Jacob G Malone
Affiliation: University of Basel
- YfiBNR mediates cyclic di-GMP dependent small colony variant formation and persistence in Pseudomonas aeruginosaJacob G Malone
Biozentrum, University of Basel, Basel, Switzerland
PLoS Pathog 6:e1000804. 2010..This study establishes YfiBNR as an important player in P. aeruginosa persistence, and implicates a central role for c-di-GMP, and by extension the SCV phenotype in chronic infections...
- Genomic and genetic analyses of diversity and plant interactions of Pseudomonas fluorescensMark W Silby
Department of Molecular Biology and Microbiology, Tufts University School of Medicine, Centre for Adaptation Genetics and Drug Resistance, Boston, MA 02111, USA
Genome Biol 10:R51. 2009..A functional genomic in vivo expression technology (IVET) screen provided insight into genes used by P. fluorescens in its natural environment and an improved understanding of the ecological significance of diversity within this species...
- The YfiBNR signal transduction mechanism reveals novel targets for the evolution of persistent Pseudomonas aeruginosa in cystic fibrosis airwaysJacob G Malone
Biozentrum of the University of Basel, Basel, Switzerland
PLoS Pathog 8:e1002760. 2012..aeruginosa during chronic lung infections. These experiments uncover an important new principle of in vivo persistence, and identify the c-di-GMP network as a valid target for novel anti-infectives directed against chronic infections...