurosci 5:3. 2011
    ..These results suggest a non-genomic mode of transmission of the impact of early stress in mice...
  21. doi request reprint The involvement of epigenetic defects in mental retardation
    Tamara B Franklin
    Brain Research Institute, Swiss Federal Institute of Technology, Zurich, Switzerland
    Neurobiol Learn Mem 96:61-7. 2011
    ..This review will discuss the epigenetic abnormalities associated with mental retardation, and will highlight their importance for diagnosis, treatment, and prevention of these disorders...
  22. pmc Influence of early stress on social abilities and serotonergic functions across generations in mice
    Tamara B Franklin
    Brain Research Institute, Medical Faculty of the University of Zurich, Zurich, Switzerland
    PLoS ONE 6:e21842. 2011
    ..These findings underscore the susceptibility of social behaviors and serotonergic pathways to early stress, and the persistence of their perturbation across generations...
  23. doi request reprint A cold radial maze for long-lasting spatial memory in mice
    Sandor Vizi
    Brain Research Institute, Medical Faculty, University of Zurich and Department of Biology, Swiss Federal Institute of Technology, Zurich, Switzerland
    J Neurosci Methods 213:274-81. 2013
    ..This novel behavioral technique may prove useful in studying mouse models of memory impairment-associated human conditions...
  24. doi request reprint Neurobiological disease etiology and inheritance: an epigenetic perspective
    Bechara J Saab
    Brain Research Institute, University of Zurich ETH Zurich, Winterthurerstrasse 190, 8057 Zurich, Switzerland
    J Exp Biol 217:94-101. 2014
    ..In addition, the potential adaptive value of epigenetic inheritance, and relevant current and future questions are discussed. ..
  25. doi request reprint Epigenetic inheritance in mammals: evidence for the impact of adverse environmental effects
    Tamara B Franklin
    Brain Research Institute, Medical Faculty of the University of Zürich and Department of Biology, Swiss Federal Institute of Technology, Winterthurerstrasse 190, CH 8057 Zurich, Switzerland
    Neurobiol Dis 39:61-5. 2010
    ..Environmental factors examined include exposure to toxicants, diet, and postnatal care, and DNA methylation is the main mechanism discussed in this review...
  26. doi request reprint Epigenetic codes in cognition and behaviour
    Johannes Graff
    Brain Research Institute, Medical Faculty of the University of Zürich and Department of Biology, Swiss Federal Institute of Technology, Winterthurerstrasse 190, Zurich, Switzerland
    Behav Brain Res 192:70-87. 2008
    ....
  27. doi request reprint Protein phosphatase 1-dependent bidirectional synaptic plasticity controls ischemic recovery in the adult brain
    Gaël F Hédou
    Brain Research Institute, Medical Faculty, University of Zurich and Department of Biology, Swiss Federal Institute of Technology, CH 8057 Zurich, Switzerland
    J Neurosci 28:154-62. 2008
    ....
  28. pmc Inducible molecular switches for the study of long-term potentiation
    Gael Hedou
    Institute of Cell Biology, Swiss Federal Institute of Technology, ETH Hönggerberg CH 8093, Zurich, Switzerland
    Philos Trans R Soc Lond B Biol Sci 358:797-804. 2003
    ..Further technical developments are, however, awaited for an even higher level of finesse...
  29. ncbi request reprint Calcineurin in memory and bidirectional plasticity
    Isabelle M Mansuy
    Department of Biology, Swiss Federal Institute of Technology, ETH Hönggerberg HPM D24, CH 8093, Zurich, Switzerland
    Biochem Biophys Res Commun 311:1195-208. 2003
    ..This review outlines some of CN neuronal targets and their implication in synaptic functions, and describes the role of CN in the acquisition, storage, retrieval, and extinction of memory, as well as in bidirectional plasticity...
  30. ncbi request reprint The role of protein phosphatase-1 in the modulation of synaptic and structural plasticity
    Richard P Munton
    Department of Biology, HPM D24, ETH Honggerberg, CH 8093 Zurich, Switzerland
    FEBS Lett 567:121-8. 2004
    ..This review examines one such phosphatase, PP1, and highlights recent advances in the understanding of its intervention in synaptic and structural plasticity and the mechanisms of learning and memory...
  31. ncbi request reprint Reversible blockade of experience-dependent plasticity by calcineurin in mouse visual cortex
    Yupeng Yang
    Department of Ophthalmology and Visual Science, Yale University School of Medicine, New Haven, Connecticut 06520, USA
    Nat Neurosci 8:791-6. 2005
    ..These results imply that the balance between protein kinases and phosphatases is critical for visual cortex plasticity...
  32. pmc The reinforcing effects of chronic D-amphetamine and morphine are impaired in a line of memory-deficient mice overexpressing calcineurin
    Grazyna Biala
    INSERM U513, 8 rue du General Sarrail, 94010 Creteil Cedex, France
    Eur J Neurosci 21:3089-96. 2005
    ..The present results emphasize the essential role of hippocampal-dependent learning and memory in the development of drug addiction...
  33. ncbi request reprint Partial inhibition of PP1 alters bidirectional synaptic plasticity in the hippocampus
    Anne Jouvenceau
    INSERM, U549, Paris, F 75014, France
    Eur J Neurosci 24:564-72. 2006
    ....
  34. pmc Proteolytic degradation of SCOP in the hippocampus contributes to activation of MAP kinase and memory
    Kimiko Shimizu
    Department of Pharmacology, The University of Washington, Seattle, WA 98195, USA
    Cell 128:1219-29. 2007
    ..Overexpression of SCOP completely blocked memory for novel objects. We conclude that degradation of SCOP by calpain contributes to activation of MAPK during memory formation...
  35. ncbi request reprint Abeta oligomer-mediated long-term potentiation impairment involves protein phosphatase 1-dependent mechanisms
    Marlen Knobloch
    Division of Psychiatry Research, University of Zurich, 8008 Zurich, Switzerland
    J Neurosci 27:7648-53. 2007
    ..Overall, these results reveal that PP1 is a key player in the mechanisms of AD pathology...
  36. ncbi request reprint Protein phosphatase 1 is a molecular constraint on learning and memory
    David Genoux
    Institute of Cell Biology, Swiss Federal Institute of Technology, Department of Biology, ETH Honggerberg, CH 8093 Zurich, Switzerland
    Nature 418:970-5. 2002
    ..Our findings emphasize the physiological importance of PP1 as a suppressor of learning and memory, and as a potential mediator of cognitive decline during ageing...